Development of Halo Nevus Around Nevus Spilus as a Central Nevus, and the Concurrent Vitiligo

Halo nevus is a benign melanocytic nevus that is surrounded by a hypopigmented zone. The most frequent association with halo nevus is vitiligo, and this also appears in nearby regions, as well as at other remote sites. Although the mechanism for developing the depigmentation around nevus spilus is uncertain an immunologic process may be responsible for the finding of inflammatory infiltrates of the upper dermis in the depigmented lesions. We report here on a 13-year-old boy who showed a depigmented zone around a nevus spilus on the right side of his neck with simultaneous vitiligo lesions on the face.

A Case of Congenital Melanocytic Nevi Following Blaschko's Lines / 대한피부과학회지

Nevus spilus, also known as speckled lentiginous nevus, is a relatively common cutaneous lesion that is characterized by multiple pigmented macules within a pigmented patch. It may be congenital or acquired, and it can show the histological features of congenital melanocytic nevus (CMN). The possible relationship between nevus spilus and CMN has been contentious. We report a case of a congenital nevus that followed the line of Blaschko and clinically manifested as nevus spilus, but showed the histological features of CMN.

Congenital Café-au-Lait Spot and Sequentially Occurred Nevus Spilus

No abstract available.

A Case of Nevus Spilus with Vitiligo / 대한피부과학회지

We report a 25-year-old woman who developed depigmentation within a congenital nevus spilus on the right hand at the age of 15 years. Other vitiligo-like lesions apart from the nevus spilus developed on the right third finger and both feet at the age of 19 and 22, respectively. Histopathologic studies of nevus spilus revealed increased basal pigmentation from brownish patch and junctional activity and dermal aggregation of nevus cells from pigmented papules. Depigmented macule developed within a nevus spilus and revealed absence of melanin pigmentation at the basal layer of the epidermis and perivascular inflammatory infiltrates in the upper dermis. The mechanism of the development of the depigmentation within a congenital nevus spilus is uncertain. But inflammatory infiltrates of upper dermis in depigmented lesion suggest that an immunologic process, similar to the development of halo nevus, may be responsible.