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With the progress of high-throughput sequencing technologies and bioinformatics,and deepening understanding of immune system,immunomics has evolved from initially deciphering gene sequences of B cell receptor(BCR)and T cell receptor(TCR)to unraveling and mapping interactions between host immune system and antigens,as well as panorama of host immune system response mechanisms,which now encompasses various research areas,such as antigen epitopeomics,immunogenomics,immunopro-teomics,antibodyomics and immunoinformatics.Based on a large amount of immunological research data,immunological databases such as ImmPort,VDJdb and IEDB have been established to accelerate discovery of new antigen epitopes and study of immune response mechanisms.Immunomics has revealed the association between immune system and diseases,promoted the development of novel vac-cines and immunotherapeutic strategies,and effectively drove the development of personalized medicine and precision medicine.In recent years,integration of immunome with exposome and fusion it with artificial intelligence will have a significant impact on compre-hensively understanding immune system's response and regulatory mechanisms to environmental factors,as well as deciphering molecular mechanisms underlying disease occurrence and progression.
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During the COVID-19 epidemic, our national guidelines have suggested that surgical patients should wear a mask to decrease the potential transmission of COVID-19 in the operating room, as long as the condition allows. However, so far, there is no study to discuss the influence of wearing a mask on the ventilation and blood oxygenation status in patients of spontaneous breathing with supplementary oxygen through an anesthetic facemask. This is a before-after study in the same patient, and 10 healthy volunteers were recruited, by testing the arterial blood gas parameters at key time points before and after oxygen inhalation to evaluate the effects of two different supplementary oxygen methods ('disposable medical mask + anesthetic facemask' and 'anesthetic facemask only') on the oxygenation of subjects. Our data demonstrated whether wearing a disposable medical mask or not could effectively increase the oxygen supply of the subjects compared with the basic value before oxygen inhalation; however, compared with the group without mask, the arterial oxygen partial (PaO
Sujets)
Humains , COVID-19 , Volontaires sains , Masques , Oxymétrie , Oxygène/sangRésumé
OBJECTIVE:To compare the bioequivalence between alfuzosin hydrochloride sustained release tablets and the imported alfuzosin common tablets.METHODS:20 health volunteers were assigned to receive oral single dose of 5mg sustained-release and imported tablets of alfuzosin by self crossover way,with alfuzosin concentration in serum determined by HPLC.The pharmacokinetic parameters were calculated;the statistical analysis was carried out and the bioequiavailability was evaluated.RESULTS:The main pharmacokinetic parameters of the sustained-release and the imported tablets of alfuzosin were as follows:Cmax:(28.92? 9.63) ?g? L-1 vs.(32.92? 10.23) ?g? L-1;tmax:(2.7? 0.6) h vs.(1.4? 1.0) h;AUC0～ ∞:(221.14? 59.46) ?g? h? L-1 vs.(245.68? 67.20) ?g? h? L-1;t1/2:(6.68? 0.85) vs.(4.73? 1.22) h;AUC0～ 24:(215.20? 49.63) vs.(226.30? 53.60) ?g? h? L-1.The relative bioavailability of alfuzosin hydrochloride sustained release tablets was(92.2? 13.2) %.CONCLUSION:The 2 preparations of alfuzosin are bioequivalent.
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OBJECTIVE:To determine the formula of alfuzosin rapid-release and sustained-release bilayer tablet and its preparation METHODS:The compositions of rapid-release layer were selected by orthogonal design and the compositions of sustained-release layer were determined according to its percentage of dissolution RESULTS:The rapid-release layer contained alfuzosin 1mg,lactose 35mg,sodium carboxylmethyl starch 1mg and starch 8mg The sustained-release layer contained alfuzosin 4mg,HPMC 50mg and MC 70mg CONCLUSION:The formula of the tablet is reasonable and the preparation simple