Research on serum metabolic markers of menopausal syndrome based on / 中国临床药理学与治疗学

AIM: To find specific metabolic markers for women entering peri-menopausal period and patients with menopausal syndrome based on

Research on the rules of Traditional Chinese Medicine treatments of insomnia based on Ancient and Modern Medical Records Cloud Platform / 国际中医中药杂志

Objective:To explore the rules of prescription and medication of Traditional Chinese Medicine (TCM) syndrome differentiation treatment for insomnia.Methods:We screened the medical records related to insomnia from the ancient medical cases, modern medical cases, famous medical cases and shared medical record database, and then we put data into the Ancient and Modern Medical Case Cloud Platform (V 1.5.7). The platform software Data mining was applied and performed by frequency analysis, correlation analysis, and drug pair analysis. Results:This study collected 664 cases related to insomnia, like difficulty in falling sleep, early waking up, easy to wake up, dreaminess. The top 5 syndromes included internal phlegm-heat, imbalance between heart-yang and kidney-yin, liver stagnation transforming into fire, heart and spleen deficiency, restless mind. There were 664 prescriptions, 414 TCM medications, where the top 5 medications included Glycyrrhizae Radix et Rhizoma, Poria, Rehmanniae Radix, Ziziphi Spinosae Semen, Angelicae Sinensis Radix. The effect of high-frequency medications were nourishing the heart and calming the mind, clearing heat and dissipating phlegm, soothing the liver and relieving depression, and nourishing yin and yang. The top five drug-combinations included Ostreae Concha- Longgu, Poria- Glycyrrhizae Radix et Rhizoma, Citri Reticulatae Pericarpium- Poria, Angelicae Sinensis Radix- Rehmanniae Radix, Bupleuri Radix- Glycyrrhizae Radix et Rhizoma. Conclusions:TCM syndrome differentiation for insomnia focus on the heart. The medications are mainly to nourish the heart and calm the mind, supplemented by clearing heat, replenishing heart and spleen, soothing the liver and relieving stagnation, nourishing yin and blood for the symptoms relief, with treatment priciple of seeking both temporary and permanent solutions.

Common syndrome factors of menopausal syndrome based on questionnaire investigation among experts / 中西医结合学报

Objective: To select the common syndrome factors of menopausal syndrome through questionnaire investigation among experts. Methods: Firstly, a questionnaire was constructed on the basis of our previous research, and then investigation of the experts by the questionnaire was carried out. The experts came from twelve tertiary hospitals (6 cities) in China, and engaged in clinical practice of gynecology of traditional Chinese medicine (TCM) or integrated traditional Chinese and Western medicine. The common TCM syndrome factors of menopausal syndrome were selected based on consent degree of the experts in mean value, full marks ratio, rank sum and variation coefficient. Results: One hundred sets of the questionnaires were sent out and ninety-eight sets were returned back. The callback rate was 98%. In accordance with cumulative percentage of expert agreement and complete agreement more than 50% and the coefficient variation less than 0.25, we confirmed the common TCM syndrome factors of menopause syndrome. The syndrome factors related to disease location were kidney, liver, heart, and spleen, and those related to the nature of disease were yin deficiency, deficiency of essence, yang deficiency, hyperactivity of yang, qi deficiency, qi stagnation, blood deficiency, and blood stasis. Conclusion: Expert consultation questionnaire can collect consensus opinions of experts and is effective for identifying common TCM syndrome factors of a disease. The TCM syndrome factors acquired through the study may provide the evidence for establishment of TCM syndrome diagnosis criteria for the disease in future.

Distribution characteristics of common syndrome types and syndrome elements extracted by experts' experience in perimenopausal and postmenopausal women / 中西医结合学报

To compare the distribution characteristics of common syndrome types and syndrome elements of menopause syndrome in perimenopausal and postmenopausal women on the basis of standardized syndrome differentiation extracted by experts' experiences.

A perspective of developing syndrome diagnostic criteria based on syndrome factors and combination of disease in modern medicine system and syndrome in traditional Chinese medicine system / 中西医结合学报

Syndrome differentiation treatment is the traditional model of diagnosis and treatment of diseases in traditional Chinese medicine (TCM). To establish scientific diagnostic criteria of TCM syndrome is one of the key points in TCM study. In this paper, the basic models of the relevant diagnostic criteria of TCM syndrome and existed problems were reviewed. The authors pointed out the advantages of establishing diagnostic criteria of TCM syndrome based on TCM syndrome factors and combination of disease in Western medicine system and TCM syndrome, in which not only the characteristics of the disease in Western medicine were considered, but also the complexity and flexibility of syndrome identification and convenient application in clinical practice were resolved. The basic model and frame of the above diagnostic criteria and the procedures and methods used in developing the diagnostic criteria were also described and discussed.

Literature analyses on distribution characteristics of TCM syndromes and syndrome elements of menopausal syndrome / 中华中医药杂志

Objective: To probe into distribution on characteristics of TCM syndromes and syndromes elements of menopausal syndrome.Methods:The literature about menopausal syndrome in past 20 years were collected.The principle of evidence-based medicine was used to establish the databank with EpiData2.0,and the literature meeting the enrolled criteria were recorded and checked.SPSS12.0 software was adopted to analyze frequency-times of syndromes and syndromes elements.Results:The top three syndromes are yin-deficiency of both liver and kidney,yin-deficiency of kidney,yang-deficiency of kidney;The kidney,liver,and heart are the top three locations of syndromes elements;And yin-deficiency,yang-deficiency and fire are the top three pathogenesis types of syndromes elements.Conclusion: Distribution of TCM syndrome types of menopausal syndrome is scattered.It lead to clinical syndrome differentiation is complicated.Compared with it,syndrome elements can reflect the substance of disease more concise and active.

Symptom Characteristic of Stagnation of Liver-QI with Deficiency of the Spleen Syndrome and Modern Literature Study on Standards of Syndrome Differentiation / 中华中医药杂志

Now syndrome study becomes the important research content in our country' TCM field,normalization of the symptoms standardization of syndromes especially becomes scientific research focal point in this field,furthermore some studies exists the conditions of symptoms short of norm and standards of syndrome differentiation discordant,as well stagnation of liver-QI with deficiency of the spleen is clinical common syndrome,so this article carried out all round analysis and investigations on the modern literature of stagnation of liver-QI with deficiency of the spleen syndrome recent ten years,to aim at analyzing the symptom characteristic and standards of syndrome differentiation on stagnation of liver-QI with deficiency of the spleen syndrome,to provide the bases of standardization and normalization of stagnation of liver-QI with deficiency of the spleen syndrome.

Connotation of "Fatigue" Symptom and Thought of Its Quantization Evaluation / 中华中医药杂志

This article analyzed the universality of fatigue existing and the significance of quantization evaluation on fatigue.It expounded the recognition of fatigue in traditional Chinese medicine,and further more proposed the methods of quantization evaluation on fatigue.

The effect of electrode positions on multifocal visual evoked potential / 中华眼底病杂志

Objective To compare the effect of electrode positions o n multifocal visual evoked potential(mf-VEP). Methods Ten healt hy individuals were tested with RETIscan multifocal VEP system 3.20, each indiv idual was tested with four electrode positions: the active and reference electro de were placed 2.0 cm above and below the inion in Ch1;3.0 cm above and 4.5 cm below the inion in Ch2;2.0 cm on both right and left side of the inion in C h3 and 4.0 cm on both right and left side of the inion in Ch4. The summed ampli tudes of hemifield mf-VEP were analyzed and compared according to different ele ctrode positions. Results The difference among summed amplitud es of the upper or lower hemifield mf-VEP recorded with Ch1、Ch2、Ch3 and Ch4 w as statistically significant;and the difference between Ch2 and the other chann els was statistically significant too. The difference among summed amplitudes of the horizontal sites whose amplitudes were small when recorded with Ch2 and sum med amplitudes of the corresponding sites recorded with Ch3 and Ch4 were statist ically significant;and the difference between Ch4 and the other channels was st atistically significant too. Conclusions compared to Ch1、Ch3 and Ch4, Ch2 can make a better recording of mf-VEP. As for some sites, especi ally those along horizontal line, horizontal electrodes could improve the amplit udes of mf-VEP recorded with vertical electrodes,and Ch4 could do better to im prove the mf-VEP recorded with Ch2 than Ch3.