Résumé
Objective To evaluate the influence of Fuzheng Huayu decoction on different pathological stages fibrotic liver tissue and activated hepatic stellate cells (HSCs). Methods Use a carbon tetrachloride (CCl4)-induced liver cirrhosis rat model system. The drug intervention was administered via oral-gastric irrigation in building, the end of week 2 and 4. Rats were batch sacrificed at the end of week 2 , 4, and 6. Liver fibrosis was evaluated by histology, and expression of a-smooth muscle actin (α-SMA) was determined by immunohistochemistry. Between-group comparisons were made by completely random design and ANOVA with Bonferroni correction. Results At the end of weeks 2, 4 and 6, the model group and drug intervention groups had significantly higher area ratio of liver fibrosis and higher expression of α-SMA than the normal group, but the three drug intervention groups had significantly less area ratio of liver fibrosis and less expression of α-SMA than the model group and the drug intervention 1 group showed the most robust decrease (P<0.05). Conclusion The Fuzheng Huayu decoction leads to down-regulated α-SMA expression and reduced degree of liver fibrosis on different pathological stages of fibrotic liver tissue, and the earlier drug intervention, the better the results.
Résumé
OBJECTIVE To analyze the direct economic loss caused by hospital infection.METHODS A case-control study was adopted to analyze the direct economic loss due to hospital infection and longer stay in hospital.RESULTS The average economic loss due to hospital infection was RMB 7 538 yuans per case.The infection of(respiratory) system disease caused the highest economic loss among the diseases of different systems with the(average) loss of RMB 15 197 yuans per case.And the loss due to septicemia was the highest than other sites of infection,with average loss of RMB 11 150 yuans per case.The average time of stay in hospital was 9.34 days per(case).CONCLUSIONS Hospital infection can increase the patients′economic burden,prolong the time of(hospitalization).Therefore,it is of great economic and social benefit to prevent and control hospital infection.