Efficacy Observation of Long-term low doses of Azithromycin combined with Budesonide/Fomoterol in the treatment of stable Ⅲ to Ⅳ COPD patients / 实用医学杂志

Objective To investigate the safety and efficacy of long-term low doses of Azithromycin combined with Budesonide/Fomoterol in the treatment of stable Ⅲ to Ⅳ COPD patients. Methods Collect the confirmed COPD patients of our hospital, they were randomly divided into two groups: the control group (160μg/ 4.5 μg, Bid), the joint group (160 μg/ 4.5 μg/ Bid + azithromycin 250 mg qd). Then Observe the PEF, FEV1, FEV1/FVC, mMRC, 6 MWT, AECOPD of the two groups after treatment for 3 months and 6 months. Results the index of PEF, FEV1, FEV1/FVC of joint group improved more significantly (P 0.05), joint group improved more significantly than control group after 6 months (P < 0.05). Conclusion the therapy of Long-term low doses of azithromycin combined with Budesonide/Fomoterol can more significantly improve lung function index , as the treatment time extended , it can significantly improve clinical symptoms ,reduce the number of exacerbations than single inhaled Budesonide/Fomoterol .

Epidemiology investigation on chronic kidney disease among patients with bronchial asthma / 中华肾脏病杂志

Objective To study the prevalence of chronic kidney disease (CKD) among patients with bronchial asthma in Zhengzhou.Methods A total of 655 patients (older than 14years) were interviewed and received physical,uria and blood examination.Bronchial asthma and CKD were diagnosed according to related definition.Results The prevalence of albuminuria,hematuria,reduced eGFR and CKD was 9.41%,10.37%,3.03% and 17.38% respectively in the above special patients,which was higher than that of the general population.Women had higher prevalence of CKD than men (21.47% vs 13.99%,χ2=6.060,P=0.014).Prevalence of 1 to 5 stage of CKD was 8.61%,5.10%,3.03%,0.48% and 0.16% respectively.In the acute phase of asthma,prevalence of CKD (24.42%) was significantly higher than that in chronic duration and clinical remission period (χ2=12.445,P=0.002) and the same significant differences were found in albuminuria and reduced eGFR (χ2=19.619,P＜0.01 and χ2=9.305,P=0.010).Conclusion The bronchial asthma patients have higher incidence of renal damage and should be estimated,especially in the acute phase.