The association of family history of herpes zoster and the risk of incident herpes zoster: the SHEZ Study

BACKGROUND@#We investigated whether family histories of herpes zoster (HZ) are associated with the risk of incident HZ in a Japanese population.@*METHODS@#A total of 12,522 Japanese residents aged ≥50 years in Shozu County participated in the baseline survey between December 2008 and November 2009 (the participation rate = 72.3%). They were interviewed at baseline by research physicians regarding the registrants' history of HZ. A self-administered questionnaire survey was conducted to evaluate the potential confounding factors. 10,530 participants without a history of HZ were followed up to ascertain the incidence of HZ during 3-years follow-up until the end of November 2012 with Japanese nationals. We estimated hazard ratios (HRs) of incident HZ according to first-degree family histories using the Cox proportional hazard regression after adjusting for age, sex, and other potential confounding factors.@*RESULTS@#Compared to no HZ history of each family member, a history of brother or sister was associated with a higher risk of incident HZ while histories of father and mother were not. The multivariable HR (95%CI) of incident HZ for a history of brother or sister was 1.67 (1.04-2.69). When comparing to no family histories of all first-degree relatives, the multivariable HRs (95%CIs) were 1.34 (0.77-2.34) for a history of brother or sister alone, but 4.81 (1.78-13.00) for a history of mother plus brother or sister. As for the number of family histories, the multivariable HRs (95%CIs) were 1.08 (0.76-1.54) for one relative (father, mother, or brother or sister) and 2.75 (1.13-6.70) for two or more relatives.@*CONCLUSION@#Family histories of mother plus brother or sister and two or more first-degree relatives were associated with a higher risk of incident HZ.

Professor Konosuke Fukai: a great scientist and excellent diplomat

Everyone who contacted Professor Konosuke Fukai, a scientist renowned as an innovator and virologist, was impressed by his unique character with humanitarian and unselfish attitude. He helped developing countries enormously to improve their public health by introducing the newest knowledge and techniques especially in vaccine production. He supported many young scientists throughout the world in their study of basic research resulting in improvement of research ability in their countries. Though it is almost 10 years since Professor Konosuke Fukai passed away in 1998 at the age of 78, we can easily remember him not because he was taller than the average Japanese but because of his distinguished achievements in fields ranging from basic research to public health. He was a pioneer in the field of virology in Japan that got going after the Second World War. In addition, impelled by his humanism, he applied his techniques and experiences to the promotion of medical research and public health in many developing countries. It is, therefore, not too much to say that he was not merely a great scientist but an excellent diplomat with scientific knowledge.