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Article de Chinois | WPRIM | ID: wpr-872671

RÉSUMÉ

Volatile oil of traditional Chinese medicine (VOTCM) is a plant volatile component obtained through distillation or supercritical fluid extraction. The volatile oil is rich in terpenes and phenylpropanoids, with many different effect. It is not only widely used in healthcare products, but also has a variety of pharmacological effect, such as analgesia, antioxidant, antibacterial, anti-inflammatory, anti-tumor effect. Malignant tumor is an important threat to human health. At present, the drugs commonly used in clinical treatment of tumors are expensive with certain toxic and side effect. Although new treatment technologies are also being promoted step by step, they have higher treatment costs than traditional chemotherapies, and the long-term efficacy remained to be further confirmed. The effect of volatile oil of traditional Chinese medicine(TCM) on cancer is receiving more and more attention. In particular, it has a significant inhibitory effect on lung, liver, colon, and stomach cancer. Specifically, it can not only reduce the side effect of chemotherapy drugs, but also effectively prolong or stop the tumor recurrence, with special effects in treatment and adjuvant treatment. At the same time, various anti-tumor mechanisms of volatile oils have been discovered, such as inducing tumor cell apoptosis, inhibiting tumor blood vessel formation, inhibiting tumor cell proliferation, inducing tumor cell differentiation, interfering with multidrug resistance, and regulating the body's immune function. However, there are still some problems in the basic research, achievement transformation, and product development of volatile oil of TCM, which restricts its clinical and daily application. This paper summarizes the antitumor mechanism of volatile oil of TCM by consulting relevant domestic and foreign literatures, analyzes the current situation of volatile oils, and proposes improvement directions for its problems and development, in the expectation of laying the foundation for the research of volatile oil of TCM in anti-tumor research.

2.
Article de Chinois | WPRIM | ID: wpr-801753

RÉSUMÉ

Rosmarini Officinalis Herba is a common shrubby aromatic plant, which is widely used in traditional food and folk medicine. At present, most of relevant researches focus on rosemary's essential oil, ethanol and water extract, which not only plays an important role in food preservation, preservation and condiments, but also is often used to improve acne, dandruff, circulation function, alleviate muscle pain and fatigue and treat asthma, bronchitis. It has a high application value, and a variety of other pharmacological effects. However, Rosmarini Officinalis Herba has not been included in the Chinese Pharmacopoeia, with no quality evaluation standard for its medicinal use. The products in the market may have some potential safety hazards in the use process. Therefore, the full understanding of the chemical constituents and pharmacological effects of rosemary is crucial for a comprehensive study of the properties and applications of Rosmarini Officinalis Herba. Through the collation and analysis of relevant literatures at home and abroad, it is concluded that Rosmarini Officinalis Herba has anti-cancer, anti-bacterial, anti-oxidation, anti-inflammatory, anti-depression and other pharmacological effects. The chemical constituents extracted from Rosmarini Officinalis Herba are rich in acid phenols, flavonoids, terpenoids and essential oils. Up to now, there are no systematic and comprehensive report on the chemical constituents and pharmacological effects of Rosmarini Officinalis Herba. This paper reviews the progress of the researches on the chemical constituents and pharmacological effects of Rosmarini Officinalis Herba, and discusses its application, in the expectation to lay a foundation for the future research on food development, drug research and clinical application of rosemary.

3.
Article de Chinois | WPRIM | ID: wpr-801922

RÉSUMÉ

Leukemia is a hematopoietic hyperplastic disease with an increasing incidence year by year, involving bone marrow and lymphatic system. The disease is complex and a highly heterogeneous disease, including a variety of subtypes, with difficulties in treatment and a poor prognosis. Currently, retinoic acid and its derivatives, arsenic are commonly used in clinical treatment as leukemia cell differentiation inducers. However, their clinical range of treatment is mostly restricted to granulocytic leukemia, with a high price and certain toxic and side effects. With the development of molecular genetics, molecular biology, second-generation sequencing and other technologies, the etiology and pathology of leukemia has been significantly studied, but the specific pathogenesis of leukemia has still been unclear. With the further promotion of molecular targeted drugs, chimeric antigen receptor T-cell immunotherapy (CAR-T) and hematopoietic stem cell transplantation, although the treatment of leukemia has entered a new field, compared with traditional chemotherapy, these therapies have high costs, and the long-term efficacy is yet to be further confirmed. After years of basic research and clinical research, traditional Chinese medicine(TCM) volatile oil in the treatment of leukemia has made remarkable achievements. Essential oil can alleviate the toxic and side effect of chemotherapy drugs, effectively prolong or prevent the relapse of leukemia, inhibit the proliferation of leukemia cells, and promote the apoptosis of leukemia cells. In this paper, the authors reviewed relevant domestic and foreign literatures by literature tracking method, summarized the anti-leukemia mechanism of essential oil of TCM, analyzed the characteristics and existing problems of essential oil of TCM, and proposed the improvement direction, in order to provide reference for accelerating the research and development and innovation of essential oil in the treatment of leukemia.

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