RESUMO
Fanconi anemia (FA) is an autosomal recessive inherited disease and the most common hereditary bone marrow failure syndrome, which can lead to bone marrow failure, increased risk of cancer, and developmental abnormalities. FANCD2 is a member of the FA gene family and has become the focal point of FA signaling. Research has found that FANCD2 plays an important role in the occurrence and development of tumors and can participate in regulating ferroptosis as a related gene. This article reviews the mechanism of action of FANCD2 and its research progress in tumors, in order to provide new directions and ideas for the diagnosis and treatment of diseases.
RESUMO
To evaluate the expression of cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1α) in non-small cell lung cancer (NSCLC) and its correlation with clinicopathological features. Methods: PRKAR1α expressions in 79 NSCLC patients and matched adjacent non-carcinoma tissues were analyzed by using qRT-PCR and immunohistochemistry. Results: The negative rates of PRKAR1α protein in NSCLC, lung squamous cell carcinoma (SCL) and lung adenocarcinoma (ACL) were 58.2%, 77.8%, 32.4%, respectively. Compared to the matched adjacent non-carcinoma tissues, there were significant differences in levels of PRKAR1α mRNA and protein in ACL (P0.05). The expression of PRKAR1α protein was positively correlated with histological type, TNM stage, and lymph node metastasis (P0.05). Conclusion: Low expression of PRKAR1α in ACL might be involved in the pathogenesis, which might serve as a novel diagnostic candidate.
Assuntos
Feminino , Humanos , Masculino , Adenocarcinoma , Química , Classificação , Genética , Adenocarcinoma de Pulmão , Biomarcadores Tumorais , Carcinoma Pulmonar de Células não Pequenas , Química , Genética , Carcinoma de Células Escamosas , Química , Genética , Subunidade RIalfa da Proteína Quinase Dependente de AMP Cíclico , Fisiologia , Perfilação da Expressão Gênica , Imuno-Histoquímica , Neoplasias Pulmonares , Química , Classificação , Genética , Metástase Linfática , Genética , Estadiamento de Neoplasias , RNA MensageiroRESUMO
It was proposed that the items incurrent testing itemsdatabase should be classified , ranked , amal-gamated or disintegrated , the testing items and their names should be standardized , and the link between current testing itemsdatabase and new standards should be established according to the new standards by taking their problems into consideration, such as non-standard link, repetition of a same item, non-standard names of testing item and method, in order to improve the effectiveness of main testing methods, lay a foundation for the verifica-tion, and provide reference for the link between new and old items in other provinces.