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Mem. Inst. Oswaldo Cruz ; 110(1): 1-22, 03/02/2015. tab, graf
Article de Anglais | LILACS | ID: lil-741625

RÉSUMÉ

An increasingly asked question is 'can we confidently link bats with emerging viruses?'. No, or not yet, is the qualified answer based on the evidence available. Although more than 200 viruses - some of them deadly zoonotic viruses - have been isolated from or otherwise detected in bats, the supposed connections between bats, bat viruses and human diseases have been raised more on speculation than on evidence supporting their direct or indirect roles in the epidemiology of diseases (except for rabies). However, we are convinced that the evidence points in that direction and that at some point it will be proved that bats are competent hosts for at least a few zoonotic viruses. In this review, we cover aspects of bat biology, ecology and evolution that might be relevant in medical investigations and we provide a historical synthesis of some disease outbreaks causally linked to bats. We provide evolutionary-based hypotheses to tentatively explain the viral transmission route through mammalian intermediate hosts and to explain the geographic concentration of most outbreaks, but both are no more than speculations that still require formal assessment.


Sujet(s)
Animaux , Humains , Antinéoplasiques d'origine végétale/isolement et purification , Antioxydants/isolement et purification , Acides gras/analyse , Déchets industriels/analyse , Malus/composition chimique , Huiles végétales/isolement et purification , Graines/composition chimique , Antinéoplasiques d'origine végétale/effets indésirables , Antinéoplasiques d'origine végétale/économie , Antinéoplasiques d'origine végétale/pharmacologie , Antioxydants/effets indésirables , Antioxydants/économie , Antioxydants/pharmacologie , Lignée cellulaire tumorale , Phénomènes chimiques , Cellules CHO , Cricetulus , Prolifération cellulaire/effets des médicaments et des substances chimiques , Compléments alimentaires/effets indésirables , Compléments alimentaires/économie , Acide gras libre/effets indésirables , Acide gras libre/analyse , Acide gras libre/économie , Acides gras/effets indésirables , Acides gras/économie , Conservateurs alimentaires/effets indésirables , Conservateurs alimentaires/économie , Conservateurs alimentaires/isolement et purification , Conservateurs alimentaires/pharmacologie , Industrie de la transformation des aliments/économie , Fruit/composition chimique , Fruit/économie , Inde , Déchets industriels/économie , Acide linoléique/effets indésirables , Acide linoléique/analyse , Acide linoléique/économie , Acide oléique/effets indésirables , Acide oléique/analyse , Acide oléique/économie , Huiles végétales/composition chimique , Huiles végétales/économie , Huiles végétales/pharmacologie
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