Swimming training potentiates the recovery of femoral neck strength in young diabetic rats under insulin therapy

OBJECTIVE: To test whether swimming training benefits femoral neck strength in young diabetic rats under insulin therapy. METHODS: A total of 60 male Wistar rats (age: 40 days) were divided equally into the following six groups: control sedentary, control exercise, diabetic sedentary, diabetic exercise, diabetic sedentary plus insulin and diabetic exercise plus insulin. Diabetes was induced with a unique intraperitoneal injection (60 mg/kg body weight) of streptozotocin. Seven days after the injection and after 12 hours of fasting, the animals with blood glucose levels ≥300 mg/dL were considered diabetic. Seven days after the induction of diabetes, the animals in the exercise groups were subjected to progressive swimming training (final week: 90 min/day; 5 days/week; 5% load) for eight weeks. The animals in the insulin groups received a daily dose of insulin (2-4 U/day) for the same period. RESULTS: Severe streptozotocin-induced diabetes reduced the structural properties of the femoral neck (trabecular bone volume, trabecular thickness and collagen fiber content). The femoral neck mechanical properties (maximum load and tenacity) were also impaired in the diabetic rats. Insulin therapy partially reversed the damage induced by diabetes on the structural properties of the bone and mitigated the reductions in the mechanical properties of the bone. The combination of therapies further increased the femoral neck trabecular bone volume (∼30%), trabecular thickness (∼24%), collagen type I (∼19%) and type III (∼13%) fiber contents, maximum load (∼25%) and tenacity (∼14%). CONCLUSIONS: Eight weeks of swimming training potentiates the recovery of femoral neck strength in young rats with severe streptozotocin-induced diabetes under insulin therapy.

Factors that influence in the turnout in ballet dancers with knee pain / Factores que influyen en el turnout em bailarinas com dolor em lãs rodillas / Fatores que influenciam no turnout em bailarinas clássicas com dor nos joelhos

The turnout, primary gesture in classical ballet, refers the 180º of the feet. The lateral rotation provides the greatest amount of degrees necessary to perform the position perfectly. If performed improperly, it can generate problems, specialy in the knees, causing pain. The aim of this study was to evaluate the factors that influence the implementation of turnout in adolescents ballet dancers with knee pain and to compare them to the dancers without pain. Twenty three (23) ballet dancers with knee pain and 26 ballet dancers without pain were evaluated for range of motion of external rotation of the hip, muscle strength, femoral neck anteversion and static and dynamic turnout. The angles were measured with a manual goniometer, and the strength of the abductor muscle groups, external rotators and hip extensors with isometric dynamometer. The analysis was performed using ANOVA and Mann-Whitney. Range of motion of external rotation of the hip, femoral neck anteversion and muscle strength were similar between groups. The dynamic turnout was lower in ballet dancers with knee pain (p=0.02) and ballerinas with angular deficits above 10% over the static group had lower turnout under the bilateral extensor muscle group (p=0.04 and 0.03, right left) and right abductor (p=0.03). Although anatomical factors can influence the lateral rotation of the turnout, the angle decreased dynamic turnout was related to the group of dancers with pain. This suggests that training based on proximal awareness of movement can prevent and minimize burdens on the knees of classical dancers teens.

El turnout, principal gesto del ballet clásico, se refiere a la posición de 180º entre los pies. La rotación lateral de la cadera proporciona una mayor cantidad de grados necesarios para realizar la posición perfectamente. Si se realiza de forma inadecuada, puede generar compensaciones, preferentemente en las rodillas, generando dolor. El objetivo de este estudio fue evaluar los factores que influyen en la ejecución del turnout en bailarinas clásicas adolescentes con dolor en las rodillas y comparar las bailarinas y sin dolor. Se evaluaron a 23 bailarinas con dolor y 26 bailarinas sin dolor en cuanto al rango de movimiento de rotación lateral de la cadera, la fuerza muscular, a la anteversión del cuello femoral y al turnout estático y dinámico. Los ángulos fueron medidos con un goniómetro manual, y la fuerza de los grupos musculares abductores, rotadores externos y extensores de la cadera con dinamómetro isométrico. El análisis se realizó por medio del ANOVA y Mann-Whitney. El rango de movimiento, la anteversión del cuello femoral y la fuerza del músculo fueron similares entre los grupos. El turnout dinámico fue menor en el grupo de bailarinas con dolor (p=0,02), y las bailarinas con déficits angulares superiores a 10% en relación al turnout estático presentaron menor fuerza del grupo muscular de los extensores bilaterales (p=0,04 y 0,03, derecha e izquierda) y abiductores derecho (p=0,03). Aunque los factores anatómicos pueden influir en la rotación lateral del turnout, la disminución del ángulo del turnout dinámico se relacionó con el grupo de bailarinas con dolor. Tal hecho sugiere que el entrenamiento basado en la conciencia proximal del movimiento puede prevenir y minimizar las sobrecargas en las rodillas de bailarinas clásicas adolescentes.

O turnout, gesto principal do balé clássico, refere-se à posição de 180º entre os pés. A rotação lateral do quadril fornece a maior quantidade de graus necessários para realizar a posição com perfeição. Se executada de forma inadequada, pode gerar compensações, preferencialmente nos joelhos, ocasionando dor. O objetivo deste estudo foi avaliar fatores que influenciam na execução do turnout em bailarinas clássicas adolescentes com dor nos joelhos e comparar a bailarinas sem dor. Foram avaliadas 23 bailarinas com dor e 26 bailarinas sem dor quanto à amplitude de movimento de rotação lateral do quadril, força muscular, à anteversão do colo femoral e ao turnout estático e dinâmico. Os ângulos foram mensurados com goniômetro manual, e a força dos grupos musculares abdutores, rotadores laterais e extensores do quadril com dinamômetro isométrico. A análise foi feita por meio do ANOVA e Mann-Whitney. A amplitude de movimento, a anteversão do colo femoral e a força muscular foram semelhantes entre os grupos. O turnout dinâmico foi menor no grupo de bailarinas com dor (p=0,02), e bailarinas com déficits angulares acima 10% em relação ao turnout estático apresentaram menor força do grupo muscular dos extensores bilateral (p=0,04 e 0,03, direita e esquerda) e abdutores direito (p=0,03). Embora fatores anatômicos possam influenciar na rotação lateral do turnout, a diminuição angular do turnout dinâmico esteve mais relacionada ao grupo de bailarinas com dor. Tal fato sugere que o treinamento baseado na conscientização proximal do movimento pode prevenir e minimizar as sobrecargas nos joelhos de bailarinas clássicas adolescentes.

Changes in Bone Mineral Density of Both Proximal Femurs after Total Knee Arthroplasty

BACKGROUND: This study investigated the effects of total knee arthroplasty (TKA) on bone mineral density (BMD) of the proximal femur in patients who underwent the procedure. METHODS: Forty-eight patients scheduled to undergo unilateral TKA because of primary knee osteoarthritis were included in this study, which was conducted at a medical center between October 2006 and October 2009. In these 48 patients, 96 hips were evaluated. Measurement of BMD was performed preoperatively and one month, three months, six months, and one year after unilateral TKA. Repeated measured analysis of variance and paired t-tests for comparison of two repeated samples were used to compare differences between time points (preoperation, one, three, six, and 12 months) and between the operative and nonoperative sides. RESULTS: Preoperatively, BMD of the femoral neck, trochanter, and total hip on the operative side were lower than on the nonoperative side; however, there was no statistical difference. BMD of both femoral neck areas was significantly lower than preoperative BMD at one month and three months after TKA. BMD of both trochanter areas was significantly lower than preoperative BMD at one month and three months after TKA. BMD of both total hips was significantly lower than preoperative BMD at three months after TKA. However, no statistical differences of changes in BMD were observed between the operative and nonoperative sides at each measurement time. CONCLUSIONS: According to our results, TKA was found to affect both proximal femurs during the acute period. However, TKA did not affect a change in BMD of the proximal femur during one year postoperative.

Relationship between Bone Mineral Density and Moderate to Severe Chronic Kidney Disease among General Population in Korea

Recent studies in Western countries have reported a significant association between glomerular filtration rate (GFR) and bone mineral density (BMD) in the absence of dialysis among the general population. However, there have been few studies regarding renal function and BMD among Korean or Asian subjects with moderate to severe (stage 3 or 4) chronic kidney disease (MS-CKD). The aim of the present study was to investigate the association between MS-CKD and BMD in the general Korean population. BMD, serum creatinine and other measures were obtained from 3,190 subjects (1,428 males and 1,762 females; the fourth Korean National Health and Nutrition Examination Survey). GFR was estimated using the Cockcroft-Gault formula, with adjustment for body surface area. After adjustment for all variables, multiple regression analysis showed that BMD in the femur neck, total femur and lumbar spine were positively associated with eGFR in both males and females. Additional analysis showed that MS-CKD was also significantly associated with osteoporosis in both males and females (odds ratio [OR] 2.20, 95% confidence interval [CI] 1.15-4.20 in males; and OR 1.96, 95% CI 1.33-2.88 in females). Individuals with MS-CKD may be at higher risk of osteoporosis even among Asians.

Low Handgrip Strength is Associated with Low Bone Mineral Density and Fragility Fractures in Postmenopausal Healthy Korean Women

Osteoporosis is a widely recognized health problem in postmenopausal women. Osteoporotic fractures reduce independency, limit daily living activities, and increase the mortality rate. Epidemiological studies have demonstrated that low handgrip strength is a risk factor for functional limitations and disabilities, and all-cause mortality. We investigated the relationship between handgrip strength and bone mineral density (BMD) of the spine, femur neck, and total hip, as well the relationship between handgrip strength and previous fragility fractures in 337 healthy postmenopausal Korean women (mean age of 59.5 +/- 6.8 yr) who were free of diseases or medications affecting bone metabolism. Age and handgrip strength were associated with BMD of the spine, femur neck, and total hip in multiple regression models. Low handgrip strength (odds ratio [OR], 0.925; range, 0.877 to 0.975; P = 0.004) and low femur neck BMD (OR, 0.019; range, 0.001 to 0.354; P = 0.008) were independent predictors of previous fragility fractures in a multiple regression model. Our results demonstrate that low handgrip strength is associated with low BMD of the spine, femur neck, and total hip, and with increased risk of previous fragility fractures.

Influence of obesity on bone density in postmenopausal women

OBJECTIVE: To evaluate the influence of obesity, age, and years since menopause on bone density. METHODS: A retrospective analysis of bone mineral density (BMD) obtained from 588 women, 41 to 60 years, previously menopaused (1-10 years before). RESULTS: Positive influence of obesity was confirmed by the significant differences in BMD at lumbar spine, femoral neck (FN), and trochanter (TR) between the groups (p < 0.01). Age and years since menopause (YSM) were negatively correlated with BMD at all sites (p = 0.000). Comparing patients within 1 to < 6 YSM versus 6 to 10 YSM, BMD was higher in the former at LS and FN (p < 0.005), despite the higher BMI in the older group (p = 0.01). Obese patients had a lower prevalence of osteoporosis at LS and FN (p = 0.009). Regression analysis identified BMI as the strongest determinant of FN and TR BMD, while YSM was the strongest determinant of LS BMD. CONCLUSION: The protective effect of obesity is overtaken by age and estradiol deficiency. We recommend that even obese postmenopausal women should be screened for osteoporosis.

OBJETIVO: Avaliar a influência de obesidade, idade e anos de menopausa sobre a densidade óssea. MÉTODOS: Análise retrospectiva da densidade mineral óssea (DMO) obtida em 588 mulheres de 41 a 60 anos, já menopausadas (1-10 anos antes). RESULTADOS: A influência positiva da obesidade foi confirmada através de diferenças significativas da DMO entre os grupos na coluna lombar (CL), colo de fêmur (CF) e trocânter (TR) (p < 0,01). Idade e anos desde a menopausa (ADM) foram correlacionados negativamente com DMO em todos os sítios (p = 0,000). Comparando-se pacientes entre 1 e < 6 ADM vs 6 e 10 AMD, a DMO foi maior no primeiro grupo na CL e CF (p < 0,005), apesar de maior DMO no grupo de mais idade (p = 0,01). Pacientes obesas tiveram uma prevalência mais baixa de osteoporose na CL e CF (p = 0,009). Análise de regressão identificou o IMC como o determinante mais forte da DMO de CF e trocânter, enquanto a ADM foi o determinante mais forte da DMO na CL. CONCLUSÃO: O efeito protetor da obesidade é sobrepujado pela deficiência de estradiol. Recomendamos que mesmo mulheres obesas na pós-menopausa devam ser examinadas para osteoporose.

Singh index screening for femoral neck osteoporosis.

The present study included 130 elderly women living in Khon Kaen, Thailand, and all but one underwent both DEXA-BMD and AP radiographs of the left hip joint. The mean (SD) of age, weight, height and BMI of the 129 participants was 72.5 (5.3) years, 49.8 (10.3) kg, 1.49 (0.06) m, and 22.21 (4.13) kg/m2, respectively. The authors found both poor sensitivity and a positive predictive value for a Singh grade of < or = 4 or < or = 3 (viz. 58 and 29 or 19 and 43 percent, respectively). The ROC curve showed the poor diagnostic value of the Singh index since the area under the curve was approximately 40% the Singh index is therefore a poor screening tool for femoral neck osteoporosis.

Evaluación del compromiso óseo en alcohólicos intermitentes y continuos, sin daño hepático evidente / Assessment of bone compromised in intermitent and continuing alcoholics without hepatic damage

The effect of chronic alcoholism on bone mass and density has been a subject of considerable controversy. The goal of the present study was to evaluate bone mineral content and density in 2 groups of alcoholic men without evidence of liver damage and determine if the modality of alcohol consumption could cause an alcohol-mediated bone loss. We studied 70 alcoholic non cirrhotic men divided into intermittent (n=38) and continuos (n=32) drinkers. They were compared to 109 normal men. Dual photon densitometry technique using a Gd 153 source was utilized and bone mineral density (BMD) of lumbar spine, femoral neck, Ward's triangle, trochanter, total body bone density (TBBD) and mineral (TBBM) were measured. Hematologic, serum and urinary tests of mineral metabolism were also carried out. No significant differences were found in lumbar spine BMD between normals and alcoholics regardless of the type of alcohol consumption and duration of alcoholism. In the femoral neck, a significant decrease in BMD was found in alcoholics when plotted as regression curves (r=25;p=0,02). In this site duration of alcoholism was significantly correlated to decreased BMD in the total group of alcoholics (r=0,27;p=0,02) and also in the continuous drinker group (r=0,40;p=0,02) when considered duration of alcohol abuse. Total bone mineral was significantly lower in alcoholics (p<0.001) and the subgroups compared to normals and correlated with duration of alcohol abuse (p=0,01). Chemical values revealed normal calcium, phosphorus, alkaline phosphatases, PTH and Ca/Cr concentration. Only serum magnesium was found disminished in 16,6 percent of studied subjects. We conclude that pure alcoholism may affect femoral neck density and total body mineral content, being proportional to the duration of alcohol abuse. Spine density appears unaffected. The type of alcoholic abuse was less important than its duration to cause bone mass abnormalities

El cuello del fémur en la tercera edad: estudio multicéntrico de la densidad mineral / The femoral neck in the third age: multicentric study

Durante un período de 6 meses en tres centros de investigación (León, Puebla y Querétaro), se estudiaron 374 casos que fueron enviados por primera vez para su examen, siendo requisito una edad mínima de 60 años. Todos los casos correspondieron al sexo femenino; la edad promedio fue de 69.25 años ñ 6.54, con límites entre 60 a 91 años. El 56 por ciento abarcó la década de 60 a 69 (208 casos), el 37 por ciento de los 70 a los 79 años (138 casos) y el 7 por ciento (28 casos) de los 80 años en adelante. En los tres centros de diagnostico se determinó la densidad mineral ósea en el cuello del fémur y se aplicaron los criterios de Johnston para interpretar los resultados. Estos revelaron un 65 por ciento de pacientes osteoporóticos, 24 por ciento de osteopénicos y sólo 17 por ciento de casos normales. De acuerdo con estos hallazgos, la osteoporosis parece ser muy frecuente en la etapa geriátrica, por lo que la cuantificación de la densidad mineral ósea en la actualidad es el mejor recurso para tomar decisiones clínicas y detectar casos con alto riesgo de fracturas de la cadera

Papel da anteversäo de colo femoral na deformidade em rotaçäo medial do quadril na paralisia cerebral / The role of anteversion of the femoral neck in medical rotation deformity of the hip in cerebral palsy

Estudou-se o papel da anteversäo do colo femoral na deformidade em rotaçäo medial do quadril na paralisia cerebral. Pesquisou-se, em 40 pacientes (80 quadris) do tipo espástico, possível correlaçäo dos ângulos de declinaçäo, bem como a do ângulo de declinaçäo com a deformidade de rotaçäo medial do quadril. Um método é apresentado pelo autor, o qual permite a comparaçäo das gravidades das alteraçöes angulares do colo femoral nas diversas idades. O autor conclui que, nesses pacientes, a anteversäo, aumentada do colo femoral pode estar, embora näo obrigatoriamente, associada `a deformidade em rotaçäo medial do quadril e, quando presente, pode vir a agravá-la; e que entre a anteversäo aumentada do colo femoral e a rotaçäo medial do quadril, nessa enfermedade, näo há relaçäo de causa e efeito, nem há correlaçäo quanto `as suas gravidades