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Bone metabolism refers to the decomposition and anabolism occurring during bone remodeling, and its balance is regulated by bone resorption and bone formation. A slight deviation of this balance causes various skeletal diseases, such as osteoporosis and renal osteodystrophy. Traditional Chinese medicine (TCM) monomers and compounds have certain advantages in treating bone metabolism diseases. The Wnt signaling pathway includes the canonical Wnt signaling pathway, dependent on β-catenin, and the non-canonical Wnt signaling pathway, independent of β-catenin. Both types of pathways can maintain bone metabolism balance by regulating bone formation and bone resorption and are essential for bone development, bone mass maintenance, and bone remodeling. A variety of TCM monomers (albiflorin, catalpol and icariin) and formulas (Zuogui pill, Yishen gugu prescription, Duzhong jiangu prescription, etc.) have been confirmed to promote differentiation of bone marrow mesenchymal stem cells, proliferation and differentiation of osteoblasts, bone injury repair, and osteoporosis improvement by activating the Wnt signaling pathway in recent years. Here, this article summarizes the research progress in the Wnt signaling pathway regulation of bone metabolism by TCM monomers and compounds to provide ideas for the clinical application of TCM and the research and development of new drugs for the prevention and treatment of bone metabolism diseases.
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BackgroundThe incidence of mental disorders is steadily increasing. However, antipsychotic medications, commonly used in treatment, can lead to drug-induced amenorrhea in female patients. This side effect significantly reduces medication adherence and increases the risk of disease recurrence. Therefore, addressing drug-induced amenorrhea in female patients has become an urgent problem requiring effective solutions. ObjectiveTo explore the efficacy and safety of traditional Chinese medicine compound in treating antipsychotic-induced amenorrhea, so as to provide guidance for the treatment of this condition using traditional Chinese medicine compound. MethodsOn September 4, 2022, a computerized search was conducted on across multiple databases, including China National Knowledge Infrastructure, VIP Database, Wanfang Database, China Biomedical Literature Database, PubMed, Cochrane Library and Embase, and randomized controlled trials (RCT) of traditional Chinese medicine compound in treating antipsychotic-induced amenorrhea were collected. The quality of the included literature was assessed using Cochrane 5.3 bias risk assessment tool. Meta-analysis was performed to assess the total effective rate, cure rate, incidence of adverse reactions and recurrence rate using RevMan 5.3. ResultsUltimately, 22 RCT involving 1 879 patients were included. Meta-analysis results showed that the total effective rate (RR=1.29, 95% CI: 1.16~1.44) and cure rate (RR=1.62, 95% CI: 1.45~1.80) of traditional Chinese medicine compound or its combination with western medicine in treating antipsychotic-induced amenorrhea were significantly higher compared to western medicine alone. Moreover, the incidence of adverse reactions (RR=0.56, 95% CI: 0.41~0.76) and recurrence rate (RR=0.16, 95% CI: 0.06~0.42) were significantly lower than those of western medicine alone. ConclusionTraditional Chinese medicine compound may offer benefits in ameliorating antipsychotic-induced amenorrhea and its safety is better than simple western medicine treatment.
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In order to provide a reference basis for the development of relevant compound preparations, this article takes a comprehensive analysis of the usage and dosage of famous classical formulas in Han dynasty from various perspectives, and gives corresponding countermeasures on this basis. Through the comprehensive analysis of the classification and statistics of Zhongjing's medication characteristics, decoction methods, administration and dosage, and combining conversion methods of weights and measures by ancient medical practitioners, along with the dosage and administration of the listed Han dynasty famous classical formulas, it was found that the "Jiangxi method" served as a general guideline for administration according to Zhongjing's original text. This method allowed for flexible dosing based on the conversion of the ancient measurements to modern equivalents[13.8 g per Liang(两)], ensuring the safe and effective medication of these formulas. After combing, it is found that although the dosage of single medicine is large in famous classical formulas from Han dynasty, the administration is flexible. The crude drug amount per administration serves as the foundational dose, with the frequency of administration adjusted flexibly according to the condition. This dosing approach becomes the key for the rational development of compound formulations of famous classical formulas. Based on the conclusions of the study, it is recommended that when developing compound formulations of famous classical formulas in Han dynasty, the original administration method and dosage should be respected. The original crude drug amount per administration should be considered as the daily foundational dose, with the frequency of administration described within a range(1 to N times per day, where N is the maximum number of administrations as per the original text). The specific frequency of administration can be adjusted flexibly by clinical practitioners based on the individual condition. This approach should also be adopted in toxicological studies, where the dosage per administration serves as the basis for toxicity research, and the toxicity profile at the maximum administration frequency should be observed, providing guidance on the clinical safety range. Corresponding drug labels should provide information within a range to indicate toxicological risk intervals.
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The efficacy of traditional Chinese medicine (TCM) and compound prescriptions is confirmed based on practical experience. It is a highly generalized expression of the clinical characteristics and scope of prescriptions and a unique expression of the medical effects of TCM. Network pharmacology, as a cross-disciplinary field based on the theory of systems biology and multi-level analysis of biological systems, has become a common virtual screening tool in TCM research and gradually developed with the progress in big data and artificial intelligence. In the context of modern medicine, the efficacy of TCM compound prescriptions has a vague concept and lacks scientific evidence. Elucidating the connotation of TCM efficacy and guiding TCM theoretical research has become one of the hotspots and difficulties in TCM research. This article explores the feasibility of using network pharmacology for the research on the efficacy of TCM compound prescriptions and investigates whether the research results can represent part of the efficacy of prescriptions. Furthermore, the research platforms and algorithms in this field are summarized. The research ideas and existing problems in this field are proposed from the aspects of efficacy concept embodiment, target screening, result verification, efficacy network building, and homogenization avoiding of network pharmacology research results. Finally, the future development directions are prospected. This article is expected to provide a reference for exploring the modern biological basis of the efficacy of TCM and compound prescriptions and for the clinical application and theoretical research of TCM.
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ObjectiveTo mine the compatibility rules of patented traditional Chinese medicine (TCM) compound prescriptions for treating chronic atrophic gastritis (CAG) by systems pharmacology and molecular docking methods, and predict the targets and molecular mechanisms of Chinese medicinals with different efficacy in the treatment of CAG. MethodThe TCM compound prescriptions for treating CAG were extracted from the patent system of the China National Intellectual Property Administration. The active components and targets of the prescriptions were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), Traditional Chinese Medicine Integrative Database (TCMID), and UniProt. The candidate targets and pathways of CAG were obtained from GeneCards, DisGeNet, Online Mendelian Inheritance in Man (OMIM), MalaCards, Kyoto Encyclopedia of Genes and Genomes (KEGG) and Reactome. The gene ontology (GO) functional annotation and KEGG pathway enrichment were realized by R Studio 4.1.2. STRING11.0 was employed to build the protein-protein interaction (PPI) network, and AutoDock Vina 4.2.6 was used for the docking between key targets and components. ResultA total of 228 TCM compound prescriptions for treating CAG were extracted. The medicinals used in these prescriptions mainly had warm or cold nature, bitter or sweet taste, tropism to the spleen, stomach, and liver meridians, and the efficacy of tonifying Qi, regulating Qi movement, clearing heat, and activating and toniying blood. The prescriptions mainly treated CAG via p53, mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), forkhead box protein O (FoxO), vascular endothelial growth factor (VEGF), and hypoxia-inducible factor-1 (HIF-1) signaling pathways. Molecular docking results confirmed that the active components in the prescriptions had docking activities with key receptor proteins. ConclusionThis study preliminarily analyzed the compatibility rules of TCM compound prescriptions in the treatment of CAG. The medicinals with different efficacy treat CAG by regulating cell proliferation, apoptosis, and oxidative stress response, preventing carcinogen production, promoting gastric acid secretion, and improving local microcirculation in a multi-target, multi-pathway, multi-link manner. The findings facilitate the research on the TCM treatment of CAG.
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ObjectiveTo explore the medication rules of traditional Chinese medicine compounds for depression in the National Patent Database using data mining, and to provide ideas for the clinical treatment and the development of new drugs for depression. MethodsThe patent data of traditional Chinese medicine compounds for the treatment of depression were searched from inception to July 1st, 2022 on the Patent Publication Announcement website of China National Intellectual Property Administration. The selected traditional Chinese medicine compounds were analyzed by using the data mining section of the ancient and modern medical record cloud platform (V2.3.5) for drug frequency, and based on this, the nature, flavor, channel entry and function of the medicinals were analyzed. Representative high-frequency herbal combinations were obtained through correlation analysis, while the classification of Chinese medicine compounds for depression was analyzed by cluster analysis, and the core combinations of herbs for the treatment of depression were screened out using complex network analysis. ResultsA total of 325 Chinese medicine compounds were included, involving 452 herbs, with a total frequency of 3532 times. The top 10 mostly used herbs were Yujin (Radix Curcumae, 122 times), Chaihu (Radix Bupleuri, 122 times), Baishao (Radix Paeoniae Alba, 109 times), Suanzaoren (Spina Date Seed, 95 times), Fuling (Poria, 94 times), Danggui (Radix Angelicae Sinensis, 94 times), Yuanzhi (Radix Polygalae, 84 times), Baizhu (Rhizoma Atractylodis Macrocephalae, 72 times), Shichangpu (Rhizoma Acori Graminei, 71 times), and Danshen (Salvia Miltiorrhiza, 61 times). The natures of the herbs were mainly warm (998 times), neutral (944 times), slightly cold (596 times) and cold (497 times); the flavors were mainly sweet (1648 times), acrid (1392 times), and bitter (1337 times); the channels of entry were mainly liver (1695 times), heart (1521 times), spleen (1326 times) and lung (1268 times). The medicinals with the function of soothing liver to relieve constraint, moistening the intestines to promote defecation, calming the heart and the mind, moving qi to relieve constraint were used more frequently. The high frequency herbal combinations by association analysis included “Chaihu (Radix Bupleuri)→ Baishao (Radix Paeoniae Alba)”, “Danggui (Radix Angelicae Sinensis)→Chaihu (Radix Bupleuri)” and “Baishao (Radix Paeoniae Alba)→ Yujin (Radix Curcumae)”. The 22 high frequency medicinals used more than 40 times could be clustered into six categories. Complex network analysis found the core herbal combination for the treatment of depression was the formula of Chaihu (Radix Bupleuri), Yujin (Radix Curcumae), Baishao (Radix Paeoniae Alba), Danggui (Radix Angelicae Sinensis), Fuling (Poria), Suanzaoren (Spina Date Seed), and Xiangfu (Cyperi Rhizoma). ConclusionTraditional Chinese medicine compounds for the treatment of depression is mainly based on the pathogenesis of constraint, stasis and deficiency, focusing on the liver, heart, spleen and lung, commonly using medicinals with the function of soothing liver to relieve constraint, fortifying spleen and nourishing heart, regulating qi and invigorating blood, and moistening the intestines to promote defecation, which can provide a reference for the clinical treatment and new drug research and development for depression.
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Diabetic kidney disease is an important microvascular complication of diabetes and the leading cause of end-stage renal disease. Its pathological characteristics mainly include epithelial mesenchymal transition(EMT) in glomerulus, podocyte apoptosis and autophagy, and damage of glomerular filtration barrier. Transforming growth factor-β(TGF-β)/Smad signaling pathway is specifically regulated by a variety of mechanisms, and is a classic pathway involved in physiological activities such as apoptosis, proliferation and differentiation. At present, many studies have found that TGF-β/Smad signaling pathway plays a key role in the pathogenesis of diabetic kidney disease. Traditional Chinese medicine has significant advantages in the treatment of diabetic kidney disease for its multi-component, multi-target and multi-pathway characteristics, and some traditional Chinese medicine extracts, traditional Chinese medicines and traditional Chinese medicine compound prescription improve the renal injury of diabetic kidney disease by regulating TGF-β/Smad signaling pathway. This study clarified the mechanism of TGF-β/Smad signaling pathway in diabetic kidney disease by expounding the relationship between the key targets of the pathway and diabetic kidney disease, and summarized the research progress of traditional Chinese medicine in the treatment of diabetic kidney disease by interfering with TGF-β/Smad signaling pathway in recent years, to provide reference for drug research and clinical treatment of diabetic kidney disease in the future.
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Humains , Néphropathies diabétiques/génétique , Médecine traditionnelle chinoise , Rein/anatomopathologie , Facteur de croissance transformant bêta/métabolisme , Transduction du signal , Transition épithélio-mésenchymateuse , Protéines Smad/métabolisme , Facteur de croissance transformant bêta-1/métabolisme , Diabète/génétiqueRésumé
At present, new concepts, new technologies, and new methods are emerging in the field of medical research, breaking through the inherent thinking patterns and research models, and promoting the transformation of the research paradigm of traditional Chinese medicine(TCM). This paper gave a case study of clinical research in Danhong Injection in the treatment of chronic stable angina, and based on the background of the study, index evaluation model, experimental design method, blind implementation of placebo, data management system, and exploration of clinical efficacy mechanism of traditional Chinese medicine compounds under the framework of modular pharmacology, the scientific idea of "proving efficacy, conforming standard, and exploring mechanism" was used as the guideline to discuss the research model of reevaluation of the effectiveness of post-marketing TCM varieties. This paper drew a target network map of Danhong Injection in the treatment of chronic stable angina for the first time, which was composed of targeted functional modules. By combining evidence-based clinical research with modular pharmacology framework, changes in the pharmacolo-gical mechanism were finally associated with changes in clinical efficacy, and the advantages of phenotypic correlation of efficacy were explored. This study is expected to provide references for the post-marketing effectiveness evaluation and new ideas for the phenotypic pharmacological mechanism study of multi-target TCM compounds and precise treatment, thereby promoting the innovative development of TCM.
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Humains , Médecine traditionnelle chinoise , Angor stable/traitement médicamenteux , Médicaments issus de plantes chinoises/usage thérapeutique , Résultat thérapeutiqueRésumé
Decoction is a traditional clinical way of traditional Chinese medicine (TCM) compound. A series of complex physical and chemical changes are often involved in the process of decoction, which presents a mixed-phase system. In most studies on the TCM compound decoction, it has always focused on the amounts of chemical substances in decoction, while the phase properties and existence forms of these components are neglected. Most of the chemical components exist in the mixed-phase system as molecules, ions or other particles. According to the particle size of the contained particles, the differences among the phases, including true solution phase, colloidal phase, suspended phase and precipitated phase, lead to their differences in pharmaceutical and biological effects. Based on the above research background, this paper takes the phase state differences of decoction as the breakthrough point, and systematically reviews the physicochemical properties, the physical structures of the active components and the biological effects of the decoction caused by the phase state differences. The phase state differences of TCM compound decoction have been found to be closely related to their efficacy, which might be a good perspective to investigate the possible mechanism. It might provide a beneficial reference for the exploration of related basic research on TCM compounds.
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Traditional Chinese medicine has unique advantages in the treatment of degenerative bone and joint diseases, and its widely used in clinical practice. In recent years, many scholars have conducted a large number of basic studies on the delay of intervertebral disc degeneration by herbal compound and monomeric components from different perspectives. In order to further elucidate its mechanism of action, this paper summarizes the in vivo and in vitro experimental studies conducted at the level of both herbal compound and single components, respectively, in order to provide references for the basic research on the treatment of lumbar intervertebral disc degeneration by Chinese medicine. A summary shows that commonly used herbal compound prescriptions include both classical prescriptions such as Duhuo Jisheng Decoction, as well as clinical experience prescriptions such as Yiqi Huoxue Recipe. Angelicae Sinensis Radix, Chuanxiong Rhizoma, Rehmanniae Radix Praeparata, Achyranthis Bidentatae Radix, and Eucommiae Cortex were used most frequently. Tonic for deficiency and blood stasis activators were used most frequently. The most utilized monomeric components include icariin, ginsenoside Re, salvianolic acid B and aucubin. The main molecular mechanisms by which herbal compound and monomeric components delay of lumbar intervertebral disc degeneration include improving the intervertebral disc microenvironment, promoting the synthesis of aggregated proteoglycans and type Ⅱ collagen in the intervertebral disc, reducing the degradation of the extracellular matrix, and inhibiting apoptosis in the nucleus pulposus cells, etc. The main signaling pathways involved include Wnt/β-catenin signaling pathway, MAPK-related signaling pathway, mTOR signaling pathway, Fas/FasL signaling pathway, PI3 K/Akt signaling pathway, NF-κB signaling pathway, JAK/STAT signaling pathway, and hedgehog signaling pathway, etc.
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Humains , Chine , Médicaments issus de plantes chinoises/usage thérapeutique , Protéines Hedgehog/métabolisme , Dégénérescence de disque intervertébral/métabolisme , Nucleus pulposus/métabolisme , Voie de signalisation WntRésumé
Rotavirus enteritis (RVE), a common infectious disease of the digestive system, is commonly found in infants and young children. Its incidence is high, posing great threats to human health. At present, no specific drugs are available in western medicine and the symptomatic treatments like fluid infusion, anti-diarrhea, correction of electrolyte disorder, protection of gastrointestinal mucosa, and regulation of intestinal microecology have been employed. In addition to the poor therapeutic efficacy, they do not perform well in preventing the onset of RVE and shortening the course of disease. Traditional Chinese medicine (TCM) exerts the therapeutic effect against RVE via multiple targets, without inducing obvious adverse reactions and the cost is low. The specific mechanism of action has yet to be fully explained. Although there are some studies exploring the role of Chinese medicinal monomers in the pathogenesis of RVE, the types involved are still not enough. The effects of Chinese medicinal monomers on autophagy-related pathways fail to be uncovered, which is attributed to the lack of large-scale experimental data and clinical evidence. There are also many problems that cannot be ignored in the related research of Chinese medicinal compounds, taking the superficial exploration and limited scope for instance. Autophagy is a highly conserved biological phenomenon that involves a variety of signaling pathways. Its dysfunction is related to multiple pathological processes. Studies have shown that autophagy plays an important role in the pathogenesis of RVE, especially in the early stage of viral infection. Autophagy induces intestinal mucosal barrier damage, intestinal nerve dysfunction, and immune abnormality, resulting in the occurrence and development of RVE. In recent years, a large number of experimental studies have confirmed that TCM fights against circulatory, respiratory, digestive, and immune system diseases as well as tumors by intervening in autophagy. At the same time, a handful of studies have suggested that Chinese medicinal monomers and compounds regulate autophagy and interfere with viral replication by affecting related signaling pathways, thus playing a positive role in reversing the progression of RVE. However, at present, there are few studies on the regulation of autophagy by TCM in the treatment of RVE, and no systematic elaboration is available. This review aimed to summarize the role of autophagy in the pathogenesis of RVE and its intervention with TCM, in order to provide more theoretical and clinical evidence for the treatment of RVE with TCM.
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Chinese traditional medicine compound is the main form of Chinese medicine clinical application. The elucidation of the effective components of traditional Chinese medicine is one of the key scientific issues to promote the modernization of traditional Chinese medicine. At present, there are many research ideas on the effective components of traditional Chinese medicine compounds. By analyzing the current status and existing problems of existing research ideas, the author proposes a "double reduction network pharmacology"(2 R network pharmacology) research method based on "prediction of dominant components-potential target selection". Chemical components with good properties were selected by ADMET property prediction technology, and compared with the blood components and target organ components to determine the dominant components with potential therapeutic effect, that is "reducing constituents"; the potential core regulatory pathway of traditional Chinese medicine compound was enriched by RNA-Seq technology combined with network database, and then the target of traditional Chinese medicine compound was mined based on the signal pathway, that is "reducing targets". To improve the efficiency and accuracy of effective component screening, the network relationship of "component target" was established by the related technology of network pharmacology. The purpose of this study is to provide practical research ideas and methods for clarifying the effective components of traditional Chinese medicine, revealing the law of compatibility of traditional Chinese medicine and clarifying the target of drug action.
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Bases de données factuelles , Médicaments issus de plantes chinoises/pharmacologie , Médecine traditionnelle chinoise , Simulation de docking moléculaire , Plan de rechercheRésumé
This article reviewed the research on the intervention of traditional Chinese medicine compound on gastric cancer. And to discover the traditional Chinese medicine with anti-tumor effect and traditional Chinese medicine ingredients have an effect on the development of tumor, such as influencing the precancerous lesions, inhibiting tumor cell proliferation, metastasis, by inhibiting tumor blood vessels to grow. It will influence tumor cell apoptosis pathway and inflammatory response. TCM compound intervention can improve human immunity, so as to prevent and treat gastric cancer.
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Stroke is a devastating cerebrovascular event that occurs as a result of cerebral vascular occlusion (ischemic stroke) or burst/bleeding (hemorrhagic stroke) leading to cerebral blood flow disruption, causing physical disability and multiple functional impairment. The incidence of ischemic stroke is higher than hemorrhagic stroke, accounting for more than half of the total incidence of stroke. The main cause of the disease is caused by atherosclerosis, various arteritis, trauma and other plaques that cause cerebral vascular disease, which may be caused by a variety of cardiovascular diseases such as atrial fibrillation. Blood, caused by blocking blood vessels in the brain. Due to the complexity of the causes of ischemic stroke, the pathogenesis and development mechanism are complex and diverse, such as energy failure, excitotoxicity, neuroinflammation, apoptosis and oxidative stress. Traditional Chinese medicine and compound have the characteristics of multi-component, multi-target, multi-effect, and can be applied to the treatment of different stages of stroke occurrence and development. Therefore, an in-depth understanding of the pathological process and related mechanisms of ischemic stroke, and the development of targeted drugs, is important to prevent the occurrence of ischemic stroke and control its development. In this paper, the timeline of the occurrence and development of ischemic stroke is the main line. The pathological process and related mechanisms are systematically reviewed. The most widely used traditional Chinese medicine and compound in clinical and basic research are summarized, in order to study the pathological study of ischemic stroke. Clinical treatment provides a theoretical basis and data reference.
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Since December 2019, there has been a sharp increase in the number of confirmed cases of pneumonia caused by the novel coronavirus (SARS-CoV-2) in China, which has caused great concern around the world. In face of severe epidemic, no specific drugs have been found in clinical practice. However, some Chinese medicine compounds have shown obvious clinical efficacy, and it is feasible to find and develop natural drugs for the treatment of novel coronavirus pneumonia from these compounds. In this paper, based on the recommends of new type of coronavirus infection pneumonia diagnosis and treatment scheme (trial version 6), the use frequency of Chinese herbal medicines was calculated. The antiviral reports of high frequency Chinese herbal medicines were reviewed, in order to provide the reference for screening the active components against SARS-CoV-2 from traditional Chinese medicine.
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To systematically evaluate the efficacy of traditional Chinese medicine(TCM) compounds combined with levodopa medicine in the treatment of Parkinson's disease(PD), and screen basic herbs to provide certain evidence-based medical proof and program for better guidance on clinical drug use. Six databases were searched to screen out the randomized controlled trial on the TCM compounds combined with levodopa medicine in the treatment of PD. Literature quality of the included studies was evaluated by improved Jadad rating scale, and the Meta-analysis was performed by RevMan 5.3 software. After the data of the basic TCM compounds involved were sorted out, the strong association rules were found by using Apriori algorithm of SPSS Modeler 18.0 software, and then the basic herbs for the treatment of PD could be picked out. A total of 20 studies were eventually included, involving 1 784 patients. Ten studies were of high-quality literature, Jadad score≥4 points. Meta-analysis showed that efficacy of TCM combined with levodopa medicine was better than levodopa medicine alone in lowering Unified Parkinson's Disease Rating Scale(UPDRS) score: UPDRS Ⅰ(MD=-0.43, 95%CI[-0.62,-0.24], P<0.000 1), UPDRS Ⅱ(MD=-2.72, 95%CI[-3.24,-2.21], P<0.000 01), UPDRS Ⅲ(MD =-1.97, 95%CI[-2.69,-1.25], P<0.000 01), UPDRS Ⅳ(MD=-0.28, 95%CI[-0.46,-0.11], P=0.002). And the improvement in UPDRS score reduction rate of TCM combined with levodopa medicine was better than that in levodopa medicine alone: effective rate(OR=4.81, 95%CI[3.50, 6.62], P<0.000 01). Data mining results showed that the basic prescription for treating PD consisted of Paeoniae Radix Alba-Rehmanniae Radix Praeparata-Gastrodiae Rhizoma in general. According to each part of UPDRS, the basic prescription for treating mentation, behavior and mood(UPDRS Ⅰ) consists of Paeoniae Radix Alba-Rehmanniae Radix Praeparata-Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle, Among which Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle might have unique efficacy. The basic prescriptions for treating UPDRS Ⅱ and UPDRS Ⅲ consisted of Paeoniae Radix Alba-Rehmanniae Radix Praeparata, or Chuanxiong Rhizoma-Angelicae Sinensis Radix(two drug combinations). However, in the treatment of UPDRS Ⅳ, the drugs were scattered. But due to the limitations in the quantity and quality of clinical studies, the results obtained still need further research and clinical confirmation of its efficacy.
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Humains , Chine , Médicaments issus de plantes chinoises , Lévodopa , Médecine , Médecine traditionnelle chinoise , Maladie de ParkinsonRésumé
At present,Western medicine is widely used in the treatment of epilepsy.However,about 30%-40% of epileptic patients are resistant to them and are affected by the side effects of these drugs.Traditional Chinese medicine is effective in treating epileptic seizures and relieving complications caused by Western medicine.However,the active ingredients and mechanisms of traditional Chinese medicine remain unclear.This article reviews and summarizes the advances and mechanisms in treating epilepsy,such as Chinese medicine monomer,the extracts of single Chinese medicine and Chinese medicine compound.Chinese medicine monomers,including gastrodin,asarone,rhynchophylline,ligustrazine,tanshinone ⅡA,curcumin,etc.,have antiepileptic effects via regulating excitatory neurotransmitters and receptors,the expression of inflammatory factors,sodium/potassium ion channels and the expression of apoptotic protein,therefore protecting neurons.The extracts of single Chinese herbal including the extracts of Gastrodiae Rhizoma,Acori Tatarinowii Rhizoma,Ginseng Radix et Rhizoma,Ganoderma,Scutellariae Radix and Ginkgo Folium,etc.,have antiepileptic effects related to the inhibition of γ-aminobutyric acid receptor,upregulation of phosphatidylinositol 3-kinase signaling pathway and reduction of glutamate-induced excitotoxicity and oxidative stress response.Furthermore,these extracts can regulate ion channels and reduce oxidative damage of neurons.Chinese medicine compounds including Dianxian Qing Granules,Danxing Ningxian Granules,Huoxue Dingxian formulae,etc.,can improve the therapeutic effect on epilepsy through simultaneously regulating excitatory transmitters,apoptosis factors and cytokines.
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Humains , Médicaments issus de plantes chinoises , Utilisations thérapeutiques , Épilepsie , Traitement médicamenteux , Médecine traditionnelle chinoise , PhytothérapieRésumé
The chemical composition of traditional Chinese medicine (TCM) compounds is complex, the treatment is broad, and the quality control indexes cannot accurately reflect the functional properties. According to the above problems, the authors take the research process of quality markers of Qizhiweitong granules as an example to innovate the research ideas and technical methods, and constructed five progressive steps of TCM compounds quality control and evaluation model: "based on function, to figure out the attending", "components and pharmacodynamics correlation, multiple components with multiple effects", "to analyze the components, and systematically integrate them", "spectrum and effect correlation, from a spectrum to see the efficiency", and "from the content-effect colour atla to see the quality". Based on the multiple effects of components, multiple components of multi-effect pharmacological efficacy evaluation system were established. All-time isobaric multiwavelength fusion fingerprint technology was improved and developed. "Spectrum-effect colour atla" software was research and developed for the first time, to realize the "visualization" of TCM efficacy. The aim of this work is to provide an exploratory solution for the integrated quality control of TCM compounds.
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Hepatocellular carcinoma(HCC) is the most common malignancy in the world. Although there is progress in HCC diagnosis and treatment, it is still the third leading cause of cancer death worldwide because it is not easily diagnosed early and the disease progresses quickly. China is a high-risk area for HCC, and the number of cases is high and on the rise. Its prevention and treatment is a pressing problem. At present, western medicine is still unclear about the complex pathogenesis and clinical treatment of HCC. There are still many shortcomings and huge challenges. Traditional Chinese medicine(TCM) has its unique advantages in the treatment of HCC. With an overall concept, it has unique therapeutic effect and fewer side effect on HCC,it can not only inhibit tumor growth, but also alleviate patients' clinical symptoms and improve their quality of life. Therefore, the study of the effect of TCM in treating HCC has attracted the attention from many clinicians and researchers. However, the chemical composition of TCM formula is complex, with many targets and huge network of pharmacodynamic mechanisms, which greatly limits the research on the development of clinical drugs for the Chinese medicine formula. In recent years, there have been achievements in the studies of anti-hepatocarcinoma efficacy and mechanism of action of Chinese medicine compound, which mainly focused on the compound's effect in inhibiting the proliferation of hepatocarcinoma cells, blocking cell cycle and inducing apoptosis and autophagy, inhibiting liver cancer cell invasion and metastasis, regulating the immune function, synergism and attenuation, and reversing the drug resistance. In this paper, domestic and foreign literatures on the above-mentioned pharmacodynamics and mechanism of anti-liver cancer of TCM compound were studied, analyzed, summarized and summarized. This paper briefly reviews the research progress of its anti-hepatocarcinoma mechanism, and provides scientific ideas and evidence for the future study of the anti-hepatocarcinoma mechanism of TCM compound and its rational clinical application.
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Diabetes mellitus complicated with cerebral infarction is the commonest and most serious vascular complication of diabetes mellitus. With a high disability and mortality rate, it seriously threatens human health. Because the pathogenesis is still unclear, more and more scholars have focused on the research of diabetic cerebral infarction at home and abroad. Traditional Chinese medicine(TCM) compounds have a remarkable curative effect in the treatment of diabetic cerebral infarction. Its mechanisms of action mainly include anti-hypertension, reduction of blood sugar and lipid, promotion of vascular regeneration and vascular endothelial function, anticoagulation, anti-thrombosis, improvement of nerve function defect, reduction of infarct volume, improvement of hemorheological, inhibition of inflammation and platelet aggregation, and promotion of collateral circulation. Through literature search, this paper summarizes the research progress of the mechanisms of TCM compounds in treating diabetic cerebral infarction in recent five years at home and abroad, in order to provide reference for clinical treatment.