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1.
Article de Chinois | WPRIM | ID: wpr-1019979

RÉSUMÉ

H 1-antihistamines are widely used in the treatment of various allergic diseases, but there are still many challenges in the safe and rational use of H 1-antihistamines in pediatrics, and there is a lack of guidance on the prescription review of H 1-antihistamines for children.In this paper, suggestions are put forward from the indications, dosage, route of administration, pathophysiological characteristics of children with individual difference and drug interactions, so as to provide reference for clinicians and pharmacists.

2.
Article de Chinois | WPRIM | ID: wpr-1019980

RÉSUMÉ

Anti-seizure medications (ASMs) are the main therapy for epilepsy.There are many kinds of ASMs with complex mechanism of action, so it is difficult for pharmacists to examine prescriptions.This paper put forward some suggestions on the indications, dosage forms/routes of administration, appropriateness of usage and dosage, combined medication and drug interaction, long-term prescription review, individual differences in pathophysiology of children, and drug selection when complicated with common epilepsy, for the reference of doctors and pharmacists.

3.
China Pharmacy ; (12): 1298-1301, 2023.
Article de Chinois | WPRIM | ID: wpr-974674

RÉSUMÉ

OBJECTIVE To construct the drug clinical comprehensive evaluation index system and quantitative grading in China, and to provide a reference for scientifically carrying out comprehensive clinical evaluation of drugs. METHODS The analytic hierarchy model was used to establish the drug clinical comprehensive evaluation index system, the weight of the evaluation index and the quantitative grading of each index were determined through expert consultation and model calculation. RESULTS The results of expert consultation were integrated by using the analytic hierarchy model, and the drug clinical comprehensive evaluation index system was obtained: including six first-level indicators of effectiveness, safety, economy, suitability, accessibility and innovation, as well as twenty-three second-level indicators of recommended status, medication for special populations, and drug treatment costs; the weight of each indicator was calculated through estimation-matrix method. CONCLUSIONS The analytic hierarchy model can construct the drug clinical comprehensive evaluation index system and quantitative grading in China, which can provide methodological references for comprehensive analysis and decision-making, thus making the clinical comprehensive evaluation of drugs completer and more scientific.

4.
China Pharmacy ; (12): 275-279, 2023.
Article de Chinois | WPRIM | ID: wpr-961657

RÉSUMÉ

At present, there are still some problems in China’s clinical comprehensive drug evaluation, such as the unscientific design of the evaluation content, the nonstandard evaluation method and organizational process, and the evaluation results not meeting the decision-making needs. It is urgent to carry out quality control over the whole process of the clinical comprehensive drug evaluation project. From the technical point of view, the quality control methods of clinical comprehensive drug evaluation are discussed through three links of the evaluation content and design (giving the quality control key points of the theme selection process and scheme design), the evaluation method (discussing the quality control elements of two common evaluation methods, i. e. documentary evidence method and real-world research) and result application transformation (giving suggestions on quality control from the comprehensive analysis of evaluation results, transformation of evaluation results and decision-making), so as to promote the quality improvement of clinical comprehensive drug evaluation.

5.
Article de Chinois | WPRIM | ID: wpr-474967

RÉSUMÉ

This article discussed characteristics of current off-label drug use in China and other countries,and analyzed the current administration and future development,making valuable reference for off-label drug use.

6.
Acta Pharmaceutica Sinica ; (12): 1330-5, 2015.
Article de Chinois | WPRIM | ID: wpr-505054

RÉSUMÉ

The study aims to develop an LC-MS/MS method for the simultaneous determination of amygdalin and paeoniflorin in urine samples, and to investigate their urinary excretion characteristics in healthy volunteers after intravenous infusion administration of Huoxue-Tongluo lyophilized powder for injection (HTLPI). The urine samples were extracted by methanol, and then separated on a Hedera ODS-2 column with a mobile phase of acetonitrile and 5 mmol · L(-1) ammonium acetate buffer solution containing 0.05% formic acid (20:80). Electrospray ionization source was applied and operated in the positive ion mode using MRM. The method exhibited good linearity over the concentration range of 0.03 -40 µg · mL(-1). The values on both the occasions (intra- and inter-day) were all within 15% at three concentration levels. No matrix effect and carry-over effect were observed. Amygdalin and paeoniflorin were stable in human urine under different storage conditions. Approximately 79.6% of the administered amount of amygdalin was excreted unchanged in urine within 24 h and which was 48.4% for paeoniflorin. The developed LC-MS/MS method can be applied to evaluate the urinary excretion of amygdalin and paeoniflorin.

7.
China Pharmacy ; (12)2007.
Article de Chinois | WPRIM | ID: wpr-529628

RÉSUMÉ

OBJECTIVE:To ensure a long-term medication in children with asthma,prevent the attack of asthma and ensure safe,effective and correct drug use in these patients.METHODS:The pharmaceutical care for the asthma children was carried out through pharmacists’ involvement in assisting doctors to establish the treatment plan,carrying out medicine-use education and drug use consultation for patients,setting up the medicine-use record and so on.RESULTS & CONCLUSION:The practice of pharmaceutical care can markedly improve the compliance,safety and efficacy of drug use in asthma children as well as improving their quality of life.

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