Progress in research of etiology of childhood obesity based on interaction between genes and environment / 中华流行病学杂志

Childhood obesity is a global public health problem, which can not only endangers children's health, but also might be an important cause of chronic diseases in adulthood. In recent years, with the in-depth development of precision medicine research, more and more research evidences have shown that there are interactions between environmental factors, such as early intrauterine environment, children's diet, physical activity and children's gene factor on the incidence of childhood obesity, which can result in or inhibit the incidence and development of childhood obesity. This paper summarizes the progress in research in this field to reveal the effects and potential mechanisms of genetic factors and environmental factors on the incidence of childhood obesity in order to provide reference for the precise prevention and control of childhood obesity under different genetic backgrounds.

Risk factors on chronic obstructive pulmonary disease among greenhouse workers in Liaoning province / 中华流行病学杂志

Objective To study the risk factors of chronic obstructive pulmonary disease (COPD) among greenhouse farmers in Liaoning province.Methods According to geographical differences in Liaoning province,stratified-cluster-random sampling method was used.A total of 5420 greenhouse farmers working in more than 800 greenhouses were investigated with unified questionnaire,physical examination,blood routine examination,blood gas analysis,chest X-ray and pulmonary function tests.Diagnosis of COPD was made according to the criteria for "chronic obstructive pulmonary disease of diagnosis and treatment guidelines" (2007 revision) by the Chinese Respiratory Disease Society.Results The total number of farmers under study was 5880,including 5420 respondants(92.18％) with effective data.Risk factors were found on age(x2＝32.530,P=0.000),time working in greenhouses every day ( x2 =21.311,P =0.000 ),frequency of ventilation ( x2 =9.791,P=0.007) and the location of the greenhouses(x2=73.645,P=0.000).When using SPSS 17.0 for the single factor logistic regression analysis,results indicated that smoking(OR＝1.976,95％CI:1.672-2.334),age ( OR =4.188,95 ％ CI:3.718-4.718 ),greenhouses for fungus ( compared with vegetables,OR=1.302,95％CI:1.016-1.669),flowers and plants (compared with vegetables greenhouses,OR=1.503,95％ CI:1.201-1.880) were the risk factors of COPD among greenhouse farmers while the protective factor was the years of working in the greenhouse (OR=0.684,95％ CI:0.609-0.767).Conclusion The overall morbidity of COPD among greenhouse farmers in Liaoning province was 17.47％ with various risk factors.

Effects of yixintong on regulating cellular calcium channels / 中国中药杂志

<p><b>OBJECTIVE</b>To explore the protecting mechanism of Yixintong for heart ischemia-reperfusion injury at cellular and subcellular levels, by observing the effects of Yixintong on three kinds of calcium channels.</p><p><b>METHOD</b>The effects of Yixintong on Ca2+ influx on leak calcium channel, receptor-operationg calcium channel (ROC) and pulse-dependent calcium channel (PDC) were observed respectively, by using rat aortic smooth muscle cell and radioactive 45Ca technique.</p><p><b>RESULT</b>Yixintong has no effects on leak calcium channel, but can inhibit the Ca2+ influx in ROC and PDC significantly.</p><p><b>CONCLUSION</b>Yixintong can inhibit the Ca2+ influx in slow channel in a dose-dependent manner.</p>