1.
Journal of Korean Medical Science
; : S27-S28, 2000.
Artigo
em Inglês
| WPRIM
| ID: wpr-117533
RESUMO
1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.
Assuntos
5-Metoxitriptamina/farmacologia , Acetilcolina/farmacologia , Animais , Cálcio/metabolismo , Cobaias , Ductos Pancreáticos/metabolismo , Ductos Pancreáticos/efeitos dos fármacos , Secretina/farmacologia , Serotonina/farmacologia , Serotonina/metabolismo , Serotonina/análogos & derivados , Vasodilatadores/farmacologia
2.
Journal of Korean Medical Science
; : S16-S16, 2000.
Artigo
em Inglês
| WPRIM
| ID: wpr-117537
RESUMO
No abstract available.