Progress in Application of Heparin Coating in Blood Contact Medical Devices / 中国医疗器械杂志

Blood compatibility is the main restriction of blood-contacting medical devices in clinical application, especially long-term blood-contacting medical devices will stimulate the immune defense mechanism of the host, resulting in thrombosis. Heparin anticoagulant coating links heparin molecules to the surface of medical device product materials, improves the compatibility between the material surface interface and the body, and reduces the host immune defense reactions. This study reviews the structure and biological properties of heparin, the market application status of heparin-coated medical products, the insufficiency and improvement of heparin coating, which can provide a reference for the application research of blood contact medical devices.

Analysis of EEG in the elderly with mild cognitive impairment based on Lempel-Ziv complexity / 生物医学工程学杂志

We studied the mechanism of electroencephalography (EEG) in the elderly with mild cognitive impairment (MCI) by analyzing the Lempel-Ziv complexity (LZC) of EEG during a cognitive task. We recorded the EEG simultaneously when they were asked to judge whether the color of two graphics was matched or not. The results showed that the LZC of EEG in the MCI group was significantly higher than those in the normal control group early in the period of cognitive activities (P < 0.05). The LZC in MCI patients decreased gradually over time, while results of the normal group kept unchanged. There was no significant difference in LZC between two types of tasks. The two groups showed similar regularity in spatial distribution.