Effect of mindfulness-based stress reduction on negative emotion and coping style of patients with newly diagnosed silicosis / 中国职业医学

OBJECTIVE: To investigate the effects of mindfulness-based stress reduction(MBSR) on anxiety, depression and coping style of patients with newly diagnosed silicosis. METHODS: A total of 156 cases of patients with newly diagnosed silicosis were randomly divided into the control group and the intervention group by convenient sampling method, with 78 cases in each group. Patients in the control group were given routine care only, patients in the intervention group received MBSR intervention for 8 weeks on the basis of routine care. The Self-Rating Anxiety Scale, Self-Rating Depression Scale and Medical Response Questionnaire investigated the scores of anxiety, depression and coping styles in the two groups before and after the intervention. RESULTS: Before intervention, there was no significant difference in the scores of anxiety, depression and each dimension of medical response such as facing, avoidance and resignation dimensions in the two groups(P>0.05). After intervention, the anxiety and depression scores of patients in the intervention group decreased [(54.9±3.8) vs(45.5±3.8) and(57.5±3.9) vs(48.7±3.3), respectively, P<0.01] compared with the control group. The facing dimension scores of medical response increased [(19.0±1.3) vs(21.8±1.2), P<0.01], and the scores of avoidance dimension and resignation dimension of medical response decreased [(13.0±2.9) vs(12.2±2.1) and(10.3±1.6) vs(8.0±1.5), respectively, P<0.05]. CONCLUSION: The MBSR training can improve the negative emotion such as anxiety and depression in patients with silicosis, and encourage them to cope with the disease in a positive way.

MSCT and MR three-dimensional turbo field echo sequences in diagnosis of children bilateral tracheal bronchi / 中国医学影像技术

Objective: To observe clinical value of MSCT and MR three-dimensional turbo field echo (3D-TFE) in diagnosis of children bilateral tracheal bronchi. Methods: Data of 14 cases of children bilateral tracheal bronchi examined with MSCT or MR were retrospectively reviewed. Minimum intensity projection was used to reconstruct the airway in 10 children who underwent MSCT scanning, while maximum intensity projection was used to appear the airway in 4 children underwent MR 3D-TFE. According to MSCT or MRI, bilateral tracheal bronchi were divided into standard type (bilateral tracheal bronchi originated from the upper part of tracheal eminence), critical type (bilateral tracheal bronchi originated from the beginning of tracheal eminence) or mixed type (bilateral tracheal bronchi originated from different locations). The characteristics and other heart anomalies of these children were recorded. Results: Bilateral tracheal bronchi were showed clearly on both MSCT and MR 3D-TFE images. Among 14 cases, 8 cases (8/14, 57.14%) were found with standard type bilateral tracheal bronchi, 5 cases (5/14, 35.71%) were found with borderline type, 1 case (1/14, 7.14%) was found with mixed type bilateral tracheal bronchi. All 14 children (14/14, 100%) were detected with asplenia syndrome. The most common cardiac malformations included common atrioventricular canal (12/14, 85.71%), pulmonary stenosis (11/14, 78.57%) and persistent left superior vena cava (11/14, 78.57%). Conclusion: MSCT and MR 3D-TFE sequences have good diagnostic value for assessing bilateral tracheal bronchi.

Effect of mindfulness-based stress reduction on surgical stress of bronchoalveolar lavage in patients with pneumoconiosis / 中国职业医学

OBJECTIVE: To evaluate the intervention effect of mindfulness-based stress reduction(MBSR) on surgical stress of bronchoalveolar lavage(BAL) in patients with pneumoconiosis. METHODS: A total of 102 patients with pneumoconiosis who undergoing selective BAL were randomly divided into control group and MBSR group with 51 cases in each group by a convenient sampling method. The patients in the control group received routine nursing, the MBSR group received 5 times of MBSR treatment. All patients were investigated using the Self-Rating Anxiety Scale(SAS), Self-Rating Depression Scale(SDS) and Chinese Version Perceived Stress Scale(CPSS) before the first BAL and after the last BAL. RESULTS: Before the first BAL, the scores of SAS, SDS and CPSS in these two groups were compared and showed no statistical significance(P>0.05). After the last BAL, the scores of SAS, SDS and CPSS were lower in the MBSR group than that of the control group and the same group before the first BAL(P<0.01).CONCLUSION: The MBSR could effectively reduce the pressure perception level of patients with pneumoconiosis who undergoing selective BAL, improve their anxiety and depression and promote the smooth implementation of BAL.

Relationship between placental thickness,MRI signs and postpartum hemorrhage in patients with placenta accreta / 实用放射学杂志

Objective To explore the relationship between placental thickness,MRI signs and postpartum hemorrhage in placenta accreta(PA)patients.Methods 28 PA patients with postpartum hemorrhage and 3 9 PA patients without postpartum hemorrhage were analyzed retrospectively.We compared the clinical features and MRI signs between the two groups,and analyzed the correlation between placental thickness and PA related postpartum hemorrhage.Results The mean placental thickness was significantly higher in the hemorrhage patients (62.04±13.826)mm than that in the patients without hemorrhage (39.72±11.362)mm.Among the clinical features, there were no correlations between age,previous intrauterine operation history,previous cesarean section history and occurrence of the PA related postpartum hemorrhage.The following MRI signs were related to the occurrence of the PA related postpartum hemorrhage,including placenta previa,local bulging of the uterine,heterogeneous signal intensity in the placenta,intraplacental hypointensity bands,intraplacental abnormal vascularity,scar covered by placenta,abnormal signal intensity around the cervix,thinning of myometrium.Conclusion Measurement of placental thickness by MRI combined with placenta previa,local bulging of the uterine,heterogeneous signal intensity in the placenta,intraplacental hypointensity bands,intraplacental abnormal vascularity,scar covered by placenta,heterogeneous signal intensity around the cervix, thinning of myometrium are valuable in predicting PA related postpartum hemorrhage.

The Incidence of Tinnitus Among Occupational Noise Exposure Workers / 听力学及言语疾病杂志

Objective To investigate the correlation between incidence rate of tinnitus and noise exposure time,age,hearing condition in noise exposure workers.Methods A total of 1 985 noise exposure workers (age between 20～60 years old;working length between 1 ～30 years) in a large dockyard were randomly selected as the subject of this study with 1 831 male workers and 154 female workers in average 36.3±8.25 years old.The average noise exposure time was 9.1±6.50 years and pure tone threshold of final candidates in sound-proofed environment was evaluated (at 0.25～8 kHz).The subjects were divided into four groups according to the subjective tinnitus level:mild tinnitus,moderate tinnitus,severe tinnitus and no tinnitus to analysis the correlation among incidence rate of tinnitus and noise exposure time,age,hearing condition,etc.Results Among all 1 985 subjects enrolled the occurrence rate of tinnitus was 20.55％ (408/1 985),with 367 acquired mild tinnitus(89.95％),39 acquired moderate tinnitus (9.56％) and 2 for severe tinnitus (0.49％).Mild tinnitus and moderate tinnitus showed a multi-step raising according to noise exposure time.Mild tinnitus increased continually with age while moderate tinnitus showed an accumulation in age group over 55 years old.Female was less likely to be annoyed by tinnitus than male.Conclusion Tinnitus can be early warning of auditory damage by noise exposure;older male group with longer noise exposure time is more vulnerable to tinnitus.Tinnitus acquired in noise environment is more likely to be mild.

Human umbilical cord mesenchymal stem cells co-culture ameliorates the innate immunity of podocytes induced by high glucose / 中华肾脏病杂志

Objective To explore the effects of human umbilical cord mesenchymal stem cells (HUC-MSCs) on the innate immunity of podocytes mediated by Toll-like receptor (TLR)signaling pathway under high glucose (HG) condition.Methods Podocytes were divided into four groups according to the treatment:normal glucose group (NG),mannitol control group (NG+MA),high glucose group (HG) and HUC-MSCs co-culture group (HG+MSC).After 72 hours treatment,the protein levels of interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),heat shock protein 70 (HSP70),high-mobility group box-1 (HMGB1)in culture medium were measured by ELISA.Real-time PCR was used to detect the mRNA expressions of TLR2 and TLR4.Western blotting was used to detect the protein expressions of TLR2,TLR4,myeloid differentiation factor 88 (MyD-88) and phospho-P65 (p-P65).Immunofluorescence staining was used to study the localization of p-P65 in podocytes.Results High glucose induced the inflammation of podocytes by activating the TLR signaling,which increased the secretion of IL-6,TNF-α,HSP70,HMGB1,the mRNA level of TLR2,TLR4 and the protein level of TLR2,TLR4,MyD-88 and p-P65 (all P ＜ 0.05).High glucose also activated NF-κB and induced its nuclear translocation.HUC-MSCs co-culture decreased the inflammation and restrained the TLR signaling.Conclusions HUC-MSCs co-culture decreases the inflammation and innate immunity of podocytes induced by HG.

Comparative study on image diagnosis and pathological results of non-epithelial ovarian tumors / 实用放射学杂志

Objective To improve the imaging diagnosis and differential diagnosis of non-epithelial ovarian tumor.Methods 34 patients with non-epithelial ovarian tumor confirmed by pathology were analyzed retrospectively.The image features of each patients were analyzed and compared with surgical pathology.Results The results exhibited 13 cases of teratoma,6 cases of ovarian granulosa cell tumor, 6 cases of ovarian fibroma, 5 cases of thecoma, 2 cases of dysgerminoma,and 2 cases of endodermal sinus tumor.All kinds of non-epithelial ovarian tumors had its imaging manifestations and clinical features.Conclusion Non-epithelial ovarian tumors have certain characteristic CT and MR performance,and combining the onset age,clinical symptoms and biochemical examination,can make the qualitative diagnosis.

Clinical significance of heart rate variability decrease in elderly patients with multiple organ disorders / 中国综合临床

Objective To explore the clinical significance of the heart rate viability decrease in the elderly patients with multiple organ disorders.Methods Two hundred and fifty-nine elderly patients with multiple organ disorders, with underlying diseases as coronary heart disease, hypertension, diabetes, cerebrovascular disease,chronic obstructive pulmonary disease,chronic bronchitis and malignant tumor were enrolled in this study,a retrospective analysis was made on the dynamic electrocardiogram data of the research objects.According to SDNN,123 cases were assigned into the normal HRV group(SDNN≥100ms); 50 cases were divided into the moderately decreased HRV group(50ms≤SDNN<100ms),and 36 cases were divided into the severely decreased HRV group(SDNN<50ms).The average heart rate within 24 hours,clinical diagnosis,and discharge record of the three groups were analyzed.Results As HRV decreased,SDNN decreased gradually (normal HRV group 116(104~131)ms,moderately decreased HRV group 85(67.5~91)ms,severely decreased HRV group 40(35~48)ms),the average heart rate within 24 hours gradually increased(normal HRV group 67(60~76)times/min,moderately decreased HRV group 78(66~84)times/min,severely decreased HRV group 91(80~112)times/min),the differences among the three groups were statistically different(P<0.05).The differences among the groups in the rates of coronary heart disease,hypertension, diabetes,cerebrovascular diseases,chronic bronchitis and chronic heart failure were not statistically significant(P>0.05).The rate of malignant tumor in severely decreased HRV group was 8.3%,significantly higher than that in normal HRV group(0),the difference was statistically significant(P<0.01).In severely decreased HRV group,the rates of chronic obstructive pulmonary disease(25%),chronic renal failure(30.56%),respiratory failure(25%),uremic cardiomyopathy(13.89%),hypoproteinaemia(41.67%)and anemia(41.67%)were significantly higher than those in normal HRV group(1.63%,0.9%,0.81%,0,6.5%,8.94%)and moderately decreased HRV group(7%,11%,2%,3%,11%,11%),the differences were statistically significant(P<0.05) .In moderately decreased HRV group,the rate of chronic renal failure(11%)was higher than that in normal HRV group(0.9%),the difference was statistically significant(P<0.05).Mortality in severely decreased HRV group(41.66%)was significantly higher than that in normal HRV group(2.44%)and moderately decreased HRV group(8%),the difference among the three groups was statistically significant(P<0.05).Conclusion For elderly patients with multiple organ disorders,along with severely decreased HRV,they face the risks of severe imbalances of automatic nervous system,fast heart rate,serious illness,poor nutrition,high mortality.

Effect of the Combination of Xiyanping and Cefazolin on the Function of Neutrophils in Mice / 生物医学工程学杂志

Xiyanping is used to treat infectious diseases with antibiotics in clinic. The aim of this study is to investigate the mechanism of Xiyanping through studying the effect of the combination of Xiyanping with Cefazolin on the chemotaxis and phagocytic function of peripheral blood neutrophils in mice. Ten healthy mice were in control group. Forty healthy mice in experimental group were infected with staphylococcus aureus, and were randomly divided further into four groups, i. e. model group, Xiyanping group, Cefazolin group and combination group (Xiyanping with Cefazolin). Mice in the control group and model group were given normal saline (NS) through abdomen while those in other groups were given Xiyanping, Cefazolin, and Xiyanping with Cefazolin, respectively. The chemotaxis of peripheral blood neutrophils was detected with the transwell method, and the phagocytic function of peripheral blood neutrophils was analyzed with flow cytometry (FCM). In the present study, there was no significance on the chemotactic index of peripheral blood neutrophils in all the groups (P > 0.05). The actual phagocytotic rate and index of peripheral blood neutrophils in the blank group, Xiyanping group, and the combination group were significantly higher than those of the model group and Cefazolin group (P < 0.05). However, those were not significant in the blank group, Xiyanping group, and the combination group (P > 0.05) or between the model group and Cefazolin group (P> 0.05). Our results suggested the combination of Xiyanping and Cefazolin could enhance the therapeutic effect by improving the phagocytic function of peripheral blood neutrophils.

Expressions and correlations of Survivin, Ki67 and p53 in laryngeal squmous cell carcinoma / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the expression of Survivin, p53 and Ki67 in laryngeal carcinoma and the relation with clinical data.@*METHOD@#Immunohistochemical staining (SP) was used to detect expression of Survivin, p53 and Ki67 of 64 cases with laryngeal carcinoma, 26 cases with precancerosis, 34 cases with vocal polyps.@*RESULT@#The positive expression rates of Survivin, p53 and Ki67 were 59.4%, 68.8%, 65.6% respectively in laryngeal carcinoma, which were significantly higher than those in precancerosis and vocal polyps (P 0.05). The expression of Survivin, Ki-67 and p53 was positively correlated (r = 0.607, 0.541, 0.648, P < 0.01) in laryngeal carcinoma.@*CONCLUSION@#Survivin, p53 and Ki-67 may play an important role in the carcinogenesis and progress of laryngeal carcinoma. They may play synergetic roles in the process of carcinogenesis of laryngeal carcinoma.

Effect and safety of titanium zirconium niobium tin alloy and nichrome for dental defects / 中国组织工程研究

BACKGROUND:Titanium zirconium niobium tin al oy (Ti-Zr-NB-Sn al oy) has good tissue structure, mechanical properties, corrosion resistance and biocompatibility, which is an ideal dental material. OBJECTIVE:To explore the efficacy and safety of Ti-Zr-NB-Sn al oy in dental restoration. METHODS:A retrospective analysis was performed on clinical data of 87 cases of dental defects, including 43 males and 44 females, aged 22-41 years. Of the 87 cases, 43 cases were repaired with Ti-Zr-NB-Sn al oy as observation group, and the other 44 cases were treated with nichrome as control group. After 36 months of fol ow-up, the therapeutic efficacy, dental restoration conditions, dental prosthesis conditions and patient satisfaction were observed and compared. RESULTS AND CONCLUSION:Al the 87 patients were fol owed up for 36 months. After the fol ow-up, the total effective rate and patient satisfaction were higher in the observation group than the control group (P<0.05). In the control group, there were four cases of swol en gums, four cases of bleeding gums, four cases of al ergies, three cases of gum gray line, and six cases of mucosal pain;in the observation group, there was only one case of swol en gums, and the dental restoration was better in the observation group than the control group (P<0.05). For the dental prosthesis, there were 10 cases of dental stent damage and 20 cases of dental stent loosening in the control group;and only one case of dental stent damage and one case of dental stent loosening in the observation, and the observation group was superior to the control group in the dental prosthesis (P<0.05). Experimental findings suggest that Ti-Zr-NB-Sn al oy for repair of dental defects has good biocompatibility and security.

Correlation of survivin, p53 and Ki-67 in laryngeal cancer Hep-2 cell proliferation and invasion

Objective:To investigate the mechanism of survivin, p53 and Ki-67 on Hep-2 human laryngeal cancer endothelial cell proliferation and invasion.Methods:Laryngeal squamous cell carcinoma and paracancerous normal tissues were collected, total RNA was extracted from tissues,survivin,p53and Ki-67gene mRNA expression levels in laryngeal cancer and the adjacent tissues were detected by Real-time PCR. Human laryngeal cancer Hep-2 epithelial cells were selected,survivin gene was overexpressed, and cell proliferation was detected by MTT.p53 andKi-67gene expression changes in overexpressedsurvivin gene were detected by Western blot. Changes in Hep-2 cell invasive ability were studied whensurvivin was overexpressed as detected by Transwell invasion assay.Results: In the adjacent tissues, survivin,p53andKi-67 gene relative expression levels were 1.72 ± 0.9, 13.7 ± 5.7 and 5.7 ± 1.3, respectively; while in cancer tissues, gene relative expression levels were 53.7 ± 8.3, 66.7 ± 5.2 and 61.0 ± 3.1, respectively, which was significantly increased. As detected by MTT, relative cell survival rate within 12 h ofsurvivinoverexpression were: load control group, (88.5±1.6)%; overexpressed group, (90.3±1.9)%. Transwell invasion assay results indicated that overexpressedsurvivincould significantly increase the relative survival rate of cells. Conclusions:Expressions ofp53,Ki67 and survivin are increased in cancer; and there is a positive correlation betweensurvivin, p53andKi67 expressions in laryngeal carcinoma.

Study of mechnism and effect of fentanyl on proliferation in gastric cancer cell SGC-7901 / 中国生化药物杂志

Objective To explore mechnism and effect of fentanyl on proliferation of gastric cancer SGC-7901 cell.Methods Gastric cancer SGC-7901 cell was cultured with fentanyl of 0 (negative control), 0.5, 5 and 50 nmol/L, MTT method was used to detect the effect of fentanyl on SGC-7901 viability.The effect of fentanyl on SGC-7901 cell cycle was measured by flow cytometry.The level of cell related protein,cell cycle protein cyclin D1, Bcl-2.Results Compared with control group, fentanyl (0.5, 5, 50 nmol/L) could inhibit SGC-7901 cell viability, and the inhibitory rate was highest at 48 h.0.5, 5, 50 nmol/L fentanyl made cell cycle arrested in G1 phase.Compared with control group, fentanyl can significantly inhibit cyclinD1 and Bcl-2 expression with drug concentration increasing(P<0.05).Conclusion These results suggeste fentanyl inhibit proliferation of gastric cancer SGC-7901 cell.

Clinical Observation of Acupoint Application plus Pricking Sifeng (EX-UE10) for Infantile Chronic Cough / 上海针灸杂志

Objective To observe the treatment difference of using acupiont application alone, pricking Sifeng (EX-UE10) alone, and combination of the two therapies in treating infantile chronic cough. Method Ninety patients were randomized into 3 groups (acupoint application group, pricking Sifeng group, and a combining group), 30 in each group. Same points were selected for the three groups:Feishu (BL13), Pishu (BL20), Shenshu (BL23), and Sifeng (EX-UE 10). By follow-up research of the symptom scale, the therapeutic efficacies were compared. Result The total effective rate was 83.3%in the acupoint application group, 80.0%in the pricking Sifeng (EX-UE 10) group, and 93.3%in the combining group;meanwhile, the symptom scores were significantly changed after intervention in all three groups (P＜0.05). Conclusion Separate use and combining use of acupoint application and pricking Sifeng (EX-UE 10) all can improve the condition of infantile chronic cough, while the combining use can produce a significantly higher therapeutic efficacy, thus it’s a safe, effective, and easy-to-operate external treatment in traditional Chinese medicine.

Effects of internal fixation with simvastatin coating on healing of rat osteoporotic fractures at late period / 中国组织工程研究

BACKGROUND:As a lipid-lowering drug, simvastatin has been proved to be effective in promoting bone formation. Previous studies have demonstrated that local y applied simvastation accelerated fracture healing at middle phase in osteoporotic rats, while no study focuses on the influence of local y applied simvastatin on fracture healing at late period in an osteoporotic rat. OBJECTIVE:To investigate the effect of simvastatin local y applied from a bioactive polymer coating of implants on osteoporotic fracture healing at late period. METHODS:Female Sprague-Dawley rats were divided into sham group, osteoporotic fracture group and simvastatin group. In the sham group, the abdominal cavity was exposed without ovariectomy. Six weeks later, femur fracture models were established in normal or osteotoporotic Sprague-Dawley rats, and intramedul ary stabilization was achieved with uncoated titanium Kirschner wires in normal rats (sham group),with polylactic acid coated titanium Kirschner wires (osteoporotic fracture group) and with simvastatin/polylactic acid coated titanium Kirschner wires (simvastatin group). Femurs were harvested after 12 weeks, bone mineral density was determined with dual X-ray absorptiometry, and then radiographic and histological analysis was performed for analysis of fracture healing. Immunohistochemical evaluation was employed for bone morphogenetic protein 2 expression. RESULTS AND CONCLUSION:The bone mineral densities of both the total fractured femur and fractured site 12 weeks after fracture in the osteoporotic fracture group and simvastatin group were markedly decreased compared to normal fractured rats. The bone mineral density of the fractured site was significantly higher in the simvastatin group than the osteoporotic fracture group. Radiographic results demonstrated completely finished cal us remodeling in the sham group;poor healing, pale cal us density and blurred fracture line were seen in the osteoporotic fracture group;disappearance of fracture line, bone defects fil ed with cal us, and deep periosteal reaction were found in the simvastatin group. X-ray scores in the sham and simvastatin groups were significantly higher than that in the osteoporotic group (P<0.05). Hematoxylin-eosin staining showed a delayed healing process in the osteoporotic group, and revealed a significantly processed cal us with regular-shaped newly formed bone trabeculae in the simvastatin group. Immunohistochemical evaluation showed no significant difference in the bone morphogenetic protein 2 expression between any two groups. These findings suggest an improved fracture healing under local application of simvastatin in osteoporotic rats.

Report of two cases of calcifying epithelioma in children / 临床耳鼻咽喉头颈外科杂志

The presenting symptom of calcifying epithelioma was a hard, slowly growing subcutaneous mass. The two cases in this paper were both girls. The five and eight year-old girls were occurred in anteri or inferior of ear lobe and in preauricular respectively. This tumor was composed of two cell types: the shadow cells and basophilic cells with small calcifying areas. The tumor was finally removed without replase in a year follow-up.

In vitro study for detecting the effects of Bazhen decoction on proliferation and activation of T lymphocytes / 生物医学工程学杂志

This study was designed to detect the effects of Bazhen decoction on the proliferation and activation of T lymphocytes. T lymphocytes were isolated. The effects of Bazhen decoction on the prolifertion and activation of T lymphocytes, and on the secretion of IFN-gamma IL-2 from T lymphocytes, were detected by MTT, Flow cytometry and ELISA. Results showed that proliferation of T lymphocytes was promoted significantly by different concentration of Bazhen decoction; and after different time, the relationships of "the longer the time, the higher the concentration, and the more enhanced the proliferation" came to be apparent. After 72h, T lymphocytes were activated with different concentration of Bazhen decoction, the rate of CD69+ T cells increased signficantly, the secretion of IFN-gamma and IL-2 increased signficicantly, and the effect exhibited a dose-dependent manner. The results of this epxeriment indicated that Bazhen decoction could promote the proliferation and activation of T lymphocytes.

Management of advanced head and neck cancer with intertissue injection of 32P radioisotope / 中国耳鼻咽喉头颈外科

OBJECTIVE To observe the effect of 32P intertissue injection on advanced head and neck cancer. METHODS Eight patients with advanced head and neck cancer were treated with 32P injection into the tumors according to the size of the cancer as determined by CT scan. RESULTS Local tumors were controlled evidently and the pain of the patients were alleviated. The survival periods of the 8 cases ranged from 3 to 18 months (average 14.2 months). CONCLUSION 32P intertissue injection offer an useful method for patients with advanced head and neck cancer .

Study of the Antagonist Effects of Sodium Salicylate on the Cisplatin Induced Hearing Impairment in Guinea Pigs / 听力学及言语疾病杂志

Objective To investigate the antagonist effects of sodium salicylate(NaSA) on the cisplatin(CDDP) induced hearing impairment in guinea pigs.Methods 60 guinea pigs were randomly divided into four groups: ①CDDP +NaSA(50 mg/kg) group,②CDDP +NaSA(100 mg/kg) group,③CDDP +NaSA(150 mg/kg) group and ④CDDP +NS(normal saline) control group.Auditory brainstem response(ABR) and distortion product otoacoustic emission(DPOAE) were used to evaluate their effects on hearing threshold and DPOAE amplitudes.Results The ABR responses of groupsⅠ,Ⅱ and Ⅲ were significantly lower than in the control group(P0.05).The ABR responses for group Ⅰ were significantly higher than group Ⅲ(P