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1.
Biosci. j. (Online) ; 35(4): 1153-1160, july/aug. 2019. tab, ilus, graf
Artigo em Inglês | LILACS | ID: biblio-1048850

RESUMO

The effects of agricultural practices on greenhouse gases emissions (e.g. CO2) at the soil-atmosphere interface have been highlighted worldwide. The use of ground limestone has been considered as the main responsible for CO2 emission from soils. However, liming is need as conditioner of acidic soils and the CO2 emission can be compensated due to carbon sequestration by plants. This study simulated under laboratory conditions the effects of two common agricultural practices in Brazil (P-fertilization and liming) on soil CO2 emission. Columns made of PVC tubes containing 1 kg of a typical Dystrophic Red Latosol from Cerrado region were incubated with CaCO3 (simulating liming), CaSiO3 (simulating slag), and different doses of KH2PO4 (simulating P-fertilization). The soil columns were moistened to reach the field capacity (0.30 cm3cm-3) and, during 36 days, CO2 emissions at the soil surface were measured using a portable Licor LI-8100 analyzer coupled to a dynamic chamber. The results showed that CO2 emission was influenced by phosphate, carbonate, and silicate anions. When using CaSiO3, accumulated CO2 emission (36-day period) was 20% lower if compared to the use of CaCO3. The same amount of phosphate and liming (Ca-carbonate or Ca-silicate) added to the soil provided the same amount of CO2 emission. At the same P dose, as Si increased the CO2emission increased. The highest CO2 emission was observed when the soil was amended with the highest phosphate and silicate doses. Based on this experiment, we could oppose the claim that the use of limestone is a major villain for CO2 emission. Also, we have shown that other practices, such as fertilization using P + CaSiO3, contributed to a higher CO2 emission. Indeed, it is important to emphasize that the best practices of soil fertility management will undoubtedly contribute to the growth of crops and carbon sequestration.


Os efeitos das práticas agrícolas nas emissões de gases de efeito estufa (e.g., CO2) na interface solo-atmosfera têm sido destacados em todo o mundo. O uso de calcário tem sido considerado oprincipal responsável pela emissão de CO2 em solos. Entretanto, a calagem é necessária como condicionador de solos ácidos e a emissão de CO2 pode ser compensada devido ao sequestro de carbono pelas plantas. Este estudo simulou, em condições de laboratório, os efeitos de duas práticas agrícolas comuns no Brasil (adubação fosfatada e calagem) na emissão de CO2 do solo. Colunas de tubos de PVC, contendo 1 kg de amostra de um Latossolo Vermelho Distrófico típico da região de Cerrado, foram incubadas com CaCO3 (simulando calagem), CaSiO3 (simulando escória) e diferentes doses de KH2PO4 (simulando fertilização com P). As colunas de soloforam umedecidas para atingir a capacidade de campo (0,30 cm3 cm-3) e, durante 36 dias, as emissões de CO2na superfície do solo foram medidas usando um analisador portátil Licor LI-8100 acoplado a uma câmara dinâmica. Os resultados mostraram que a emissão de CO2 foi influenciada pelos ânions fosfato, carbonato esilicato. Ao usar CaSiO3, a emissão de CO2 acumulada (período de 36 dias) foi 20% menor se comparado ao uso de CaCO3. A mesma quantidade de fosfato e calcário (Ca-carbonato ou Ca-silicato) adicionado ao solo proporcionou a mesma quantidade de emissão de CO2. Na mesma dose de P, o Si aumentou a emissão de CO2. A maior emissão de CO2 foi observada quando o solo foi alterado com as maiores doses de fosfato e silicato. Com base neste experimento, nega-se que o uso de calcário em solos é um grande vilão para a emissão de CO2. Além disso, foi mostrado que outras práticas, como a fertilização usando P + CaSiO3, contribuíram para uma maior emissão de CO2. Assim, é importante enfatizar que práticas adequadas de manejo da fertilidade do solo, sem dúvida, contribuirão para o crescimento das culturas e o sequestro de carbono.


Assuntos
Acidez do Solo , Zonas Agrícolas , Gases de Efeito Estufa , Fosfatos , Carbonatos , Silicatos , Ânions
2.
J. appl. oral sci ; 26: e20170589, 2018. tab, graf
Artigo em Inglês | LILACS, BBO | ID: biblio-954496

RESUMO

Abstract High concentrations of hydrogen peroxide can cause adverse effects on composition and structure of teeth. However, the addition of calcium and fluoride in bleaching agents may reduce enamel demineralization. Objective: To evaluate chemical changes of sound and demineralized enamels submitted to high concentrations of hydrogen peroxide containing fluoride (F) or calcium (Ca). Material and Methods: Enamel blocks of bovine incisors with standard dimensions were obtained and half of them were submitted to pH-cycling to promote initial enamel caries lesions. Sound and demineralized enamel samples were divided into (n=10): (C) Control (no whitening treatment); (HP) 35% hydrogen peroxide; and two experimental groups: (HPF) 35% HP+0.2% F and (HPC) 35% HP+0.2% Ca. Experimental groups were submitted to two in-office bleaching sessions and agents were applied 3 times for 15 min to each session. The control group was kept in remineralizing solution at 37°C during the bleaching treatment. The surface mineral content of sound and demineralized enamels was determined through Fourier Transform Raman spectroscopy (FT-Raman), Energy dispersive Micro X-ray fluorescence spectroscopy (μ-EDXRF); and the subsurface, through cross-sectional microhardness (CSMH). In addition, polarized light microscopy (PLM) images of enamel subsurface were observed. Results: According to three-way (FT-Raman and μ-EDXRF analyses) or two-way analysis of variance (ANOVA) (CSMH) and Tukey test (α=5%), the calcium or fluoride added to high-concentrated bleaching agents increased phosphate and carbonate concentrations on sound and demineralized enamels (p<0.05). However, HPC and HPF were unable to completely reverse the subsurface mineral loss promoted by bleaching on sound and demineralized enamels. The calcium/ phosphate (Ca/P) ratio of sound enamel decreased after HP treatment (p<0.001). Conclusion: Even though experimental bleaching agents with Ca or F reduced mineral loss for both sound and demineralized enamel surfaces, these agents were unable to reverse the enamel subsurface demineralization.


Assuntos
Animais , Bovinos , Cálcio/química , Desmineralização do Dente/induzido quimicamente , Esmalte Dentário/efeitos dos fármacos , Clareadores Dentários/química , Fluoretos/química , Peróxido de Hidrogênio/química , Fosfatos/química , Valores de Referência , Espectrometria por Raios X , Análise Espectral Raman , Propriedades de Superfície/efeitos dos fármacos , Fatores de Tempo , Clareamento Dental/efeitos adversos , Clareamento Dental/métodos , Teste de Materiais , Carbonatos/química , Reprodutibilidade dos Testes , Esmalte Dentário/química , Clareadores Dentários/efeitos adversos , Testes de Dureza , Microscopia de Polarização
3.
J. appl. oral sci ; 26: e20170084, 2018. graf
Artigo em Inglês | LILACS, BBO | ID: biblio-893718

RESUMO

ABSTRACT Objective: This study aimed to evaluate bone repair in rat dental sockets after implanting nanostructured carbonated hydroxyapatite/sodium alginate (CHA) and nanostructured carbonated hydroxyapatite/sodium alginate containing 5% strontium microspheres (SrCHA) as bone substitute materials. Methods: Twenty male Wistar rats were randomly divided into two experimental groups: CHA and SrCHA (n=5/period/group). After one and 6 weeks of extraction of the right maxillary central incisor and biomaterial implantation, 5 μm bone blocks were obtained for histomorphometric evaluation. The parameters evaluated were remaining biomaterial, loose connective tissue and newly formed bone in a standard area. Statistical analysis was performed by Mann-Withney and and Wilcoxon tests at 95% level of significance. Results: The histomorphometric results showed that the microspheres showed similar fragmentation and bio-absorbation (p>0.05). We observed the formation of new bones in both groups during the same experimental periods; however, the new bone formation differed significantly between the weeks 1 and 6 (p=0.0039) in both groups. Conclusion: The CHA and SrCHA biomaterials were biocompatible, osteoconductive and bioabsorbable, indicating their great potential for clinical use as bone substitutes.


Assuntos
Animais , Masculino , Estrôncio/farmacologia , Regeneração Óssea/efeitos dos fármacos , Carbonatos/farmacologia , Durapatita/farmacologia , Substitutos Ósseos/farmacologia , Alvéolo Dental/efeitos dos fármacos , Nanoestruturas/uso terapêutico , Alginatos/farmacologia , Osteogênese/efeitos dos fármacos , Osteogênese/fisiologia , Estrôncio/química , Fatores de Tempo , Regeneração Óssea/fisiologia , Carbonatos/química , Distribuição Aleatória , Reprodutibilidade dos Testes , Transplante Ósseo/métodos , Resultado do Tratamento , Ratos Wistar , Espectroscopia de Infravermelho com Transformada de Fourier , Durapatita/química , Substitutos Ósseos/química , Alvéolo Dental/fisiologia , Ácido Glucurônico/farmacologia , Ácido Glucurônico/química , Nanoestruturas/química , Alginatos/química , Ácidos Hexurônicos/farmacologia , Ácidos Hexurônicos/química
4.
Artigo em Chinês | WPRIM | ID: wpr-319616

RESUMO

The aim of this paper is to apply near infrared spectroscopy techniques to construct a rapid identification method for 8 kinds of mineral Chinese Medicines containing carbonates. The qualitative model using clustering analysis method in OPUS software can identify accurately 8 kinds of carbonate-containing mineral Chinese medicines. The near-infrared quantitative model was established by using partial least squares method (PLS) for 7 mineral Chinese Medicines in which main component is calcium carbonate. Compared with the results by EDTA titration, the established quantitative analysis model for calcium carbonate content showed a good prediction result that when the content is between 47.61% -99.17%, the average relative deviation of the prediction result is 0.24% and the average recovery rate was 100.3%. The results also showed that the model using near infrared spectroscopy can get not only a rapid identification of the 8 mineral Chinese medicines containing carbonates, but also an accurate and reliabe content determination of calcium carbonate for the 7 mineral Chinese medicines which contain the component.


Assuntos
Carbonatos , Medicina Tradicional Chinesa , Minerais , Química , Software , Espectrofotometria Infravermelho , Métodos , Fatores de Tempo
5.
Artigo em Inglês | WPRIM | ID: wpr-152654

RESUMO

BACKGROUND AND PURPOSE: Sleep-disordered breathing (SDB) is suggested to be strongly associated with ischemic strokes. Risk factors, stroke subtypes, stroke lesion distribution, and the outcome of SDB in stroke patients remain unclear in Korea. METHODS: We prospectively studied 293 patients (159 men, 134 women; age 68.4+/-10.5) with acute ischemic stroke. Cardiovascular risk factors, stroke severity, sleep-related stroke onset, distribution of stroke lesions, and 3-month score on the modified Rankin Scale (mRS) were assessed. Stroke severity was assessed by the US National Institutes of Health Stroke Scale (NIHSS) and the mRS. The apnea-hypopnea index (AHI) was determined 6.3+/-2.2 days after stroke onset with the Apnea Link portable sleep apnea monitoring device. RESULTS: The prevalence of SDB (defined as an AHI of > or =10) was 63.1% (111 men, 74 women). Those in the SDB group were older, had higher NIHSS and mRS scores, greater bulbar weakness, and a higher incidence of sleep-associated stroke onset. Among risk-factor profiles, alcohol consumption and atrial fibrillation were significantly related to SDB. The stroke outcome was worse in patients with SDB than in those without SDB. The lesion location and specific stroke syndrome were not correlated with SDB. CONCLUSIONS: SDB is very common in acute cerebral infarction. Different risk-factor profiles and sleep-related stroke onsets suggest SDB as a cause of ischemic stroke. The higher NIHSS score and greater bulbar involvement in the SDB group seem to show the influence of ischemic stroke on the increased SDB prevalence.


Assuntos
Humanos , Masculino , Consumo de Bebidas Alcoólicas , Hidróxido de Alumínio , Apneia , Fibrilação Atrial , Carbonatos , Infarto Cerebral , Incidência , Prevalência , Estudos Prospectivos , Fatores de Risco , Síndromes da Apneia do Sono , Acidente Vascular Cerebral
6.
Artigo em Inglês | WPRIM | ID: wpr-143750

RESUMO

Gastritis is an inflammatory condition of the gastric mucosa induced by Helicobacter pylori infection, autoimmunity and chemical agents. Although Sydney system was devised for semiquantitative methods of gastritis, most physicians and pathologists consider it to be too complex and bothersome to use for routine diagnosis. Moreover, Sydney system does not reflect the overall gastritis condition and it cannot directly predict increased gastric cancer risk. To overcome these limitations, a new gastritis staging method, called Operative Link for Gastritis Assessment (OLGA) system was designed by the international group of gastroenterologists and pathologists. This system may achieve simplification of reports for the gastritis condition and it can aid in predicting gastric cancer risk and planning patient surveillance. Herein, we reviewed the routine evaluation methods, clinical implication and advantage/limitations of the OLGA system.


Assuntos
Humanos , Hidróxido de Alumínio , Atrofia , Autoimunidade , Carbonatos , Mucosa Gástrica , Gastrite , Helicobacter pylori , Metaplasia , Neoplasias Gástricas
7.
Artigo em Inglês | WPRIM | ID: wpr-143759

RESUMO

Gastritis is an inflammatory condition of the gastric mucosa induced by Helicobacter pylori infection, autoimmunity and chemical agents. Although Sydney system was devised for semiquantitative methods of gastritis, most physicians and pathologists consider it to be too complex and bothersome to use for routine diagnosis. Moreover, Sydney system does not reflect the overall gastritis condition and it cannot directly predict increased gastric cancer risk. To overcome these limitations, a new gastritis staging method, called Operative Link for Gastritis Assessment (OLGA) system was designed by the international group of gastroenterologists and pathologists. This system may achieve simplification of reports for the gastritis condition and it can aid in predicting gastric cancer risk and planning patient surveillance. Herein, we reviewed the routine evaluation methods, clinical implication and advantage/limitations of the OLGA system.


Assuntos
Humanos , Hidróxido de Alumínio , Atrofia , Autoimunidade , Carbonatos , Mucosa Gástrica , Gastrite , Helicobacter pylori , Metaplasia , Neoplasias Gástricas
8.
Journal of Stroke ; : 153-163, 2013.
Artigo em Inglês | WPRIM | ID: wpr-206667

RESUMO

Cerebral microbleeds (CMBs) are tiny, round dark-signal lesions that are most often detected on gradient-echo MR images. CMBs consist of extravasations of blood components through fragile microvascular walls characterized by lipohyalinosis and surrounding macrophages. The prevalence of CMBs in elderly subjects with no history of cerebrovascular disease is around 5%, but is much higher in patients with ischemic or hemorrhagic stroke. Development of CMBs is closely related to various vascular risk factors; in particular, lobar CMBs are thought to be associated with cerebral amyloid angiopathy. The presence of CMBs has been hypothesized to reflect cerebral-hemorrhage-prone status in patients with hypertension or amyloid microangiopathy. Stroke survivors with CMBs have been consistently found to have an elevated risk of subsequent hemorrhagic stroke or an antithrombotic-related hemorrhagic complication, although studies have failed to establish a link between CMBs and hemorrhagic transformation after thrombolytic treatment. A large prospective study is required to clarify the clinical significance of CMBs and their utility in a decision-making index.


Assuntos
Idoso , Humanos , Hidróxido de Alumínio , Amiloide , Carbonatos , Angiopatia Amiloide Cerebral , Hemorragia Cerebral , Hipertensão , Macrófagos , Prevalência , Acidente Vascular Cerebral , Sobreviventes
9.
Artigo em Inglês | WPRIM | ID: wpr-217167

RESUMO

OBJECTIVES: The aim of this study was to investigate the relationship between the apical foramen morphology and the length of merged canal at the apex in type II root canal system. MATERIALS AND METHODS: This study included intact extracted maxillary and mandibular human premolars (n = 20) with fully formed roots without any visible signs of external resorption. The root segments were obtained by removing the crown 1 mm beneath the cementum-enamel junction (CEJ) using a rotary diamond disk. The distance between the file tip and merged point of joining two canals was defined as Lj. The roots were carefully sectioned at 1 mm from the apex by a slow-speed water-cooled diamond saw. All cross sections were examined under the microscope at x50 magnification and photographed to estimate the shape of the apical foramen. The longest and the shortest diameter of apical foramen was measured using ImageJ program (1.44p, National Institutes of Health). Correlation coefficient was calculated to identify the link between Lj and the apical foramen shape by Pearson's correlation. RESULTS: The average value of Lj was 3.74 mm. The average of proportion (P), estimated by dividing the longest diameter into the shortest diameter of the apical foramen, was 3.64. This study showed a significant negative correlation between P and Lj (p < 0.05). CONCLUSIONS: As Lj gets longer, the apical foramen becomes more ovally shaped. Likewise, as it gets shorter, the apical foramen becomes more flat shaped.


Assuntos
Humanos , Academias e Institutos , Hidróxido de Alumínio , Dente Pré-Molar , Carbonatos , Coroas , Cavidade Pulpar , Diamante , Ápice Dentário
10.
Artigo em Inglês | WPRIM | ID: wpr-35736

RESUMO

Obesity is a state of chronic low-grade systemic inflammation. This chronic inflammation is deeply involved in insulin resistance, which is the underlying condition of type 2 diabetes and metabolic syndrome. A significant advance in our understanding of obesity-associated inflammation and insulin resistance has been recognition of the critical role of adipose tissue macrophages (ATMs). Chemokines are small proteins that direct the trafficking of immune cells to sites of inflammation. In addition, chemokines activate the production and secretion of inflammatory cytokines through specific G protein-coupled receptors. ATM accumulation through C-C motif chemokine receptor 2 and its ligand monocyte chemoattractant protein-1 is considered pivotal in the development of insulin resistance. However, chemokine systems appear to exhibit a high degree of functional redundancy. Currently, more than 50 chemokines and 18 chemokine receptors exhibiting various physiological and pathological properties have been discovered. Therefore, additional, unidentified chemokine/chemokine receptor pathways that may play significant roles in ATM recruitment and insulin sensitivity remain to be fully identified. This review focuses on some of the latest findings on chemokine systems linking obesity to inflammation and subsequent development of insulin resistance.


Assuntos
Adipocinas , Tecido Adiposo , Hidróxido de Alumínio , Carbonatos , Quimiocina CCL2 , Quimiocinas , Citocinas , Diabetes Mellitus Tipo 2 , Inflamação , Insulina , Resistência à Insulina , Macrófagos , Obesidade , Proteínas , Receptores de Quimiocinas
11.
Artigo em Inglês | WPRIM | ID: wpr-48520

RESUMO

Statistics is the science of data. As the foundation of scientific knowledge, data refers to evidentiary facts from the nature of reality by human action, observation, or experiment. Clinicians should be aware of the conditions of good data to support the validity of clinical modalities in reading scientific articles, one of the resources to revise or update their clinical knowledge and skills. The cause-effect link between clinical modality and outcome is ascertained as pattern statistic. The uniformity of nature guarantees the recurrence of data as the basic scientific evidence. Variation statistics are examined for patterns of recurrence. This provides information on the probability of recurrence of the cause-effect phenomenon. Multiple causal factors of natural phenomenon need a counterproof of absence in terms of the control group. A pattern of relation between a causal factor and an effect becomes recognizable, and thus, should be estimated as relation statistic. The type and meaning of each relation statistic should be well-understood. A study regarding a sample from the population of wide variations require clinicians to be aware of error statistics due to random chance. Incomplete human sense, coarse measurement instrument, and preconceived idea as a hypothesis that tends to bias the research, which gives rise to the necessity of keen critical independent mind with regard to the reported data.


Assuntos
Humanos , Hidróxido de Alumínio , Viés , Carbonatos , Recidiva
12.
Artigo em Inglês | WPRIM | ID: wpr-85965

RESUMO

BACKGROUND: Hemodynamic optimization improves postoperative outcomes in high-risk surgery patients. The monitoring of cardiac output (CO) and dynamic parameters of fluid responsiveness can guide hemodynamic optimization. We conducted a survey to assess the current hemodynamic monitoring and management practices of Korean anesthesiologists during high-risk surgery. METHODS: E-mails containing a link to our survey, which consisted of 33 questions relating to hemodynamic monitoring during high-risk surgery, were sent to 3,943 members of the Korean Society of Anesthesiologists (KSA). The survey web page was open from December 30, 2011 to March 31, 2012. RESULTS: A total of 139 anesthesiologists responded during the survey period. Invasive arterial pressure (97.2%) and central venous pressure (93.4%) were routinely monitored. CO was monitored in 58.5% of patients; stroke volume variations were monitored in 50.9% of patients. However, CO was consistently optimized by < 20% of anesthesiologists. An arterial pressure waveform-derived CO monitor was the most frequently used device to monitor CO (79.0%). Blood pressure, urine output, central venous pressure, and clinical experience were considered to be the best indicators of volume expansion than CO or dynamic parameters of fluid responsiveness. CONCLUSIONS: The survey revealed that KSA members frequently monitor CO and dynamic parameters of fluid responsiveness during high-risk surgery. However, static indices were used more often to judge volume expansion. The current study reveals that CO is not frequently optimized despite the relatively high incidence of CO monitoring during high-risk surgery in Korea.


Assuntos
Humanos , Hidróxido de Alumínio , Pressão Arterial , Pressão Sanguínea , Carbonatos , Débito Cardíaco , Pressão Venosa Central , Correio Eletrônico , Hemodinâmica , Incidência , Coreia (Geográfico) , Compostos Organotiofosforados , Volume Sistólico , Resultado do Tratamento
13.
Artigo em Inglês | WPRIM | ID: wpr-97222

RESUMO

OBJECTIVES: Obstructive sleep apnea syndrome (OSAS) is associated with repeated hypoxia and re-oxygenation. This characteristic of OSAS may cause oxidative stress and DNA damage. However, the link of OSAS with oxidative stress and DNA damage is still controversial. In the current study, we investigated whether OSAS causes DNA damage using alkaline single-cell gel electrophoresis (comet assay) and measuring oxidative stress by monitoring serum malondialdehyde (MDA) levels. METHODS: From March 2009 to August 2010, 51 patients who underwent polysomnography (PSG) during the night were enrolled in this study. We obtained serum from the patients at 6 AM. DNA damage and oxidative stress were evaluated using a comet assay and measuring serum MDA, respectively. We divided the patients into two groups according to the existence of comets appearing in the comet assay. Group 1 included 44 patients with negative assay results and group 2 consisted of seven patients with positive comet assay findings. We compared the age, gender proportion, PSG data (respiratory disturbance index [RDI], lowest O2 saturation level, and arousal index [AI]), time of disease onset, smoking habits, and serum MDA levels between the two groups. RESULTS: The average age and gender proportion of the two groups were not statistically different (P>0.05). The average of RDI for group 1 was 30.4+/-18.4 and 8.0+/-7.7 (P0.05). No relationship between positive comet assay results and OSAS severity was identified. CONCLUSION: Results of the current study showed that OSAS was not associated with DNA damage as measured by comet assays or oxidative stress according to serum MDA levels.


Assuntos
Humanos , Hidróxido de Alumínio , Hipóxia , Nível de Alerta , Carbonatos , Ensaio Cometa , DNA , Dano ao DNA , Malondialdeído , Estresse Oxidativo , Polissonografia , Apneia Obstrutiva do Sono , Fumaça , Fumar
14.
Korean Journal of Medicine ; : 774-780, 2013.
Artigo em Coreano | WPRIM | ID: wpr-168932

RESUMO

Helicobacter pylori (H. pylori) infection is known to be negatively associated with allergic diseases including asthma in epidemiologic studies, mainly from the western countries. Bronchial asthma and allergic diseases are initiated by T-cells producing T-helper type 2 (Th2) cytokines (e.g. interleukin-4 (IL-4) and IL-5), which is inhibited by Th1 responses. H. pylori infection appears to inhibit Th2 responses, as well as to drive Th1 inflammation, and recent studies using experimental models of allergic airway disease elucidated a direct link between H. pylori infection and suppression of allergic airway disease through the induction of regulatory T cells. H. pylori has been implicated as a factor in idiopathic urticaria. Its eradication, however, has been shown conflicting results only. Therefore, routine H. pylori eradication for patients with chronic urticaria is not recommended. In Korea, prevalence of H. pylori infection shows a decreasing trend, and studies on association of H. pylori infection with asthma is warranting in the population.


Assuntos
Humanos , Hidróxido de Alumínio , Asma , Carbonatos , Citocinas , Helicobacter , Helicobacter pylori , Hipersensibilidade , Inflamação , Interleucina-4 , Coreia (Geográfico) , Modelos Teóricos , Prevalência , Linfócitos T , Linfócitos T Reguladores , Urticária
15.
Korean Journal of Medicine ; : 769-773, 2013.
Artigo em Coreano | WPRIM | ID: wpr-168933

RESUMO

Helicobacter pylori has been considered as the possible etiology in many extragastric disease. Hematologic diseases such as immune thrombocytopenic purpura (ITP) and iron-deficiency anemia have been proposed to associate with H. pylori infection, although the hypothesis of an etiological role has not yet been fully investigated. Systematic reviews and meta-analysis have shown a significant increase of platelet counts in ITP patients in whom eradiation was successful compared with untreated, failed eradication or H. pylori-negative patients. H. pylori infection has emerged as a one of causes of refractory iron-deficiency anemia which is unresponsiveness to oral iron therapy. A link between H. pylori infection and iron- deficiency anemia was shown in recent meta-analyses and H. pylori eradication increased hemoglobin levels in these patients. The effect of H. pylori on iron stores may be greatest in those with marginal dietary iron intake or other stressors of iron stores. The guideline of Korean College of Helicobacter and Upper Gastrointestinal Research (2009) and other guidelines of western and Japan recommend that H. pylori should be sought and eradicated in the patients with ITP and unexplained iron-deficiency anemia.


Assuntos
Humanos , Hidróxido de Alumínio , Anemia , Anemia Ferropriva , Carbonatos , Helicobacter , Helicobacter pylori , Doenças Hematológicas , Hemoglobinas , Ferro , Ferro da Dieta , Japão , Contagem de Plaquetas , Púrpura Trombocitopênica Idiopática
16.
Artigo em Inglês | WPRIM | ID: wpr-176442

RESUMO

Liver damage induced by ovarian stimulation has been demonstrated in some cases reported in the literature. However, there has never been a fruitful debate on this topic. The present manuscript tried to fill this gap. We reported a case of a 35-year-old nulliparous woman admitted to our obstetric emergency room for severe pre-eclampsia. She had been subjected to four cycles of controlled ovarian stimulation for intrauterine insemination. At 32 weeks of gestation, she developed severe pre-eclampsia, which led to HELLP syndrome complicated by fatal liver failure. The etiological link between ovarian stimulation and HELLP syndrome is intriguing. Further investigations are needed to understand whether repeated ovarian stimulation may represent a risk factor in pre-eclamptic patients.


Assuntos
Feminino , Humanos , Gravidez , Hidróxido de Alumínio , Carbonatos , Emergências , Frutas , Síndrome HELLP , Inseminação , Fígado , Falência Hepática , Síndrome de Hiperestimulação Ovariana , Indução da Ovulação , Pré-Eclâmpsia , Fatores de Risco
17.
Artigo em Inglês | IMSEAR | ID: sea-140202

RESUMO

Pulp calcifications are a frequent finding on bitewing and periapical radiographs in older age-groups but their occurrence in the entire dentition in young subjects is unusual. We report such an unusual occurrence of generalized pulp calcification in a 13-year-old Indian female. Radiographic examination of the dentition revealed pulp calcifications in all permanent teeth, located mostly in the pulp chamber but with some in the root canals. The patient's dental, medical, and family history was noncontributory. Biochemical analysis of the removed pulp calcification from one of the teeth during endodontic treatment showed large amounts of calcium, phosphorus, and carbonate. However, metabolic evaluation of patient through liver and kidney function tests and other blood investigations did not reveal any metabolic disorder. The patient was also evaluated for any systemic, syndromic, or genetic involvement but this was also noncontributory. Therefore, we propose that this unusual case of generalized pulp calcification is of idiopathic origin. In this work, histopathological and biochemical evaluations of the pulp calcification was done to try and understand the initiation and progress of calcifications in pulpal tissue.


Assuntos
Adolescente , Cálcio/análise , Carbonatos/análise , Polpa Dentária/química , Polpa Dentária/patologia , Calcificações da Polpa Dentária/metabolismo , Calcificações da Polpa Dentária/patologia , Cavidade Pulpar/química , Cavidade Pulpar/patologia , Eritrócitos/patologia , Feminino , Humanos , Magnésio/análise , Mesoderma/patologia , Fósforo/análise , Radiografia Interproximal , Sódio/análise , Dente não Vital/metabolismo , Dente não Vital/patologia
18.
Artigo em Inglês | WPRIM | ID: wpr-14881

RESUMO

BACKGROUND: Although it is rare for the fracture itself to become a life threatening injury in patients suffering from rib fracture, the lives of these patients are occasionally threatened by other associated injuries. Especially, early discovery of patients with rib fracture and intra-abdominal organ injury is extremely important to the prognosis. This study analyzed the link between rib fracture and intra-abdominal injury to achieve improved treatment. MATERIALS AND METHODS: Among trauma patients that had visited the hospital emergency room from January 2007 to December 2009, a retrospective study was conducted on 453 patients suffering from rib fracture due to blunt trauma. Rib fracture was classified according to location (left, right, and bilateral), and according to level (upper rib fracture [1-2nd rib], middle rib fracture [3-8th rib], and lower rib fracture [9-12th rib]). The researched data was statistically compared and analyzed to investigate the correlation between the location, level, and number of rib fracture and intra-abdominal organ injury. RESULTS: Motor vehicle injury was found to be the most common mechanism of injury with 208 cases (46%). Associated injuries accompanied with rib fracture were generated in 276 cases (61%). Intra-abdominal organ injury was discovered in 97 cases (21%). Liver injury was the most common intra-abdominal injury associated with rib fracture with 39 cases (40%), followed by spleen injury, with 23 cases (23%). Intra-abdominal injury according to level of rib fracture was presented as upper rib fracture in 11 cases (11%), middle rib fracture in 31 cases (32%), and lower rib fracture in 55 cases (57%), thus verifying that intra-abdominal injuries were commonly accompanied in lower rib fractures (p=0.03). In particular, significant increase of intra-abdominal injury was presented in fractures below the 8th rib (p=0.03). The number of intra-abdominal injuries requiring emergency operations was significantly higher in patients with more than 6 rib fractures (p=0.04). CONCLUSION: Intra-abdominal organ injury is more common in patients with lower rib fracture, especially fractures below the 8th rib. Intra-abdominal organ injuries generated in multiple rib fracture patients with more than 6 fractures significantly higher severity. These cases must be thoroughly inspected and carefully observed as there is possibility of emergency operation.


Assuntos
Humanos , Abdome , Hidróxido de Alumínio , Carbonatos , Emergências , Fígado , Veículos Automotores , Prognóstico , Estudos Retrospectivos , Fraturas das Costelas , Costelas , Baço , Estresse Psicológico
19.
Gut and Liver ; : 280-283, 2012.
Artigo em Inglês | WPRIM | ID: wpr-19375

RESUMO

Hyperplastic polyposis syndrome (HPS) is a rare condition characterized by the presence of numerous hyperplastic polyps (HPs) in the colon and rectum. Patients with HPS have an increased risk of colorectal cancer. This link is associated with gene mutations, especially B type Raf kinase (BRAF). However, a case of HPS associated with gene mutations has seldom been reported in Korea. Here, we describe a case of HPS in which a BRAF mutation was present in a 34-year-old woman. She had more than 110 HPs in the stomach and colorectum, which we removed. All of the polyps were diagnosed histologically as HPs, and no adenomatous or malignant changes were noted. We performed a BRAF and K-ras mutation analysis as well as a microsatellite analysis on the resected colon polyps. BRAF mutations were found in the resected colon polyps, but there was no evidence of K-RAS mutation or microsatellite instability.


Assuntos
Adulto , Feminino , Humanos , Hidróxido de Alumínio , Carbonatos , Colo , Neoplasias Colorretais , Coreia (Geográfico) , Instabilidade de Microssatélites , Repetições de Microssatélites , Fosfotransferases , Pólipos , Reto , Estômago
20.
Artigo em Coreano | WPRIM | ID: wpr-146671

RESUMO

BACKGROUND: Increasing evidence suggests that the entry of proinflammatory factors into the brain induces the activation of microglia, astrocytes, and oligodendrocytes and then produces the more proinflammatory cytokines and reactive oxygen species that can ultimately lead to neuronal death. This has clinical implications and provides a link between periperal inflammation and neuroinflammation. Peroxisome proliferator-activated receptors (PPARs), a member of the nuclear hormone receptor superfamily, has been implicated in the regulation of immunity and inflammation in rodents and humans. The objective of this study was to investigate whether the increased expression of PPAR with fenofibrate treatment was altered in the immune system of mice brain tissue after Lipopolysaccharide (LPS) was injected intraperitoneally. METHODS: PPARs expression was investigated in the brain tissues of BalB/c mice (n=6) under four situationssterile saline injection (control), LPS injection to generate periperal inflammation, LPS injection (5 mg/kg) with pretreated fenofibrate, and fenofibrate injection (100 mg/kg). RESULTS: Fenofibrate has protective effects against the increase of LPS-induced proinflammatory cytokines including interleukin (IL)-1beta, IL-6, and tumer necrosis factor-alpha in serum and brain tissue, measured using the enzyme linked immunosorbent assay, reverse transcriptase-polymerase chain reaction, and Western blot analysis. Also fenofibrate pretreatment markedly suppressed the reduction of PPARs mRNA and protein level by LPS injection. Moreover, the increased activation of PPARs abrogated the reduction of ABCD3, ACOX1, and catalase expression leading to an increase in the antioxidative capacity in brain tissue blocking the production of lipid peroxidation after LPS administration. CONCLUSION: The antiinflammatory and antioxidative properties of fenofibrate may be useful in ameliorating the progression of neuronal diseases.


Assuntos
Animais , Humanos , Camundongos , Hidróxido de Alumínio , Astrócitos , Western Blotting , Encéfalo , Carbonatos , Catalase , Citocinas , Ensaio de Imunoadsorção Enzimática , Fenofibrato , Sistema Imunitário , Inflamação , Interleucina-6 , Interleucinas , Peroxidação de Lipídeos , Microglia , Necrose , Neurônios , Oligodendroglia , Receptores Ativados por Proliferador de Peroxissomo , Espécies Reativas de Oxigênio , RNA Mensageiro , Roedores
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