A Clinical Study of Evaluate the Efficacy of Vishatinduka Taila Kati Basti in the Management of Katigraha (Low Back Pain)

Katigraha is a Vataja Nanatmaja vyadhi and not explained as a separate disease, but rather as a symptom in another disease like as Ashmari, Arshas, Bhagandara etc. We have a brief summary of Katigraha along with symptoms, etiological causes, and treatment in Amavatadhikara Adhyaya of Bhavaprakasha, and in Vatavyadhi Adhikara of Gadanigraha. Along with specific symptoms like Katishoola and Katigraha caused either Shuddha or Sama vayu. In contemporary science, we can compare the Katigraha with low back pain (lumbago) suffering from Low back pain is an emerging problem in adolescents, with an incidence that is the highest in the third decade of life worldwide. Katibasti is the process in which, retaining of warm medicated oil in a specially formed frame prepared from Masha dough in lumbo-sacral region. It performs the combined action of Snehana and Swedana. Katibasti is a type of Snigdha Sweda, as warm oil is used which produce both the Snehana and Swedana effect, attempt has been made with Vishatinduka Taila for Katibasti purpose. In present study using Vishatinduka Taila Katibasti is done for 7 days for 30 minutes daily.

Large drusen following long-standing retinal detachment.

We report an interesting finding of multiple large drusen in an eviscerated eye with a longstanding retinal detachment. The origin and composition of the drusen is also speculated on the basis of special stains.

ProRegIn: a regularity index for the selection of native-like tertiary structures of proteins.

Automated protein tertiary structure prediction from sequence information alone remains an elusive goal to computational prescriptions. Dividing the problem into three stages viz. secondary structure prediction, generation of plausible main chain loop dihedrals and side chain dihedral optimization, considerable progress has been achieved in our laboratory (http://www.scfbio-iitd.res.in/bhageerath/index.jsp) and elsewhere for proteins with less than 100 amino acids. As a part of our on-going efforts in this direction and to facilitate tertiary structure selection/rejection in containing the combinatorial explosion of trial structures for a specified amino acid sequence, we describe here a web-enabled tool ProRegIn (Protein Regularity Index) developed based on the regularity in the Phi, Psi dihedral angles of the amino acids that constitute loop regions. We have analysed the dihedrals in loop regions in a non-redundant dataset of 7351 proteins drawn from the Protein Data Bank and categorized them as helix-like or sheet-like (regular) or irregular. We noticed that the regularity thus defined exceeds 86% for Phi barring glycine and 70% for Psi for all the amino acid side chains including glycine, compelling us to reexamine the conventional view that loops are irregular regions structurally. The regularity index is presented here as a simple tool that finds its application in protein structure analysis as a discriminatory scoring function for rapid screening before the more compute intensive atomic level energy calculations could be undertaken. The tool is made freely accessible over the internet at www.scfbio-iitd.res.in/software/proregin.jsp.