Anti-leishmanial and structure-activity relationship of ring substituted 3-phenyl-1-(1, 4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives

A series of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives were synthesized and tested for in vitro leishmanicidal activity against amastigotes of Leishmania amazonensis in axenical cultures and murine infected macrophages. Structure-activity relationships demonstrated the importance of a radical methoxy at position R3', R4' and R5'. (2E)-3-(3,4,5-trimethoxy-phenyl)-1-(3,6,7-trimethyl-1,4-dioxy-quinoxalin-2-yl)-propenone was the most active. Cytotoxicity on macrophages revealed that this product was almost six times more active than toxic.

Los intentos de deslegitimación del derecho al aborto en Puerto Rico / Intents to delegitimatize the right to abortion in Puerto Rico

Analysis of the access to abortion in Puerto Rico is important because, together with Cuba, they are the only countries where abortion is legal in Latin America. This article analyzes the socio-political trends of the debate and discourses through which the discussion of the pro-option and antiabortion sectors have developed in the current situation of Puertorican law and their links with the arguments of those sectors in the United States. Even in this framework of legality, the right to abortion in Puerto Rico has been the object of a process of attacks by the antiabortion sectors that has limited its exercise, and it continues to be a taboo and polemical matter; maybe tolerated, but questioned and undermined as a right, and as a result, delegitimized. The Island situation makes it possible to consider that eradicating the legal prohibition of the practice is not a sufficient element for abortion to become a social need and a right of women in their own conscience, in public opinion and in state interventions.