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Background: Tumor budding refers to single or small cluster of tumor cells detached from the main tumor mass in histological sections. In colon cancer high tumor budding is associated with worse prognosis and correlates with metastatic lymph nodes. We studied tumor budding in modified radical mastectomy specimens to evaluate its utility as a prognostic factor by correlating high tumor budding score with known prognostic markers of breast cancer like axillary lymph nodal metastasis, clinical staging, tumor size, lymphovascular invasion, hormonal status and pathological grading. Aim was to evaluate tumor budding in invasive breast carcinoma and to describe clinical features and histopathological spectrum of Invasive Breast Carcinoma with/without lymph node metastasis on H&E slides. Secondly, to find association between grades of tumor budding and various clinical, gross, microscopic and immunohistochemical variables. Methods: The present study is a cross sectional study of 70 modified radical mastectomy specimens from June 2018 to Dec 2022. Along with tumor budding various prognostic parameters like hormonal markers, pathological grading and clinical grading were evaluated. Immunohistochemical marker Pancytokeratin was utilized for counting the tumor buds, wherever necessary. Statistical Analysis: Chi Square test was utilized to study significant differences between variables, p<0.05 was considered statistically significant. Results: A high tumor budding score (?4/HPF) had significant association with axillary lymph node involvement and clinical staging. Conclusions: In our study we detected the association of high tumor budding, PTB in invasive breast carcinoma with axillary lymph node involvement and clinical staging. Hence our results highlight the importance of tumor budding as a prognostic factor and submit that this histological feature could be included in diagnostic protocols just as in carcinoma of the colon.
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The phytoconstituents of the plant are directly or indirectly linked to the medicinal and advantageous qualities of the genus and are essential to the plant's self-defense against a variety of biotic and abiotic challenges. Plant genera have been divided into subcategories depending on the presence of these compounds, such as medicinal, anti-inflammatory, anti-stomachic, anti-cancer, and anti-diarrhoeal. The Convolvulaceae family, which includes the genus Distimake formerly known as Merremia, is known for having high alkaloid content. The present investigation is centered on the identification and assessment of bioactive compounds from two distinct species in this genus—Merremia aegyptia and Merremia dissecta—using GC-MS analysis. Distimake aegyptius (L.) A.R. Simoes and Staples and Distimake dissectus (Jacq.) A.R. Simoes and Staples are the new names for these species. The highest peak area percentage was reported for 1,2,4 butane triol (26.84%)in D. aegyptius stem sample, 1,2- benzene dicarboxylic acid, dibutyl ester (48.17%) from D. aegyptius seed sample, 1,3,4,5-tetrahydroxy cyclohexane carboxylic acid (Quinic Acid) (20.35%) in D. dissectus stem sample and (3?)-Ergost-5-en-3-ol (Campesterol) (18.19%), stigmasta-5,22-dien-3-ol (19.23%), and gamma sitosterol (24.56%) in the D. dissectus seed sample making it a good source of phytosterols. These phytosterols possess antioxidant, anti-cancerous, anti-inflammatory, anti-hypercholesterolemic, and antidiabetic properties. GC-MS results revealed that some common phytochemicals were found in both the Merremia specie
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Background: Acute respiratory distress syndrome (ARDS) is a common reason for respiratory failure in critically unwell patients. Noncardiogenic pulmonary edoema that develops suddenly, acute hypoxemia, and the need for mechanical ventilation are its defining features. This study's major objective was to examine the likelihood of cor-pulmonale in ARDS patients receiving protective ventilation, as well as its prognosis over the long term. Methods: S. C. B. medical college in Odisha, India served as the setting for this prospective observational study. 100 consecutive patients with moderate to severe ARDS were included in the trial in accordance with the Indian criterion. With an average PEEP of 91 cm H2O and a plateau pressure cap of 31 cm H2O, these patients were ventilated. Results: There were 100 patients altogether, 63 males and 37 females, with a mean age of 59-19 years. The interval between the diagnosis of ARDS and TEE was typically 0.75-0.97 days. There were 100 cases of cor pulmonale, which was shown to be common (21.09%). Lung injury occurred more frequently in patients with cor pulmonale compared to other patients when an infectious cause was involved [37 (79.06%) vs. 67 (57.61%)]. Conclusions: The incidence of cor pulmonale in ARDS patients undergoing ventilation with restricted airway pressure is an interesting finding. In our investigation, it showed up as an independent risk factor for 28-day mortality and was linked to sepsis and high driving pressure readings.
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Chickpea is the most dominant pulse having a major share under area shown 65 per cent and production 72 per cent followed by lentil and field pea. Pulse beetle, Callosobruchus chinensis L. is a primary pest of stored chickpea which causes 50-60 per cent loss in seed weight and 45.5-66.3 per cent loss in protein content of the seeds (Rustamani et al., 1985) and injudicious and indiscriminate use of hazardous synthetic chemicals for preventing storage losses in chickpea may lead to human and animal health issues due to residual hazards. Therefore, the biorational management of the pulse beetle in stored chickpea has been undertaken keeping biology in mind will prevent the loss as well as protect human health hazard.The experiments on non-chemical biorational approaches like effect of desiccant beadswhich control the pulse beetle efficiently but have lesser toxicity hazards to non-target organisms and the environment was studied in the Department of Entomology, College of Agriculture, OUAT, BBSR, Odisha during 2018-2021.The results showed that desiccant beads viz., zeolite and sodium aluminium silicate impregnated with chickpea seeds in the ratio of 1:1 proved effective in suppression of the pulse beetle in chickpeaduring six months of storage.
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Wheat (Triticum aestivum L.) belonging to family “Gramineae” and genus “Triticum”, is one of the world’s most widely cultivated food grain crop, due to its wider adaptability to different agro-climatic and soil conditions. Karnal bunt (Tilletia indica) is an important wheat disease with implications for wheat grain quality and inflicts changes in chemical composition of infected grains. IDM modules evaluated under pot and field condition revealed that all the thirteen modules were significantly effective and observed lower disease incidence of karnal bunt. Module M11 andM8 recorded nil (0.00%) disease incidence in both condition. The maximum incidence was recorded (0.425%) and (0.81%) in M12 followed by M5 (0.395%) and (0.68%) whereas minimum incidence was observed in M9 (0.002%) and (0.05%) under pot and field respectively. However, in the field maximum yield (44.65 q/ha) and test weight (36.04 g) was recorded in module M11, followed by (44.30q/ha) and (35.91g) in M8, while, minimum yield (40.35q/ha) and test weight (35.30g) was observed in M12.
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Rhinosporidiosis is a chronic granulomatous disease caused by Rhinosporidium seeberi commonly affecting nasal mucosa, conjunctiva, and urethra. Subcutaneous tumor nodule presentation is rare and often mimics as sarcoma. Such tumoral rhinosporidiosis has been reported rarely. This report describes a 60-year male who presented with a solitary, firm, nontender swelling in posterior aspect of right leg with an ulcer and mimicking clinically as soft tissue sarcoma. Histopathology was diagnostic. Surgical excision was found to be useful.
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Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Extensive rhabdoid morphology in ACC has been described recently in very few cases. The proportion of rhabdoid morphology and the role of SMARCB1/ INI1 expression in these tumor cells to diagnose the specific variant is not described in the literature. We reviewed the clinicopathological features of nine cases of adrenocortical neoplasm. Out of which, three cases of ACC showed predominant rhabdoid morphology. Large discohesive cells with abundant cytoplasm containing eosinophilic inclusions, eccentric vesicular nucleus, and prominent nucleoli. INI1 immunostain was retained in all cases. We reported the rhabdoid variant of ACC, a novel entity, and its diagnostic approach from their histological mimickers. Identifying more cases of this entity will help to clearly understand the pathogenesis, biologic behaviour, and any specific molecular alterations in the future.
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Background: Urban Primary Health Centres (UPHC)are different from conventional rural PHCs in term of size, functions, focus on ambulatory care, limited staff and infrastructure. UPHC is also expected to deliver certain job-functions of Subcentre through its outreach services. In view of these considerations, it is, therefore, appropriate that a separate list of standards is developed. Methods: This was a cross-sectional study conducted on 320 Recently delivered women (up to 24 months) and children less than 24 months of age residing in catchment areas of urban PHCs and 8 urban primary health centers of Lucknow district, using multistage sampling technique. Results: The infrastructural availability at urban PHCs showed that clean drinking water for patients was available at only 75 % of U-PHCs. Unfortunately, only 50 % of the labs were functional. Additionally, essential tests for ANC were available at only 50 % of U-PHCs. Majority (48.7%) of RDW were not aware of U-PHCs nearby. Most (26.7%) common reason cited for non-utilization of U-PHCs was the availability of better hospital/ bigger hospitals nearby. According to 8.7 %, doctors/staff are not available all time at U-PHCs. About 12.8 % of RDW also reported that the delivery facility was not available. According to 18.0 % RDW, several other reasons were unavailability of drugs, inadequate cleanness, distance, staff behaviour, etc. Conclusions: Only four (50%) labs were functional at UPHC. The main reason of non-utilization of urban primary health centers not aware about location of U-PHC nearby and bigger hospitals nearby, investigations not available, several other reasons were unavailability of drugs, inadequate cleanness, distance, staff behaviour
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Primary pericardial neoplasms account for 6.7–12.8% of all primary tumors arising in the cardiac region. Pericardial tumors are most likely to be metastatic and are an extension of the primary tumors from the surrounding structures. Sarcomas of the pericardium are rare. Myxoid liposarcoma (ML) represents about 5% of all the soft-tissue sarcomas in adults. They are usually located in the deep soft tissues of the extremities. There have been less than 20 cases of pericardial liposarcomas reported on PubMed since 1973. Here, we present a rare case of primary giant pericardial myxoid liposarcoma (ML) in a 46-year-old female diagnosed on frozen section and later was confirmed histopathologically.
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Background: Due to rapid urbanization, there is an increase in population in slums often lacking access to basic health services. Objective: The purpose of this study was to assess the utilization of reproductive and child health services by recently delivered women and their children residing in catchment areas of urban PHCs, to evaluate their level of satisfaction and to determine the factors associated with utilization of these services by recently delivered women. Settings and Design: The study was conducted in the catchment areas of urban primary health centre of Lucknow. Methods and Material: A cross-sectional study was conducted among 320 women having children less than 24 months in the slums covered under selected U-PHCs, sampled through a multi-stage random sampling technique using a semi-structured questionnaire. Statistical analysis used: SPSS-26 and MedCalc software were used for data analysis. Results: Utilization of RCH services by recently delivered women from UPHC was 39%. About 24% of recently delivered women availed ANC services from UPHC and 56.7% utilized family planning services and 95.8% immunization services for children. Child care services for diarrhea and ARI were availed by 9.9 and 3.1% of women, respectively. Satisfaction regarding maternal care and immunization services was seen in 84 and 95.8% of women. Poor satisfaction regarding child care was seen in 56.5% of women. Conclusions: The utilization of RCH services was found to be poor in the study population. Most recently delivered women were satisfied with all services except child care.
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Ovarian Sertoli Leydig cell tumors (SLCT) accounts for less than 0.5% of all ovarian malignancies. The incidence of primary extra-ovarian SLCT is extremely rare with reported cases occurring in young adult women till now. We report case of primary retroperitoneal extra-ovarian SLCT in a seven-year girl child without any hormonal manifestation. She presented with complaint of left side abdominal swelling associated with intermittent pain for a duration of six months. CT scan revealed a huge retroperitoneal space-occupying lesion abutting the dorsal vertebrae and present posterior to pancreas, spleen and left kidney. The tumor was diagnosed as extraovarian Sertoli Leydig cell tumor with intermediate differentiation on histopathology and immunohistochemistry.
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Objectives: Military flying is a complex task and requires high level of physical fitness of aviators. Various aviation stressors such as acceleratory force, hypoxia, cold weather conditions and decompression sickness place enormous stress on human physiological systems of the aviators. Individuals with Hb <13 g/dL (males) are being placed in the lower medical category which makes them unfit to fly. The present study was undertaken to assess the implication of low haemoglobin (Hb) on exercise capacity and hypoxia tolerance. Materials and Methods: Twenty-five individuals with anaemia and 15 healthy controls participated in the study. The participants were subjected to normobaric hypoxia (NH) equivalent to an altitude of 15,000 feet. Different physiological parameters such as heart rate (HR), systolic and diastolic blood pressure (SBP and DBP), respiratory rate (fR) and arterial oxygen saturation (SpO2) were measured during NH. Participants also performed maximal aerobic capacity (V?O2 max) and maximal anaerobic capacity test in bicycle ergometer. Results: HR, SBP, DBP and fR in anaemic subjects were higher than healthy controls during NH, whereas SpO2 in anaemic subjects was lower as compared to healthy controls. Anaemic individuals had a lower VO2 max than their healthy counterparts. Critical power and anaerobic work capacity were lower in anaemic subjects than healthy controls. Conclusion: There is a deterioration in exercise capacity and hypoxia tolerance in individuals with low Hb levels. Adequate precaution should be exercised for permitting military aviators to fly with low Hb level.
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Background: Aging is a universal and inevitable process of life. Elderly people are the most vulnerable group in terms of their health. In India geriatric-aged population is increasing day by day. Understanding the morbidities and health-seeking behavior of the elderly is essential for strengthening geriatric health-care services delivery. Objectives: The objectives of the study were (1) to assess the morbidity pattern in elderly people and (2) to know the health-seeking behavior of the aged population. Materials and Methods: This community-based, cross-sectional, and descriptive study was conducted among 160 elderly individuals over a period of 3 months from February 2019 to April 2019. Participants were interviewed and clinically examined for the assessment of sociodemographic detail, morbidity profile, and health-seeking behavior. Results: Of 160 study subjects, 71 were males and 89 were females. The majority (61.3%) of the elderly were in the age group of 60–69 years. Overall the prevalence of morbidity was high, i.e., 76.9%. The most common illness was a nonspecific generalized weakness (48.1%) and gastrointestinal problems (44.4%). Majority of them (65.4%) have faith in allopathic medicines and used government facilities. Of the total morbid elderly, 15.5% of them could not get medical advice. Conclusions: High prevalence of morbidity among elderly population stresses the need to provide suitable health facilities and affordable health care to the elderly. Non-specific generalized weakness was one of the most important problems in this age group. Further research is to be done to know the cause of this weakness. Policymakers must focus on rural elderly and their beliefs which prevent them from seeking healthcare.
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The present study was conducted in the Department of Animal Reproduction Gynaecology and Obstetrics, College of Veterinary Science and Animal Husbandry, OUAT, BBSR in collaboration with ICAR-Central Island Agricultural Research Institute, Portblair (Andaman and Nicobar Island). Crossbred cattle with the history of anoestrus and repeat breeding were considered for the present investigation. The basic difference in serum biochemical and mineral profiles of cattle reared under two quite different ecosystems namely Island and coastal ecosystem was estimated which might be due to the variability in rainfall, ambient temperature, day light length and humidity. The incidence of different infertility conditions in both the ecosystems also might vary as per the environment. Serum samples were collected for estimations of biochemical parameters like total protein, glucose, cholesterol, Ca, P and Ca:P ratio. The overall incidence of infertility was recorded to be 47.62 % in island and 45.90 % in coastal ecosystem. No significant difference in serum levels of total protein, glucose, cholesterol, zinc, copper and manganese could be observed in between cattle reared in both ecosystems. It was concluded that the variations in humidity, ambient temperature, rain fall and day light length between Portblair, Andaman and coastal climate of Odisha, did not have much effect on reproduction of cattle
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In India, white revolution was started during 1970’s with Operation flood programme. After this revolution, production of milk in India had tremendously increased. Contribution of diary sector has continuously increased in Indian Gross Domestic Product (GDP). Livestock sector has emerged as an essential growth driver of the Indian wealth. This study is associated with time series data of five major milk producing states in 2017-18 in India. The milk production projection has been made using Auto Regressive Integrated Moving average model (ARIMA) for year 2024-25. From the forecasted figures, Uttar Pradesh would be leading states of India in milk production with 37.68 MMT in year 2024-25. Whole India milk production would reach 252.948 MMT in year 2024-25. This projection helps in formulating national agricultural policy as well as proper planning for products into dairy sector
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@#Introduction: An increased tibial tuberosity-trochlear groove (TTTG) distance is used for deciding a treatment plan in patello-femoral instability (PFI). The centre of the patellar tendon and the chondral trochlear groove can be directly visualised on MRI, and measured, giving the patellar tendontrochlear groove (PTTG) distance. A study was designed to compare the inter-rater and the test-retest reliabilities of PTTG and TTTG measurements in MRI of patients without PFI and in a group with PFI. Materials and Methods:This cross-sectional reliability study was done on archival MRI films of 50 patients without patellar instability and 20 patients with patellar instability. TTTG and PTTG distances were independently measured by two orthopaedic surgeons and two radiologists. A hybrid PTTG measurement with bony landmarks on the femoral side and the patellar tendon landmark on the tibial side, was used to estimate the influence of the differences in the femoral and tibial landmarks on the difference in reliabilities. The intra-class correlation coefficient (ICC) was calculated for all four raters, as well as separately for each rater. Results: The PTTG distance had a higher inter-rater reliability (ICC=0.86, 95% CI=0.79-0.92) compared to the TTTG distance (ICC=0.70, 95% CI=0.59-0.80) in patients without PFI. Similar trends were seen in patients with PFI (0.83 vs 0.66). The inter-rater reliability for the hybrid PTTG distance was found to lie in between the TTTG and PTTG. Conclusions:The MRI-based PTTG distance had better inter-rater reliability compared with the MRI-based TTTG distance.
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Background: Corneal blindness is one of the major causes of blindness and vision can be successfully restored by corneal transplantation. Eye donation can improve the availability of cornea, but it depends on awareness and willingness in general population. Objectives: The objectives of this study were to assess the awareness and willingness of urban population of western UP about eye donation and to correlate factors with willingness. Materials and Methods: A cross-sectional study was conducted among randomly selected 400 residents >30 years of age of urban field practice area of the Department of Community Medicine, TMMC and RC, Moradabad. Pre-tested structured questionnaire was used to obtain information about the awareness and perception regarding eye donation. Results: Of 400 participants, 75% were aware about eye donation and 25% were ignorant; print and electronic media were the most common source of information. 51.6 % knew about the time limit of eye donation. 63.5% were willing for eye donation; willingness for eye donation was significantly higher in younger age group, males, and well-educated participants. Conclusion: Our study establishes the need to improve the awareness of eye donation in the study population. The most idealist public health approach would be, to reduce the occurrence of vision loss due to corneal diseases, with effective preventive policies, but as a short-term goal, the key way to deal with corneal blindness is to obtain the required number of corneas for transplantation.
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Background: Bio-medical waste is perilous and can be a health hazard. There is considerable role of medical undergraduates, interns and post-graduates in preventing hazardous consequences from mishandling of bio-medical waste. Aims & Objectives: To assess the knowledge, attitude and practice about Bio-medical waste management among medical undergraduates, interns and post-graduate students. Methodology: A cross-sectional study was carried out among 75 participants including MBBS students, interns and post-graduate students (25 from each group) at King George’s Medical University, Lucknow through purposive sampling technique over a period of one month. A structured self-administered questionnaire was used for data collection. Data were analyzed using Chi-square, Fischer-exact, one-way ANOVA and Post Hoc (Tukey) Tests. Results: MBBS students had more knowledge and the better attitude towards BMW management guidelines as compared to interns and post-graduates(p<0.001), while post-graduate students were more aware of the needle-stick injury and were correctly practicing BMW management as compared to MBBS students and interns(p<0.001). Conclusions: Knowledge, attitude and practice regarding BMW management is still inadequate among MBBS students, interns and post-graduates, so repeated training-retraining and supportive supervision regarding the same should be foster. Strict regulations and surprise perusals might be a strong impetus for medical students and other health personnel.
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Hepatosplenic T-cell lymphoma (HSTCL) is a rare extranodal T-cell lymphoma that shows preferential sinusoidal infiltration of spleen and liver. It usually shows bright expression of surface CD3 (sCD3) with restriction for γδ-T cell receptors (TCR). We present a case of a 34-year-old male who presented with hepatosplenomegaly and B symptoms. His peripheral blood and bone marrow (BM) was involved by atypical lymphoid cells that were CD2+, CD7+, CD56+, cytoplasmic CD3+, and sCD3− on immunophenotyping by flow cytometry. As sCD3 is a lineage marker for T-cell lymphomas, the loss of sCD3 posed a diagnostic dilemma. However, typical pattern of sinusoidal BM and liver involvement by CD3+ cells and TCR gene rearrangement positivity led to final diagnosis of HSTCL. The differential diagnosis, workup, and clinical course of the case are discussed. To the best of our knowledge, only one case of de novo HSTCL with negative sCD3 has been reported before in the literature.