Comparison of clinical features and prognosis between thymoma alone and thymoma with myasthenia gravis / 中华放射肿瘤学杂志

Objective To investigate the clinicopathological features and prognosis in patients with thymoma and patients with thymoma and myasthenia gravis ( MG) . Methods A retrospective analysis was performed on the clinicopathological data of 161 patients pathologically diagnosed with thymoma alone or thymoma and MG from 2008 to 2014. In those patients, 128 had thymoma with MG and 33 had thymoma alone. The survival rates were calculated using the Kaplan?Meier method and analyzed using χ2 test or Fisher′s exact probability test. Results The mean age of onset was 45. 2 years for patients with thymoma and MG and 48. 5 years for patients with thymoma alone. In patients with thymoma and MG, 74. 2% had a tumor diameter of ≤5 cm, while 75. 8% of patients with thymoma alone had a tumor diameter of ≥5 cm. According to the Masaoka staging system, 78. 1% of patients with thymoma and MG had stage Ⅰ+Ⅱdisease, while 51. 1% of patients with thymoma alone had stage Ⅲ+Ⅳ disease. There was no significant difference in the 3?year overall survival ( OS) rate between the two groups ( 98. 1% vs. 81. 8%, P=1. 000) . The 5?year OS rate was significantly higher in patients with thymoma and MG than in patients with thymoma alone ( 91. 1% vs. 42. 9%, P= 0. 000 ) . In all patients, 140 patients with complete resection had significantly higher 3?and 5?year OS rates than 21 patients with incomplete resection ( 97. 2% vs. 58. 8%, P=0. 000;92. 7% vs. 25. 0%, P=0. 000). In patients with stage Ⅱ disease, there were no significant differences in the 3?or 5?year OS rates between patients with complete resection alone ( n=25) and patients with complete resection and postoperative radiotherapy ( n=25) ( 95% vs. 100%, P=1. 000;86% vs. 100%, P=0. 467). Conclusions Compared with patients with thymoma alone, patients with thymoma and MG have an earlier age of onset, substantially smaller tumor diameters, and earlier Masaoka stages. MG and complete resection are positive prognostic factors for patients with thymoma. Radiotherapy after complete resection can reduce the recurrence rate in patients with stage Ⅱ disease.

Clinical features and prognosis of thymoma with myasthenia gravis: an analysis of 126 patients / 中华放射肿瘤学杂志

Objective To investigate the clinical and pathological features and prognostic factors for thymoma with myasthenia gravis (MG).Methods The clinical and pathological data of 126 patients with thymoma and MG confirmed by postoperative pathological examination from 2008 to 2014 were analyzed retrospectively.The Kaplan-Meier method was used to calculate survival rates;the log-rank test was applied for univariate prognostic analysis;the Cox regression model was applied for multivariate prognostic analysis.Results The numbers of patients who received the follow-up visits at 3 and 5 years were 88 and 45,respectively (the patients who were admitted before the end of October 2011 and the end of October 2009).The 3-and 5-year survival rates were 97.9％ and 91.8％,respectively.The 3-and 5-year survival rates for patients with WHO types A+AB+B1 +B2 and B3 were 98.6％/95.2％ and 90.6％/92.9％,respectively (P=0.764),and those for patients with Masaoka stages Ⅰ-Ⅱ and Ⅲ-Ⅳ were 98.6％/95.2％ and 97.4％/72.7％,respectively (P=0.791).The 3-and 5-year survival rates for patients with complete and partial resection were 97.8％/91.7％ and 100.0％/50.0％,respectively (P=0.964),and those for patients with complete resection alone and complete resection+postoperative radiotherapy were 96.8％/93.1％ and 100.0％/94.7％,respectively (P=1.000).Conclusions The major treatment modality for thymoma with MG is complete resection followed by radiotherapy according to the specific circumstances after surgery.Complete resection,postoperative radiotherapy,WHO type,and Masaoka stage may be associated with prognosis.

Investigation and analysis of influence of social support and coping style on depression mood of infertile patients / 中国实用护理杂志

Objective This study aims to explore the social support,coping style on depressive mood of infertile patients.Methods 165 infertility patients were collected as the research object,and they were investigated with the self-rating depression scale,social support scale and coping style questionnaire.Results 34.55％,48.48％ of the patients with education background of junior middle school,high school appeared depression.Subjective support and positive coping had significant positive correlation.The availability of support and positive coping had significant positive correlation.Positive coping and depression had significant negative correlation,negative coping and depression had significant positive correlation.Educational level and depression demonstrated inverted U shape relationship; coping style had direct effect and indirect effect on infertile female patients with depression.Conclusions Use of active coping without negative coping can reduce depressive mood,improve patients' social support in order to reduce mental stress level.

Effects of comprehensive intervention on prevention of complications after total hip replacement in senile patients / 中国实用护理杂志

Objective To investigate the effect of postoperative complications to the aged after total hip replacement.Methods According to hospitalization order,120 patients undergoing total hip replacement operation were assigned into the intervention group and the control group with 60 patients in each group.In the intervention group,the patients received comprehensive intervention of diet nursing,psychological nursing,complication prevention and rehabilitation exercise.The control group received usual care.Then duration of hospital stay,incidence of complication,psychological state and compliance with functional exercises were compared between two groups.Results In the intervention group,the hospitalization time was shorter,the incidence rate of complication was lower,and psychological state and compliance with functional exercises were better than the control group.Conclusions The comprehensive intervention can reduce the incidence rate of complication,shorten hospitalization time,raise quality of care and facilitate recovery of patients.

Clinical research in humidifying methods of artificial airway / 中国实用护理杂志

Objective To explore the best humidifying methods of artificial airway by comparison of different humidifying approaches.Methods 124 patients were divided into the control group (60 cases) and the treatment group (64 cases).Two methods,continuous airway humidifying by the trace injection pump and continuous airway humidifying by oxygen atomization were adopted.The humidifying effect,tolerance rate of patients,the airway complications and nursing cost were compared between the two groups.Results The method of continuous airway humidifying by oxygen atomization had better effect,was easy to be tolerated,less complications and less cost.Conclusions Continuous airway humidifying by oxygen atomization is a safe,effective,low-cost method,it is easy to be tolerated by patients and is worthy of being popularized.

Observation on sterile effect of sterile adhesive tape on opened infusion bottle mouth / 中国实用护理杂志

Objective To discuss the sterile effect of sterile adhesive tape on opened infusion bottle mouth. Methods From February to May, 2009, 400 infusion bottles were chosen and divided into the observation group and the control group with 200 bottles in each. The bottle mouth in the observation group was covered with sterile adhesive tape, while the control group used iodophor. The incidence of infusion reaction, disposable materials and time consuming of nurses were compared. Results No infusion reaction occurred in both groups. But disposable materials and time consuming was less in the observation group compared with the control group. Conclusions Application of sterile adhesive tape in sterilization of opened infusion bottle mouth is safe, reliable, simple and economic, it can save time and increase work efficiency of nurses.

Research in effect of cerebrospinal fluid replacement in treatment of subarachnoid hemorrhage and its nursing countermeasures / 中国实用护理杂志

Objectives To investigate the effect of cerebrespinal fluid replacement using three- way pipe on subarachnoid hemorrhage and the nursing points were summarized. Methods 80 subarachnoid hemorrthage patients were divided into the treatment group and the control group with 40 patients in each group. The control group received traditional medical treatment and routine nursing. The treatment group received cerebrospinal fluid replacement.The incidence of complication,death and clinical effect were com-pared between the two groups and the data under χ2 test and t test. Results Each index in the treatment group was better than that of the control group. Conclusions Intensified nursing after cerebrospinal fluid replacement can improve treatment effect, alleviate prognosis and supply reference for future nursing work for this disease.

The effect of entrapment of CpG sequence with cationic PLG nanoparticles on the immune responses of mice to pig paratyphoid vaccine / 生物医学工程学杂志

Cationic PLG nanoparticles and liposome were prepared and used as package molecules to pack up pUC18-CpG. The effects of the packed pUC18-CpG on the cellular and humoral immune responses were detected in the mice that were inoculated with pig paratyphoid vaccine. The results showed that compared with the control, the amount of IgG and the titre of specific antibody were significantly increased in the sera of mice immunized with the CpG plasmid entrapped by cationic PLG nanoparticles; the proliferation and induced IL-2 bioactivity of lymphocytes were significantly enhanced in the spleen of the immunized mice; the stimulatory effect of cationic PLG nanoparticles was similar to or stronger than that of cationic liposome. These indicated that cationic PLG nanoparticle could be employed as an effective package molecule to promote the immunostimulatory effect of pUC18-CpG.