RÉSUMÉ
Objective. To investigate prevalence of poor self-rated health and its association with individual and household-level characteristics among adults and elderly in Brazil. Materials and methods. Cross-sectional study with Brazilian National Household Sample Survey 2008 (n=257 816). Crude and multilevel-adjusted Poisson regression models were fitted. Results. After adjusted analysis, poor self-rated health was significantly associated with higher household income, living alone, not having piped water nor garbage collection, lower education, not having health insurance, female sex, higher age, being a current or previous smoker, physical inactivity, having chronic diseases, having physical impairment. Subjects living in rural areas also had higher prevalence of poor self-rated health. The factors most strongly associated with the outcome were physical impairment and reporting three or more chronic diseases. Conclusions. Socioeconomic, health related behaviors, and physical health were associated with poor self-rated health.
Objetivo. Investigar la prevalencia de la percepción negativa de salud y su asociación con características individuales a nivel de los hogares en adultos y adultos mayores de Brasil. Material y métodos. Estudio transversal con datos de la Encuesta Nacional de Hogares de 2008 (n=257 816). Se estimaron modelos de regresión de Poisson multinivel crudos y ajustados. Resultados. Después del análisis ajustado, la autopercepción negativa de salud se asoció significativamente con mayor ingreso, vivir solo, no tener agua corriente ni recolección de basura, baja educación, carecer de seguro de salud, sexo femenino, mayor edad, tabaquismo, inactividad física, enfermedades crónicas y deterioro físico. Los habitantes de zonas rurales también tuvieron mayor prevalencia de percepción negativa. Los factores más fuertemente asociados fueron impedimento físico y presentación de tres o más enfermedades crónicas. Conclusiones. Factores socioeconómicos, comportamientos relacionados con la salud y salud física se asociaron con la percepción negativa.
Sujet(s)
Adulte , Humains , Antimétabolites antinéoplasiques/sang , Phénylacétates/sang , Phénylbutyrates/sang , Antimétabolites antinéoplasiques/usage thérapeutique , Concentration en ions d'hydrogène , Tumeurs/sang , Tumeurs/traitement médicamenteux , Phénylacétates/usage thérapeutique , Phénylbutyrates/usage thérapeutique , Liaison aux protéines , Sérumalbumine/métabolismeRÉSUMÉ
This study compared the physicochemical properties and interfacial adaptation to canal walls of Endo-CPM-Sealer, Sealapex and Activ GP with the well-established AH Plus sealer. The following analyses were performed: radiopacity, pH variation and solubility using samples of each material and scanning electron microscopy of root-filled bovine incisors to evaluate the interfacial adaptation. Data were analyzed by the parametric and no-parametric tests (α=0.05). All materials were in accordance with the ANSI/ADA requirements for radiopacity. Endo-CPM-Sealer presented the lowest radiopacity values and AH Plus was the most radiopaque sealer (p=0.0001). Except for ActiV GP, which was acidic, all other sealers had basic chemical nature and released hydroxyl ions. Regarding solubility, all materials met the ANSI/ADA recommendations, with no statistically significant difference between the sealers (p=0.0834). AH Plus presented the best adaptation to canal walls in the middle (p=0.0023) and apical (p=0.0012) thirds, while the sealers Activ GP and Endo-CPM-Sealer had poor adaptation to the canal walls. All sealers, except for ActiV GP, were alkaline and all of them fulfilled the ANSI/ADA requirements for radiopacity and solubility. Regarding the interfacial adaptation, AH Plus was superior to the others considering the adaptation to the bovine root canal walls.
Este estudo comparou as propriedades físico-químicas e a adaptação interfacial às paredes do canal dos cimentos Endo-CPM-Sealer, Sealapex e Activ GP com o bem estabelecido cimento AH Plus. As seguintes análises foram realizadas: radiopacidade, variação de pH e de solubilidade utilizando amostras de cada material, e microscopia eletrônica de varredura utilizando incisivos bovinos obturados para avaliar a adaptação interfacial. Os dados foram analisados utilizando testes paramétricos e não-paramétricos (α=0,05). Todos os materiais estavam de acordo com os requerimentos da ANSI/ADA para radiopacidade, sendo que o Endo-CPM-Sealer apresentou os menores valores de radiopacidade e o AH Plus foi o cimento mais radiopaco (p=0,0001). Exceto o Activ GP, que foi ácido, todos os outros cimentos apresentaram natureza química básica e liberaram íons hidroxila. Com relação à solubilidade, todos os materiais estavam de acordo com as recomendações da ANSI /ADA, sem diferença significante entre os cimentos (p=0,0834). O AH Plus apresentou a melhor adaptação às paredes do canal nos terços médio (p=0,0023) e apical (p=0,0012), enquanto que os cimentos Activ GP e Endo-CPM-Sealer apresentaram uma pobre adaptação às paredes do canal. Em conclusão, todos os cimentos, exceto o Activ GP, foram alcalinos e todos preencheram os requerimentos da ANSI/ADA para radiopacidade e solubilidade. Com relação à adaptação interfacial, o AH Plus foi superior aos demais para adaptação às paredes do canal radicular de incisivos bovinos.
Sujet(s)
Animaux , Femelle , Humains , Souris , Inhibiteurs de l'angiogenèse/pharmacologie , Antinéoplasiques/pharmacologie , Tumeurs du sein/traitement médicamenteux , Tumeurs du sein/anatomopathologie , Dextrane/pharmacologie , Inhibiteurs de croissance/pharmacologie , Cellules cancéreuses en culture/effets des médicaments et des substances chimiques , Cellules cancéreuses en culture/anatomopathologie , Inhibiteurs de l'angiogenèse/usage thérapeutique , Antinéoplasiques/usage thérapeutique , Milieux de culture conditionnés/pharmacologie , Relation dose-effet des médicaments , Dextrane/composition chimique , Dextrane/usage thérapeutique , Endothélium vasculaire/cytologie , Endothélium vasculaire/effets des médicaments et des substances chimiques , Endothélium vasculaire/physiologie , Inhibiteurs de croissance/usage thérapeutique , Souris de lignée BALB C , Souris nude , Nécrose , Phénylacétates/pharmacologie , Phénylacétates/usage thérapeutique , Tests d'activité antitumorale sur modèle de xénogreffe/statistiques et données numériquesRÉSUMÉ
Purpose: To compare the effects of preoperative use of topical anti-inflammatory prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery. Design: Randomized clinical trial. Materials and Methods: This single-center, masked, randomized clinical study comprised 140 patients scheduled for cataract surgery. Patients (35 in each group) were randomized to receive placebo, prednisolone acetate, ketorolac tromethamine 0.4% or nepafenac. These eye drops were administered three times daily for the two days prior to surgery. The pupillary diameters were measured by the surgeon using a compass prior to the corneal section and at the end of surgery. The primary outcome was the number of patients with pupil ≥ 6mm at the end of the surgery; the secondary outcome was the number of patients with pupil ≥ 6mm at the beginning of the surgery. Results: All the patients achieved pupil ≥ 6mm at the beginning of the surgery. The number of patients in the prednisolone (29/35), nepafenac (31/35) and ketorolac (30/35) groups with pupil ≥ 6mm was greater than in the placebo group in the maintenance of intraoperative mydriasis (19/35 – P =0.003). There was no statistical difference among the prednisolone, nepafenac and ketorolac groups in the maintenance of intraoperative mydriasis (P =.791). There were no complications during surgery or related to the preoperative use of the eye drops. Conclusion: Preoperative use of ketorolac, prednisolone and nepafenac was effective in maintaining intraoperative mydriasis when compared with placebo.
Sujet(s)
Benzèneacétamides/administration et posologie , Benzèneacétamides/usage thérapeutique , Extraction de cataracte/complications , Humains , Kétorolac trométhamine/administration et posologie , Kétorolac trométhamine/usage thérapeutique , Mydriase/traitement médicamenteux , Mydriase/étiologie , Mydriase/prévention et contrôle , Patients , Phénylacétates/administration et posologie , Phénylacétates/usage thérapeutique , Placebo/administration et posologie , Placebo/usage thérapeutique , Prednisolone/administration et posologie , Prednisolone/analogues et dérivés , Prednisolone/usage thérapeutique , Période préopératoire , Essais contrôlés randomisés comme sujetRÉSUMÉ
Objetivo En el contexto de reformas de los sistemas de salud es impostergable el desarrollo de proyectos de investigación evaluativa para identificar buenas prácticas. En este sentido el objetivo de este estudio fue identificar indicadores de gobernanza y protección social en salud. Métodos Investigación evaluativa con universo de estudio referido al sistema de salud para no asegurados en seis Estados de México. Para los datos primarios se realizaron entrevistas a profundidad con informantes clave de los Estados participantes; para los datos secundarios se utilizaron estadísticas oficiales y los resultados del proyecto macro sobre reformas, políticas de salud y gobernanza en México. El procesamiento y análisis de datos se realizó con dos paquetes de software: Atlas Ti y Policy Maker. Resultados Una lista de fortalezas y debilidades se presenta como evidencia de la gobernanza del sistema de salud. La rendición de cuentas en el nivel federal, aunque no está ausente, se mantiene con un carácter prescriptivo, en los Estados y municipios aún está ausente un sistema de rendición de cuentas y de transparencia en la asignación de recursos y en cuanto a las estrategias de democratización de la salud. Conclusiones En todos los Estados hay bajos niveles de gobernanza y dificultad en la conducción efectiva de programas y estrategias de reforma con falta de precisión en las reglas y los roles con que operan los diferentes actores del sistema de salud.
Objective Evaluative research projects for identifying good practice have been postponed regarding health system reform. This study was thus aimed at identifying health governance and social protection indicators. Methods This study involved evaluative research regarding the health system for the uninsured part of the population in six Mexican states. The primary data was obtained from in-depth interviews with key players from the participating states; official statistics and the results of a macro-project concerned with Mexican health and governance reform and policy was used for secondary. Atlas Ti and Policy Maker software were used for processing and analysing the data. Results A list of strengths and weaknesses was presented as evidence of health system governance. Accountability at federal level (even though not lacking) was of a prescriptive nature and a system of accountability and transparency regarding the assignment of resources and strategies for the democratisation of health in the states and municipalities was still lacking. Conclusions All six states had low levels of governance and experienced difficulty in conducting effective reform programmes and strategies involving a lack of precision regarding the rules and roles adopted by different health system actors.