RESUMO
A soluble antigen complex (SAC) derived from the ruptured promastigotes of Leishmania donovani parasites (LD-SAC) was used for complement fixation test (CFT) in leprosy Cases of tuberculoid and borderline tuberculoid leprosy, post-kala azar dermal leishmaniasis (TT, BT, PKDL) and control sera gave negative CFT. Smear-positive cases of borderline (BB, BL) and lepromatous (LL) leprosy and drug-resisting cases of pulmonary tuberculosis gave positive CFT; smear-negative cases of LL leprosy sera also gave positive CFT. Sera of smear-negative inactive LL patients contained only PGL-1 and PDIM antigens for a long time after they become inactive. Therefore, the positive CFT in inactive LL makes us suspect whether PGL-1 is present in LD promastigotes.
Assuntos
Adulto , Animais , Antígenos de Bactérias/imunologia , Antígenos de Protozoários/análise , Testes de Fixação de Complemento , Reações Cruzadas , Glicolipídeos/análise , Humanos , Leishmania donovani/crescimento & desenvolvimento , Leishmaniose Visceral/imunologia , Hanseníase/diagnóstico , Hanseníase Dimorfa/diagnóstico , Hanseníase Virchowiana/diagnóstico , Hanseníase Tuberculoide/diagnóstico , Masculino , Pessoa de Meia-Idade , Mycobacterium leprae/imunologia , Tuberculose Resistente a Múltiplos Medicamentos/diagnósticoRESUMO
Eighteen Schiff Bases of 3-amino-2-methylquinazolin-4(3H)-ones were synthesised and screened for anti-inflammatory and diuretic activity. Anti-inflammatory activity was identified in PNG-1, PNG-13, PNG-14, PNG-15 and PNG-17.