RESUMO
Objective To discuss influence and curative effect of montelukast on serum leukotriene B4,C4 and D4 levels of children with cough variant asthma (CVA). Methods Seventy-four cases of children with CVA were divided into observation group and control group at random. The children in control group were given ketotifen tablets 0.5~1 mg for one time twice a day. The children in observation group were given 5 mg montelukast dulcet through the mouth per time once a day for 8 weeks. The clinical curative effect and drug adverse reaction (DAR) was observed, and the changes of serum leukotriene B4,C4 and D4 levels of children in two groups before and after treatment were compared as well. Results After 8 weeks'treatment,the serum leukotriene B4,C4 and D4 levels of children in two groups were de-clined with different degrees (P<0.01 or P<0.05),and the declining rate in observation group was higher than that in control group (P<0.05). After 8 weeks' treatment,the total clinical efficiency of children in observation group was much higher than that in control group (P<0.05). No obvious DAR were appeared on children in two groups during treatment. Conclusion Montelukast has favorable curative effect and security on CVA,whose main reason is the rela-tionship with reducing serum leukotriene B4,C4 and D4 levels.