Research progress of the exosomes as drug delivery vehicles of Chinese herbal drugs / 药学学报

As a new carrier of intercellular information, the exosomes is widely regarded as a natural drug carrier for its extensive distribution, non-immunity and targeting in human body. Chinese herbal drugs act at multiple targets and through different pathways in the prevention and treatment of diseases, but the preparation is relatively simple, there is a low solubility in the effective ingredients and low bioavailability, which limit the efficacy of the medicine. Using the new drug delivery approach of the exosomes, it is better to deliver the effective components to target cells. In this review, we reviewed the biological characteristics of exosomes and its application as a carrier of Chinese herbal drugs.

Research on Prevention and Treatment of Cardiovascular Disease by Translational Medicine Based Chinese Medicine / 中国中西医结合杂志

Translational medicine is inevitable in the development of modern medicine, and the uprising concept of translational medicine provides an opportunity for the development of Chinese medicine (CM). Their ideas are well communicated. There are two patterns of researching on CM based on translational medicine: 'literature to bench to bedside' and 'bench to bedside to bench'. CM has her advantages in preventing and treating cardiovascular disease. Effective methods for preventing and treating cardiovascular disease by CM should be further studied based on translational medicine concepts.

A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis / 中国结合医学杂志

<p><b>OBJECTIVE</b>To determine the optimum treatment for viral myocarditis (VMC).</p><p><b>METHODS</b>A total of 126 VMC patients were randomly divided into the control group (42 cases) that was treated with conventional Western medicine, and the intervention group (84 cases) that was treated with a combination of Chinese medicine (CM) and Western medicine intervention termed optimum proposal of integration of disease and syndrome (OPIDS). Before and after 4 weeks of treatment, the integral of CM syndrome, self-rating depression and anxiety scales (SDS and SAS, respectively), echocardiograms (ECGs), heart rate variability and left ventricular systolic function were observed.</p><p><b>RESULTS</b>Compared with the control group, the intervention group showed significant reductions on the SDS and SAS (P <0.05); improvement of premature ventricular beats, atrioventricular blocks, ST-segment abnormalities, and significant T wave changes (P <0.05); greater reductions in standard deviation of NN intervals (SDNN), standard deviation for per 5 min averages NN intervals (SDANN), and root-mean-square of successive difference of NN intervals (rMSSD) (P <0.05); and increases in cardiac output, stroke volume, and ejection fraction, the last of which was statistically significant (P <0.05). Overall, the treatment efficacy rate was significantly better P<0.05) in the intervention group (75.61%) compared with the control group (69.70%).</p><p><b>CONCLUSION</b>OPIDS is quite effective in treating VMC and improves symptoms such as anxiety and depression, left ventricular systolic dysfunction, premature ventricular contraction, and cardiac autonomic nervous system dysfunction. [</p><p><b>REGISTRATION</b>Chinese clinical trial center (No. ChiCTR-TRC-00000298)].</p>

Current research situation of atherosclerotic vulnerable plaque and discussion of the efficacy of simiao yongan decoction / 中国中西医结合杂志

The vulnerable plaque is the basis for atherosclerosis (AS) plaque rupture and thrombosis, thus further leading to the occurrence of acute cardiovascular events (ACEs). By analyzing the current research situation of atherosclerotic vulnerable plaque, identifying that inflammation and thrombosis are key links in plaque vulnerability, and the roles of white blood cell and platelet aggregation, endothelial cell adhesion and their common connection mechanisms: PS/PSGL-1 in inflammation and the formation of thrombosis. From the viewpoints of inhibiting cell adhesion, fighting against inflammation reaction and thrombosis, the research ideas of Simiao Yongan Decoction in stabilizing atherosclerotic vulnerable plaque were explored.

Analysis on the Chinese medicine syndrome and therapy in patients with coronary heart disease after intervention / 中国中西医结合杂志

Along with the extensive application of intervention in treating coronary heart disease (CHD), problems such as post-interventional restenosis, no reflowing, and slow flowing, and so on increasingly emerge. Chinese medicine and pharmacy occupy advantages covering preventing post-intervention risk factors, improving and relieving patients' symptoms, and so on. It is a good support and supplement for routine therapies in modern medicine. Taking the pathological stages of CHD and clinical problems of coronary intervention as the breakthrough points, the Chinese medical syndromes and correspondent Chinese medicine recipes and herbs were preliminarily studied by combining Chinese medicine's recognition and clinical observation on coronary intervention.