Associação do estado nutricional com pressão arterial de escolares do município de Porto Alegre / Association of nutritional status with blood pressure of school children in the municipality of Porto Alegre

Introdução: De acordo com a Organização Mundial da Saúde, as Doenças Cardiovasculares têm sido a principal causa de morte nas últimas duas décadas. Como fatores de risco para estas doenças podemos citar o excesso de peso e níveis alterados de pressão arterial. Mudanças nesse panorama requerem, principalmente, um foco na prevenção dessas doenças. Identificar o aumento dos níveis pressóricos precocemente e avaliar o estado nutricional da população mais jovem é de extrema importância para a prevenção de doenças crônicas, especialmente as cardiovasculares. Objetivo: Avaliar a associação entre estado nutricional e pressão arterial em escolares do município de Porto Alegre/RS. Metodologia: Trata-se de um estudo transversal, realizado com crianças e adolescentes, de ambos os sexos, com idades entre 7 e 17 anos de escolas públicas e privadas no município de Porto Alegre. Resultados: Participaram da pesquisa 1.228 indivíduos. Em relação ao estado nutricional e aos níveis pressóricos, a maioria dos estudantes encontra-se na faixa de normalidade. As variáveis idade, sexo, tipo de escola e classificação do IMC mantiveram-se associadas à prevalência de Hipertensão arterial, mesmo após ajuste para estas variáveis de confusão. Conclusão: No presente trabalho, foi encontrada associação entre o estado nutricional e os níveis de pressão arterial de crianças e adolescentes. Contudo, são necessários mais estudos que explorem as possíveis causas, hereditárias, ambientais e comportamentais para tais achados. (AU)

Introduction: According to the World Health Organization, Cardiovascular Diseases have been the leading cause of death in the last two decades. As risk factors for these diseases, we can mention being overweight and altered levels of blood pressure. Changes in this scenario require, mainly, a focus on the prevention of these diseases. Identifying the increase in blood pressure levels early and assessing the nutritional status of the younger population is extremely important for the prevention of chronic diseases, especially cardiovascular diseases. Objective: To evaluate the association between nutritional status and blood pressure in schoolchildren in the city of Porto Alegre/RS. Methodology: This is a cross-sectional study carried out with children and adolescents, of both sexes, aged between 7 and 17 years old from public and private schools in the city of Porto Alegre. Results: A total of 1,228 individuals participated in the research. Regarding nutritional status and blood pressure levels, most students are in the normal range. The variables age, sex, type of school and BMI classification remained associated with the prevalence of arterial hypertension, even after adjusting for these confounding variables. Conclusion: In the present study, an association was found between nutritional status and blood pressure levels in children and adolescents. However, further studies are needed to explore the possible hereditary, environmental and behavioral causes for such findings. (AU)

Implementation of a Telecardiology Service in a Health Unit in the City of Porto Alegre, Brazil: A Pilot Study

Abstract Background: The implementation of Telecardiology in primary care in the city of Porto Alegre, Brazil, is a viable and promising strategy. It would decrease the distance between patient and specialized professional services by reducing unnecessary referrals and improving the quality of primary care and satisfaction of patients and health professionals. Objective: To implement a Telecardiology service and assess user satisfaction using the CARDIOSATIS scale. Methods: This was a pilot study developed by a partnership between the Institute of Cardiology and the Telehealth Center of Rio Grande do Sul. The study was carried out at Eri Flores-Vila Vargas health center in the city of Porto Alegre, from May to October 2019, and included 21 patients attending the health center. The descriptive analysis of data was performed using the SPSS program (Statistical Package for the Sciences) version 23. Data normality was checked using the Kolmogorov-Smirnov test. Statistical significance was set at 10%. Results: Mean age of participants was 43.8 ± 16.1 years. The most common risk factors in the sample were physical inactivity (81%) and smoking (43%). Most patients had normal electrocardiogram (ECG) readings. The time elapsed from the performance of the ECG test, transmission of the ECG traces to Telehealth, and return of the final ECG report to the health center was 0-7 days. The CARDIOSATIS scale revealed a high prevalence of "very satisfied" users for the general satisfaction domain, and only 14.3% of patients were dissatisfied with their health. Conclusions: Telecardiology reduced the distance between patient and the specialized professional, with a high level of patient and health professional satisfaction. Our study can serve as a basis for the implementation of a telecardiology network in the city of Porto Alegre in the future.

Increased Maximal Expiratory Pressure, Abdominal and Thoracic Respiratory Expansibility in Healthy Yoga Practitioners Compared to Healthy Sedentary Individuals

Abstract Background Increasing thoracic expansion is effective at reducing blood pressure in hypertensive subjects. Yoga prescribes many respiratory techniques with a growing number of practitioners. However, very little is known whether sedentary or yoga practitioners show measurable differences in their respiratory patterns. Objective This study aims to demonstrate differences between healthy sedentary individuals and healthy yoga practitioners regarding maximal respiratory pressures and thoracic and abdominal respiratory expansibility. Methods Maximal inspiratory and expiratory pressures (MIP and MEP, respectively) were evaluated by manovacuometry, while respiratory expansion was assessed by the cirtometry of abdominal (CA), thoracic xiphoidal (CTX), and thoracic axillary (CTA) circumferences at rest (end expiratory moment) and at full inspiration in healthy sedentary individuals (SED) and yoga practitioners (YOGA). A delta derived from rest and full inspiration measures (ΔCA, ΔCTX, and ΔCTA, respectively), followed by a percentage of each item (ΔCA/CA, ΔCTX/CTX, and ΔCTA/CTA) was then calculated. Groups were compared by means of an unpaired Student's t-test, with a significance level p < 0.05. Results All respiratory expansion measures were significantly higher in in the YOGA group. A significantly higher MEP (cmH2O) was also detected in yoga practitioners: SED 89.3 ± 19.3 and YOGA 114.7 ± 24.8 ( p = 0.007), along with decreased heart rate at rest (bpm): SED 84±6 and YOGA 74±15 ( p = 0.001). Conclusions Yoga practitioners have shown greater thoracic and abdominal expansion and increased MEP, when compared to healthy sedentary individuals, as well as significantly lower heart rates at rest and body mass index (BMI). However, whether or not these findings are related to respiratory patterns is uncertain.

Effects of sympathectomy on myocardium remodeling and function

OBJECTIVES: To evaluate the effects of sympathectomy on the myocardium in an experimental model. METHODS: The study evaluated three groups of male Wistar rats: control (CT; n=15), left unilateral sympathectomy (UNI; n=15), and bilateral sympathectomy (BIL; n=31). Sympathectomy was performed by injection of absolute alcohol into the space of the spinous process of the C7 vertebra. After 6 weeks, we assessed the chronotropic properties at rest and stress, cardiovascular autonomic modulation, myocardial and peripheral catecholamines, and beta-adrenergic receptors in the myocardium. The treadmill test consisted of an escalated protocol with a velocity increment until the maximal velocity tolerated by the animal was reached. RESULTS: The bilateral group had higher levels of peripheral catecholamines, and consequently, a higher heart rate (HR) and blood pressure levels. This suggests that the activation of a compensatory pathway in this group may have deleterious effects. The BIL group had basal tachycardia immediately before the exercise test and increased tachycardia at peak exercise (p<0.01); the blood pressure had the same pattern (p=0.0365). The variables related to autonomic modulation were not significantly different between groups, with the exception of the high frequency (HF) variable, which showed significant differences in CT vs UNI. There was no significant difference in beta receptor expression between groups. There was a higher concentration of peripheral norepinephrine in the BIL group (p=0.0001), and no significant difference in myocardial norepinephrine (p=0.09). CONCLUSION: These findings suggest that an extra cardiac compensatory pathway increases the sympathetic tonus and maintains a higher HR and higher levels of peripheral catecholamines in the procedure groups. The increase in HF activity can be interpreted as an attempt to increase the parasympathetic tonus to balance the greater sympathetic activity.

Stress and Food Consumption Relationship in Hypertensive Patients / Estresse e Consumo Alimentar em Pacientes Hipertensos

Abstract Background: Stress is a state of threat to the balance of the organism, which can cause biological and psychological changes. In hypertensive patients, stress can interfere with blood pressure levels, influence on food choices and neglect of the diet. Objective: This study aims to describe the relationship between stress and dietary intake of hypertensive patients. Methods: A transversal study was carried out at the Arterial Hypertension Clinic of the Cardiology Institute of Rio Grande do Sul, Brazil. The participants were aged ≥ 18 years and hypertensive. Blood pressure, food consumption and anthropometric measurements were collected. The variables related to stress were evaluated by the Lipp's Stress Symptoms Inventory (LSSI) for adults. Significance level of 5% has been considered for all analyzed data. Results: The number of participants was 100. There was a higher prevalence of the female sex (67%), the mean age of the study population was 55.87 ± 12.55 years. Among the participants, 86% were classified in some of the stress phases, on which 57% were in the resistance phase. It was observed that there was no correlation between the presence of stress (as well as their actions), pressure levels and food consumption. The consumption of foods rich in lipids and individuals with a prevalence of psychological symptoms of stress displayed a significant association. Conclusions: Rich in fat dietary has been the first choice in patients with psychological symptoms of stress. Further studies regarding remodeled dietary intake and blood pressure levels in relation to the stress phases are suggested. These findings are important to contribute to the development of prevention and treatment strategies for cardiovascular diseases.

Resumo Fundamento: O estresse é um estado de ameaça ao equilíbrio do organismo, podendo causar alterações biológicas e psicológicas. No paciente hipertenso o estresse pode interferir nos níveis pressóricos e gerar influência nas escolhas alimentares e negligência da dieta. Objetivo: Este estudo tem como objetivo descrever a relação entre o estresse e consumo alimentar de pacientes hipertensos. Métodos: Estudo transversal, desenvolvido no Ambulatório de Hipertensão Arterial do Instituto de Cardiologia do Rio Grande do Sul. Participaram da pesquisa indivíduos hipertensos com idade > 18 anos. Foram coletados dados de pressão arterial, consumo alimentar e medidas antropométricas. As variáveis relacionadas ao estresse foram avaliadas pelo inventário de sintomas de stress para adultos de Lipp (ISSL). Em todas as análises foi considerando um nível de significância 5% (p < 0,05). Resultados: O número de participantes foi de 100. Houve maior prevalência no sexo feminino (67%), a idade média da população estudada foi 55,87 ± 12,55 anos. Dos participantes, 86% se classificaram em alguma das fases do estresse, sendo que destes, 57% estavam na fase de resistência. Observou-se que não houve correlação entre a presença de estresse (bem como suas fases), níveis pressóricos e consumo alimentar. O consumo de alimentos ricos em lipídios em hipertensos com sintomas de estresse apresentou significância estatística. Conclusão: Os alimentos ricos em gordura prevaleceram entre as escolhas alimentares nos pacientes com sintomas psicológicos de estresse. Sugere-se mais estudos em relação a alteração do consumo alimentar e níveis pressóricos em relação às fases do estresse.

Using a 3D printer in cardiac valve surgery: a systematic review

SUMMARY BACKGROUND: The use of the 3D printer in complex cardiac surgery planning. OBJECTIVES: To analyze the use and benefits of 3D printing in heart valve surgery through a systematic review of the literature. METHODS: This systematic review was reported following the Preferred Reporting Items for Systematic Review and registered in the Prospero (International Prospective Register of Systematic Reviews) database under the number CRD42017059034. We used the following databases: PubMed, EMBASE, Scopus, Web of Science and Lilacs. We included articles about the keywords "Heart Valves", "Heart Valve Prosthesis Implantation", "Heart Valve Prosthesis", "Printing, Three-Dimensional", and related entry terms. Two reviewers independently conducted data extraction and a third reviewer solved disagreements. All tables used for data extraction are available at a separate website. We used the Cochrane Collaboration tool to assess the risk of bias of the studies included. RESULTS: We identified 301 articles and 13 case reports and case series that met the inclusion criteria. Our studies included 34 patients aged from 3 months to 94 years. CONCLUSIONS: Up to the present time, there are no studies including a considerable number of patients. A 3D-printed model produced based on the patient enables the surgeon to plan the surgical procedure and choose the best material, size, format, and thickness to be used. This planning leads to reduced surgery time, exposure, and consequently, lower risk of infection.

RESUMO INTRODUÇÃO: A impressora 3D é utilizada como coadjuvante no planejamento de cirurgias de cardiopatias complexas. OBJETIVOS: Analisar o uso e os benefícios da impressão 3D em cirurgias de válvula cardíaca por meio de revisão sistemática da literatura. MÉTODOS: Esta revisão sistemática foi conduzida de acordo com os itens do Preferred Reporting for Systematic Reviews e registrada no banco de dados Prospero (Registro Prospectivo Internacional de Revisão Sistemática) sob o número CRD42017059034. Foram utilizados os seguintes bancos de dados: PubMed, Embase, Scopus, Web of Science e Lilacs. Incluídos artigos com os termos de busca "Heart Valves", "Heart Valve Prosthesis Implantation", "Heart Valve Prosthesis", "Printing, Three-Dimensional" e termos relacionados. Dois revisores independentes conduziram a extração dos dados e um terceiro (revisor) solucionou as discordâncias. Todas as tabelas usadas para a extração de dados estão disponibilizadas em site próprio. A ferramenta Cochraine Collaboration foi utilizada para avaliar o risco de viés na inclusão de estudos. RESULTADOS: Identificados 301 artigos e 13 relatos de casos e séries de casos que atenderam aos critérios de inclusão. A amostra envolveu 34 pacientes, com idade de 3 meses a 94 anos. CONCLUSÃO: Até o presente momento, não há estudos que contemplem um número considerável de pacientes. A impressão de um modelo 3D produzida a partir do protótipo do paciente permitirá ao cirurgião planejar a cirurgia, bem como escolher o melhor material, tamanho, formato e espessura da válvula a ser utilizada. Esse planejamento reduz o tempo de cirurgia, a exposição e, consequentemente, a redução do risco de infecção.

Intervenção sobre fatores de risco emcrianças e adolescentes / Risk factor intervention in children and adolescents

As doenças cardiovasculares estão entre as principais causas de mortalidade no mundo e não afligem apenas os adultos. Muitos trabalhos têm demonstrado que elas já podem ser vistas na infância. Entre os fatores de risco para a doença cardiovascular, pode-se destacar a dislipidemia, o baixo peso ao nascer e a obesidade infantil. A detecção de dislipidemia na infância é crucial, por ser considerada a fase estratégica para a implementação de medidas de prevenção da aterosclerose no âmbito populacional. Embora as causas ambientais ou poligênicas sejam as mais frequentes, é importante a identificação de formas genéticas como a hipercolesterolemia familiar e hipertrigliceridemias de base genética, pois medidas relacionadas aos hábitos de vida e terapêutica medicamentosa devem ser iniciadas preco-cemente, evitando-se complicações e mudando a história natural dos desfechos clínicos. Outros estudos têm demonstrado que o baixo peso ao nascer também contribui para o desenvolvimento tardio de hipertensão arterial, doença coronariana e disfunção endotelial. Possivelmente, por conta das agressões ao sistema vascular em desenvolvimento. No en-tanto, os mecanismos ainda são incertos. Evidências sugerem que alguns biomarcadores, tais como os níveis de ácido úrico e homocisteína e a baixa concentração de óxido nítrico observados em crianças com baixo peso ao nascer, podem estar associados a alterações deletérias na vida adulta. Por fim, o terceiro fator que deve ser considerado é a obesidade infantil. Essa desordem tem causa multifatorial e pode favorecer o surgimento das etapas iniciais da aterosclerose, como a disfunção endotelial, já na infância. Porém, é um fator de risco modificável, e as estratégias de prevenção e intervenção baseiam-se, na maioria dos casos, em mudanças do estilo de vida, como alimentação saudável e exercício físico.

Cardiovascular disease is one of the leading causes of mortality in the world and does not affect adults alone. Many papers have shown that it can already be seen in childhood. The most significant risk factors for cardiovascular disease include dyslipidemia, low birth weight and childhood obesity. Screening for dyslipidemia in childhood is crucial as this is considered a strategic phase for the implementation of measures aimed at preventing atherosclerosis in the population setting. Although environment or polygenic causes are the most common, it is important to identify genetic forms such as familial hypercholesterolemia and hypertriglyceridemia, since measures related to lifestyle and pharmacotherapy must be initiated early in life to avoid complications and change the natural history of clinical outcomes. Other studies have shown that low birth weight also contributes to the late development of hypertension, coronary artery disease and endothelial dysfunction, possible due to injury to the developing vascular system. However, the mechanisms are still uncertain, and evidence suggests that some biomarkers, such as uric acid and homocysteine levels, and the low concentration of nitric oxide observed in low birthweight children, may be associated with deleterious changes in adulthood. Finally, the third factor to be considered is childhood obesity. This disorder has a multifactorial etiology and may favor the onset of the first stages of atherosclerosis, such as endothelial dysfunction, in young children. However, it is a modifiable risk factor, and prevention and intervention strategies are largely based on lifestyle changes such as healthy diet and exercise

Hypertension as a risk factor for female sexual dysfunction: cross-sectional study / Hipertensão como fator de risco para disfunção sexual feminina: estudo transversal / La hipertensión como un factor de riesgo para la disfunción sexual femenina: estudio transversal

ABSTRACT Objective: to evaluate the sexual dysfunction in hypertensive patients compared to normotensive patients. Method: this was a cross-sectional study. Samples were composed of 54 hypertensive patients and 54 normotensive patients. The female sexual dysfunction was evaluated by the Female Sexual Function Index (FSFI). Results: the average FSFI score differed highly between hypertensive and normotensive patients (22.4± 7.4 versus 26.8 ±5.4, p< 0.001). Among hypertensive patients, 63% showed sexual dysfunction in opposition to 39% of normotensive patients (p=0.02). Hypertensive women had 1.67 more chances of showing the dysfunction than women with normal blood pressure. Conclusion: the sexual dysfunction prevalence is higher in hypertensive than in normotensive women hence, hypertension is a potentiator factor for female sexual dysfunction.

RESUMO Objetivo: avaliar a disfunção sexual em pacientes hipertensas em comparação com pacientes normotensas. Método: estudio transversal. Las muestras estaban compuestas por 54 pacientes hipertensos y 54 normotensos. La disfunción sexual femenina fue evaluada por el Índice de Función Sexual Femenina (FSFI). Resultados: a pontuação média do FSFI foi muito diferente entre pacientes hipertensas e normotensas (22,4 ± 7,4 versus 26,8 ± 5,4, p <0,001). Da amostra de pacientes hipertensas, 63% apresentaram disfunção sexual, ante 39% da amostra de pacientes normotensas (p=0,02). As mulheres hipertensas apresentaram 1,67 vezes mais chances de ter a disfunção do que mulheres com pressão arterial normal. Conclusão: a prevalência de disfunção sexual é maior em mulheres hipertensas do que em mulheres normotensas. Portanto, a hipertensão é um fator que potencializa a disfunção sexual feminina.

RESUMEN Objetivo: evaluar la disfunción sexual en pacientes hipertensos en comparación con pacientes normotensos. Método: estudio transversal. Las muestras estaban compuestas por 54 pacientes hipertensos y 54 normotensos. La disfunción sexual femenina fue evaluada por el Índice de Función Sexual Femenina (FSFI). Resultados: el puntaje FSFI promedio fue muy diferente entre pacientes hipertensos y normotensos (22.4±7.4 versus 26.8 ± 5.4, p<0.001). El 63% de los pacientes de la muestra de hipertensos demonstraron disfunción sexual, en oposición al 39% de la muestra de pacientes normotensos (p=0,02). Las mujeres hipertensas presentaron 1.67 más posibilidad de mostrar la disfunción que las mujeres con presión arterial normal. Conclusión: la prevalencia de disfunción sexual es mayor en mujeres hipertensas que en mujeres normotensas. Entonces, la hipertensión es un potenciador de la disfunción sexual femenina.

Protective effects of accumulated aerobic exercise in infarcted old rats / Efeitos protetores do exercício aeróbio acumulado em ratos idosos infartados

Background: Aerobic exercise exerts cardioprotective effects on myocardial infarction. However, there is lack of information about the possible protective effects of continuous or accumulated aerobic exercise performed prior to myocardial infarction in aging. Objective: To evaluate the preventive effects of continuous or accumulated aerobic exercise on physical capacity, pulmonary congestion and ventricular weight in rats submitted to myocardial infarction. Methods: Old male Wistar rats were divided into four groups: sham control, sedentary infarcted, continuous aerobic exercise submitted to myocardial infarction, and accumulated aerobic exercise submitted to myocardial infarction. Body weight and maximum speed were evaluated at the beginning and at the end of the protocol. Trained groups performed continuous (1 h a day) or accumulated (30 minutes in the morning and 30 minutes in the afternoon) exercise. All groups, except the sham control, were submitted to myocardial infarction surgery at the end of the protocol. Heart, skeletal muscles, as well as wet and dry lung were weighed. The significance level in statistical analysis was established at p < 0.05. Results: Both continuous and accumulated exercise caused an increase in physical capacity in rats, as well as prevented its further impairment after myocardial infarction, and in the accumulated exercise group this prevention was greater. The continuous exercise group demonstrated an increase in lung water content, while the accumulated exercise group presented a reduction in body weight and an increase in left ventricle relative weight. Conclusion: In conclusion, the data of the present study indicate that accumulated aerobic exercise present a better protective effect than continuous aerobic training in the context of myocardial infarction and aging

Análise da população atendida por meio de tele-eletrocardiograma em serviço móvel de urgência / Analysis of the population attended through a tele-electrocardiography in mobile emergency medical service / Análisis de la población asistida por medio de tele-electrocardiograma en el servicio de urgencia móvil

O estudo aqui apresentado teve como objetivo analisar a população atendida por meio de teleeletrocardiografia realizada por serviço público que pode ser referência para outros em matéria de atendimento pré-hospitalar móvel de urgência no município de Porto Alegre. Trata-se de estudo transversal retrospectivo. Foram analisados 1.338 eletrocardiogramas realizados de setembro 2013 a agosto 2014 pelo Samu/POA, com laudo a distância feito no Hospital do Coração (HCor) em São Paulo. Utilizou-se a metodologia embasada nas diretrizes STROBE (Strengthening the Reporting of Observational Studies in Epidemiology). Em 115 (8,6%) desses tele-eletrocardiogramas, os pacientes foram diagnosticados com supradesnivelamento do segmento ST. Esta alteração eletrocardiográfica prevaleceu no gênero masculino (p = 0,012) com idade acima de 60 anos (p = 0,014). Dor torácica típica retroesternal foi mencionada por 314 homens (54,3%) e 726 mulheres (56,3%). Síncope foi relatada por 94 homens (16,3%) e 107 mulheres (14,2%). A dispneia foi um sintoma apontado por 47 homens (8,1%) e 84 mulheres (11,1%). Os resultados do estudo revelaram que alterações eletrocardiográficas sugestivas de SCA (Síndrome coronariana aguda) predominam em homens idosos; embora as mulheres solicitem o serviço de atendimento com mais frequência, o supradesnivelamento do segmento ST mostrou-se preponderante no gênero masculino. A dor torácica ter sido mencionada como o sintoma mais referido está em concordância com a literatura atual. =O conhecimento de nossa realidade pode auxiliar a elaboração de protocolos de serviço.(AU)

The study presented now had as objective to analyze the population attended by tele-electrocardiography in a public service that is a reference for mobile emergency medical service in the city of Porto Alegre, RS, Brazil. It is a retrospective cross-sectional study. We analyzed all electrocardiograms performed by Samu Porto Alegre, from September 2013 to August 2014, and their medical reports produced remotely by the Hospital do Coração (HCor), SP, Brazil. The study was based on the STROBE (Strengthening Reporting Observational Studies Epidemiology) guidelines. From tele-electrocardiograms, 115 (8.6%) patients were diagnosed having a ST-segment elevation. This electrocardiographic alteration was more prevalent in men (p = 0.012) who were 60 years old or over (p = 0.014). Among the symptoms expressed by patients, 314 (54.3%) men and 726 (56.3%) women felt typical retrosternal chest pain. Syncope was reported by 94 (16.3%) men and 107 (14.2%) women. Dyspnea was a symptom reported by 47 (8.1) men and 84 (11.1) women. The results of the study revealed that electrocardiographic alterations suggesting ACS (Acute Coronary Syndrome) are more prevalent in elderly men. Although women request more frequently the mobile emergency medical service, the ST-segment elevation was more prevalent in men. The chest pain was the most symptom mentioned, a result in agreement with the current literature. The knowledge of our reality can help the organization of service protocols.

El estudio presentado aquí ha tenido el objetivo de analizar la población atendida a través de tele-electrocardiografía, en servicio público que es referencia en atención pre-hospitalaria móvil de emergencia, en el municipio de Porto Alegre, RS, Brasil. Consiste en un estudio transversal retrospectivo. Fueron analizados electrocardiogramas realizados entre los meses de septiembre/2013 y agosto/2014 por el Samu/POA, con laudos emitidos a distancia por el Hospital del Corazón (HCor), SP, Brasil. El estudio es basado en las directrices del STROBE (Strengthening the Reporting of Observational Studies in Epidemiology). En 115 (8,6%) de estos tele-electrocardiogramas, los pacientes fueron diagnosticados con supra desnivel del segmento ST. Esta alteración electrocardiográfica fue más predominante en el género masculino (p = 0,012), con edad superior a 60 años (p = 0,014%). Dolor en el pecho típíco retroesternal fue mencionado por 314 hombres (54,3%) y 726 mujeres (56,3%). Síncope fue relatado por 94 hombres (16,3%) y 107 mujeres (14,2%). La disnea fue un síntoma mencionado por 47 hombres (8,1%) y 84 mujeres (11,1%). Los resultados del estudio revelaron que alteraciones sugestivas de SCA (Síndrome coronario agudo) son más predominantes en los hombres con edad superior a 60 años; las mujeres suelen recurrir a el servicio de atención con más frecuencia, entretanto, el suspradesnivel del segmento ST ha prevalecido en el género masculino. El dolor en el pecho fue el síntoma más mencionado, hecho que coincide con la literatura actual. El conocimiento de nuestra realidad puede auxiliarnos a elaborar protocolos de servicio.

The cardiac profile and electrocardiographic standard of at-height workers

SUMMARY BACKGROUND The Medical Control Program for Occupational Health establishes the required supplementary exams, according to the activity exercised by the worker and its inherent risks. The Regulatory Norm No. 35, recently deployed, stipulates that at-height workers must undergo electrocardiogram exams as an additional routine examination. OBJECTIVE To evaluate the electrocardiographic standard in at-height. METHODOLOGY A cross-sectional study, developed from May 2014 to January 2015 with male at-height workers. Anthropometric and clinical data were collected after the electrocardiogram (ECG). The workers included in the program were evaluated by an occupational medicine service of Serra Gaúcha, responsible for medical assessment and occupational tests. All workers were assessed by the researcher. RESULTS A total of 561 at-height workers participated in the study. The average age was 35.9 ± 12.2 years. A total of 176 (31%) presented electrocardiographic changes in the analysis of the resting ECG. Regarding the amendments in the resting ECG, 15.7% were attributed to changes in ventricular repolarization, 8% as blocks conductions, and 5.8% as left ventricular overload. Demographic variables were not associated with changes in the electrocardiographic tracing CONCLUSION This study demonstrated the electrocardiographic alterations and the profile of at-height workers. These findings can help determine prevention strategies and provide warnings of possible future harms to the health of these workers.

RESUMO FUNDAMENTO O Programa de Controle Médico e Saúde Ocupacional estabelece a realização de exames complementares de acordo com a atividade exercida pelo trabalhador e os riscos a ela inerentes. A Norma Regulamentadora n0 35, implantada recentemente, estabelece que trabalhadores que exercem funções em altura realizem o eletrocardiograma como um exame complementar de rotina. OBJETIVO Avaliar o padrão eletrocardiográfico dos trabalhadores em altura por meio da realização do ECG de repouso. MÉTODOS Estudo transversal, desenvolvido de maio de 2014 a janeiro de 2015 com trabalhadores masculinos que exercem funções em altura. Foram coletados dados clínicos e demográficos e, após, realizado o eletrocardiograma (ECG). Os trabalhadores incluídos eram vinculados a um serviço de medicina do trabalho da Serra Gaúcha, destinado à realização de avaliação médica e exames ocupacionais. Todos foram avaliados pela pesquisadora. RESULTADOS Participaram 561 trabalhadores em altura. A média de idade foi de 35,9±12,2 anos, e 176 (31%) apresentaram alterações eletrocardiográficas na análise dos ECG de repouso. Das alterações do ECG de repouso, 15,7% foram atribuídas a alterações da repolarização ventricular; 8% como bloqueios de condução e 5,8% como sobrecarga de ventrículo esquerdo. As variáveis demográficas não estavam associadas com alterações no traçado eletrocardiográfico. CONCLUSÃO Este estudo verificou que a prevalência de sobrecarga de ventrículo esquerdo e alteração da repolarização ventricular, nos trabalhadores em altura, é maior quando comparada a estudos populacionais brasileiros. A associação de fatores de risco e alterações eletrocardiográficas em indivíduos difere de populações específicas.

ACE gene dosage determines additional autonomic dysfunction and increases renal angiotensin II levels in diabetic mice

OBJECTIVES: The present study aimed to investigate cardiovascular autonomic modulation and angiotensin II (Ang II) activity in diabetic mice that were genetically engineered to harbor two or three copies of the angiotensin-converting enzyme gene. METHODS: Diabetic and non-diabetic mice harboring 2 or 3 copies of the angiotensin-converting enzyme gene were used in the present study. Animals were divided into 4 groups: diabetic groups with two and three copies of the angiotensin-converting enzyme gene (2CD and 3CD) and the respective age-matched non-diabetic groups (2C and 3C). Hemodynamic, cardiovascular, and autonomic parameters as well as renal Ang II expression were evaluated. RESULTS: Heart rate was lower in diabetic animals than in non-diabetic animals. Autonomic modulation analysis indicated that the 3CD group showed increased sympathetic modulation and decreased vagal modulation of heart rate variability, eliciting increased cardiac sympathovagal balance, compared with all the other groups. Concurrent diabetes and either angiotensin-converting enzyme polymorphism resulted in a significant increase in Ang II expression in the renal cortex. CONCLUSION: Data indicates that a small increase in angiotensin-converting enzyme activity in diabetic animals leads to greater impairment of autonomic function, as demonstrated by increased sympathetic modulation and reduced cardiac vagal modulation along with increased renal expression of Ang II.

Efeitos de um programa de acompanhamento multidisciplinar em hipertensos sobre o controle autonômico cardiovascular: ensaio clínico randomizado / Effects of a multidisciplinary monitoring program in hypertensive patients on the cardiovascular autonomic control: randomized clinical trial

Introdução: A hipertensão arterial sistêmica (HAS) é uma doença crônica, considerada como principal fator de risco para mortalidade por acidente vascular cerebral (AVC) e doença coronariana (DC) (40% óbitos). Apesar disso e da alta prevalência na população não existe um bom controle dos valores da pressão arterial (PA) dentro de metas pressóricas determinadas pelas Diretrizes nos indivíduos acometidos. Acredita-se que a disponibilização de um programa de atenção e acompanhamento do paciente hipertenso de natureza multidisciplinar (MULTIHAS), possa colaborar para a adesão e, consequentemente, para o melhor controle da PA. Além disso, a possibilidade de avaliar nesses pacientes a Variabilidade da Frequência Cardíaca (VFC) pode fornecer informações sobre o Sistema Nervoso Autônomo (SNA) e seu controle sobre o coração. Objetivo: Avaliar o efeito de um programa de assistência multiprofissional (MULTIHAS) sobre o controle autonômico cardiovascular e a PA em pacientes em hipertensos. Métodos: Ensaio clínico randomizado, controlado, em hipertensos submetidos a dois tipos de tratamentos: o multiprofissional grupo MULTIHAS composto pelos profissionais (médico, enfermeiro, nutricionista, fisioterapeuta e psicólogo) e o convencional (grupo Controle) (médico e o enfermeiro). Foram avaliadas variáveis como uso de medicações, bioquímica do sangue, índice de massa corporal (IMC), escore de qualidade de vida (QV), PA e VFC. As visitas no grupo MULTIHAS eram efetuadas a cada dois meses a todos os profissionais. No grupo Controle as visitas também ocorriam a cada dois meses acompanhados, somente, pelo médico e pelo enfermeiro. Ao final de um ano todas as variáveis foram novamente avaliadas em ambos grupos. Resultados: Após um ano de tratamento o grupo MULTIHAS apresentou diferença significativa no escore da QV(p<0,005) e nos valores do IMC (p<0,001); na posição supina tiveram melhora a PAS (p=0,015), a PAM (p=0,034), a VFC (p= 0,051) e no componente de alta frequência da VFC - HFabs (p= 0,042) em relação ao grupo Controle. No registro da FC pelo frequencímetro (Polar RS800 CX da Finlândia) esta respondeu à manobra ortostática nos valores da PAS (p=0,016), PAD (p=0,028), sendo a variância total da FC (p= 0,047) bem como o componente de baixa frequência da VFC - LFabs (p= 0,045) significativamente diferentes em relação ao grupo Controle. Conclusão: O atendimento multiprofissional deve ser considerado como um potencial recurso no manejo da pressão arterial, do IMC, do escore de QV bem como do sistema nervoso autônomo, pois esses parâmetros foram otimizados quando comparados ao grupo Controle.

Introduction: Systemic arterial hypertension (SAH) is a chronic high prevalent disease and a major risk factor for cardiovascular events such stroke (CVA) and coronary heart disease (CHD) (40% of deaths). Despite this, there is a lack of adequate control of blood pressure (BP) levels according with those described on guidelines for hypertensive patients. It is believed that specific care programs and multidisciplinary monitoring of the hypertensive patient (MULTIHAS) can contribute to improved BP control in this population. Moreover, the autonomic nervous system and its control over cardiovascular function are alter in this patients and can contribute to poor prognostic and outcomes in this population. Objective: To evaluate the effect of a multidisciplinary assistance program (MULTIHAS) on the cardiovascular autonomic control and BP levels in hypertensive patients, with one year follow-up. Methods: Randomized controlled trial, conducted in hypertensive patients undergoing two different interventions: multi professional attention (MULTIHAS group) of different health time members (doctor, nurse, dietitian, physical therapist and psychologist) and conventional attention (control group) of doctor and nurse. The variables evaluated were BP and HRV (Heart rate variability), and secondary: body mass index (BMI), quality of life score (QOL), medication use and blood biochemistry The visits of MULTIHAS occurred every two months with all the multi professional team. Control group visits also occurred every two months accompanied only by the doctor and the nurse. After one year, all variables were assessed again in both groups. Results: After 1 year of treatment, the MULTIHAS group had a significant difference in the QOL score (p <0.005) and in the BMI values (p <0.001) ; the BP and HRV showed a small improvement in supine SBP (p = 0.015), in MBP (p = 0.034), in HRV (p = 0.051), and in the high frequency component of HRV - HFabs (p = 0.042) compared to the control group. During the recording of FC the frequency meter (Polar RS800 CX of Finland), it responded to the orthostatic maneuver in the values of SBP (p = 0.016), DBP (p = 0.028), the total HR variance (p = 0.047) LFabs (p = 0.045) were significantly different in relation to the control group. Conclusion: Multidisciplinary care should be considered as a potential resource in the management of blood pressure, BMI, QOL score as well as the autonomic nervous system, since these parameters were optimized when compared to the Control group.

Exercise training on cardiovascular diseases: Role of animal models in the elucidation of the mechanisms

Abstract Cardiovascular diseases, which include hypertension, coronary artery disease/myocardial infarction and heart failure, are one of the major causes of disability and death worldwide. On the other hand, physical exercise acts in the preventionand treatment of these conditions. In fact, several experiments performed in human beings have demonstrated the efficiency of physical exercise to alter clinical signals observed in these diseases, such as high blood pressure and exercise intolerance. However, even if human studies demonstrated the clinical efficiency of physical exercise, most extensive mechanisms responsible for this phenomenon still have to be elucidated. In this sense, studies using animal models seem to be a good option to demonstrate such mechanisms. Therefore, the aims of the present study are describing the main pathophysiological characteristics of the animal models used in the study of cardiovascular diseases, as well as the main mechanismsassociated with the benefits of physical exercise.(AU)