RÉSUMÉ
The objective of this work was to determine the methemoglobinemia and correlate with dapsone levels in multibacillary leprosy patients under leprosy multi-drug therapy. Thirty patients with laboratory and clinical diagnosis of multibacillary leprosy were enrolled. Dapsone was analyzed by high performance liquid chromatography and methemoglobinemia by spectrophotometry. The mean dapsone concentrations in male was 1.42 g/mL and in female was 2.42 g/mL. The mean methemoglobin levels in male was 3.09 µg/mL; 191 percent, and in female was 2.84 ± 1.67 percent. No correlations were seen between dapsone levels and methemoglobin in male and female patients. Our results demonstrated that the dosage of dapsone in leprosy treatment does not promote a significant methemoglobinemia.
Sujet(s)
Adolescent , Adulte , Femelle , Humains , Mâle , Jeune adulte , Dapsone/sang , Antilépreux/administration et posologie , Lèpre multibacillaire/traitement médicamenteux , Méthémoglobinémie/diagnostic , Chromatographie en phase liquide à haute performance , Clofazimine/administration et posologie , Dapsone/administration et posologie , Dapsone/effets indésirables , Antilépreux/effets indésirables , Lèpre multibacillaire/sang , Méthémoglobinémie/induit chimiquement , Rifampicine/administration et posologie , Spectrophotométrie , Jeune adulteRÉSUMÉ
Este trabalho demonstra o isolamento de Fonsecaea pedrosoi de espinhos da planta Mimosa pudica L., a partir do local de suposta infecção identificado pela paciente infectada. O diagnóstico clínico de cromoblastomicose foi estabelecido pelo achado de corpos fumagóides no exame microscópico direto e pelas culturas de F. pedrosoi do material obtido da lesão da paciente. A mesma espécie foi isolada da paciente e da planta. A microscopia eletrônica de transmissão da superfície dos espinhos evidenciou a disposição conidial característica de F. pedrosoi. Estes dados indicam que a planta M. pudica deve ser uma fonte natural de infecção do fungo F. pedrosoi.