Epidemiology of spatiotemporal distribution of respiratory bacterial infections in Sanmenxia City in 2012 - 2022 / 公共卫生与预防医学

Objective To analyze the spatiotemporal distribution characteristics of respiratory bacterial infections in Sanmenxia City from 2012 to 2022, and explore key areas for respiratory infection prevention and control. Methods Respiratory bacterial infection cases admitted to our hospital from 2012 to 2022 was collected, use OpenGeoDal software for spatial autocorrelation analysis, and SaTScan software for spatiotemporal scanning analysis. Results From 2012 to 2022, 8762 cases of respiratory bacterial infection were reported in Sanmenxia , with an average annual incidence of 173.47/100 000 and a standardized incidence of 132.63/100 000，and the overall incidence showed a downward trend (χ2=48.093，P“high- high” gathering area, which is a key region to prevention and control.

Risk factors for acute ischemic stroke in patients with lung cancer / 国际脑血管病杂志

Objective:To investigate the risk factors of acute ischemic stroke in patients with lung cancer.Methods:Patients with lung cancer admitted to Beijing Friendship Hospital, Capital Medical University from July 2019 to August 2021 were retrospectively included. The demographics and baseline clinical data of the patients were collected. According to whether acute ischemic stroke had occurred, the patients were divided into a case group and a control group.Results:According to the propensity matching score method, 26 patients with lung cancer were included in the case group and 104 in the control group. There were significant differences in age, tumor staging, metastasis and treatment of lung cancer, hypertension, diabetes, hyperlipidemia, atrial fibrillation, alcohol consumption, diastolic blood pressure, systolic blood pressure, hemoglobin, triglyceride and squamous cell carcinoma associated antigen (SCC) between the two groups (all P<0.05). Multivariate logistic regression analysis showed that older individuals (odds ratio [ OR] 1.087, 95% confidence interval [ CI] 1.063-1.211; P=0.007), lung cancer treatment ( OR 1.698, 95% CI 1.139-2.532; P=0.009), hypertension ( OR 5.647, 95% CI 1.921-16.597; P=0.002), diabetes ( OR 3.082, 95% CI 1.020-9.311; P=0.046), hyperlipidemia ( OR 5.163, 95% CI 1.020-9.311; P=0.002), atrial fibrillation ( OR 5.105, 95% CI 1.852-14.39; P=0.006), alcohol consumption ( OR 0.30, 95% CI 0.123-0.733; P=0.008), diastolic blood pressure ( OR 1.032, 95% CI 0.123-0.733; P=0.022), systolic blood pressure ( OR 1.032, 95% CI 1.003-1.061; P=0.031), hemoglobin ( OR 1.358, 95% CI 0.985-1.871; P=0.042), and SCC ( OR 1.535, 95% CI 1.069-2.204; P=0.02) were the independent risk factors for acute ischemic stroke in patients with lung cancer. Conclusions:Lung cancer related ischemic stroke is more common in elderly patients, and such patients have higher levels of hemoglobin, triglycerides, and SCC. Age, lung cancer treatment, common vascular risk factors, hemoglobin, and SCC are the potential risk factors for acute ischemic stroke in patients with lung cancer.

A Real-time Reconstruction Method of CBCT Short Scan Based on Attenuation Compensation / 中国医疗器械杂志

Aiming at the problem of timeliness of CBCT reconstruction, a CBCT fast short scan reconstruction method is proposed. At the same time, the image reconstruction process in which a new attenuation compensation algorithm is applied to improve image quality. When performing FDK three-dimensional reconstruction of a single-frame acquisition image, the Parker-weighted image is calculated in real time, and a new attenuation compensation algorithm is applied in the back projection process to complete the short scan Parker-weighted reconstruction. This method simulates the CBCT synchronous acquisition and reconstruction process by establishing collection and reconstruction threads. Under the premise of satisfying the reconstruction quality, the reconstruction can be completed within 1 to 2 seconds after the patient collection is completed, which achieves the purpose of real-time.

Initial practice on quality control tests and action limits setting of birdcage head coils / 中国医学影像技术

Objective To establish clinical quality control method with testing the birdcage head coils and setting up the action limits.Methods Three different MR devices (GE 1.5T HDi,GE 3.0T HD and GE 3.0T 750W) and corresponding birdcage coils were tested.Axial T1WI was performed to scan ACR phantom.SNR,percent image uniformity (PIU) and percent signal ghosting (PSG) were measured for six times,and the mean values and standard deviations (SD) were calculated.Based on the results,the action limits for each parameter were set.Results The mean value of SNR for the three devices was 262.14,280.47 and 474.24,and SD was 18.43,29.67 and 29.95,respectively;the action limits were ≥225.28,≥221.13 and ≥414.34,respectively;the mean value of PIU for the three devices was 95.00％,83.17％ and 84.33％,SD was 0.63％,1.17％ and 0.82％,respectively;the action limits were ≥93.74％,≥82.00％ (corrected) and ≥82.69％,respectively.The mean value of PSG for the three devices was 0.11％,0.07％ and 0.14％,SD was 0.12％,0.03％ and 0.11％,respectively;the action limits were ≤0.35％,≤0.13％ and ≤0.36％,respectively.Conclusion All of SNR,PIU and PSG for three MR devices were consistent with the action limits in this study.

Gut microbiota and type 1 diabetes mellitus / 国际儿科学杂志

Recent researches have shown that gut microbiota play an important role in pathogenesis of immune-related disorders.Type 1 diabetes mellitus,as an autoimmune disease,has received increasing attention,especially in terms of the relationship between the pathogenesis and intestinal microbiota.Change of gut microbiota is an important risk factor of the pathogenesis of type 1 diabetes mellitus which have been confirmed with the animal model studies.This article reviews the role of gut microbiota in the pathogenesis of type 1 diabetes mellitus,and the influence of gut microbiota on host immune response for possible prevention and treatment of type 1 diabetes mellitus in the future.

Stability tests and action limits setting for central frequency and transmitter gain of MRI scanners / 中国医学影像技术

Objective To test the central frequency (CF) and transmitter gain(TG) of MRI scanners,and set up their action limits.Methods Three different MRI devices (GE 3.0T HD,GE 1.5T HDi and GE 3.0T 750W) were tested by scanning American College of Radiology (ACR) phantom with the axial T1WI series.In the pre-scanning of T1WI series for the ACR phantom,the CF and TG were recorded.It was tested for eight times when MRI scanners were in good condition.The action limits of CF and TG were calculated based on mean values and standard deviations.Results The mean values of CF for three devices were (127 725 772.38±39.68)Hz,(63 875 740.13± 34.15)Hz,and (127 771 958.38±12.19)Hz,respectively.Their action limits were ≤119.04 Hz,≤68.30 Hz,and ≤36.57 Hz,respectively.The mean values of TG for three devices were (125.25±1.28)dB,(101.75±1.98)dB,and (113.25±0.89)dB,respectively.Their action limits were (125.25±2.56)dB,(101.75±3.96)dB,and (113.25±1.78)dB,respectively.Conclusion The CF and TG for three MRI scanners are all consistent with the action limits in this study.The CF and TG action limits will provide criterions for the clinical quality control.

pp65 antigen and human cytomegalovirus infection / 国际儿科学杂志

HCMV infection can cause hepatopathy,pneumonia,diarrhea,thrombocytopenic purpura,and sensorineural hearing loss(SNHL),with high morbility and mortality.pp65(phosphoprotein 65),a major constitutive protein of virion,is closely associated with viral gene expression,immune evasion and cell metabolism.pp65 antigenemia level has positive correlation with clinical symptom,which can guide the preemptive therapyand improve prognosis,is considered as one of the golden standard methods of active cytomegalovirus infection.In this paper,the pp65 protein properties,pathogenesis,application in diagnosis and prevention are reviewed.

Investigation and practice of magnetic field homogeneity evaluation methods for MRI equipment / 中国医学影像技术

Objective To explore the evaluation methods of magnetic field uniformity and the practical operations,in order to provide references for clinical quality control.Methods Based on MRS phantom and 32 cm uniform spherical phantom,the evaluation methods of magnetic field uniformity were used to detect MRI equipment in department of radiology,including spectral peak and the bandwidth difference.Results The full width at half maximum (FWHM) of MRS phantom was 0.08 ppm,the inhomogeneity values on coronal,sagittal and axial detected by the bandwidth difference method was 0.15 ppm,0.08 ppm and 0.18 ppm,respectively.Conclusion The magnetic field homogeneity of the above mentioned MRI equipment is favorable,which accords with magnetic field uniformity detection standard.

Initial practice on cross-talk tests for MRI scanners / 中国医学影像技术

Objective To detect the cross-talk RF signal interference of three MRI scanners,in order to deepen the understanding of cross-talk RF signal interference.Methods Three different GE magnetic resonance imaging scanners (GE 1.5T HDi,installation time:2012;GE 3.0T HD,installation time:2006;GE 3.0T 750W,installation time:2016) were tested.The axial T1-weighted sequence was used to scan ACR phantom.Slice gaps with 5.0 mm,1.0 mm,0.5 mm and 0 were performed,respectively.SNR values were also recorded.Based on the results,the percentage change charts of SNR with slice gaps were made.Test standard was set as SNR decreased less than 20 ％ when the slice gap reduced from 5 mm to 0.Results When slice gap was reduced from 5 mm to 0,SNRs for three scanners decreased by 18.16 ％,23.57％ and 10.75％,respectively.Both the results of cross-talk obtained with GE 1.5T HDi and GE 3.0T 750W scanner met the test standard,while the result obtained with GE 3.0T HD (used for more than 10 years) was below the standard.Conclusion The cross-talk RF signal interference still exists for three MRI scanners.The test result of the scanner used for the longest time is unqualified.The quality control test of cross-talk should be done in the daily work.

Status and tendency of clinical quality control procedure and regulation for MRI equipment / 中国医学影像技术

Clinical quality control of MRI equipment is a significant part of quality assurance.The purpose of quality control is to assure the performance and specification stability of MRI scanner,and to provide high quality images for clinical diagnosis.Many foreign countries have already developed and established highly sophisticated quality control procedure and regulation for MRI system,and the application is also relatively popular.However,this work has just begun in China,need to be further developed.The current status and future trend of clinical quality control procedure as well as regulation for MRI equipment were reviewed in this article.

The clinical effectiveness analysis of early use of low molecular weight heparin and aspirin in the treatment of acute cerebral infarction / 中国基层医药

Objective To study the clinical effectiveness analysis of early use of low molecular weight hepa-rin and aspirin in the treatment of acute cerebral infarction.Methods 120 cases with acute cerebral infarction were randomly divided into the observation group and the control group according to a random number table,with 60 cases in each group.The patients of the control group were treated with aspirin,while the patients of the observation group were given low molecular weight heparin on the basis of the control group.Both groups were treated for one month,and the therapeutic effects and adverse reactions of the two groups were compared.Results The total efficiency of the ob-servation group was 96.7%(58 /60),which was significantly higher than the 76.7%(46 /60)of the control group, the difference was statistically significant(χ2 =12.051,P =0.019);The neurological deficits after treatment of the observation group was (16.21 ±2.05 )points,which was significantly lower than (26.04 ±1.03)points of the control group,the difference was statistically significant (t =10.372,P =0.027 ).Conclusion Acute cerebral infarction early use of low molecular weight heparin and aspirin had better clinical efficacy,and it can significantly promote the recovery of neurological function in patients.

Abuse tendency among dementia caregivers: a qualitative research / 中国实用护理杂志

Objective To explore the feelings of the caregivers of dementia patients,and find the resource of the caregiver's abuse tendency to dementia patients in community.Methods The data of 10 caregivers were collected through deep interviews,and the Colaizzi analysis method was used to analyze the data.Results Through repeatedly reading,arranging,analysis,separation,and theme refining,five themes were drawn:lack of related knowledge and care skills,care tasks making caregivers tired,the economic burden,lack of social support,low sense of worth.Conclusions When concerning the problems caused by dementia patients,it's necessary to appeal the society and government to provide feasible service and assistance on the issue of abuse tendency,which is produced by the caregivers during the process of taking care of them.

The effect of tuftsin and thymopentin on phagocytic function in mice / 中国免疫学杂志

The stimulate effects of synthetical endogenous peptides, tuftsin (Tuf) and thymopentin(TP5), on phagocytic function were studied. After subcutaneous administration (sc) of Tuf, thelysozyme content in both M? and sera, and the acid phosphatase activity in M?, were increasedin a dose-dependent manner. The peak time of serum lysozme level following a sigle sc injectionof Tuf was about on the 6th day. The elevation of lysozyme in sera was delayed and enhancedstrongly by Freund incomplete adjuvant (FIA). In cylcophosphamide (Cy) treated mice,TP5further increased both lysozyme content amd acid phosphatase activity in M?activated byCy, and recovered the lysozyme level in spleen inhibited by cy. The results suggested thatTP5could not only activate the funceion of M?, but recover the number of M?decreased by im-mumoimhibitant.