Unusual presentation of Sheehan's syndrome with severe hyponatremia and recurrent symptomatic hypoglycemia: A case report / Journal of the ASEAN Federation of Endocrine Societies

@#<p style="text-align: justify;">Sheehan's syndrome (SS) is postpartum hypopituitarism caused by necrosis of the pituitary gland. The onset in most cases is several months or even years after the inciting delivery, so it is often unrecognized and not adequately treated. Because SS often evolves slowly, it is usually diagnosed late. We report a 47-year old woman with loss of consciousness. Fourteen years ago, she had postpartum hemorrhage with subsequent amenorrhea and failure to lactate. Laboratory investigation showed low blood sugar and serum sodium levels, amid normal cortisol and thyroid function tests. Magnetic resonance imaging (MRI) of the pituitary revealed an empty sella consistent with SS. The presentation of hypoglycemia and hyponatremia are less known complications of Sheehan's syndrome with only a few documented in case reports.</p>

promoter region [G-800A and C-509T] polymorphisms of transforming growth factor-01 gene among young women with recurrent urinary tract infection

Recurrent urinary tract infection [UTI] is common among young women and one of its risk factors is genetic. Polymorphisms in promoter region [G-800A [rs 1800468] and C-509T [rsl800469]] of transforming growth factor-[beta1 [TGF-beta1] gene play pivotal roles in several infection diseases but the association of these polymorphisms with recurrent UTI remains unclear. The aim of this study was to assess the correlation of TGF-beta1 G-800A and C-509T polymorphisms with recurrent UTI in young women. TGF-beta1 G-800A and C-509T polymorphisms among 34 recurrent UTI patients and 34 healthy subjects, aged 15-50 years old, were evaluated with polymerase chain reaction-restriction fragment length polymorphism [PCR-RFLP] and confirmed by DNA sequencing. At position -800, genotypes showed no significant differences between recurrent UTI patients [GG 97.1%; GA 2.9%; AA 0%] and normal control [GG 97%; GA 0%; AA 2.9%] young women. Dominant and recessive model analyses did not find significant correlation between recurrent UTI patients and normal control young women. At position -509, allelic and genotypic frequencies showed no significant differences between recurrent UTI patients [CC 20.6%; CT 61.8%; TT 17.7%] and control individuals [CC 2.9%; CT 73.6%; TT 23.5%]. This study found that there is no strong correlation between polymorphisms of TGF-beta1 G-800A and C-509T and recurrent UTI