Résumé
Objective:To explore the clinical characteristics and related socio-demographic factors of schizo-phrenia patients with different ages of onset.Methods:Totally 2 016 patients with schizophrenia aged 15 to 70 were selected according to the diagnostic criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition.All of the patients were interviewed by psychiatrists using the Mini International Neuropsy-chiatric Interview to diagnose schizophrenia,Clinical-Rated Dimensions of Psychosis Symptom Severity(CRDPSS)and the Positive and Negative Syndrome Scale(PANSS)to assess symptoms.The cut-off points were 18 and 25 years old for three age groups,i.e.early onset(EOS),youth onset(YOS)and adult onset(AOS).Statistical analy-ses were performed by analysis of variance Pearson correlation analysis,and multivariate linear regression.Results:The early-onset patients had the highest total PANSS score(73.8±28.0)and CRDPSS score(11.7±5.4).Fe-male gender,high education level,Han ethnicity,early onset age,and slower onset of illness were negatively corre-lated with the total and dimension score of PANSS scale and CRDPSS scale(standardized regression coefficient:0.04-0.47),and income level and smoking were negatively correlated with those score(standardized regression coefficient:-0.04--0.14).Conclusion:Early-onset schizophrenia patients have more severe symptoms,and fe-male,high education level,early-onset disease,and chronic onset are the risk factors of symptom severity in patients with schizophrenia.
Résumé
A method was developed for the simultaneous determination of 17 characteristic ingredients of plant extracts, including paeoniflorin, hydroxysafflor yellow A, calycosin_7_glucoside ferulic acid, etc. , in hair growth cosmetics using ultra high performance liquid chromatography ( UPLC ) . Different cosmetic samples were extracted by ultrasonic_assisted extraction with the solvent of methanol/water (4∶1, V/V) solution. After demulsified by the addition of appropriate amount of NaCl and high speed centrifugation, the supernatant was transferred and analyzed with UPLC. The separation was conducted on a Waters reversed phase column of ACQUITY UPLC CSH C18(50 mm×2. 1 mm, 1. 7μm), and the mobile phases were methanol and the solution of 0. 05% phosphate in water. The detection was performed with a photodiode_array ( PDA) detector. The linear range was 0 . 2-25 mg/L with correlation coefficients higher than 0 . 999 . The limits of detection were within 0. 3-1. 5 mg/kg, and the limits of quantification were from 1. 0 to 4. 0 mg/kg. The average recoveries of 17 characteristic ingredients were within 93 . 5%-105 . 0%, with the intra_and inter_day precision ( n=6 ) less than 4. 6%. This method was simple, rapid, with good_repeatability, and had been applied to the analysis of real samples.
Résumé
Objective:To explore the brain function asymmetry characters of the patients with major depressive disorder (MDD).Methods:The study examined the ear advantage of 58 healthy subjects, 115 patients with MDD using two kinds of rhyming words by the method of focused attention. Results:1.In healthy group, no ear advantage was found in true words test, but appeared significant right ear (left-hemisphere) advantage in pseudo-words test. 2.In MDD group, there was also no ear advantage in true words test, but appeared enhanced right ear (left-hemisphere) advantage in pseudo-words test. There was a significant difference between the MDD and healthy subjects. Among patient group, 3. by true words test, no ear advantage was found in those with a comorbid anxiety disorder, but those without comorbid anxiety appeared right ear advantage. By pseudo-word test, both patients with or without comorbid anxiety appeared right ear (left-hemisphere) advantage, and those without had larger advantage. there was a significant difference between this two groups. 4.HAMD, HAMA and SCL-90 ratings had no relation to asymmetry scores of true words or that of pseudo-words.Conclusions:1. both healthy control and MDD patients have no ear advantage for process and cognition of true words in, but as for that of pseudo-words, both of them appear right ear (left-hemisphere) advantage, with the MDD patients have greater advantage. 2.The patients with or without a comorbid anxiety disorder were different in response, patients with comorbid anxiety appear more close to normal control. 4. Asymmetry scores don’t correlate significantly with the scores of HAMD, HAMA or SCL-90. 5.The pseudo-words is the better choice as stimuli for dichotic listening test.