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Protein-protein interactions (PPI) are involved in a variety of biological processes, including cell-to-cell interactions, metabolism and development control. The misregulation, post-translational modification and interference of PPI are related to a variety of human diseases, making the regulation of these interactions a very attractive field of drug discovery. In recent years, the interaction between MDM2 and p53 has become a research hotspot, which plays an important role in the treatment of tumors. But unfortunately there are no such inhibitors approved all over the world. In this view, recent advances of MDM2-p53 inhibitors were briefly described and its inhibitors with potential therapeutic activities in clinical studies were introduced.
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BACKGROUND: Benefits of healthy people participating in physical activity are valued by governments, organizations and individuals, but the benefits of spinal cord injury (SCI) to physical activity are neglected. With the increase in the incidence of SCI, participating in physical activity to keep fit is recommended for SCI patients. OBJECTIVE: To review the relevant literatures on physical activity and health promotion of SCI at home and abroad, and systematically summarize the benefits of physical activity to SCI, so as to provide reference for participating in physical activity. METHODS: The first author recruited the Web of Science and the PubMed databases with the keywords of "spinal cord injury, physical activity, sport, exercise, health, fitness" in English and Chinese, respectively. RESULTS AND CONCLUSION: Physical activity has a positive effect on cardiovascular health, functional independence, quality of life, muscle strength, psychological and social adaptation in SCI patients, and the impact on bone density needs a further investigate. Physical activity holds a positive effect on the health of SCI patients, and it is hoped that SCI patients will actively carry out physical activity to improve or maintain health status. SCI patients exhibit individual differences, so in the use of physical activity to promote health, it is necessary to make individualized sports program to obtain satisfactory effectiveness.
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Objective:To develop a catheter of movable tracheal cannula for single lung ventilation so as to compensate the existed disadvantages of using double-lumen bronchial catheter and bronchial occlusive device in single lung ventilation in present.Methods: A long tracheal catheter was installed into a short endotracheal catheter so as to form a complete catheter of tracheal cannula. The internally installed catheter could be rotated and moved in the cannula. After then, the front-end direction of internally installed catheter was chose through rotated the catheter according to the requirement of operation, and the single lung ventilation could be achieved when the internally installed catheter was pushed forward and was inserted in left or right bronchus. After the operation, the internally installed catheter exited out from bronchus to trachea and was used to implement double lung ventilation, or it was pulled out from outer cannula and the double lung ventilation was implemented by using outer cannual.Results: The ventilation effect of single-lung was doubtless when the catheter of movable tracheal cannula was inserted in left or right bronchus by using internally installed catheter. The technique of intubation tube was simpler than that of double-lumen bronchial catheter and bronchial occlusive device. The internally installed catheter could rotate in the outer cannula so as to protect tracheal wall and avoid oxygen deficit of patient during the processes of replacing tracheal catheter and the difficulty of replacing tracheal catheter post-operation of double-lumen bronchial catheter. Besides, it also could avoid the injury risk of anastomotic stoma of esophageal surgery caused by mis-insertion of tracheal catheter in esophagus.Conclusion: This kind of removable tracheal cannula has reasonable design, simple operation of intubation and better clinical practicability, and its feasibility is better that the product is transformed.
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Objective:To develop a catheter of movable tracheal cannula for single lung ventilation so as to compensate the existed disadvantages of using double-lumen bronchial catheter and bronchial occlusive device in single lung ventilation in present.Methods: A long tracheal catheter was installed into a short endotracheal catheter so as to form a complete catheter of tracheal cannula. The internally installed catheter could be rotated and moved in the cannula. After then, the front-end direction of internally installed catheter was chose through rotated the catheter according to the requirement of operation, and the single lung ventilation could be achieved when the internally installed catheter was pushed forward and was inserted in left or right bronchus. After the operation, the internally installed catheter exited out from bronchus to trachea and was used to implement double lung ventilation, or it was pulled out from outer cannula and the double lung ventilation was implemented by using outer cannual.Results: The ventilation effect of single-lung was doubtless when the catheter of movable tracheal cannula was inserted in left or right bronchus by using internally installed catheter. The technique of intubation tube was simpler than that of double-lumen bronchial catheter and bronchial occlusive device. The internally installed catheter could rotate in the outer cannula so as to protect tracheal wall and avoid oxygen deficit of patient during the processes of replacing tracheal catheter and the difficulty of replacing tracheal catheter post-operation of double-lumen bronchial catheter. Besides, it also could avoid the injury risk of anastomotic stoma of esophageal surgery caused by mis-insertion of tracheal catheter in esophagus.Conclusion: This kind of removable tracheal cannula has reasonable design, simple operation of intubation and better clinical practicability, and its feasibility is better that the product is transformed.
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<p><b>OBJECTIVE</b>To study and evaluate the clinical effect of root canal therapy bypassing intracanal separated instruments.</p><p><b>METHODS</b>32 teeth were selected as the test group, from which the intracanal separated instruments couldn't be taken out, adopted the method of root canal preparation and obturation bypassing broken instruments. Meanwhile, 13 teeth were selected as the control group, in which the fractured instruments couldn't be taken out from root canal, and not be cured bypassing broken instruments. 30 teeth were selected as the conventional therapy group, in which the instruments were not fractured, the routine root canal therapy were adopted. The clinical efficacy of three groups were observed and evaluated through periapical index and clinical examination two years later.</p><p><b>RESULTS</b>After two years, 25 teeth were followed up in test group, the success rate of root canal therapy was 80.00%; 11 teeth were followed up in control group, the success rate of root canal therapy was 36.36%. All of the failed cases in two groups were the teeth with broken instruments in tip of root canal. In conventional therapy group, 22 teeth were followed up, and the success rate of root canal therapy was 90.91%.</p><p><b>CONCLUSION</b>Root canal therapy bypassing intracanal separated instruments is a feasible and effective method in treating the teeth with broken instruments.</p>