T-cell lymphoma with rhabdomyolysis: case report and literature review

Rhabdomyolysis refers to the destruction or disintegration of striated muscles. This syndrome is characterized by muscle breakdown and necrosis, resulting in the leakage of intracellular muscle constituents into the circulation and extracellular fluid. We report a rare case of rhabdomyolysis complicating multi-organ failure caused by T-cell lymphoma in a 32-year-old woman. The final diagnosis was rhabdomyolysis caused by peripheral T-cell lymphoma based on bone marrow aspirate and biopsy.

Simultaneous Occurrence of Angioimmunoblastic T-cell Lymphoma and Plasma Cell Leukemia

No abstract available.

Primary Pulmonary T-Cell Lymphoma: a Case Report

Primary pulmonary T-cell lymphoma is an extremely rare malady, and we diagnosed this in a 52-year-old male who was admitted to our hospital with cough for the previous two weeks. The chest CT demonstrated multiple variable sized mass-like consolidations with low density central necrosis in the peripheral portion of both the upper and lower lobes. Positron emission tomography (PET) showed multiple areas of hypermetabolic fluorodeoxyglucose (FDG) uptake in both lungs with central metabolic defects, which correlated with central necrosis seen on CT. The histological sample showed peripheral T-cell lymphoma of the not otherwise specified form. The follow-up CT scan showed an increased extent of the multifocal consolidative lesions despite that the patient had undergone chemotherapy.

Case of Small Bowel Perforation due to Enteropathy-Type T-Cell Lymphoma

Enteropathy-type T-cell lymphoma (ETTL) is a rare disease with a poor prognosis. According to the World Health Organization (WHO) classification, it is a subtype of the peripheral T-cell lymphomas. This disease is associated with gluten-sensitive enteropathy, has a high risk of intestinal perforation and obstruction, and is refractory to chemotherapeutic treatment. We report the case of a 73-year-old woman who was diagnosed with enteropathy-type T-cell lymphoma of the small intestine, which was positive for the markers of cytotoxic T cells, CD3, CD8, and CD56, on immunohistochemical staining after resection of the perforated terminal ileum.

Newly Developed Multiple Myeloma in a Patient with Primary T-Cell Lymphoma of Bone

Primary non-Hodgkin's lymphoma of bone (PLB) is rare, and generally presents as a single extensive and destructive bone lesion. Histopathologically, most cases present as diffuse large B-cell lymphoma, and T-cell lymphoma is rare. By contrast, multiple myeloma is a disease defined as the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin. We report a case of multiple myeloma that developed during treatment of PLB in a type of T-cell. A 48-yr-old man was diagnosed as T-cell PLB, stage IE, 18 months ago. The patient received the chemoradiotherapy and salvage chemotherapy for PLB. However, the lymphoma progressed with generalized bone pain, and laboratory findings showed bicytopenia and acute renal failure. On bone marrow biopsy, the patient was diagnosed as having multiple myeloma newly developed with primary T-cell lymphoma of bone. In spite of chemotherapy, the patient died of renal failure.

A Case of Non-Hodgkin's Lymphoma in a Patient with Crohn's Disease / 대한소화기학회지

Although adenocarcinoma is a well known complication of chronic inflammatory bowel disease, primary gastrointestinal lymphoma occurring in Crohn's disease is rare. A 40-year-old man with 10 year-history of Crohn's disease had multiple longitudinal ulcerative lesions on descending colon in follow-up colonoscopic examination. Microscopic examination of proximal descending colon revealed peripheral T cell lymphoma and other site of the descending colon was consistent with Crohn's disease. The patient reached complete remission of malignant lymphoma after three cycles of combined chemotherapy. He has been well for 10 months with sulfasalazine maintenance therapy but was admitted to the hospital due to spontaneous bowel perforation of ascending colon. Right hemicolectomy was done, but the patient died of post-surgical recurrent mesenteric abscess and sepsis. To the best of our knowledge, this is the first case of Non-Hodgkin's lymphoma complicating Crohn's disease in Korea which was confirmed by immunohistochemical studies.

T-Cell Lymphoma Presenting as Painful Ophthalmoplegia

PURPOSE: To present a case of peripheral T-cell lymphoma presenting as painful ophthalmoplegia. METHODS: A 61-year-old woman presented with a 2-week history of headache and eyeball pain. Examination showed mild exophthalmos, complete ophthalmoplegia, and ptosis of the left eye. Under the impression of nonspecific orbital inflammation, she was treated with oral prednisone with initial response. Two months later, she revisited the clinic with exacerbated symptoms. Anterior orbitotomy and incisional biopsy was performed for the inferior rectus muscle lesion. RESULTS: Histopathologic examination revealed an infiltrate of atypical lymphoid cells between degenerative muscle bundles. It was consistent with peripheral T-cell lymphoma. A metastatic workup was performed without any evidence of extraorbital tumor. The patient was recommended to be treated with chemotherapy, however, refused to take the treatment. The patient died of progression of the disease in a month. CONCLUSIONS: T-cell lymphoma in the orbit can present as painful ophthalmoplegia and take a rapid clinical course. The disease should be regarded as one of the differential diagnosis for painful ophthalmoplegia refractory to corticosteroid therapy.

Anaplastic T-cell lymphoma presenting as fatal acute liver failure

Acute liver failure (ALF) is an uncommon manifestation of liver disease and constitutes a medical emergency for which early identification is necessary. Hepatic involvement by hematologic malignancies although frequent, rarely causes severe hepatic dysfunction. Even more, acute hepatic failure as the first manifestation of a hematologic malignancy is extremely uncommon, although some cases have been reported in the literature. We describe the case of a 61 y/o puertorrican veteran who developed acute hepatic failure secondary to massive infiltration of the liver by a recurrent non-Hodgkin's lymphoma.

Linfomas No-Hodgkin de células B y T primarias intestinales e infección por virus de Epstein Barr en la población uruguaya / B-cell and Primary T-cell intestinal no-Hodgkin lymphomas and Epstein Barr virus infection in the Uruguayan population

El propósito del presente trabajo es establecer si existe asociación entre los linfomas No-Hodgkin (LNH), a células B y T, y la infección por el virus de Epstein Barr (VEB) en la población uruguaya. El VEB se encuentra universalmente asociado con linfoma tipo Burkitt, periférico de células T, carcinoma nasofaríngeo indiferenciado y linfomas "Natural Killer", mostrando importante variación geográfica. La Enfermedad de Hodgkin (EH), y los linfomas B esporádicos procedentes de América Latina, han evidenciado mayores tasas de asociación con la infección por VEB que los originados en los países occidentales. En los LNH de células T de origen gastrointestinal, la frecuencia en la positividad para el VEB está influida por el sitio anatómico del tumor primario y el fenotipo de la célula neoplásica, siendo independiente de la presencia o ausencia de enteropatia. Analizamos 14 casos de linfomas a células B y T primarios intestinales en pacientes HIV negativos, diagnosticados por microscopía óptica y e inmunomarcación, evaluando la coexistencia con el VEB con técnicas de inmunohistoquimica (IHQ) con EBV LMP-1. En dos (14,3 por ciento) de los casos se comprobó esta asociación, siendo los restantes negativos para la infección por VEB. Los dos linfomas con evidencia de infección por el VEB fueron: uno, en mujeres y, el otro, en hombres, ambos de fenotipo a células B y ambos del subtipo difuso a grandes células, el subtipo que representó 72 por ciento de los linfomas estudiados.

Bone Marrow is Involved in Less than 10% of Patients with Nasal-Type NK/T Cell Lymphoma at Initial Diagnosis

To evaluate the frequency of bone marrow involvement by nasal-type NK/T cell lymphoma, we retrospectively studied biopsy specimens from 40 patients by EBV in situ hybridization (ISH). Three patients had marrow involvement at initial diagnosis (7.5%). In one patient (1/40, 2.5%), the disease in bone marrow was recognized by routine morphological assessment, while two other patients had minimal involvement of lymphoma cells which was recognized only by EBV in situ hybridization (2/40, 5%). Two patients had a disseminated disease at diagnosis and died 6 days and 214 days after diagnosis. One patient had diffuse colonic lesion and died 82 days later. In conclusion, marrow involvement in nasal NK/T cell lymphoma is infrequent at initial diagnosis, and EBV ISH is a useful technique for identifying the minor subgroup of patients which have easily overlooked neoplastic involvement.

Primary Calcified T-Cell Lymphoma of the Urinary Bladder: A Case Report

Primary malignant lymphoma of the urinary bladder is extremely rare, and to our knowledge, no case described in the radiologic literature has been accompanied by calcification. We report a case in which the condition was associated with calcification, and describe the pelvic CT and MR imaging findings.

A Case of Enteropathy-associated T-cell Lymphoma Presenting with Recurrent Hematochezia / 대한소화기학회지

Enteropathy-associated T-cell lymphoma (EATL) is an unusual primary gastrointestinal lymphoma, particularly associated with celiac sprue. This tumor usually affects the jejunum and grossly presents as multiple circumferential ulcers without the formation of definite tumor masses. Moreover, mesenteric lymph nodes are commonly involved. The patients have typically suffered from abdominal pain, diarrhea, or weight loss whereas some patients may manifest with nonspecific symptoms for a period of years or an acute emergency of perforation, obstruction, or hemorrhage. The clinical course of EATL is very unfavorable and the prognosis is poor. Both celiac sprue and EATL are very rare diseases in Asia, except India and Middle East. We report a 60-year-old male diagnosed as having EATL after segmental small bowel resection, who presented with recurrent gastrointestinal bleeding.

Malignant lymphoma associated with hanseniasis

There are few reports in the world medical literature concerning association between leprosy and malignant lymphoma. It seams that, although defects in immune system related to leprosy are multiple and complex, no increase in incidence of malignant lymphoma among leprosy patients can be detected. This is also true for Brazil, where leprosy is an endemic disease, which poses an important public health problem. For this reason, the authors report on three cases of malignant lymphoma: one low grade, B-cell lymphoma (immunocytoma): one high grade, T-cell lymphoma and one mixed cellularity Hodgkin's disease in patients previously diagnosed as having leprosy.

Linfoma T de fenotipo inmaduro asociado a una policitemia vera / T lymphoma of immature phenotype associated with polycythenia vera

Se presenta un paciente de 20 años con poliadenopatías, esplenomegalia hiperleucocitosis y una biopsia de médula ósea que mostró una panmielosis con predominio d eelementos inmaduros. El estudio histopatológico de la biopsia de un ganglio linfático sugirió el diagnóstico de leucemia mieloide crónica en crisis blástica. El fenotipo inmunológico de las células blásticas mostró predominio de celulas T con fenotipo inmaduro CS1+, CD7+. El linaje celular T se confirmó por estudios de reordenamiento genético. Presenta además eritrocitosis, saturación arterial de O2 de 92% y trombocitosis, características de policitemia vera. Luego de quimioterapia Vincristina y Prednisona, recae a los dos meses con síntomas similares y con células de ganglio linfático del mismo fenotipo T inmaduro. Se replantea el diagnóstico como linfoma T asociado a un síndrome mieloproliferativo y policitemia, y se lo trata con Ciclofosfamida-Vincristina-VM26-Prednisona. Luego de una segunda recaída, dos meses después, se le indica un protocolo BFM, al que responde parcialmente. Cinco meses después el paciente presenta una tercera recaída, donde las células de ganglio muestran nuevamente fenotipo T inmaduro. No responde a un tratamiento con esquema m-BACOD, la enfermedad progresa, falleciendo luego de una hemorragia masiva por un paro cardiorespiratorio