Manejo de tejidos blandos en trauma de miembros inferiores: a propósito de un caso / Soft tissue management in lower limb trauma: about a case

Los miembros inferiores están sujetos frecuentemente a traumas que ocasionan daño de estructuras vitales y que pueden dejar secuelas funcionales y estéticas en las personas. Las lesiones de tejidos blandos son las que asientan en la piel, tejido celular subcutáneo, aponeurosis, músculos, vasos y nervios. Del manejo oportuno y adecuado de las lesiones que se presenten posteriores a un trauma de tejidos blandos dependerá el resultado, el tiempo de recuperación, costos de hospitalización y sobre todo la preservación de las funciones de locomoción y sostén del miembro afectado

The lower limbs are frequently exposed to traumas that cause vital structures damage and can leave functional and aesthetic sequelae in patients. Soft tissue lesions are those that affect the skin, subcutaneous cellular tissue, fascia, muscles, vessels, and nerves. The result, recovery time, hospitalization costs and, above all, the preservation of the locomotion and support functions of the affected limb will depend on the timely and adequate management of injuries that occur after a soft tissue trauma.

Resposta dos parâmentros do andar após intervenção com dicas auditivas rítmicas em idosos com doença de Parkinson / Response of gait parameters after intervention with rhythmic auditory cues in older people with parkinson's disease

Introdução: os comprometimentos do andar em idosos com doença de Parkinson (DP) estão associados à elevada ocorrência de quedas e à redução dos níveis de independência. O objetivo do estudo foi comparar a resposta dos parâmetros do andar em idosos com doença de Parkinson (DP), durante, imediatamente após e até uma hora após o término de uma sessão de treinamento do andar com e sem dicas auditivas rítmicas, utilizando três ritmos diferentes para o grupo dica (10% abaixo da cadência preferida, cadência preferida e 10% acima) e um ritmo diferente para o grupo controle (velocidade usual de cada participante). Métodos: vinte e nove idosos foram aleatoriamente distribuídos em dois grupos: "controle" e "dica". As sessões de intervenção tiveram 30 minutos de duração e a diferença entre os grupos foi a utilização de dicas auditivas rítmicas oferecidas por um metrônomo no grupo dica. O andar foi avaliado antes, durante e até uma hora após a sessão de intervenção. Resultados: os grupos apresentaram desempenhos similares ao longo das avaliações, com aumento do comprimento do passo e redução da variabilidade da duração do passo. Conclusão: a sessão de intervenção com dicas auditivas rítmicas apresentou efeitos similares aos da sessão de treino sem dica para o andar de idosos com DP.(AU)

Introduction: Gait impairments in older people with Parkinson's disease (PD) are associated with a high occurrence of falls and reduced levels of patients' independence. The objective of the study was to compare the response of gait parameters in older people with Parkinson's disease (PD), during, immediately after, and up to 1h after the end of a single locomotion training session with and without rhythmic auditory cues, using 3 different rhythms for the tip group (10% below the preferred cadence, preferred cadence and 10% above) and 1 different rhythm for the control group (usual speed of each participant). Materials and method: 29 older people were randomly assigned to two groups: Control and "Cue". The intervention sessions lasted 30 minutes and the difference between the groups was the use of rhythmic auditory cues offered by a metro-nome in the Cue group. Gait was assessed before, during, and up to 1 hour after the intervention session. Results: The groups showed similar performances throughout the assessments, with increased step length and reduced step time variability in response to the intervention (compared to the baseline assessment). Conclusion: The intervention session with rhythmic auditory cues had similar effects on gait as the session without cues in older people with PD.(AU)

Flexibility and achilles tendon: a brief review / Flexibilidade e tendão de aquiles: uma breve revisão

Performing flexibility training in an exercise program is important to improve range of motion (ROM). Tendons have a profound impact on the general function of the musculoskeletal system, influence the limitation of ROM, and its structure and mechanical properties can benefit from stretching protocols. The systematic use of lower limbs in locomotion caused the Achilles tendon to become the largest and strongest tendon in the human body. Therefore, understanding the best prescription and frequency of flexibility exercise leads to changes in tendon properties is essential for an appropriate and effective exercise routine. Thus, the aim of this review was to organize and discuss publications about the implications of triceps surae stretching in ROM, as well as its influence on tendon properties. Acute studies show that continuous stretching times between five and 10 minutes cause decreased tendon stiffness, which is not seen in fractionated stretching times less than five minutes. Chronic studies, in turn, also don't present significant results in stiffness with fractionated times and studies with continuous times were not found. Thus, it is not possible to know if a continuous stretching time (longer than one minute) or a total time longer than five minutes but fractionated, can influence the tendon stiffness. (AU)

A realização de treino de flexibilidade como rotina em um programa de exercícios é importante para melhorar amplitude de movimento (ADM). Os tendões têm um impacto profundo na função geral do sistema musculoesquelético, influenciam na limitação da ADM, e sua estrutura e propriedades mecânicas podem se beneficiar de protocolos de alongamento. O uso sistemático dos membros inferiores na locomoção fez com que o tendão de Aquiles se tornasse o maior e mais forte tendão do corpo humano. Portanto, entender qual a melhor prescrição e frequência de exercício de flexibilidade para que ocasione alterações nas propriedades tendíneas é essencial para uma rotina de exercícios adequada e eficaz. Sendo assim, o objetivo dessa revisão de literatura foi organizar e discutir publicações sobre as implicações do alongamento do tríceps sural na ADM, bem como sua influência nas propriedades tendíneas. Estudos agudos mostram que tempos contínuos entre cinco e 10 minutos de alongamento estático causam diminuição da rigidez tendínea, o que não é visto em tempos intervalados inferiores a cinco minutos. Os estudos crônicos, por sua vez, também não apresentam resultados significativos na rigidez com protocolos de alongamento intervalados e estudos com protocolos contínuos não foram encontrados. Dessa forma, não é possível saber se um tempo contínuo de alongamento (superior a um minuto) ou um tempo superior a cinco minutos, intervalado, podem influenciar na rigidez tendínea. (AU)

Avaliação motora de crianças através do TGMD-3 / Motor assessment of children through TGMD-3

O presente trabalho trata-se de um estudo realizado com 17 crianças com faixa etária entre 4 e 5 anos, todas matriculadas no Centro de Educação Infantil ­ campus da Universidade Estadual de Londrina (CEI-UEL), tendo como objetivo avaliar o desempenho motor dessas crianças através do TGMD-3, antes e após uma intervenção motora, realizada no CEI-UEL. A intervenção foi composta de 29 sessões de 60 minutos em que eram trabalhadas diferentes habilidades motoras, após a qual foi aplicado novamente o TGMD-3 para avaliar se a intervenção havia influenciado positivamente o desempenho das crianças da amostra. Nossos resultados mostraram que para a variável somatória das habilidades de locomoção e habilidades com bola foi apresentado um aumento na comparação do pré-teste para o pós-teste, porém somente nas habilidades de locomoção foi encontrada significância na melhora. Quanto ao percentil, nas habilidades com bola foi encontrado um desempenho inferior no pós-teste, mas sem que houvesse diferença significativa entre os resultados; já para as habilidades de locomoção foi encontrada uma melhora no pós-teste do percentil, mas sem diferença significativa em comparação ao pré-teste. Com relação ao escore não foi encontrada diferença significativa para as habilidades, porém nas habilidades de locomoção houve desempenho superior no pós-teste e nas habilidades com bola houve desempenho inferior. Como conclusão, podemos inferir que a intervenção motora foi positiva para a melhora do desempenho das crianças, mas não para todas as variáveis analisadas, demonstrando que a intervenção motora pode ser uma ferramenta benéfica para o desempenho motor de crianças.

The present work is a study carried out with 17 children aged between 4 and 5 years old, all enrolled at the Child Education Center - campus of Universidade Estadual de Londrina (CEI-UEL), with objective of evaluating children motor performance through the TGMD-3, before and after a motor intervention, performed at CEI-UEL. The intervention consisted of 29 60-minute sessions with different motor skills, and after the 29 sessions, TGMD-3 was applied again to assess whether the intervention had positively influenced the performance of the children in the sample. Our results showed that for the sum of the walking and ball skills showed an increase in the comparison of the pre-test to the post-test, but only in the walking skills the difference was significant. As for the percentile, in the skills with the ball a lower performance was found in the post-test, but without any significant difference between the results; for the locomotion skills, an improvement was found in the post-test according to the percentile, not showing a significant difference compared to pretest. Regarding the score, no significant difference was found for the skills, but in the locomotion skills there was a superior performance in the post-test and in the skills with ball there was a lower performance. As a conclusion, we can deduce that motor intervention was positive for improving children motor performance, but not for all variables, showing that the motor intervention could be a beneficial tool to children motor performance.

Neural mechanism for modulation of auditory response of the striatum by locomotion / 南方医科大学学报

OBJECTIVE@#To explore whether the characteristic responses to sound stimulations of the auditory neurons in the striatum is regulated in different behavioral states.@*METHODS@#The auditory neurons in the striatum of awake C57BL/6J mice were selected for this study. We recorded the auditory response of the striatum to noises over a long period of time by building a synchronous in vivo electrophysiological and locomotion recording system and using glass microelectrode attachment recording. By analyzing the running speed of the mice, the behavioral states of the mice were divided into the quiet state and the active state, and the spontaneous activity and evoked responses of the auditory neurons in the striatum were analyzed in these two states.@*RESULTS@#Compared with those recorded in the quiet state, the spontaneous activity of the auditory neurons in the striatum of the mice increased significantly (37.06±12.02 vs 18.51±10.91, P < 0.001) while the auditory response of the neurons decreased significantly (noise intensity=60 dB, 3.45±2.99 vs 3.04±2.76, P < 0.001) in the active state.@*CONCLUSION@#Locomotion has a significant inhibitory effect on the auditory response of the striatum, which may importantly contribute to the decline of sound information recognition ability in the active state.

Changes in sensitivity of bilateral medial vestibular nuclear neurons responding to input stimuli during vestibular compensation and the underlying ionic mechanism / 生理学报

Vestibular compensation is an important model for developing the prevention and intervention strategies of vestibular disorders, and investigating the plasticity of the adult central nervous system induced by peripheral injury. Medial vestibular nucleus (MVN) in brainstem is critical center for vestibular compensation. Its neuronal excitability and sensitivity have been implicated in normal function of vestibular system. Previous studies mainly focused on the changes in neuronal excitability of the MVN in lesional side of the rat model of vestibular compensation following the unilateral labyrinthectomy (UL). However, the plasticity of sensitivity of bilateral MVN neurons dynamically responding to input stimuli is still largely unknown. In the present study, by using qPCR, whole-cell patch clamp recording in acute brain slices and behavioral techniques, we observed that 6 h after UL, rats showed a significant deficit in spontaneous locomotion, and a decrease in excitability of type B neurons in the ipsilesional rather than contralesional MVN. By contrast, type B neurons in the contralesional rather than ipsilesional MVN exhibited an increase in response sensitivity to the ramp and step input current stimuli. One week after UL, both the neuronal excitability of the ipsilesional MVN and the neuronal sensitivity of the contralesional MVN recovered to the baseline, accompanied by a compensation of spontaneous locomotion. In addition, the data showed that the small conductance Ca2+-activated K+ (SK) channel involved in the regulation of type B MVN neuronal sensitivity, showed a selective decrease in expression in the contralesional MVN 6 h after UL, and returned to normal level 1 week later. Pharmacological blockage of SK channel in contralateral MVN to inhibit the UL-induced functional plasticity of SK channel significantly delayed the compensation of vestibular motor dysfunction. These results suggest that the changes in plasticity of the ipsilesional MVN neuronal excitability, together with changes in the contralesional MVN neuronal sensitivity, may both contribute to the development of vestibular symptoms as well as vestibular compensation, and SK channel may be an essential ionic mechanism responsible for the dynamic changes of MVN neuronal sensitivity during vestibular compensation.

Relações pessoa-cidade: mobilidade urbana e qualidade de vida em Porto Alegre (RS) / Person-city relationships: urban mobility and quality of life in Porto Alegre (RS) / Relaciones persona-ciudad: movilidad urbana y calidad de vida en Porto Alegre (RS)

A estrutura e o planejamento dos espaços urbanos influenciam a relação pessoa-cidade, na qual a mobilidade urbana representa um importante fator, que impacta diretamente a qualidade de vida dos habitantes, pois implica acesso aos bens e serviços da cidade. Este estudo transversal buscou avaliar os preditores de percepção de qualidade de vida em três grupos de usuários, de acordo com seu modal de transporte prioritário (G1 - veículo particular/aplicativo de carros, G2 - transporte público coletivo e G3 - bicicleta/caminhada). Os participantes foram 417 moradores da cidade de Porto Alegre (RS), com idade entre 18 e 60 anos, pedestres ou que se utilizem de equipamentos de transporte urbano em sua rotina semanal. Os instrumentos contemplaram os blocos: dados sociodemográficos; percepção de qualidade de vida; meios de transporte e avaliação objetiva e afetiva da cidade. A análise de dados foi realizada utilizando-se regressão linear múltipla. Como resultados, foram obtidos três modelos, um para cada grupo. Todos apresentaram, como preditores de percepção de qualidade de vida, motivos para o uso do transporte prioritário e avaliação objetiva da cidade. Os preditores diferentes entre os grupos foram a idade mais elevada (G1); o fato de ter nascido na cidade e uma avaliação afetiva positiva da cidade (G2); e a experiência de relacionamento social devido ao meio de transporte (G3). O estudo contribuiu para um melhor entendimento dos fatores relacionados à mobilidade urbana que influenciam a percepção de qualidade de vida em centros urbanos.(AU)

The structure and planning of urban spaces influence the person-city relationship, in which urban mobility represents an important factor, which directly impacts the quality of life of the inhabitants, since it implies access to the city's goods and services. This cross-sectional study sought to assess the predictors of quality of life perception in three groups of users, according to their priority transportation modal (G1 - private vehicle/ride sharing apps, G2 - public transportation, and G3 - bicycle/walking). The participants were 417 residents of the city of Porto Alegre (state of Rio Grande do Sul - RS), aged between 18 and 60 years, pedestrians or who use urban transport equipment in their weekly routine. The instruments included: sociodemographic data; perception of quality of life; means of transportation; and objective and affective assessment of the city. Data analysis was performed using multiple linear regression. As a result, three models were obtained, one for each group. All of them presented reasons for using the priority transportation and objective assessment of the city as predictors of quality of life perception. The different predictors between the groups were the highest age (G1); the fact of being born in the city and a positive affective evaluation of the city (G2); and the experience of social relationships due to the means of transportation (G3). The study contributed to a better understanding of the factors related to urban mobility that influence the quality of life perception in urban centers.(AU)

La estructura y la planificación de los espacios urbanos influyen en la relación persona-ciudad, en la que la movilidad urbana representa un factor importante, que tiene un impacto directo en la calidad de vida calidad de vida de los habitantes, ya que implica el acceso a los bienes y servicios de la ciudad. Este estudio transversal buscó evaluar los predictores de la percepción de calidad de vida en tres grupos de usuarios, de acuerdo con su modalidad de transporte prioritario (G1 - vehículo privado, aplicación de automóvil, G2 - transporte público colectivo y G3 - bicicleta/caminar). Los participantes fueron 417 residentes de la ciudad de Porto Alegre (RS), con edades entre 18 y 60 años, peatones o que utilizan equipos de transporte urbano en su rutina semanal. Los instrumentos incluyeron los bloques: datos sociodemográficos; percepción de calidad de vida; medios de transporte y evaluación objetiva y afectiva de la ciudad. El análisis de los datos se realizó mediante regresión lineal múltiple. Como resultado, se obtuvieron tres modelos, uno para cada grupo. Todos ellos presentaron, como predictores de percepción de calidad de vida, razones para usar el transporte prioritario y evaluación objetiva de la ciudad. Los predictores distintos entre los grupos fueron la edad más alta (G1); el haber nacido en la ciudad y una evaluación afectiva positiva de la ciudad (G2); y la experiencia de relaciones sociales debido al transporte (G3). El estudio contribuyó a una mejor comprensión de los factores relacionados con la movilidad urbana que influencian la percepción de calidad de vida en los centros urbanos.(AU)

Cadmium and Mercury Exposure: Oxidative, Neurobehavioural and Histological Alterations to the Cerebellum of Wistar Rats

Background: The unprecedented increase in metal exposure has been aided by modern industrialization and anthropogenic activities. Cadmium and mercury are recognized as two of the most common heavy metals with destructive impacts on most organ systems. The present study was designed to investigate and improve existing literature on the possible deleterious effects of cadmium and mercury exposure. Methods: Adult Wistar rats were treated with cadmium chloride (5 mg/kg/day) and mercury chloride (4 mg/kg/day) for 14 days. Body, brain and cerebellar weights, motor deficits, antioxidant and lipid peroxidation activities as well as histological alterations to the cerebellum were evaluated at the end of the experiment. Results: Findings showed a significant reduction in body and brain weights, dysregulation of antioxidant enzymes activity and impaired locomotion and exploratory activity in treated rats. Also, an increase in lipid peroxidation and degeneration of Purkinje cells of the cerebellum was observed in treated rats. Conclusion: Overall, these results corroborate previous findings that cadmium and mercury induce deleterious effects on the cerebellum and central nervous system. In addition, this study helps to provide an anatomical perspective and information on the exact cerebellar changes induced by cadmium and mercury in Wistar rats.

La experiencia de la movilidad cotidiana desde la mirada de las personas con discapacidad / Experiences from mobility through the sight of disabledpeople

En el presente trabajo se incorpora al estudio de la movilidad cotidiana desde el reconocimiento de experiencias de las personas con discapacidad y la relación con el espacio urbano. El debate sobre la movilidad cotidiana en la ciudad desprende varios frentes de análisis, refiere a una solicitud coyuntural de dinámicas urbanas en correspondencia con los actores sociales; así mismo, propone una observación multidisciplinaria desde enfoques teóricos-metodológicos para la argumentación de la realidad social contemporánea. La propuesta es una delimitación sobre enfoques que ofrece la panorámica sobre el fenómeno de la movilidad y las implicaciones de nuevas categorías, así como la incorporación de otros actores que se deben contemplar para establecer un proceso de inclusión y accesibilidad. Se suscribe en un esquema desde las prácticas de la movilidad con relación a una escala a nivel micro (tanto en lo espacial como lo social) que favorece la detección de diferenciaciones en el mismo entorno bajo características particulares. La dinámica de la movilidad cotidiana refleja diversas problemáticas urbanas que precisan abordarse no sólo en términos de cantidad sino de calidad. Tales dificultades dentro del entorno urbano implican cuestiones como el tiempo, contemplado desde la espera del transporte, el traslado, el trasbordo y las eventualidades que llegasen a ocurrir; así como la distancia, los trayectos entre los centros laborales o educativos y las zonas residenciales. Todas estas contradicciones dentro de la vida cotidiana presentan otro matiz para los individuos de características diferentes, para personas con discapacidad, adultos mayores, menores de edad que comparten en el espacio como transeúntes de la ciudad.

This paper is incorporated to everyday mobility studies from recognizing experiences of people with disabilities in relation to the urban space. The debate on everyday mobility in the city allows different ways to be analyzed; it refers to a relevant request about urban dynamics linked to social actors. Likewise it is a proposal to observe through a multidisciplinary approach and focus on theory and methodology to discuss about current social reality. The proposal is a boundary among approaches which offers a perspective about the phenomenon of mobility and new categories and the incorporation of other actors that must be considered to establish a process of inclusion and accessibility. It is an outline from mobility practices in relation to micro scale from special to social aspects that allows detecting distinctions in the same surroundings under individual characteristics.

Active play interventions on motor skills of preschoolers: a systematic review / Intervenções com brincar ativo nas habilidades motoras de pré-escolares: uma revisão sistemática

Active play can contribute to the reduction of sedentary time and generate potential benefits for the performance of fundamental motor skills in children. Thus, the aim of this systematic review was to provide a synthesis of evidence on the contributions of active play to fundamental motor skills in children aged 2 to 5 years typically developed, as well as to verify the differences between the intervention protocols used in the studies. The studies were identified by searching the PubMed, Web of Science and Lilacs databases. Clinical trials available in English, conducted in typically developing children, were included, and studies with the theme of electronic games were excluded. Two independent researchers examined the studies and conducted data extraction. Eight articles were included in the systematic review; three identified that children who experienced interventions with free active play had better performance in handling and balance skills. Four studies identified that children who practiced guided active play had better performance in locomotion, manipulation and balance skills, one study found no significant difference. We concluded that the practice of active play, especially guided active play, positively contributes to the fundamental motor skills of children aged 3 to 5 years typically developed. (AU)

Brincadeiras ativas podem contribuir para redução do tempo sedentário e gerar potenciais benefícios para o desempenho das habilidades motoras fundamentais em crianças. Assim, o objetivo desta revisão sistemática foi fornecer uma síntese das evidências sobre as contribuições do brincar ativo para a habilidades motoras fundamentais em crianças de 2 a 5 anos tipicamente desenvolvidas, bem como verificar as diferenças entre os protocolos de intervenção utilizados nos estudos. Os estudos foram identificados por meio de busca nas bases de dados PubMed, Web of Science e Lilacs. Foram incluídos os ensaios clínicos disponíveis em inglês, realizados em crianças com desenvolvimento típico, e excluídos os estudos com a temática de jogos eletrônicos. Dois pesquisadores independentes examinaram os estudos e conduziram a extração de dados. Oito artigos foram incluídos na revisão sistemática; três identificaram que as crianças que vivenciaram intervenções com brincadeira ativa livre tiveram melhor desempenho nas habilidades de manuseio e equilíbrio. Quatro estudos identificaram que crianças que praticavam brincadeiras ativas orientadas tinham melhor desempenho nas habilidades de locomoção, manipulação e equilíbrio, um estudo não encontrou diferença significativa. Concluímos que a prática da brincadeira ativa, especialmente a orientada, contribui positivamente para o desempenho das habilidades motoras fundamentais de crianças de 3 a 5 anos tipicamente desenvolvidas. (AU)

Foot rotation asymmetry in Down syndrome and the relationship with crawling and walking onset: a cross-sectional study / A marcha de base alargada na síndrome de Down e a relação com o engatinhar e os primeiros passos: um estudo transversal

INTRODUCTION: Down syndrome individuals have different gait patterns, which include specific characteristics such as foot rotation asymmetryOBJECTIVE: The aim of this study was to analyze the relationship between this asymmetry and the hands-and-knees crawling pattern before gait acquisition in Down syndrome children, as well as the possible association of this gait to gender, ethnicity, comorbidities, physiotherapy, and occupational therapy interventionsMETHODS: In this cross-sectional study, 361 children with or without foot rotation asymmetry were selected. An online questionnaire was administered to the parents or guardians of those childrenRESULTS: Hands-and-knees crawling decreased the prevalence of foot rotation asymmetry in Down syndrome children. The longer it took for walking onset, the higher the prevalence of this asymmetry. Indeed, for each month of delay, there was a 7% increase in prevalence. There was a significant relationship between orthopedic alterations in knees or flat feet and foot rotation asymmetry. There was no significance related to gender, ethnicity, other comorbidities, physiotherapy, or occupational therapy interventionsCONCLUSION: The findings in this study revealed that foot rotation asymmetry might be related to the acquisition of motor skills, hands-and-knees crawling and the walking onset

INTRODUÇÃO: As pessoas com síndrome de Down (SD) apresentam diferentes padrões de marcha, incluindo algumas características específicas como a marcha de base alargadaOBJETIVO: O objetivo deste estudo foi analisar a relação entre a marcha de base alargada e a aquisição motora engatinhar em quatro apoios adquiridas antes da marcha em crianças com SD, bem como a provável associação desta marcha com gênero, etnia, comorbidades e tratamentos de fisioterapia e terapia ocupacionalMÉTODO: Neste estudo transversal, foram selecionados 361 indivíduos que apresentaram ou não marcha de base alargada. Um questionário on-line foi administrado para pais / responsáveis destas criançasRESULTADOS: O engatinhar em quatro apoios diminuiu a prevalência da marcha de base alargada em crianças com SD. Quanto maior o tempo em meses para os primeiros-passos, maior a prevalência de base alargada, sendo que, a cada mês de atraso, a prevalência aumenta em 7%. Foi observada significância entre as alterações ortopédicas em joelhos e pés planos e a marcha de base alargada. Não foi encontrada significância relacionada a gênero, etnia, outras comorbidades, fisioterapia ou terapia ocupacionalCONCLUSÃO: Os achados deste estudo mostraram que o aparecimento da base alargada pode estar relacionado às aquisições motoras, engatinhar em quatro apoios, e aos primeiros passos

Influência do estímulo visual e posição dos membros superiores no controle postural ortostático de crianças e adolescentes / Influence of visual stimulus and upper limbs' position in the orthostatic postural control of children and adolescents

O objetivo do estudo foi verificar a influência do estímulo visual e posicionamento dos membros superiores no controle postural ortostático e avaliar o efeito do sexo e idade nas respostas posturais de crianças e adolescentes. Estudo transversal, com amostra de 84 participantes com idade entre 11 e 14 anos, ambos os sexos (55 meninas), de escola pública de Goiânia (GO). Além do exame físico, o controle postural foi avaliado na posição ortostática pela baropodometria computadorizada em três condições: olhos abertos, olhos fechados e olhos abertos com ombros a 90° de abdução. A ausência do estímulo visual gerou maior instabilidade postural em comparação à condição de olhos abertos. Em relação as diferenças existentes entre os sexos, foi observado que as meninas tiveram menores valores de deslocamento anteroposterior e área da elipse que os meninos. Comparando-se os olhos abertos e fechados, as meninas apresentaram maiores valores na área da elipse e os meninos nos deslocamentos anteroposterior e látero-lateral. Ao analisar o efeito da idade foi observado que o grupo com 13 e 14 anos apresentou maiores valores em todas as variáveis analisadas. A ausência do estímulo visual aumentou os valores da área da elipse no grupo com 11 e 12 e dos deslocamentos no grupo com 13 e 14 anos. Não foi verificado efeito interativo entre sexo e idade. Na condição de abdução dos membros superiores não houve diferença no controle postural. Conclui-se que a ausência do estímulo visual foi mais impactante na manutenção do controle postural ortostático em crianças e adolescentes em relação as outras condições avaliadas, existindo diferença entre os sexos e a idade, em que os meninos e o grupo com 13 e 14 anos realizaram mais ajustes para manter o controle postural. (AU)

The aim of this study was to verify the influence of visual stimulus and positioning of the upper limbs in the orthostatic postural control, and to assess the effects of gender and age in the postural responses of children and adolescents. This was a transversal study involving 84 participants (of which 55 were girls) from public schools in Goiania (GO - Brazil) with age between 11 and 14 years. Besides physical examination, the participants' postural control was assessed in the orthostatic position by computerized baropodometry in three different conditions: eyes-open, eyes-closed, and eyes-open with shoulders at 90º abduction. The absence of visual stimulus generated more postural instability in relation to the eyes-open condition. Regarding gender differences, the girls had lower anteroposterior and ellipse area displacement than boys. Comparing the eyes-open and eyes-closed conditions, the girls presented higher values in the ellipse area and the boys presented higher values in the anteroposterior and laterolateral displacements. Analyzing the effect of age, the participants between 13 and 14 years old presented higher values in all variables. The absence of visual stimulus increased the values of the ellipse area in the participants between 11 and 12 years of age and the values of displacements in the participants between 13 and 14 years of age. Interactive effect between genders and age has not been verified. There were no postural control differences in the upper limbs abduction condition. Conclusion: The absence of visual stimulus was more impacting in the support of orthostatic postural control in children and adolescents than the other conditions assessed; the boys and the participants between 13 and 14 years of age made more adjustments in order to maintain postural control. (AU)

A artrodese lombar e as alterações dos parâmetros espaço-temporais da marcha / Lumbar arthrodesis and the changes in spatiotemporal parameters of gait

As dores lombares podem causar frequentes incapacidades a longo prazo. O tratamento inicial de problemas lombares é realizado através de medicamentos e de fisioterapia; mas a cirurgia de artrodese também pode ser considerada para alguns casos específicos. Entretanto, acredita-se que a artrodese lombar pode afetar negativamente a marcha. O principal objetivo deste estudo foi identificar possíveis alterações nos parâmetros cinemáticos da marcha de indivíduos submetidos a artrodese lombar. Fizeram parte da amostra quinze indivíduos com médias de idade de 55,40 anos, de peso de 79,84 quilogramas, de altura de 1,60 metros e de tempo de pós operat ório de 59,33 meses. Um sistema de cinemetria capturou a trajetória tridimensional da marcha. Para a avaliação funcional, o questionário de Roland Morris (RMDQ) foi utilizado. O teste t para uma amostra foi utilizado para comparar com as variáveis da marcha com a normalidade; e o teste de correlação de Spearman, para verificar as correlações entre os parâmetros da marcha e o RMDQ, tempo de procedimento cirúrgico e idade. Os valores de velocidade (p < 0,0001), do comprimento da passada (p < 0,0001) e da largura do passo (p < 0,0001) apresentaram-se inferiores quando comparado aos valores normativos. Os resultados do questionário de RMDQ demonstraram que os participantes apresentaram níveis baixos de funcionalidade; com uma correlação forte e estatisticamente significativa (p < 0,05) entre a funcionalidade e a velocidade, cadência, tempo da passada e largura do passo. Resultados similares também foram encontrados em pacientes em tratamento conservador, demonstrando a falta de eficiência desse procedimento cirúrgico. Por isso, de ve-se questionar as reais necessidades da artrodese lombar, avaliando a gravidade e os objetivos de cada paciente com o intuito esgotar ao máximo as po ssibilidades de tratamento conservador antes da opção pela artrodese lombar. (AU)

Low back pain can cause frequent long-term disabilities. The initial treatment for low back problems is medication and physiotherapy; but arthrodesis surgery can also be considered for some specific cases. However, it is believed that lumbar arthrodesis can negatively affects gait. The main objective of this study was to identify possible changes in gait kinematic parameters after lumbar arthrodesis. Sample was composed by fifteen individuals with a mean age of 55.40 years, weighing 79.84 kilograms, height of 1.60 meters and postoperative time of 59.33 months. A kinematic system captured the three -dimensional trajectory of the gait. For functionality evaluation, the Roland-Morris Disability Questionnaire (RMDQ) was used. The t-test for one sample was used to compare gait variables with normality; and the Spearman correlation test was used to verify the correlations between gait par ameters and RMDQ, surgical time and age. The values of velocity (p < 0.0001), stride length (p < 0.0001) and step width (p < 0.0001) were lower when compared to normative values. The results of the RMDQ showed that participants had low levels of functionality; with a strong and statistically significant correlation (p < 0.05) between functionality and velocity, between functionality and cadence, between functionality and stride time, and between functionality and stride widt h. Similar results were also found in patients under conservative treatment, demonstrating this surgical procedure is inefficiency. Therefore, should be asked the real needed for lumbar arthrodesis, measuring the severity and objectives of each patient in order to fully exhaust the possibilities of conservative treatment b efore opting for lumbar arthrodesis. (AU)

Enfermedad podal en bovinos: prevalencia y asociación con algunas variables / Podal disease in cows: prevalence and association with some variables

RESUMEN La enfermedad podal constituye uno de los síndromes más difíciles de controlar en la industria lechera. El presente estudio tuvo como objetivo cuantificar la prevalencia de enfermedad podal, evaluando su asociación con factores como raza, orden de parto y peso. Se trata de un estudio retrospectivo que utiliza los registros sanitarios y productivos de un hato lechero ubicado en el trópico alto de Colombia. Los componentes raciales presentes fueron Fl Holstein x Blanco Orejinegro, 3/4 Holstein 1/4 Blanco Orejinegro, 5/8 Holstein 3/8 Blanco Orejinegro y Holstein 100%. Se consideraron 6 órdenes de parto. La variable enfermedad podal presenta una distribución binomial. El efecto de los factores se verificó utilizando un modelo lineal generalizado, por medio de una regresión logística (PROC GENMOD SAS versión 9.4). En caso de existir diferencias significativas, se aplicó el procedimiento LSMEANS del SAS (versión 9.4) y un Odds Rattio entre los niveles que presentaron significancia. La prevalencia de enfermedad podal en el hato fue de 10,55%. Los factores de riesgo considerados fueron estadísticamente significativos: componente racial (p < 0,0009), orden parto (p < 0,0001) y peso medio de las vacas (p < 0,0001). Se observó un incremento en la prevalencia de la enfermedad asociado a la raza Holstein, orden de parto alto y bajo peso corporal. La prevalencia de enfermedad podal fue mayor en vacas Holstein puras y menor en vacas Holstein cruzadas con Blanco Orejinegro, debido a la resistencia por heterosis que la raza criolla aporta. El incremento del orden de parto al igual que el bajo peso se relacionan con una mayor prevalencia de esta enfermedad.

ABSTRACT Foot disease is one of the most difficult syndromes to control in the dairy industry. The goal of this study was to quantify the prevalence of foot disease, evaluating its association with factors such as race, calving order and weight. This is a retrospective study using the health and production records of a dairy herd located in the high tropics of Colombia. The racial components present were F1 Holstein x Blanco Orejinegro, 3/4 Holstein 1/4 Blanco Orejinegro, 5/8 Holstein 3/8 Blanco Orejinegro, Holstein 100%. 6 delivery orders were considered. The variable foot disease presents a binomial distribution. The effect of the factors was verified using a generalized linear model, by means of a logistic regression (PROC GENMOD SAS version 9.4). In the event of significant differences, the SAS LSMEANS procedure (version 9.4) and an Odds Ratio were applied between the levels that presented significance. The prevalence of foot disease in the herd was 10,55%. The risk factors considered were statistically significant: racial component (p < 0,0009), calving order (p < 0,0001) and average weight of the cows (p < 0,0001). An increase in the prevalence of the disease was observed associated with the Holstein breed, high calving order and low body weight. The prevalence of foot disease was higher in pure Holstein cows and lower in Holstein cows crossed with Blanco Orejinegro due to the resistance due to heterosis that the creole breed contributes. The increase in the delivery order as well as the low weight are related to a higher prevalence of this disease.

Locomotion and righting behavior of sea stars: a study case on the bat star Asterina stellifera (Asterinidae) / Comportamiento de locomoción y enderezamiento en estrellas de mar: un caso de estudio sobre la estrella Asterina stellifera (Asterinidae)

Introduction: The locomotion behavior of an organism involves the integration of aspects like body symmetry, sensory and locomotor systems. Furthermore, various ecological factors seem to be related to locomotion characteristics, such as foraging strategy, migration trends, response to predators and competitors, and environmental stress. Objective: To analyze locomotion and the influence of body symmetry in the crawling and righting movements of the sea star Asterina stellifera. Methods: We carried out laboratory experiments in aquariums in the presence/absence of water current and on a horizontal and vertical surface. Results: The speed is similar to speed in other species of similar size. Both the speed and linearity of displacement were independent of individual body size. A water current leads to faster crawling and straight paths, but there is no rheotaxis: streams do not affect locomotion. Speed and linearity of displacement were independent of individual body size. The displacement pattern described here may be an adaptation of organisms that present dense populations in communities with high prey abundance, as is the case of A. stellifera. Conclusions: Like other asteroids, this species did not show an Anterior/Posterior plane of symmetry during locomotion, or righting movement: it does not tend to bilaterality.

Introducción: El comportamiento de locomoción de un organismo implica la integración de aspectos como la simetría corporal, los sistemas sensorial y locomotor. Además, varios factores ecológicos parecen estar relacionados con las características de la locomoción, como la estrategia de alimentación, las tendencias migratorias, la respuesta a los depredadores y competidores y el estrés ambiental. Objetivo: Analizar el patrón general de locomoción y la influencia de la simetría corporal en la locomoción y enderezamiento de la estrella de mar Asterina stellifera. Métodos: Realizamos experimentos de laboratorio en acuarios en presencia / ausencia de corriente de agua y en superficie horizontal y vertical. Resultados: La velocidad es similar a la velocidad en otras especies de tamaño similar. Tanto la velocidad como la linealidad del desplazamiento fueron independientes del tamaño corporal individual. Una corriente de agua conduce a una velocidad de desplazamiento mayor y a trayectorias más rectas, pero no hay reotaxis: una corriente de agua no afecta el patrón de locomoción. La velocidad y la linealidad del desplazamiento fueron independientes del tamaño corporal individual. El patrón de desplazamiento aquí descrito puede ser una adaptación de organismos que presentan densas poblaciones en comunidades con alta abundancia de presas, como es el caso de A. stellifera. Conclusiones: Al igual que otros asteroides, esta especie no mostró un plano de simetría Anterior / Posterior durante la locomoción o el movimiento de enderezamiento: no tiende a la bilateralidad.

Efectos de la actividad locomotriz voluntaria gestacional sobre la morfología cardiaca en crías murinas / Effects of gestational voluntary locomotor activity on cardiac morphology in murine offspring

RESUMEN: El objetivo del presente estudio es analizar los efectos de la actividad locomotriz voluntaria gestacional, como un tipo de entrenamiento físico, sobre la morfología de la bomba cardíaca de la cría, en modelo murino de la cepa CF-1. 12 hembras gestantes fueron divididas aleatoriamente en un grupo control y un grupo que realizó actividad locomotriz voluntaria, accediendo a una rueda de actividad durante los primero 12 días de gestación. Se evaluó la morfología cardiaca mediante cortes transversales, midiendo espesor y área de las paredes del ventrículo derecho, ventrículo izquierdo y septum, tanto en valores absolutos como en valores relativos a la masa corporal del individuo. Se observó que la masa corporal de las crías control (GC) fue significativamente mayor que las del grupo cuyas hembras accedieron a la rueda de actividad (GE) (p<0.01). Solo hubo diferencias en los valores absolutos de espesores y áreas miocárdicas de ventrículo derecho, entre el grupo GE y GC (p<0.05), pero al evaluar los espesores y áreas relativos a la masa corporal se observó que las crías del grupo GE presentaron espesores y áreas significativamente mayores que las que grupo GC (p<0.01). En conclusión, la actividad física gestacional altera el desarrollo morfológico de la bomba cardíaca en ratones CF-1, aumentando significativamente el espesor y área de las paredes miocárdicas en relación a la masa corporal total de la cría.

SUMMARY: The objective of the present study is to analyze the effects of gestational voluntary locomotor activity, as a type of physical training, on the morphology of the offspring´s heart pump, in a murine model of the CF-1 strain. Twelve (12) pregnant females were randomly divided in a control group and a group performing voluntary locomotor activity, by accessing an activity wheel during the first 12 days of gestation. Cardiac morphology was evaluated using cross sections, measuring thickness and area of the walls of the right ventricle, left ventricle, and septum, both in absolute values and values relative to the individual's body mass. It was observed that the body mass of the control pups (CG) was significantly higher than those of the group whose females accessed the activity wheel (GE) (p <0.01). Differences were observed only in absolute values of thickness and myocardial areas of the right ventricle, between the GE and GC group (p <0.05). However, when evaluating the thickness and areas relative to body mass, it was observed that the offspring of the GE group presented thicknesses and areas significantly larger than those in the GC group (p <0.01). In conclusion, gestational physical activity alters the morphological development of the heart pump in CF-1 mice, significantly increasing the thickness and area of the myocardial walls in relation to offspring total body mass.

Effects of Toluene on the Development of the Inner Ear and Lateral Line Sensory System of Zebrafish / 生物医学与环境科学（英文）

Objective@#The aim of this study was to explore the ototoxicity of toluene in the early development of zebrafish embryos/larvae.@*Methods@#Zebrafish were utilized to explore the ototoxicity of toluene. Locomotion analysis, immunofluorescence, and qPCR were used to understand the phenotypes and molecular mechanisms of toluene ototoxicity.@*Results@#The results demonstrated that at 2 mmol/L, toluene induced zebrafish larvae death at 120 hours post fertilization (hpf) at a rate of 25.79% and inhibited the rate of hatching at 72 hpf. Furthermore, toluene exposure inhibited the distance travelled and average swimming velocity of zebrafish larvae while increasing the frequency of movements. As shown by fluorescence staining of hair cells, toluene inhibited the formation of lateral line neuromasts and middle line 1 (Ml @*Conclusion@#This study indicated that toluene may affect the development of both the inner ear and lateral line systems in zebrafish, while the lateral line system may be more sensitive to toluene than the inner ear.

Engagement in different sport disciplines during university years and risk of locomotive syndrome in older age: J-Fit

BACKGROUND@#Among former Olympic-level athletes, engagement in different sport disciplines has been associated with mortality risk in subsequent years. However, limited evidence is available on whether engagement in different sport disciplines at a young age is associated with locomotive syndrome (LS) risk later in life. This study examined the relationship between engagement in different sport disciplines during university years and LS risk in older age among former university athletes.@*METHODS@#Participants were 274 middle-aged and 294 older men alumni who graduated from a school of physical education in Japan. LS risk was defined as answering "yes" to any of the Loco-check questions. Data on university sports club membership were collected using questionnaires. University clubs were classified into three groups of cardiovascular intensity (low, moderate, high), following the classification system of sport disciplines by the American College of Cardiology. This classification considers the static and dynamic components of an activity, which correspond to the estimated percent of maximal voluntary contraction reached and maximal oxygen uptake achieved, respectively. University clubs were grouped based on the risk of bodily collision (no, yes) and extent of physical contact (low, moderate, high). Relationships between engagement in different sport disciplines and LS risk were analyzed using Cox proportional hazards models, and adjusted for age, height, weight, joint disease, habitual exercise, and smoking and drinking status.@*RESULTS@#Adjusted hazard ratios and 95% confidence intervals associated with the low, moderate, and high cardiovascular intensity sports were 1.00 (reference), 0.48 (0.22-1.06, P = 0.070), and 0.44 (0.20-0.97, P = 0.042) in older men, respectively; however, there was no significant association between these parameters among middle-aged men. Engagement in sports associated with physical contact and collision did not affect LS risk in either group.@*CONCLUSIONS@#Engagement in sports associated with high cardiovascular intensity during university years may reduce the risk of LS in later life. Encouraging young people to participate in such activities might help reduce LS prevalence among older populations.

Locomotor activity in Aedes aegypti with different insecticide resistance profiles

ABSTRACT OBJECTIVE: To evaluate locomotor activity in four field populations of Ae. aegypti with different insecticide resistance profiles from the state of São Paulo for two years. METHODS: This study comprised the susceptible Rockefeller strain and four populations from São Paulo, Brazil: two considered populations with "reduced susceptibility" to pyrethroids (Campinas and Marília), and two "resistant populations" (Santos and Ribeirão Preto). First, 2016 and 2017 eggs from these five populations were hatched in laboratory. Virgin females underwent experiments under laboratory conditions at 25°C, with 12:12h light/dark (LD) photoperiod; 24-hour individual activity was recorded using a locomotor activity monitor (LAM). RESULTS: In females from 2016 field populations, both resistant populations showed significant more locomotor activity than the two reduced susceptibility populations and the Rockefeller strain (p < 0.05). As for females from 2017 field populations, reduced susceptibility populations showed a significant increased locomotor activity than the Rockefeller strain, but no significant difference when compared to Santos resistant population (p > 0.05). CONCLUSIONS: Our results indicate that insecticide-resistant Ae. aegypti populations show increased locomotor activity, which may affect the transmission dynamics of their arboviruses.

Safety assessment of multiple repeated percutaneous punctures for the collection of cerebrospinal fluid in rats

The objective of this study was to examine the safety of multiple repeated percutaneous punctures of cisterna magna for collecting cerebrospinal fluid (CSF) and preliminarily determine the optimal time interval and volume at each collection. Sixty Wistar rats were randomly assigned to six groups: 10 d-0 μL, 10 d-100 μL (100 μL CSF collected at an interval of 10 days), 10 d-150 μL, 15 d-0 μL, 15 d-100 μL, and 15 d-150 μL. CSF was collected by percutaneous puncture of the cisterna magna at four time-points. Simultaneously, locomotor activity, cisterna magna pressure, and acetylcholine levels in the CSF were monitored. Compared with the 10 d-0 μL group, the escape latency by Morris water maze was significantly prolonged in the 10 d-100 μL and 10 d-150 μL groups (P<0.05). Compared with the 15 d-0 μL group, the indices of 15 d-100 μL and 15 d-150 μL groups had no significant differences. When compared with that at the first training, the exception of the 10 d-150 μL and 15 d-150 μL groups, significant differences in escape latency were found at the 6th attempt (P<0.05). Compared with baseline readings for each group, the cisterna magna pressure in the 10 d-150 μL group began to decrease significantly from the third measurement (P<0.05). The optimal time interval during four CSF collections (100 μL per collection) via cisterna magna percutaneous puncture was determined to be 15 days. The procedure did not significantly affect learning processes, performance, or other related indices.