RÉSUMÉ
Objective @#To explore the application of ZnxNi1-xS@ DOX nanostructures in combined photothermal- chemotherapy treatment of tumors,and to provide new ideas for the study of tumor treatment methods.@*Methods@#The morphology and elementary composition of ZnxNi1-xS nanostructures were characterized by scanning emission e- lectron microscopy and other methods.The photothermal properties of ZnxNi1-xS nanostructures were explored by infrared thermal camera.The release of DOX under different temperature and pH was investigated by fluorescence spectrophotometer.The biosafety of ZnxNi1-xS nanostructures and the in vitro antitumor properties of ZnxNi1-xS@ DOX nanostructures were investigated by MTT assay. @*Results @#The as-prepared ZnxNi1-xS nanostructure had good dispersion and uniform size.The ZnxNi1-xS nanostructures had good photothermal effect.The drug release behavior showed temperature and pH responsiveness.The MTT assay showed that ZnxNi1-xS nanostructures were nontoxic to normal cells.ZnxNi1-xS@ DOX nanostructures could significantly inhibit the growth of tumor cells under near-infra- red illumination.@*Conclusion @#The as-prepared ZnxNi1-xS nanostructure has good biocompatibility,on the basis of which the ZnxNi1-xS@ DOX nanostructures achieve good antitumor performance,which can be used for combined photothermal-chemotherapy treatment of tumors.
RÉSUMÉ
Developing tumor-specific drug delivery systems with minimized off-target cargo leakage remains an enduring challenge. In this study, inspired from the natural cryptobiosis explored by certain organisms and stimuli-responsive polyphenol‒metal coordination chemistry, doxorubicin (DOX)-conjugated gelatin nanoparticles with protective shells formed by complex of tannic acid and Fe