Research progress of vascular endothelial growth factor in the mechanism of blood-retinal barrier damage by diabetic retinopathy / 国际眼科杂志(Guoji Yanke Zazhi)

Diabetic retinopathy(DR)is one of the common causes of visual impairment and blindness in adults, which is caused by various pathogenesis. Although the mechanism of DR has not been elucidated yet, the destruction of blood-retinal barrier is a key process. As a highly endothelial-specific factor in promoting the growth of vascular endothelial cell, vascular endothelial growth factor(VEGF)plays a crucial role in the formation of pathological retinal neovascularization and the destruction of blood-retinal barrier. Therefore, a comprehensive understanding of the etiology and pathogenesis of blood-retinal barrier damage promoted by VEGF is critical for exploring the pathogenesis of DR. In this study, the underlying relationship between VEGF and the mechanism of blood-retinal barrier damage, including retinal vascular endothelial cell permeability, vascular inflammatory response, apoptosis, oxidative stress, mitochondrial damage and endoplasmic reticulum stress, with a view to providing a reference for the study in VEGF in the pathogenesis of blood-retinal barrier damage in DR.

Brief review of the cultivation and utilization of rat resources / 中国实验动物学报

Rat is one of representative laboratory animals since the genetic and the environment is comparatively easy to control.Laboratory rats are widely used in the area of physiology,neuroethology,pathology and toxicology due to the approximately ten times larger body size compared to mouse,offering several unique advantages in surgical procedures and clinical sampling of blood,tissues,etc.This paper reviews the cultivation and utilization history of the laboratory rat resources abroad such as strain breeding,preservation and database establishment to provide references for collecting,sharing and utilizing laboratory rat resources in our country.

AUTORADIOGRAPHIC OBSERVATION OF GOSSYPOL EFFECT ON REABSORPTION AND EXCRETION OF ~(42)KCL IN THE RENAL TUBULES / 解剖学报

The present study was designed to investigate the effect of gossypol on the reabsorption and excretion of ~(42)K in rats and guinea pigs by using autoradiographic technique, and selected the well known tubulo-toxic agent, gentamicin as a positive control for a comparative study to evaluate whether gossypol exerts nephrotoxic effect. Our results confirmed that gentamicin could induce significant decrease or inhibit ~(42)K reabsorption and cause structural damage of renal tubules. Gossypol could also affect the reabsorption function of proximal tubule, but did not appear to act as a tubulotoxic agent comparable with gentamicin to cause injury of the renal tubules.