[Epigenetic of autoimmune diseases: a focus on systemic lupus erithematosis]

The genetic bases of most of the autoimmune diseases are identified with specified gene luci. Most of these diseases are multifactorial with considerable effect of environmental factors. But it is not yet obviously clear that how these factors can affect on genetic factors. These environmental mechanisms which affect on gene expression are called "epigenetics". In this article we will discuss about "epigenetics of autoimmune diseases