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Article de Chinois | WPRIM | ID: wpr-1026857

RÉSUMÉ

Objective To optimize the ethanol extraction technology parameters of Jinlei Compound through orthogonal experiment combined with beetle antennae search(BAS)-back propagation(BP)neural network.Methods On the basis of the optimal extraction concentration obtained by single factor investigation,the ratio of solid to liquid,extraction time and extraction times were set as the orthogonal test factors.The entropy weight method was used to calculate the comprehensive scores of the yield of luteolin,kaempferol,swertianin and dry paste.Then,the BAS-BP neural network model was established,and the optimum extraction process was predicted by the BAS.Results BAS-BP neural network optimized Jinlei Compound alcohol extraction process was as follows:solid-liquid ratio 1:10,extraction time of 0.5 h,extraction times of 3,the comprehensive score was 96.352 6.The optimal process parameters obtained by orthogonal design were:solid-liquid ratio 1:10,extraction for 0.5 h,extraction for 3 times,the comprehensive score 90.988 0.The comprehensive score of BAS-BP neural network model was slightly better than that of orthogonal experiment,but the difference between the two was small.The optimal extraction process of Jinlei Compound was determined by comprehensive production practice as the ratio of solid to liquid 1:10,extraction for 0.5 h,extraction for 3 times.Conclusion The optimized process based on BAS-BP neural network has higher extraction efficiency and good stability,which can provide reference for subsequent development and quality control.

2.
China Pharmacist ; (12): 393-399, 2023.
Article de Chinois | WPRIM | ID: wpr-1025894

RÉSUMÉ

Objective To optimize the water extraction and alcohol precipitation process of Radix Paeoniae Rubra-Cortex Moutan drug pair(1∶1).Methods L9(34)orthogonal experiment was used.The ratio of material to liquid,extraction time and times of extraction were taken as the factors,and the extraction amount of paeoniflorin and paeonol and the yield of dry extract were taken as the indexes.Hassan's method was used for multi-index comprehensive scoring to optimize the water extraction process.The extract density,ethanol volume fraction and standing time were taken as the factors,and the transfer rate of paeoniflorin and paeonol and the yield of dry extract were taken as the indexes.At the same time,the alcohol precipitation process was optimized according to the actual situation of large-scale production.Results The optimal extraction process was to add 10 times of water and decoct for 1 time,60 min for each extraction.The optimal alcohol precipitation process was as follows:the density of the liquid was 1.20 g·mL-1(30℃),95% ethanol was added to make the alcohol content up to 60% ,and the liquid was left standing for 60 h.Conclusion The optimized process of water extraction and alcohol precipitation is stable,reliable and with good repeatability,which can provide reference for the follow-up study of Radix Paeoniae Rubra-Cortex Moutan drug pair.

3.
Zhongcaoyao ; Zhongcaoyao;(24): 1537-1541, 2020.
Article de Chinois | WPRIM | ID: wpr-846525

RÉSUMÉ

Objective: To optimize the inclusion process for the volatile oil in Huaweishu Granules. Methods: Taking the ratio of volatile oil to β-cyclodextrin, inclusion temperature, stirring speed and stirring time as the factors, the inclusion process conditions were optimized by orthogonal test, the weight coefficients of each index were determined by entropy weight method, and the inclusion complex was verified by thin layer chromatography. Results: The inclusion rate of volatile oil obtained by stirring method was the highest, with the ratio of β-cyclodextrin to volatile oil of 10:1, the inclusion temperature was 40 ℃, the stirring time was 1 h, and the stirring rate was 400 r/min. Conclusion: The optimized volatile oil inclusion process is stable and feasible, with high inclusion rate of volatile oil and yield of inclusion compound.

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