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Hindustan Antibiot Bull ; 1994 Feb-May; 36(1-2): 34-8
Artigo em Inglês | IMSEAR | ID: sea-2430

RESUMO

Polyene antibiotics are known for their remarkable antifungal properties. The alkali metal and quaternary alkylammonium salts of amphotericin B, nystatin and aureofungin have been prepared by ion-exchange method. The physico-chemical and biological properties of these salts have been studied with a view to evaluate their therapeutic advantages over the parent compounds. While the majority of the salts reported herein showed more water solubility; triethylammonium salts, unlike the other alkali metal salts, possessed marginally improved or similar bioactivity in comparison to their parent antibiotic having reduced toxicity.


Assuntos
Anfotericina B/química , Antifúngicos/química , Candida albicans/efeitos dos fármacos , Físico-Química , Metais/química , Nistatina/química , Fenômenos Químicos , Polienos/química , Compostos de Amônio Quaternário/química
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