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Objective To understand the pathogen detection of hospitalized patients before antimicrobial therapy in a hospital through implementation of comprehensive intervention measures,and provide reference basis for the de-velopment of targeted measures.Methods Hospitalized patients who received therapeutic antimicrobial agents in this hospital were selected as the research subjects.Patients who were hospitalized from January to May 2022 were selected as the pre-intervention group,comprehensive intervention measures were taken from June to October 2022,and those who were hospitalized from November 2022 to March 2023 were selected as the post-intervention group.The pathogen detection rate before antimicrobial therapy,sterile specimen detection rate,antimicrobial use rate,de-tection rate of key multidrug-resistant organisms of patients before and after the intervention were analyzed.Results Compared to before intervention,the proportion of pathogen detection rate before antimicrobial therapy(62.09％vs 74.04％),detection rate of healthcare-associated infection diagnosis-related pathogens(62.82％vs 92.73％),and sterile specimen detection rate(35.17％vs 41.06％)of hospitalized patients after intervention all increased signifi-cantly,with statistically significant differences(all P＜0.05).After intervention,pathogen detection rate before the combination use of key antimicrobial agents was not statistically different from before intervention(93.33％vs 90.48％,P＞0.05),while antimicrobial use rate was lower than before intervention(39.93％vs 44.95％,P＜0.05).There was no statistically significant difference in the detection rate of key multidrug-resistant organisms be-fore and after intervention(all P＞0.05).Conclusion Adopting scientific and rational intervention measures can improve the pathogen detection rate,provide a reference basis for the rational use of antimicrobial agents.There was no significant improvement in the pathogen detection rate before the combination use of key antimicrobial agents and the detection rate of key multidrug-resistant organisms,indicating that relevant measures still need to be further optimized.
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AIM: To analyze the effect of conbercept combined with laser photocoagulation on patients with macular edema secondary to branch retinal vein occlusion.METHODS: According to the random number table method, 102 patients(102 eyes)with macular edema secondary to branch retinal vein occlusion who treated in our hospital from January 2019 to June 2021 were divided into observation group and control group. There were 51 patients(51 eyes)in each group. The control group was treated with laser photocoagulation and the observation group was treated with conbercept combined with laser photocoagulation. The macular foveal retinal thickness, best corrected visual acuity and incidence of complications were compared among the patients of two groups.RESULTS: After treatment at 3mo, the retinal thickness of macular fovea in the observation group was lower than that in the control group(P<0.05), the best corrected visual acuity in the observation group was higher than that in the control group(P<0.05). The incidence of complications was not different between the two groups(P>0.05).CONCLUSION:The effect of conbercept combined with laser photocoagulation for macular edema secondary to branch retinal vein occlusion is remarkable to reduce the retinal thickness of macular fovea and improve the vision of patients and the complications did not increase compared with retinal laser photocoagulation therapy alone, which were safe and effective.
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Objective@#To investigate the epidemiology of iron-deficiency anemia among children aged 0-6 years in plateau area,and to provide a basis for the formulation of prevention and treatment measures for anemia.@*Methods@#A total of 1 512 children aged 0-6 years were randomly selected from 4 counties in plateau area by stratified and cluster sampling. Blood hemoglobin level was tested. Child dietary behaviors were collected from their parents.@*Results@#There were significant differences in the prevalence of children with different age, family location, education level of main dependants, occupation of main dependants and per capita income of family(χ2=12.83,39.48,27.05,44.26,32.45, P<0.05).No significant difference for anemia prevalence in gender and nationality was found. The prevalence of anemia among children aged 0-6 years was 67.0%, and the prevalence was highest among children aged 1 years while decreased with age.Univariate analysis of variance showed that the prevalence anemia was 74.0% in rural children, which was significantly higher than children in urban area 58.6%(χ2=39.48,P<0.05). Low education and income level of caregiver, husbandry in the family, no exclusive breastfeeding under 6 months, and picky eaters positively associated with high prevalence of anemia. The prevalence rate of anemia in 0-6 months old infants fed with mixed feeding and artificial feeding (73.1%, 75.0%) was higher than that of breast feeding (48.9%) (χ2=6.78, P<0.05). Picky eating can lead to a high incidence of anemia in children.@*Conclusion@#Promoting healthy diets and correcting unhealthy dietary pattern through nutrition education to parents might be effective ways to lower the prevalence of anemia among children in plateau areas.