Clinical effect analysis of oral calcitriol and calcium in the treatment of infantile rickets / 中国现代医生

Objective To investigate the clinical effect of oral calcitriol and calcium in the treatment of infantile rickets. Methods A total of 84 children with pediatric rickets treated in the department of pediatrics of our hospital from June 2017 to June 2018 were randomly divided into two groups. The control group received conventional oral vitamin D drops and calcium acetate. The observation group received oral calcitriol combined with calcium acetate. The clinical efficacy, blood biochemical changes, bone mineral density changes, height and body weight changes were compared between the two groups. Results The effective rate of the observation group was 97.62％, which was significantly higher than that of the control group (78.57％), and the difference was statistically significant (P<0.05). The blood calcium, blood phosphorus and 25-(OH) D3 in the observation group after treatment were significantly higher those in the control group.The BALP in the observation group was significantly lower than that of the control group, and the difference was statistically significant (P<0.05). The tibia, ulnar salt level and bone mineral density were significantly higher in the observation group than those in the control group (P<0.05). The height growth and body mass growth of the observation group after treat ment were significantly higher than those of the control group. The incidences of night terror, sweating, and baldness were significantly lower than those of the control group, and the difference was statistically significant (P<0.05).Conclusion Oral calcitriol and calcium are effective in treating children with rickets, which effectively improve blood calcium level and bone density, promote growth and development of children, reduce the incidence of clinical symptoms, and have positive clinical significance.

Hyperuricemia and metabolic syndrome:research advances / 国际药学研究杂志

Hyperuricemia(HUA),which can induce oxidative stress,endothelial dysfunction,and inflammation,is closely relevant to the metabolic syndrome(MS),such as obesity,impaired fasting blood glucose,hyper-triglyceridemia,and hypertension. Moreover,HUA is of reciprocal causation with insulin resistance(IR). Here,for the prevention and treatment of metabolic diseases such as HUA and MS,the interaction and the regulatory mechanism between MS and HUA are summarized,and the situation that HUA is an important complication of MS is illustrated.