Blood transfusion trends in obstetrics and gynaecology: an Uttar Pradesh government medical college-based study

Background: Blood transfusion holds utmost importance in comprehensive obstetric care and Gynaecology. The present study has been done to evaluate the indications of blood transfusion in the Obstetrics and Gynaecology Department. Methods: The retrospective observational study was conducted between April 2023 to April 2024 in Department of Obstetrics and Gynaecology, Government Medical College, Saharanpur. Results: A total of 257 units of Blood was transfused between April 2023 to April 2024 in Obstetrics and Gynaecology Department. 60.6% transfusion were in age group 21-30 years. 48.26% transfusion were in hemoglobin 7-9 gm/dl. Most common blood group transfused was B positive 40.79% and 85.2% transfusion were packed red blood cell, 84.07% had single unit blood transfusion, 57.25% had transfusion for anemia in pregnancy, 36.84% transfusion were for abnormal uterine bleeding. Conclusions: Prevalence of anemia in reproductive age group is an important reason for blood transfusion in obstetrics and gynaecology. Hence emphasis should be to treat anemia through drugs to reduce unnecessary transfusion especially single unit transfusion.

Smartphone addiction: impact on health and well-being

This study explores the increasing prevalence and negative impacts of excessive smartphone use. It emphasizes the detrimental effects on academic performance, mental health, and physical well-being, highlighting the need for intervention strategies. The review aims to summarize evidence demonstrating the significant influence of smartphone addiction on dietary behavior and lifestyle, as well as the complex interplay between mobile phone usage patterns and mental health outcomes. The document suggests that mindfulness practices, self-reflection, and seeking professional help can be effective strategies to combat smartphone addiction. Through a systematic literature search using databases like Google Scholar, NIH, and PubMed, the review gathers information on smartphone addiction's effects on health, academics, and adolescence. The conclusion calls for longitudinal studies to track the long-term impact of smartphone usage on academic performance and overall well-being. It recommends identifying at-risk groups for intervention and promoting responsible smartphone usage to prevent adverse effects. Overall, the document underscores the importance of understanding the factors contributing to smartphone addiction and implementing measures to foster genuine human interactions, balance technology use, and mitigate the hazards of smartphone addiction among adolescents.

Conditions associated with discarding of blood and its components in a blood bank of tertiary care hospital of Western Uttar Pradesh: a retrospective study

Background: Blood transfusion services in India rely on different factors for a smooth workout. Thus proper utilization of blood is necessary with minimal wasting. The aim was to evaluate the causes of discarding of blood and its components and to implement possible intervention for minimizing wastage. Methods: A retrospective study was carried out in the blood bank of Sardar Vallabh Bhai Patel Hospital, Lala Lajpat Rai Medical College, Meerut, Uttar Pradesh over a time period of 24 months from April 2019 to March 2021. Results: A total of 21627 units were collected from donors. A total of 11534 whole blood (WB), 10093 packed red blood cells (PRBC), 3245 platelets (PC), and 9669 fresh frozen plasma (FFP) were prepared. A total of 4046 units of blood and its components were discarded. The discard rate for WB, PRBC, PC and FFP was 6.25%, 7.46%, 38.39%, and 13.71% respectively. Conclusions: An average of 18.70% of blood units were discarded during this study period. The overall most common reason for discard was the date of expiry followed by transfusion transmitted infections (TTI). To minimize wastage of blood units, blood banks should be fully committed to organizing and coordinating the blood transfusion services,implementing all possible strategies as discussed in order to lower the discarding of blood and its units and to make them widely available.

High diversity in the vaginal microbiome in women following preterm premature rupture of membranes and its effect on fetomaternal outcome

Background: Premature rupture of the membranes (PROM) complicates 3% of pregnancies and its associated with adverse perinatal outcome. Methods: This was a case control study conducted over a period of two years. Our aim was to evaluate the bacterial colonization of genital tract of antenatal patients who presented with preterm premature rupture of membranes and their maternal and neonatal complications. We studied 6023 patients during our study period among which 156 patients presented with preterm premature rupture of membranes. Results: PPROM was found more commonly among age 25-30 years (46.79%) with p<0.001. Out of 156 pregnant women with PPROM, only 16 patients (10.26%) developed clinical chorioamnionitis. We observed that 43.59% patients (n=68) with PPROM underwent LSCS which was significantly higher than control group (19.93%). Among them 81.41% (n=127) of the patients delivered within 24 hours of admission. Among 156 patients, 94 (59.12%) mothers had babies with birth weight ranging between 1.5-2.5 kg as compared to control group where 30.51% mothers had low birth weight babies. The difference was statistically significant. Approximately 18.24% babies developed respiratory distress syndrome requiring ICU care in study group as compared to 3.03% in control group and the difference was statistically significant. Conclusions: It is important to diagnose the PPROM early and manage the patient until delivery for better outcome. Timely intervention after proper analysis of risk and benefit of early termination helps in reducing adverse perinatal outcomes, reduced NICU admissions and unnecessary interventions for neonates.

Anesthetic management in a challenging case of primary pulmonary synovial sarcoma

Primary pulmonary synovial sarcoma is a very rare tumor. This tumor accounts for less than 0.5% of all lung neoplasia. While synovial sarcomas are commonly reported from periarticular tissues, they are often found in lung or thorax as a metastasis from an extrapulmonary primary. However, rarely they arise primarily from lung tissue. We report a case of primary pulmonary synovial sarcoma which was indenting the right side of the heart. He was managed with neoadjuvant chemotherapy followed by surgical resection. The anesthetic management was challenging. The focus was kept on stringent invasive as well as non-invasive monitoring of cardiac and respiratory parameters. The surgery was uneventful and the patient made a successful recovery.

Hearing assessment in mobile phone users

Background: Mobile phones have become an indispensable part of today's modern world. But with various day-to-day benefits, mobile phones also bring detrimental effects on the health of users. Ear being the closest organ in contact with phones, faces maximum effect of electromagnetic waves generated by them. Chronic exposure to these waves and sounds can result in permanent hearing loss. Hence, the present study was done to assess the association between hearing loss and duration of mobile usage. Methods: This cross-sectional study was conducted on mobile phone users between the age group of 20 and 40 years in the Department of ENT, Rajindra Hospital, Patiala over 6 months (1 August 2022 to 31 January 2023). 600 volunteers were involved and divided into three groups based on the duration of mobile phone usage. Pure tone audiometry and DPOAE were used to assess the hearing loss in these subjects. Results: A variable degree of hearing loss was observed on PTA and DPOAE in all three groups with a significant association between hearing loss and the duration of mobile phone usage. A higher proportion of sensorineural hearing loss was observed in the group with mobile phone usage of more than 1 hour per day for a minimum of 4 years as compared to those who used them for <1 hour per day for a minimum of 4 years and control group (p=0.001) which was significant statistically. Conclusions: People using mobile phones for long hours are at higher risk of developing hearing loss, especially in the dominant ear.

The Indore population's morphometric study of the nutrient foramina of the dried radius

Background: Bone formation, growth and its vitality necessitates blood supply. Nutrient artery is the key source of blood supply to the long bone apart from the other important sources like periosteal, metaphyseal and epiphyseal arteries. Nutrient foramina allow nutrient artery. Typically, the direction of the nutrient foramina is towards the elbow joint in radius, away from its growing end. Knowledge of foramen index, number, direction and size of the nutrient foramina assists the surgeon to take and exact section of bone in case of bone resection and transplantation techniques. The aim of the present study is to determine the number, position, size direction of the nutrient foramina and the Foramen Index of the human dry radius bones. Methods: In the present study, 100 radius bones of unknown age and sex were taken into consideration from the department of anatomy Index Medical College, Indore (MP), India. Results: Most of the foramen was observed on the anterior surface of the bone. Nutrient foramina was found to be absent in 4 right sided and 3 left sided bones. The foramen index on right side was 34.92±4.97 cm whereas on the left side 34.79±4.43 cm. The nutrient foramen was directed towards the proximal end of radius in all the bones studied. Conclusions: In the present study the average length of the bone and foramina of the size larger are more on the right side when compared to the left side. The foramina are located mostly in the middle third of the bone of the anterior surface. This study may add to the present statistical data available on foramen index number of foramen and their location in the population of Indore region, during recent orthopaedic techniques like bone resection and transplantation.

Morphometric study of the diaphysial nutrient foramen of the humerus in the Indore population

Background: The nutrient arteries may be affected to a consequence of fracture/surgical intervention of fracture of the humeral shaft, which may result in nonunion or delayed union of fracture. Number and position of nutrient arteries must be determined. In order to preserve them during any surgical procedure of the humeral shaft, it is therefore essential to be aware of the existence of the nutrient foramen. The primary objective of this research is to identify the number, location, and orientation of nutrient foramina (NF) of humerus. Methods: The study was conducted on 100 dried humeri of unknown gender obtained from department of anatomy, Index Medical College, Indore (M.P), India. The number, location, and direction of NF were observed. Results: One nutrient foramen was present in 77% of humeri, followed by double foramen in 20% of cases and triple foramen in 3% of cases. The anteromedial surface hosted the majority (80.16%) of the NF, followed by the anterolateral (4.76%) and posterior surfaces (15.08%). The middle third of the shaft (96.03%) included the greatest number of NF, followed by the distal third (3.97%). On the distal end of the humerus, there was no nutrient foramen to be observed. All NF were directed downward. Conclusions: The location of the nutrient foramen of the humerus was not constant; it may present on anteromedial, anterolateral, or posterior surfaces. Similarly, it may present on the middle or distal third of the shaft of the humerus. This study will help surgeons planning the surgical intervention of the shaft of the humerus, which will possibly reduce the chances of nonunion or delayed union.

Ball valving laryngeal masses: a difficult “ball” in the anaesthetists’ court

Dynamic airway obstruction (also called ball-valve effect) is a serious condition often seen in glottic lesions. This is an anesthetic challenge as total airway obstruction can occur after the induction of general anesthesia. We present a case of a middle aged female who had a large laryngeal mass which was showing ball-valve effect. The patient had refused for tracheostomy despite it being the safest procedure in the circumstances. We then performed videolaryngoscopy and managed to intubate the patient with the help of some improvisation. The patient underwent a succesful and uneventful surgery.

Alleviating Damage Extent and Enhancing Yield through Ridge Planting Techniques in Maize (Zea mays L.) during Excess Soil Moisture Stress

Waterlogging is one of the major constraints limiting maize (Zea mays L.) production in India and might become more common due to irregular precipitation pattern due to climate change. The objective of this investigation was to evaluate the efficacy of planting techniques by examining of physio-morphological, and productivity of excess water sensitive maize (Zea mays L.), under excess soil moisture stress (ESM). A field experiment was conducted during the kharif season 2020 at G.B. Pant University of Agriculture and Technology, Pantnagar. The experiment consisting of two planting methods (flat and ridge), under ponding conditions (30 DAS for 7 days) along with non-ponded condition was laid out in factorial randomized block design with three replications. The recommended dose of nutrients was120:60:40kgN: P2O5:K2O/ha. The physio-biochemical and yield characteristics of the plants at different times interval after planting were evaluated. Growing of maize on ridge bed maintain comparatively aerobic condition and give better anchorage to sturdy in excess moisture resulting lowest crop lodging (12.06%) and higher yield (3501kg/ha) by 7.2% compare to flat system (3268kg/ha). In comparison to non-ponded and ponded plant showed significantly maximum growth, however lowest crop lodging percent.

The Effect of Climate Change on Wheat Production: Present Patterns and Upcoming Difficulties

Climate refers to the mean weather conditions in a certain region, impacting every aspect of the environment. Urbanisation and industrialization are causing woods to be cleared for living communities. The equilibrium of the ecosystem is upset by this shift, affecting producers, consumers, and decomposers. Plants, or producers, are an important component of the ecosystem because they supply energy. Plant sustainability and production are impacted by this change. A staple grain, wheat is greatly impacted by both temperature and CO2 levels. In addition to decreasing wheat productivity, it also increases wheat's susceptibility to many illnesses. Elevated temperatures result in increased transpiration, which in turn triggers drought, which in turn causes reduced production. According to predictions, in the next 20 to 30 years, a 2° C temperature shift might result in a serious water crisis. A scarcity of water during the grain filling and milking stages can impact production. This article covers the following topics: climate-related variables, effects on wheat production and growth, influence on disease severity, temperature increase prediction model, and CO2 curve in 2050.

Multidimensional Scope, Current Status, Uses and Contribution of Green Gold Bamboo: A Comprehensive Review

Bamboo is a versatile group of fastest growing plant which is capable of providing ecological, economical, environmental and livelihood security to the people. The study investigates uses, contribution, scope of the green gold plant bamboo. The review of this study showed that bamboo has evolved into a highly valuable and superior plant which serves for food, fodder and many more also bamboo-based products have the potential to replace wood, plastics in a variety of industrial uses without harming the nature by maintaining sustainability. So in this review paper comprehensive overview of the recent literatures about multidimensional scope of bamboo in form of its greatest potential is being discussed.

Assessment of Genotype Against Major Insect Pests of Cluster Bean in Gird Region of Madhya Pradesh

In order to assess cluster bean genotypes against the major insect during the kharif 2022, Nine cluster bean genotypes were investigated in a randomised block design with three replications: T1 - RGr 20-7, T2 - GD-567, T3 - HG 2-20 (ch), T4 - CAZG 17-4-5, T5 - RGC 1066 (ch), T6 - GD-565, T7 - RGR 20-15, T8 - RGC 1033 (ch), and T9 - X-25. Aphid, whitefly, jassid, and thrips minimum infestation were found in genotype GD-565, which was succeeded by CAZG 17-4-5. Whereas, Aphid, whitefly, jassid, and thrips populations reached their maximum in genotype RGC 1066 (ch). The GD-565 genotype was shown to be the best appropriate for growing in Madhya Pradesh's Gird area.

Revolutionizing Agriculture: A Comprehensive Review of Nanotechnology Applications

This comprehensive review paper, titled "Revolutionizing Agriculture: A Comprehensive Review of Nanotechnology Applications," explores the transformative role of nanotechnology in modern agriculture. In a world grappling with food security and environmental challenges, nanotechnology offers innovative solutions that significantly impact the agriculture sector. This paper delves into key topics, including the fundamentals of nanotechnology, various nanomaterials and their applications in agriculture, crop improvement, soil management, pest and disease control, environmental and safety considerations, and the future prospects of nanotechnology in agriculture. The review underscores the importance of nanotechnology in addressing global agricultural challenges, enhancing crop productivity, and ensuring sustainable food production while navigating environmental constraints. By examining the latest research and real-world examples, this review provides valuable insights into the burgeoning field of nanotechnology applications in agriculture, highlighting the significance of interdisciplinary research and responsible nanomaterial utilization.

A Comprehensive Review of CRISPR/Cas9 Based Strategies in Horticultural Crop Modification

The introduction of CRISPR/Cas9 gene editing technology represents a groundbreaking advancement in the realm of horticulture. It provides a precise and effective means for making targeted genetic alterations in a wide range of plant species. This abstract delves into the diverse applications of CRISPR/Cas9 within the domain of horticultural crops, with a particular emphasis on its crucial role in tackling issues related to climate change. This review paper outlines the diverse applications of CRISPR/Cas9 in horticulture, including trait improvement for enhanced stress tolerance, disease resistance, and yield optimization. It highlights specific examples of successful CRISPR-edited horticultural crops and their contributions to climate adaptation. Furthermore, it discusses the potential of CRISPR/Cas9 in accelerating the development of new crop varieties tailored to thrive in changing climatic conditions. Additionally, the ethical and regulatory considerations surrounding the use of CRISPR/Cas9 in horticulture are addressed, as they play a crucial role in determining the broader adoption of this technology. Balancing the benefits of climate-resilient crop development with potential environmental and societal implications remains a critical aspect of its application. In conclusion, the transformative potential of CRISPR/Cas9 in horticultural crop improvement and its role in addressing climate-related challenges. By harnessing the power of genetic editing, horticulturalists can create more productive crops and better equipped to withstand the uncertainties of a changing climate. However, this technology's responsible and ethical use is imperative to ensure its long-term sustainability and benefit to society.

Exploring Sustainable Practices in Modern Agronomy and their Environmental Impact- A Review

The field of agronomy is undergoing a seismic shift towards sustainability, driven by an increasing understanding of the long-term benefits and a global urgency to act against climate change. It aims to explore the multifaceted realm of sustainable agronomy, scrutinizing its practices, benefits, challenges, and future prospects. It delve into the types of sustainable practices currently in use, such as crop rotation, organic farming, and conservation tillage, highlighting their positive impact on soil health, water quality, and biodiversity. We also offer a comparative analysis, contrasting these sustainable practices with conventional methods in terms of yield, economic benefits, and environmental impact. Also, dedicated to policy implications, discussing existing government policies that support sustainable practices and offering recommendations for further policy interventions. Case studies from India and abroad serve to demonstrate the practical application and success of these methods. The transition to sustainable agronomy is fraught with challenges. Technological needs, such as the requirement for advanced machinery and analytics tools, can be a hurdle, especially for small-scale farmers. Educational gaps also present a significant challenge, as current agronomy curricula in many parts of the world are not geared towards sustainable practices. Financial constraints, often exacerbated by inadequate support systems, add another layer of complexity to the transition. Despite these challenges, the review identifies multiple avenues for future research, including the development of cost-effective technologies, educational reforms, and alternative financing models to support farmers.

A Comprehensive Review on Role of Plant Tissue Culture in Ornamental Crops: Cultivation Factors, Applications and Future Aspects

Ornamental plants are grown largely for their artistic value, floriculturists must prioritize the proliferation and improvement of quality traits, as well as the production of unique diversity. Micropropagation, clonal reliability and conservation are all crucial factors to consider. Application of in vitro techniques in ornamental plant such as in vitro embryo rescue, somatic hybridization, in vitro pollination and in vitro ploidy manipulation but to enhance, techniques like as embryo rescue and somatic hybridization are commonly employed. The creation of synthetic seed allows for season-independent seed producing and long-term seed preservation. Many factors influence ornamental plant tissue culture, including plant genotype, explants type, and the physical environment (light, temperature, humidity, and CO2), in addition to medium composition and growth regulators. We compiled and reviewed an overall update on cultivation factors, application procedures in ornamental plant tissue culture, in vitro plant enhancement approaches and future prospects in this study.

Effect of Age of Seedling and Plant Spacing on Yield and Economics of Transplanted Rice (Oryza sativa L.)

An experiment was conducted at Shradhay Bhagwati Singh Agriculture Research Farm (Hajipur), Chandra Bhanu Gupta Krishi Snatakottar Mahavidyalaya, B.K.T., Lucknow (Uttar Pradesh) during the Kharif season of 2022. The experiment was laid out in split plot design with three replications keeping three ages of seedlings viz., 21 days of the age of old seedlings, 28 days of the age of old seedlings and 35 days of the age of old seedlings in main plots and three plants spacing 20 cm x 10 cm, 25 cm x 10 cm and 15 cm x 15 cm in subplots. Results revealed that there was significant variation among different times of transplanting with respect to growth. Growth parameters were higher in paddy transplanted at 21 days of age of old seedlings as compared to the rest of the age of seedlings. The yield attributes as effective tillers m-2, panicle length (cm.), numbers of grains panicle-1, grains weight panicle-1 (g.), panicle weight (g.) and 1000 grain weight were significantly superior in paddy transplanted in 21 days of age of old seedlings. 21 days of age of old seedlings proved significantly superior in terms of grain, straw, total biological yield and harvest index when compared to the rest of the age of seedlings. The maximum N – content (%) was significantly superior in paddy transplanted in 35 days of the age of seedling in grain and straw. The N – Uptake (kg/ha.) was significantly superior in paddy transplanted in 21 days of age of seedling in grain and straw. The protein content (%) was significantly superior over in paddy transplanted at 35 days of the age of seedlings in grain and straw. The Protein – production (kg/ha.) were significantly superior in paddy transplanted at 21 days of age of seedling in grain and straw. Growth parameters such as plant height (cm.), dry matter accumulation (gm-2) and leaf area index were higher in paddy transplanted with 20 cm x 10 cm but a number of tillers (m-2) higher with 25 cm x 10 cm as compared to rest of the plant spacing. Plant spacing of 25 cm x 10 cm produced significantly more yield attributes and yield of rice. The maximum N – content (%) were significantly superior in paddy transplanted with 15 cm x 15 cm in grain and straw. The maximum N – Uptake (kg/ha.) was significantly superior in paddy transplanted with 25 cm x 10 cm in grain and straw as compared to the rest of the plant spacing. The maximum protein content (%) were significantly superior over in paddy transplanted with 15 cm x 15 cm in grain and straw. The Protein – production (kg/ha.) was significantly superior in paddy transplanted with 25 cm x 10 cm in grain and straw. Transplanting of paddy 28 days of age of old seedlings with 25 cm x 10 cm plant spacing had higher gross return, net return, and B:C ratio of rice crop.

Outcome of newborn hearing screening a prospective study

Background: Hearing is a very important part of newborn language as well as speech development, hearing loss varies degrees i.e. from hearing impairment to complete hearing loss. It has an effect on person’s physical, social, mental, educational, and economic well-being. Methods: The current study's objective was to use OAE to test newborns for hearing in the department of otorhinolaryngology and study was carried out over a period of 2 years (September 2020 to September 2022) in 2000 neonates born at Rajindra hospital Patiala by DPOAE (distortion product OAE) test. The association between maternal, neonatal, sociodemographic factors and hearing impairment in neonates were evaluated. Results: In our study 257 out of 2000 newborns had ‘Refer’ result on OAE. There was a male preponderance (1061 males and 939 females) with 7% males having ‘Refer’ results as compared to 5.85% of females.153 out of 2000 neonates with ‘Refer’ result belonged to the lower class and 9.9% newborns with ‘Refer’ result was from rural area. Perinatal illnesses like Severe anemia (1.17%), Hypertension (0.78%) also have an impact on neonatal hearing impairment. In neonatal risk factors prematurity caused hearing impairment in 7.85% of neonates, low Apgar score at birth and 1 min (8.55% and 8.35%), low birth weight (8.75%), and more than 24-hour NICU admission (3.7%) Conclusions: The screening of neonates with Otoacoustic emissions is required for early detection of neonatal hearing loss as OAE is an easy,reasonably priced and dependable procedure for infant testing on a wide scale.

Bacteriological profile of patients with biliary obstruction in tertiary care center

Background: Bile ducts are usually kept sterile by bacteriostatic and flushing effects of bile. Patients presenting with biliary obstruction especially due to benign etiology have either single or multiple bacterial organisms. Acute cholangitis carries significant morbidity with variable mortality rate. The serious presentation of such toxic patients signifies the requirement of appropriate antibiotic treatment. Choledocholithiasis followed by neoplasm and benign biliary strictures are the common predisposing factors for obstruction. Widespread use of antibiotics over years lead to change in sensitivity pattern of organisms which necessitates change in empiric antibiotic usage. Methods: This retrospective study was conducted in department of medical gastroenterology. We studied 50 patients with biliary obstruction (clinical and demographic data were recorded). The diagnosis of cholangitis was made according to TG2018. While undergoing therapeutic ERCP, bile aspirate was collected by biliary cannulation and sent for microbiological analysis. The antibiotic susceptibility pattern and rest of the data were analyzed by appropriate statistical tests. Results: Mean age of the study group was 49 years. Majority were female in study (60%). Overall, 74% had benign etiology, 32% had cholangitis. Bile cultures were positive in 64% patients 75% of them had benign etiology (gallstone being most common; 56%) and 25% had malignant etiology. Bacterobilia in cholangitis patients was statistically significant in comparison to patients without cholangitis (p-0.01). Organisms grown are mainly aerobic gram negative, most common being E. coli, Klebsiella and Pseudomonas species. Patients having bacterobilia had mortality of 6.25% during hospital stay. Conclusions: In this study we found higher sensitivity to colistin (90.6%), tigecycline (81.25%), amikacin (75%) and least sensitivity was noted for ampicillin (6.25%) followed by cefixime (12.5%). Sensitivity to previously commonly used ciprofloxacin antibiotic was 31.25%. Study confirms the significance of obtaining routine bile sample during ERCP in obstructed biliary system to prevent dreaded complications of cholangitis.