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Braz. j. microbiol ; 47(4): 1030-1038, Oct.-Dec. 2016. tab, graf
Artigo em Inglês | LILACS | ID: biblio-828208

RESUMO

Abstract An actinobacterial strain VL-RK_09 having potential antimicrobial activities was isolated from a mango orchard in Krishna District, Andhra Pradesh (India) and was identified as Arthrobacter kerguelensis. The strain A. kerguelensis VL-RK_09 exhibited a broad spectrum of in vitro antimicrobial activity against bacteria and fungi. Production of bioactive metabolites by the strain was the highest in modified yeast extract malt extract dextrose broth, as compared to other media tested. Lactose (1%) and peptone (0.5%) were found to be the most suitable carbon and nitrogen sources, respectively, for the optimum production of the bioactive metabolites. The maximum production of the bioactive metabolites was detected in the culture medium with an initial pH of 7, in which the strain was incubated for five days at 30 °C under shaking conditions. Screening of secondary metabolites obtained from the culture broth led to the isolation of a compound active against a wide variety of Gram-positive and negative bacteria and fungi. The structure of the first active fraction was elucidated using Fourier transform infrared spectroscopy, electrospray ionization mass spectrometry, 1H and 13C nuclear magnetic resonance spectroscopy. The compound was identified as S,S-dipropyl carbonodithioate. This study is the first report of the occurrence of this compound in the genus Arthrobacter.


Assuntos
Arthrobacter/isolamento & purificação , Arthrobacter/metabolismo , Mangifera/microbiologia , Anti-Infecciosos/metabolismo , Anti-Infecciosos/farmacologia , Sais/metabolismo , Temperatura , Carbono/metabolismo , Testes de Sensibilidade Microbiana , Metaboloma , Metabolômica/métodos , Concentração de Íons de Hidrogênio , Anti-Infecciosos/isolamento & purificação , Anti-Infecciosos/química , Minerais/metabolismo , Nitrogênio/metabolismo
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