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Indian J Exp Biol ; 2007 Nov; 45(11): 974-9
Article de Anglais | IMSEAR | ID: sea-62631

RÉSUMÉ

The aqueous extract of C. borivilianum (250 mg/kg for 7 days) significantly reverted the elevated levels of plasma glucose, triglycerides, cholesterol and serum corticosterone and also reduced the ulcer index, adrenal gland weight more as effectively as the standard drug (diazepam) in rats. At 125 mg/kg po, it showed a mild anti-stress activity. Under in vitro 1,1-diphenyl-2-picrylhydrazyl (DPPH*) free radical scavenging assay and lipid peroxidation assay the extract considerably inhibited, in a dose-dependent manner, the levels of DPPH* free radicals and thiobarbituric acid reactive substances, respectively thus showing significant antioxidant property. The results suggested that it could be used for the treatment of oxidative stress-induced disorders.


Sujet(s)
Glandes surrénales/effets des médicaments et des substances chimiques , Asparagaceae/composition chimique , Animaux , Antioxydants/isolement et purification , Dérivés du biphényle/composition chimique , Piégeurs de radicaux libres/isolement et purification , Hydrazines/composition chimique , Peroxydation lipidique/effets des médicaments et des substances chimiques , Mâle , Taille d'organe/effets des médicaments et des substances chimiques , Ulcère peptique/étiologie , Extraits de plantes/isolement et purification , Racines de plante/composition chimique , Poudres , Rats , Rat Wistar , Contention physique , Stress psychologique/sang
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