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1.
Rev. Nutr. (Online) ; 35: e220015, 2022. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1394674

RESUMO

ABSTRACT Objective To evaluate the nutritional and functional status, swallowing disorders, and musculoskeletal manifestations of patients with Post-Covid-19 Syndrome, stratified by the Appendicular Skeletal Muscle Mass Index. Methods This is a cross-sectional study with patients diagnosed with Post-Covid-19 Syndrome after discharge from the intensive care unit of a university hospital. The evaluated outcomes were: nutritional status (Mini Nutritional Assessment, bioimpedance and anthropometry), swallowing disorders (Dysphagia Risk Evaluation Protocol), functional status (Post-Covid-19 Functional Status Scale), and musculoskeletal manifestations. According to the Appendicular Skeletal Muscle Mass Index, patients were stratified in terms of loss or not loss of muscle mass. Results Thirty-eight patients were included in the study, 20 stratified into the no loss of muscle mass group (17 females; 49.45±12.67 years) and 18 into the loss of muscle mass group (18 males; 61.89±12.49 years). Both groups were at risk of malnutrition (Mini Nutritional Assessment scores between 17-23.5 points; No Loss of Muscle Mass Group: 21.82±3.93; Loss of Muscle Mass Group: 23.33±3.41) and obesity (No Loss of Muscle Mass Group: 33.76±6.34; Loss of Muscle Mass Group: 30.23±3.66). The groups differed in terms of bioimpedance parameters (except fat mass) and age. However, there were no differences in swallowing alterations, functional status, and musculoskeletal manifestations. Conclusion Patients with Post-Covid-19 Syndrome, stratified according to the Appendicular Skeletal Muscle Mass Index, were at risk of malnutrition and obesity. The persistence of fatigue, weakness, myalgia and arthralgia at 6 months after hospital discharge is noteworthy. These findings emphasize the importance of comprehensive care for patients with Post-Covid-19 Syndrome.


RESUMO Objetivo Avaliar o estado nutricional, status funcional, alterações de deglutição e manifestações musculoesqueléticas de pacientes com Síndrome Pós-Covid-19, estratificados pelo Índice de Massa Muscular Esquelética Apendicular. Métodos Estudo transversal composto por pacientes diagnosticados com a Síndrome Pós-Covid-19 que estiveram internados na Unidade de Terapia Intensiva de um hospital universitário. Os desfechos avaliados foram: estado nutricional (Mini Avaliação Nutricional; bioimpedância e antropometria), alterações de deglutição (Protocolo Fonoaudiológico de Avaliação do Risco de Disfagia), status funcional (Post-Covid-19 Functional Status Scale) e manifestações musculoesqueléticas. Os pacientes foram classificados, quanto à perda de massa muscular conforme o Índice de Massa Muscular Esquelética Apendicular, em grupo sem e com perda de massa muscular. Resultados Foram inseridos no estudo 38 pacientes, 20 no grupo sem perda de massa muscular (17 deles do sexo feminino; 49,45±12,67 anos) e 18 no grupo com perda de massa muscular (todos do sexo masculino; 61,89±12,49 anos). Os pacientes de ambos os grupos apresentaram risco de desnutrição (escores Mini Avaliação Nutricional entre 17-23.5 pontos; Grupo Sem Perda de Massa Muscular: 21,82±3,93; Grupo Com Perda de Massa Muscular: 23,33±3,41) e obesidade (Grupo Sem Perda de Massa Muscular: 33,76±6,34; Grupo Com Perda de Massa Muscular: 30,23±3,66). Os grupos diferiram quanto aos parâmetros da bioimpedância (exceto massa gorda) e idade. Entretanto, não foram observadas diferenças na deglutição, status funcional e manifestações musculoesqueléticas. Conclusão Os pacientes com Síndrome Pós-Covid-19, estratificados conforme o Índice de Massa Muscular Esquelética Apendicular, apresentaram risco de desnutrição e obesidade. Destaca-se a persistência de fadiga, fraqueza, mialgia e artralgia após seis meses da alta hospitalar. Esses achados ressaltam a importância do cuidado integral ao paciente com a Síndrome Pós-Covid-19.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Adulto Jovem , Músculo Esquelético/fisiopatologia , Desnutrição/fisiopatologia , COVID-19/complicações , Obesidade/fisiopatologia , Transtornos de Deglutição/fisiopatologia , Estudos Transversais/métodos , Estado Funcional , Hospitais Universitários , Unidades de Terapia Intensiva
2.
Int. braz. j. urol ; 45(4): 686-694, July-Aug. 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1019886

RESUMO

ABSTRACT Purpose The present study aimed to determine whether sarcopenia after radical cystectomy (RC) could predict overall survival (OS) in patients with urothelial bladder cancer (UBC). Materials and Methods The lumbar skeletal muscle index (SMI) of 80 patients was measured before and 1 year after RC. The prognostic significance of sarcopenia and SMI decrease after RC were evaluated using Kaplan-Meier analysis and a multivariable Cox regression model. Results Of 80 patients, 26 (32.5%) experienced sarcopenia before RC, whereas 40 (50.0%) experienced sarcopenia after RC. The median SMI change was -2.2 cm2/m2. Patients with sarcopenia after RC had a higher pathological T stage and tumor grade than patients without sarcopenia. Furthermore, the overall mortality rate was significantly higher in patients with sarcopenia than in those without sarcopenia 1 year after RC. The median follow-up time was 46.2 months, during which 22 patients died. Kaplan-Meier estimates showed a significant difference in OS rates based on sarcopenia (P=0.012) and SMI decrease (P=0.025). Multivariable Cox regression analysis showed that SMI decrease (≥2.2 cm2/m2) was an independent predictor of OS (hazard ratio: 2.68, confidence interval: 1.007-7.719, P = 0.048). Conclusions The decrease in SMI after surgery might be a negative prognostic factor for OS in patients who underwent RC to treat UBC.


Assuntos
Humanos , Masculino , Feminino , Idoso , Neoplasias da Bexiga Urinária/cirurgia , Carcinoma in Situ/cirurgia , Cistectomia/efeitos adversos , Sarcopenia/etiologia , Fatores de Tempo , Neoplasias da Bexiga Urinária/complicações , Neoplasias da Bexiga Urinária/fisiopatologia , Neoplasias da Bexiga Urinária/mortalidade , Carcinoma in Situ/complicações , Carcinoma in Situ/mortalidade , Índice de Massa Corporal , Cistectomia/métodos , Cistectomia/mortalidade , Modelos de Riscos Proporcionais , Análise Multivariada , Estudos Retrospectivos , Músculo Esquelético/fisiopatologia , Estimativa de Kaplan-Meier , Sarcopenia/fisiopatologia
3.
Asian Journal of Andrology ; (6): 170-176, 2019.
Artigo em Inglês | WPRIM | ID: wpr-1009668

RESUMO

Pelvic floor muscle exercise (PFME) is the most common conservative management for urinary incontinence (UI) after radical prostatectomy (RP). However, whether the PFME guided by a therapist (G-PFME) can contribute to the recovery of urinary continence for patients after RP is still controversial. We performed this meta-analysis to investigate the effectiveness of G-PFME on UI after RP and to explore whether the additional preoperative G-PFME is superior to postoperative G-PFME alone. Literature search was conducted on Cochrane Library, Embase, Web of Science, and PubMed, to obtain all relevant randomized controlled trials published before March 1, 2018. Outcome data were pooled and analyzed with Review Manager 5.3 to compare the continence rates of G-PFME with control and to compare additional preoperative G-PFME with postoperative G-PFME. Twenty-two articles with 2647 patients were included. The continence rates of G-PFME were all superior to control at different follow-up time points, with the odds ratio (OR) (95% confidence interval [CI]) of 2.79 (1.53-5.07), 2.80 (1.87-4.19), 2.93 (1.19-7.22), 4.11 (2.24-7.55), and 2.41 (1.33-4.36) at 1 month, 3 months, 4 months, 6 months, and 12 months after surgery, respectively. However, there was no difference between additional preoperative G-PFME and postoperative G-PFME, with the OR (95% CI) of 1.70 (0.56-5.11) and 1.35 (0.41-4.40) at 1 month and 3 months after RP, respectively. G-PFME could improve the recovery of urinary continence at both early and long-term stages. Starting the PFME preoperatively might not produce extra benefits for patients at early stage, compared with postoperative PFME.


Assuntos
Humanos , Masculino , Músculo Esquelético/fisiopatologia , Diafragma da Pelve/fisiopatologia , Modalidades de Fisioterapia , Prostatectomia/efeitos adversos , Neoplasias da Próstata/cirurgia , Resultado do Tratamento , Incontinência Urinária/terapia
4.
Braz. j. med. biol. res ; 52(12): e8576, 2019. graf
Artigo em Inglês | LILACS | ID: biblio-1055463

RESUMO

Physical exercise is a known preventive and therapeutic alternative for several cerebrovascular diseases. Therefore, the objective of the present study was to evaluate the motor performance and histomorphometry of the biceps brachii, soleus, and tibialis anterior muscles of rats submitted to a treadmill training program prior to the induction of cerebral ischemia via occlusion of the middle cerebral artery (OMCA). A total of 24 Wistar rats were distributed into four groups: Sham-Sed: sedentary control animals (n=6), who underwent sham surgery (in which OMCA did not occur); Sham+Ex: control animals exercised before the sham surgery (n=6); I-Sed: sedentary animals with cerebral ischemia (n=6); and I+Ex: animals exercised before the induction of ischemia (n=6). The physical exercise consisted of treadmill training for five weeks, 30 min/day (5 days/week), at a speed of 14 m/min. The results showed that the type-I fibers presented greater fiber area in the exercised ischemic group (I+Ex: 2347.96±202.77 µm2) compared to the other groups (Sham-Sed: 1676.46±132.21 µm2; Sham+Ex: 1647.63±191.09 µm2; I+Ex: 1566.93±185.09 µm2; P=0.0002). Our findings suggested that the angiogenesis process may have influenced muscle recovery and reduced muscle atrophy of type-I fibers in the animals that exercised before cerebral ischemia.


Assuntos
Animais , Masculino , Ratos , Condicionamento Físico Animal/fisiologia , Atrofia Muscular/prevenção & controle , Isquemia Encefálica/complicações , Músculo Esquelético/fisiopatologia , Infarto da Artéria Cerebral Média , Atrofia Muscular/etiologia , Atrofia Muscular/patologia , Isquemia Encefálica/fisiopatologia , Ratos Wistar , Modelos Animais de Doenças
5.
Braz. j. med. biol. res ; 52(12): e8786, 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1055466

RESUMO

Exercise-based training decreases hospitalizations in heart failure patients but such patients have exercise intolerance. The objectives of the study were to evaluate the effect of 12 weeks of Tai Chi exercise and lower limb muscles' functional electrical stimulation in older chronic heart failure adults. A total of 1,084 older adults with chronic systolic heart failure were included in a non-randomized clinical trial (n=271 per group). The control group did not receive any kind of intervention, one group received functional electrical stimulation of lower limb muscles (FES group), another group practiced Tai Chi exercise (TCE group), and another received functional electrical stimulation of lower limb muscles and practiced Tai Chi exercise (FES & TCE group). Quality of life and cardiorespiratory functions of all patients were evaluated. Compared to the control group, only FES group had increased Kansas City Cardiomyopathy Questionnaire (KCCQ) score (P<0.0001, q=9.06), only the TCE group had decreased heart rate (P<0.0001, q=5.72), and decreased peak oxygen consumption was reported in the TCE group (P<0.0001, q=9.15) and FES & TCE group (P<0.0001, q=10.69). FES of lower limb muscles and Tai Chi exercise can recover the quality of life and cardiorespiratory functions of older chronic heart failure adults (trial registration: Research Registry 4474, January 1, 2015).


Assuntos
Humanos , Idoso , Terapia por Estimulação Elétrica/métodos , Músculo Esquelético/fisiopatologia , Tai Chi Chuan/métodos , Extremidade Inferior/fisiopatologia , Insuficiência Cardíaca Sistólica/reabilitação , Qualidade de Vida , Doença Crônica , Resultado do Tratamento , Insuficiência Cardíaca Sistólica/fisiopatologia
6.
Acta cir. bras ; 34(5): e201900503, 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1010873

RESUMO

Abstract Purpose: To analyze the muscle changes with high-intensity aerobic training (HIAT) in an animal model of renal disease (RD). Methods: Twenty one adult Wistar rats were divided into 3 groups: healthy sedentary (HS), RD sedentary (RDS), RD aerobic training (RDAT). RDS and RDAT were subjected to unilateral renal ischemia-reperfusion (10 min) and 21days after that, RDAT was subjected to 6 weeks HIAT (swimming). Serum creatinine (Cr) and muscle morphometry (cross-sectional area = CSA) of gastrocnemius were analyzed. Results: Cr was higher (p = 0.0053) in RDS (0.82 ± 0.04) than in the others (RDAT 0.55 ± 0.04; HS 0.55 ± 0.04). Morphometric analysis (class interval of CSA in μm2/absolute frequency of muscle fibers in each class) indicated that 50th percentile occurred in: HS 7th class (3000.00-3499.00/515), RDS, 8th class (3500.00-3999.00/484), RDAT 5th class (2000.00-2499.00/856). CSA of largest fibers in RDS, RDAT, HS was 9953.00 μm2, 9969.00 μm2,11228.00 μm2, respectively. High frequency of fibers with lower CSA occurred in 4th, 5th, 6th and 7th class in RDA, absence of fibers into 22nd, 23rd classes (RDS and RDAT). Conclusion: HIAT in an animal model of RD resulted in increased the number of muscle fibers with smaller CSA.


Assuntos
Animais , Condicionamento Físico Animal/fisiologia , Músculo Esquelético/fisiopatologia , Insuficiência Renal/fisiopatologia , Valores de Referência , Natação/fisiologia , Peso Corporal/fisiologia , Traumatismo por Reperfusão/fisiopatologia , Reprodutibilidade dos Testes , Ratos Wistar , Fibras Musculares Esqueléticas/fisiologia , Creatinina/sangue , Modelos Animais de Doenças , Comportamento Sedentário , Rim/fisiopatologia , Rim/irrigação sanguínea
7.
Clinics ; 74: e981, 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1011918

RESUMO

OBJECTIVE: Muscle wasting contributes to the reduced quality of life and increased mortality in chronic obstructive pulmonary disease (COPD). Muscle atrophy in mice with cachexia was caused by Activin A binding to ActRIIB. The role of circulating Activin A leading to muscle atrophy in COPD remains elusive. METHODS: In the present study, we evaluated the relationship between serum levels of Activin A and skeletal muscle wasting in COPD patients. The expression levels of serum Activin A were measured in 78 stable COPD patients and in 60 healthy controls via ELISA, which was also used to determine the expression of circulating TNF-α levels. Total skeletal muscle mass (SMM) was calculated according to a validated formula by age and anthropometric measurements. The fat-free mass index (FFMI) was determined as the fat-free mass (FFM) corrected for body surface area. RESULTS: Compared to the healthy controls, COPD patients had upregulated Activin A expression. The elevated levels of Activin A were correlated with TNF-α expression, while total SMM and FFMI were significantly decreased in COPD patients. Furthermore, serum Activin A expression in COPD patients was negatively associated with both FFMI and BMI. CONCLUSION: The above results showed an association between increased circulating Activin A in COPD patients and the presence of muscle atrophy. Given our previous knowledge, we speculate that Activin A contributes to skeletal muscle wasting in COPD.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Atrofia Muscular/etiologia , Doença Pulmonar Obstrutiva Crônica/complicações , Ativinas/sangue , Caquexia/metabolismo , Atrofia Muscular/metabolismo , Atrofia Muscular/sangue , Índice de Massa Corporal , Estudos de Casos e Controles , Fator de Necrose Tumoral alfa/metabolismo , Fator de Necrose Tumoral alfa/sangue , Músculo Esquelético/fisiopatologia , Doença Pulmonar Obstrutiva Crônica/sangue , Ativinas/metabolismo , Subunidades beta de Inibinas
8.
Motriz (Online) ; 25(3): e101961, 2019. tab, graf, ilus
Artigo em Inglês | LILACS | ID: biblio-1040635

RESUMO

Aim: Determine the relationship between changes in oxidative stress markers, muscle damage, DOMS, and their relationship with performance in response to a session of football training during a 1-week recovery period of young football players. Methods: Nineteen young football players aged 16.7±1.0 years were included in the study. After initial evaluation for basal levels of oxidative stress and muscle damage markers, DOMS, and performance testing (Vertical Jump, Agility T-test, and RAST potency test), the athletes were submitted to a routine training session composed of squatting exercises, followed by a simulated football match of 45 minutes. Athletes were reevaluated for 3 consecutive days (24h, 48h, and 72h after the training session) during the recovery week. Results: An elevated DOMS score in the quadriceps and posterior thigh (P<0.05) and serum CK was observed 24h to 72h after the training session. Despite elevated DOMS and CK muscle damage markers, no changes were observed in the vertical jump test, RAST potency test, or agility T-test during the recovery week. In addition, no changes in the oxidative stress markers analyzed MDA, AOPP, and GSH were observed during the recovery week. Conclusion: Training sessions with squatting exercises and simulated matches promote a rise in CK and DOMS, but not sufficient to impair physical performance during the training week in young players.(AU)


Assuntos
Humanos , Masculino , Adolescente , Futebol , Estresse Oxidativo/fisiologia , Músculo Esquelético/fisiopatologia , Desempenho Atlético/fisiologia , Biomarcadores , Teste de Esforço/métodos
9.
Int. j. morphol ; 36(4): 1210-1215, Dec. 2018. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-975684

RESUMO

El entrenamiento de fuerza, especialmente con alta intensidad de carga, permite aumentar la fuerza y trofismo muscular, pero también se asocia a daño muscular inducido por ejercicio (DMIE). Una nueva modalidad de entrenamiento, combina una baja intensidad de carga con la restricción parcial del flujo sanguíneo (RPFS) alrededor del músculo, siendo prometedor en cuanto el desarrollo de la fuerza y trofismo muscular. El objetivo del estudio fue comparar el rendimiento de fuerza máxima de los músculos cuádriceps e isquiotibiales (FM-Q y FM-I) y marcadores de daño muscular (CK) e inflamación sistémica (PCRus) entre un entrenamiento de baja intensidad de carga con RPFS, versus uno de alta y otro de baja intensidad de carga sin RPFS en jóvenes físicamente activos durante cuatro semanas de entrenamiento. Veintitrés participantes midieron la FM-Q y FM-I previo y al término de la intervención; además, antes del inicio de la primera sesión, y antes y después del término de la última sesión se midió la CK y PCRus. En los tres tipos de entrenamiento se produjeron aumentos equivalentes en la fuerza máxima, a excepción de la FM-Q del entrenamiento con baja intensidad sin RPFS. Solo en el entrenamiento con RPFS la CK y PCRus se modifican al finalizar la intervención, y aun cuando el estrés miocelular parece ser más alto que en los otros tipos de entrenamiento, no indicaría daño muscular.


Strength training, especially with high load intensity, allows increasing muscle strength and trophism, but it is also associated with exercise-induced muscle damage (EIMD). A new training modality, a combination of loading with the partial restriction blood flow (PRBF) around the muscle, being promising in the development of strength and muscular trophism. The aim of the study was to compare the maximum strength (MS) performance of quadriceps and hamstrings (MS-Q and MS-I) and muscle damage biomarkers (Creatine Kinase, CK) and systemic inflammation (high sensitivity - CRP, hs-CRP) between a low intensity load training with PRBF, versus one high and another low load intensity without PRBF in physically active youngsters during four weeks of training. Twenty-three participants measured MSQ and MS-I and the intervention term. In addition, before the start of the first session, before and after the end of the last session, CK and hsCRP were measured. In the three types of training the equivalent benefits in MS are produced, an exception of the MS-Q of low intensity training without PRBF. Only in the training with PRBF, the CK and hsCPR are modified at the end of the intervention, and even though the myocellular stress seems to be higher than in the other types of training, it would not indicate muscle damage.


Assuntos
Humanos , Masculino , Adulto Jovem , Exercício Físico/fisiologia , Músculo Esquelético/lesões , Força Muscular/fisiologia , Fluxo Sanguíneo Regional/fisiologia , Proteína C-Reativa , Biomarcadores , Músculo Esquelético/fisiopatologia , Músculo Esquelético/irrigação sanguínea , Mediadores da Inflamação , Creatina Quinase
10.
Rev. Pesqui. Fisioter ; 8(4): 564-578, nov., 2018. ilus, tab
Artigo em Inglês, Português | LILACS | ID: biblio-968836

RESUMO

INTRODUÇÃO: DPOC está associada a um processo inflamatório sistêmico que pode causar sarcopenia, redução da função e massa muscular, embora sua frequência e intensidade não seja completamente conhecida em portadores dessa enfermidade. OBJETIVO: descrever a prevalência e métodos de identificação da sarcopenia na DPOC através de uma revisão sistemática. MATERIAIS E MÉTODOS: Revisão sistemática utilizando a metodologia PICO e palavras-chave (Chronic Obstructive Pulmonary Disease, Sarcopenia). Foram incluídos estudos publicados que estimaram a prevalência de sarcopenia na DPOC. Excluídos aqueles cujo método não detalhou o diagnóstico da sarcopenia. RESULTADOS: A pesquisa resultou inicialmente em 897 artigos. Desses, 877 foram excluídos, sendo 20 selecionados (15 transversais, cinco longitudinais, um caso/controle). As amostras variaram de 57 a 2.582 participantes, a maioria (70%) conduzida em ambulatório. Um estudo foi de base populacional. A idade média foi de 66 anos. A prevalência de sarcopenia na DPOC variou (4,4% a 86,5%). Os métodos diagnósticos utilizados para determinar massa muscular foram o Dual X-ray Absorptiometry, a bioimpedância e as equações de referência. A força muscular foi estimada utilizando-se a preensão manual em dinamômetros portáteis ou a flexão/extensão do joelho através do dinamômetro isocinético. A capacidade funcional foi avaliada pelo teste de caminhada dos seis minutos ou através do teste de velocidade da marcha. CONCLUSÃO: A prevalência de sarcopenia na DPOC encontrada nos estudos (4,4 a 86,5%) é muito variável. Influenciada não somente pela característica do paciente, mas também pelo local, delineamento e método diagnóstico utilizado. Uma padronização de métodos parece ser necessária para se uniformizar condutas na literatura. [AU]


COPD is associated with a systemic inflammatory process that can cause sarcopenia, reduced function and muscle mass, although its frequency and intensity is not completely known in patients with this disease. OBJECTIVE: To describe the prevalence and methods of identifying sarcopenia in COPD through a systematic review. METHODS AND MATERIALS: Systematic review using the PICO methodology and keywords (Chronic Obstructive Pulmonary Disease, Sarcopenia). We included published studies that estimated the prevalence of sarcopenia in COPD. Excluding those whose method did not detail the diagnosis of sarcopenia. RESULTS: The search resulted initially in 897 articles. Of these, 877 were excluded, of which 20 were selected (15 transverse, five longitudinal, one case / control). Samples ranged from 57 to 2,582 subjects, the majority (70%) conducted on an outpatient basis. One study was population-based. The mean age was 66 years. The prevalence of sarcopenia in COPD varied (4.4% to 86.5%). The diagnostic methods used to determine muscle mass were Dual X-ray Absorptiometry, bioimpedance and reference equations. Muscle strength was estimated using manual gripping on portable dynamometers or knee flexion / extension through the isokinetic dynamometer. Functional capacity was assessed by the six-minute walk test or gait speed test. CONCLUSION: The prevalence of sarcopenia in COPD found in the studies (4.4 to 86.5%) is very variable. Influenced not only by the patient's characteristic, but also by the location, design and diagnostic method used. A standardization of methods seems to be necessary to standardize conducts in the literature. [AU]


Assuntos
Humanos , Masculino , Feminino , Idoso , Doença Pulmonar Obstrutiva Crônica/complicações , Sarcopenia/epidemiologia , Prevalência , Músculo Esquelético/fisiopatologia , Força Muscular , Sarcopenia/diagnóstico , Teste de Caminhada
11.
Braz. j. med. biol. res ; 51(11): e7702, 2018. graf
Artigo em Inglês | LILACS | ID: biblio-951726

RESUMO

When exercises are done in intense or exhaustive modes, several acute biochemical mechanisms are triggered. The use of cryotherapy as cold-water immersion is largely used to accelerate the process of muscular recovery based on its anti-inflammatory and analgesic properties. The present study aimed to study the biochemical effects of cold-water immersion treatment in mice submitted to exercise-induced exhaustion. Swiss albino mice were divided into 4 treatment groups: control, cold-water immersion (CWI), swimming exhaustive protocol (SEP), and SEP+CWI. Treatment groups were subdivided into times of analysis: 0, 1, 3, and 5 days. Exhaustion groups were submitted to one SEP session, and the CWI groups submitted to one immersion session (12 min at 12°C) every 24 h. Reactive species production, inflammatory, cell viability, and antioxidant status were assessed. The SEP+CWI group showed a decrease in inflammatory damage biomarkers, and reactive species production, and presented increased cell viability compared to the SEP group. Furthermore, CWI increased acetylcholinesterase activity in the first two sessions. The present study showed that CWI was an effective treatment after exercise-induced muscle damage. It enhanced anti-inflammatory response, decreased reactive species production, increased cell viability, and promoted redox balance, which could decrease the time for the recovery process.


Assuntos
Animais , Masculino , Coelhos , Condicionamento Físico Animal/efeitos adversos , Condicionamento Físico Animal/fisiologia , Crioterapia/métodos , Músculo Esquelético/fisiopatologia , Músculo Esquelético/lesões , Imersão/fisiopatologia , Acetilcolinesterase/análise , Natação/lesões , Tiazóis , Fatores de Tempo , Sobrevivência Celular/fisiologia , Reprodutibilidade dos Testes , Espécies Reativas de Oxigênio/análise , Temperatura Baixa , Fluoresceínas/análise , Miosite/prevenção & controle , Antioxidantes/análise
12.
Rev. bras. epidemiol ; 21(supl.2): e180009, 2018. tab, graf
Artigo em Português | LILACS | ID: biblio-985272

RESUMO

RESUMO: Objetivo: Estimar a prevalência e os fatores associados à sarcopenia, dinapenia e sarcodinapenia em idosos residentes no município de São Paulo. Métodos: Estudo transversal de base populacional envolvendo 1.168 idosos pertencentes à terceira onda do Estudo SABE (Saúde, Bem-Estar e Envelhecimento), em 2010. Foramconsiderados sarcopênicos os idosos com índice de massa muscular esquelética ≤ 8,90 kg/m2 para homens e ≤6,37 kg/m2 para mulheres, dinapênicos aqueles com força de preensão manual < 30 kg para homens e < 20kg para mulheres, e sarcodinapênicos aqueles que apresentavam sarcopenia associada à dinapenia. Características sociodemográficas, comportamentais, condições clínicas, nutricionais e bioquímicas foram consideradas para determinar os fatores associados a cada uma das três condições por meio de regressão logística multinomial. Resultados: A prevalência de sarcopenia, dinapenia e sarcodinapenia foi, respectivamente, 4,8% (IC95% 3,6-6,3), 30,9% (IC95% 27,5-34,6) e 9,0% (IC95% 7,2-11,3). O avanço da idade e a desnutrição foram associados às três condições analisadas. O prejuízo cognitivo foi associado à dinapenia e à sarcodinapenia. A escolaridade, ter o hábito de fumar e não ter vida conjugal foram associados à sarcopenia, enquanto osteoartrite, escolaridade, ser ex-fumante e apresentar valores baixos de hemoglobina foram associados à dinapenia. Foram associados à sarcodinapenia o hábito de fumar e o risco de desnutrição. Conclusão: Dinapenia é a condição mais prevalente na população idosa, seguida pela sarcodinapenia e sarcopenia. Exceto por idade, escolaridade e desnutrição, os fatores associados à sarcopenia e à dinapenia são distintos. Entretanto, há similaridades em algumas associações quando se trata da presença de sarcodinapenia.


ABSTRACT: Objectives: To estimate the prevalence of sarcopenia, dynapenia, and sarcodynapenia and associated factors in older adults in the city of São Paulo, Brazil. Methods: A population-based, cross-sectional study was conducted with 1,168 older adults who participated in the third wave of the Health, Well-being, and Aging study in 2010 (SABE study). Men and women with skeletal muscle mass ≤ 8.90 and ≤ 6.37 kg/m2, respectively, were considered sarcopenic. Men and women with grip strength < 30 and < 20 kg, respectively, were considered dynapenic. Those with both conditions were considered sarcodynapenic. Sociodemographic, behavioral, clinical, nutritional, and biochemical characteristics were investigated as factors associated with each of the three conditions using multinomial logistic regression. Results: Theprevalence of sarcopenia, dynapenia, and sarcodynapenia was 4.8% (95%CI 3.6 - 6.3), 30.9% (95%CI 27.5 - 34.6) and 9.0% (95%CI 7.2-11.3), respectively. An increase in age and malnutrition was associated with all the three conditions. Cognitive impairment was associated with both dynapenia and sarcodynapenia. Schooling, current smoking habit, and not having a marital life were associated with sarcopenia. Osteoarthritis, schooling, being an ex-smoker, and low hemoglobin were associated with dynapenia. Smoking habit and the risk of malnutrition were associated with sarcodynapenia. Conclusion: Dynapenia is more prevalent among older adults, followed by sarcodynapenia, and sarcopenia. With the exception of age, schooling, and malnutrition, the factors associated with sarcopenia and dynapenia are different. However, there are similarities in some associations regarding the presence of sarcodynapenia.


Assuntos
Humanos , Masculino , Feminino , Idoso , Idoso de 80 Anos ou mais , Debilidade Muscular/epidemiologia , Sarcopenia/epidemiologia , Vida Independente/estatística & dados numéricos , Fatores Socioeconômicos , Brasil/epidemiologia , Avaliação Geriátrica , Modelos Logísticos , Avaliação Nutricional , Prevalência , Estudos Transversais , Fatores de Risco , Distribuição por Sexo , Distribuição por Idade , Músculo Esquelético/fisiopatologia , Debilidade Muscular/etnologia , Sarcopenia/etiologia , Pessoa de Meia-Idade
13.
J. bras. pneumol ; 43(6): 464-471, Nov.-Dec. 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-893880

RESUMO

ABSTRACT Objective: To evaluate a 24-month supervised, community-based maintenance exercise program after 3 months of pulmonary rehabilitation (PR) in comparison with a 27-month physical activity counseling program, in terms of the effects on maximal muscle strength, muscle power output, and exercise capacity, in individuals with COPD. Methods: Sixty-three men with moderate-to-severe COPD were recruited from two previous studies. Of those 63 participants, 31 were offered 3 months of PR followed by a 24-month supervised maintenance exercise program (24MME group) and 32 were offered a 27-month physical activity counseling program (27MPAC group). Measurements at 3 months and at the end of the study period included maximal strength of the upper and lower limbs, power output of the lower limbs, six-minute walk distance (6MWD), and quality of life. Results: At 27 months, the improvements in maximal strength of the upper and lower limbs were greater in the 24MME group than in the 27MPAC group (37.6 ± 28.3% and 28.4 ± 13.3%, respectively, vs. 8.8 ± 16% and 13.6 ± 16.4%, respectively; p < 0.05), as was the improvement in power output of the lower limbs (24.6 ± 18.4% vs. −2.3 ± 28.5%; p < 0.01). The increase in the 6MWD after 3 months was also greater in the 24MME group than in the 27MPAC group (33.2 ± 36.6 m vs. 2.9 ± 34.7 m; p < 0.05), although there were no differences between the two groups in terms of the Δ6MWD at 27 months (vs. baseline). Conclusions: A supervised, community-based maintenance program is a successful long-term strategy to preserve the benefits of PR on peripheral muscle function and exercise capacity in individuals with COPD. However, physical activity counseling can maintain maximal muscle strength and exercise capacity in such individuals.


RESUMO Objetivo: Avaliar um programa comunitário supervisionado de 24 meses de exercícios de manutenção precedido de 3 meses de reabilitação pulmonar (RP) em comparação com um programa de 27 meses de aconselhamento de atividade física, quanto aos efeitos na força muscular máxima, potência muscular e capacidade de exercício em indivíduos com DPOC. Métodos: Foram recrutados 63 homens com DPOC moderada a grave de dois estudos anteriores. A 31 desses 63 participantes foram oferecidos 3 meses de RP seguidos de um programa supervisionado de 24 meses de exercícios de manutenção (grupo 24MEM), e a 32, um programa de 27 meses de aconselhamento de atividade física (grupo 27MAAF). Medidas realizadas aos 3 meses e ao final do período estudado incluíram força máxima dos membros superiores e inferiores, potência dos membros inferiores, distância percorrida no teste de caminhada de seis minutos (DTC6) e qualidade de vida. Resultados: Aos 27 meses, a melhora da força máxima dos membros superiores e inferiores foi maior no grupo 24MEM que no grupo 27MAAF (37,6 ± 28,3% e 28,4 ± 13,3%, respectivamente, vs. 8,8 ± 16% e 13,6 ± 16,4%, respectivamente; p < 0,05), e houve melhora da potência dos membros inferiores (24,6 ± 18,4% vs. −2,3 ± 28,5%; p < 0,01). O aumento da DTC6 após 3 meses também foi maior no grupo 24MEM que no grupo 27MAAF (33,2 ± 36,6 m vs. 2,9 ± 34,7 m; p < 0,05), mas não houve diferenças entre os grupos quanto a ΔDTC6 aos 27 meses (vs. basal). Conclusões: Um programa comunitário supervisionado de manutenção é uma estratégia de longo prazo bem sucedida para preservar os benefícios da RP na função muscular periférica e capacidade de exercício em indivíduos com DPOC. No entanto, o aconselhamento de atividade física consegue manter a força muscular máxima e a capacidade de exercício nesses indivíduos.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Tolerância ao Exercício/fisiologia , Músculo Esquelético/fisiopatologia , Doença Pulmonar Obstrutiva Crônica/fisiopatologia , Terapia por Exercício/métodos , Força Muscular/fisiologia , Qualidade de Vida , Fatores de Tempo , Inquéritos e Questionários , Estudos Retrospectivos , Resultado do Tratamento , Doença Pulmonar Obstrutiva Crônica/reabilitação , Teste de Caminhada
14.
São Paulo med. j ; 135(5): 434-443, Sept.-Oct. 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-904112

RESUMO

ABSTRACT CONTEXT AND OBJECTIVE: Sarcopenia is an emerging public health issue in Brazil. Because of its high prevalence and the lack of national data, the objective here was to identify cutoff points for appendicular skeletal muscle (ASM) and handgrip strength in relation to fear of falling among Brazilian older adults. DESIGN AND SETTING: Cross-sectional study; in the community. METHODS: Participants underwent morphological and functional evaluations; and were asked about previous falls and fear of falling. Different adjustments to ASM and handgrip strength were used. Slow walking speed was defined as < 0.8 m/s or 1.0 m/s. Gender and age groups were compared using t tests, analysis of variance (ANOVA), chi-square test or Fisher's exact test. Receiver operating characteristic curves were used to identify cutoffs for ASM and handgrip strength in relation to fear of falling. RESULTS: 578 older adults participated in this study. Function levels decreased with increasing age, and body composition differed between the sexes. In relation to fear of falling, the cutoffs for ASM adjusted for body mass index (BMI) were < 0.85 for men and < 0.53 for women; the cutoffs for absolute handgrip strength and relative handgrip strength (adjusted for BMI) were 30.0 kgf and 21.7 kgf, and 1.07 and 0.66, for men and women, respectively. CONCLUSION: The values presented can be used as references in clinical practice and research. We recommend use of ASM adjusted for BMI and choosing between absolute and relative handgrip strength for men and women, according to study needs.


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Acidentes por Quedas , Músculo Esquelético/fisiopatologia , Força da Mão/fisiologia , Medo , Sarcopenia/diagnóstico , Velocidade de Caminhada/fisiologia , Prevalência , Estudos Transversais , Curva ROC , Músculo Esquelético/patologia , Sarcopenia/complicações , Sarcopenia/fisiopatologia
15.
Trends psychiatry psychother. (Impr.) ; 39(3): 147-157, July-Sept. 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-904585

RESUMO

Abstract Objective Anxiety as a uni- or multidimensional construct has been under discussion. The unidimensional approach assumes that there is a general trait anxiety, which predisposes the individuals to increases in state anxiety in various threatening situations. In this case, there should be a correlation between state and trait anxiety in any situation of threat. Therefore, the aim of this study was to investigate the correlation between trait and state anxiety in participants exposed to two different anxiogenic situations: interpersonal threat (Video-Monitored Stroop Test - VMST) and physical threat (third molar extraction - TME). Methods Participants with various levels of trait anxiety (general trait: State-Trait Anxiety Inventory - STAI, Hospital Anxiety and Depression Scale; specific trait: Social Phobia Inventory, Dental Anxiety Scale) had their anxious state evaluated (STAI, self-evaluation of tension level, heart rate, electromyogram activity) before, during and after the VMST or the TME. Results In VMST, trait anxiety correlated to state anxiety (psychological parameters) in all test phases. However, in TME, the only trait measurement that correlated to state anxiety (psychological parameters) was the Dental Anxiety Scale. Conclusion Trait anxiety correlates positively to state anxiety in situations of interpersonal threat, but not of physical threat.


Resumo Objetivo A ansiedade como um construto uni ou multidimensional tem estado em discussão. A abordagem unidimensional presume que há uma ansiedade-traço geral, a qual predispõe o indivíduo a aumentar a ansiedade-estado em situações de ameaça. Neste caso, deveria existir uma correlação entre estado e traço ansioso em diferentes situações ameaçadoras. Portanto, o objetivo deste estudo foi avaliar a correlação entre ansiedade-traço e ansiedade-estado em participantes que foram expostos a duas situações ansiogênicas diferentes: ameaça interpessoal (Teste de Stroop Monitorado por Vídeo - TSMV) e ameaça física (exodontia do terceiro molar - ETM). Métodos Participantes com vários níveis de ansiedade-traço (traço geral: Inventário de Ansiedade Traço-Estado - IDATE; Escala Hospitalar de Ansiedade e Depressão; traço específico: Inventário de Fobia Social, Escala de Ansiedade Dental de Corah) tiveram seus estados ansiosos avaliados (IDATE, escala analógica de tensão, frequência cardíaca, eletromiografia) antes, durante e depois do TSMV ou da ETM. Resultados No TSMV, a ansiedade-traço correlacionou-se com a ansiedade-estado (parâmetros psicológicos) em todas as fases do teste. Entretanto, na ETM, a única medida de traço que se correlacionou com a ansiedade-estado (parâmetros psicológicos) foi a Escala de Ansiedade Dental de Corah. Conclusão A ansiedade-traço correlaciona-se positivamente com a ansiedade-estado em situações de ameaça interpessoal, mas não de ameaça física.


Assuntos
Humanos , Masculino , Adolescente , Adulto , Adulto Jovem , Personalidade , Ansiedade/diagnóstico , Ansiedade/fisiopatologia , Testes de Personalidade , Escalas de Graduação Psiquiátrica , Extração Dentária/psicologia , Análise de Variância , Músculo Esquelético/fisiopatologia , Eletromiografia , Teste de Stroop , Relações Interpessoais , Dente Serotino
16.
Clinics ; 72(5): 272-275, May 2017. tab
Artigo em Inglês | LILACS | ID: biblio-840072

RESUMO

OBJECTIVE: The aim of our study was to evaluate associations between maximum voluntary contraction torques of the lower limbs and body composition for subjects with severe obesity. METHODS: Body composition was evaluated by bioelectrical impedance analysis, and maximum voluntary contraction torques of the lower limbs were measured using an isokinetic dynamometer. One hundred thirty-two patients were enrolled (100 females and 32 males). Eighty-seven patients had a body mass index between 40 and 49.9 kg/m2 (the A group), and 45 patients had a body mass index between 50 and 59.9 kg/m2 (the B group). RESULTS: Absolute extension and flexion torques had weak associations with fat-free mass but a moderate association with absolute extension torque and fat-free mass of the lower limbs. There were no significant differences between the A and B groups with respect to absolute extension and flexion torques. For the A group, absolute extension and flexion torques were moderately associated with fat-free mass and with fat-free mass of the lower limbs. For the B group, there were only moderate associations between absolute extension and flexion torques with fat-free mass of the lower limbs. CONCLUSIONS: Our findings demonstrate that both groups exhibited similar absolute torque values. There were weak to moderate associations between absolute extension and flexion torques and fat-free mass but a moderate association with fat-free mass of the lower limbs. Individuals with severe obesity should strive for greater absolute torques, fat-free mass and especially fat-free mass of the lower limbs to prevent functional limitations and physical incapacity.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Composição Corporal/fisiologia , Contração Muscular/fisiologia , Força Muscular/fisiologia , Obesidade Mórbida/fisiopatologia , Antropometria , Impedância Elétrica , Extremidade Inferior/fisiopatologia , Dinamômetro de Força Muscular , Músculo Esquelético/fisiopatologia , Valores de Referência , Índice de Gravidade de Doença , Estatísticas não Paramétricas , Torque
17.
Einstein (Säo Paulo) ; 15(1): 77-84, Jan.-Mar. 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-840289

RESUMO

ABSTRACT Objective To evaluate the effect of jumping in aquatic environment on nociception and in the soleus muscle of trained and not trained Wistar rats, in the treatment of compressive neuropathy of the sciatic nerve. Methods Twenty-five Wistar rats were distributed into five groups: Control, Lesion, Trained + Lesion, Lesion + Exercise, and Trained + Lesion + Exercise. The training was jumping exercise in water environment for 20 days prior to injury, and treatment after the injury. Nociception was evaluated in two occasions, before injury and seven after injury. On the last day of the experiment, the right soleus muscles were collected, processed and analyzed as to morphology and morphometry. Results In the assessment of nociception in the injury site, the Control Group had higher average than the rest, and the Lesion Group was larger than the Trained + Lesion and Lesion + Exercise Groups. The Control Group showed higher nociceptive threshold in paw, compared to the others. In the morphometric analysis, in relation to Control Group, all the injured groups showed decreased muscle fiber area, and in the Lesion Group was lower than in the Lesion + Exercise Group and Trained + Lesion Group. Considering the diameter of the muscle fiber, the Control Group had a higher average than the Trained + Lesion Group and the Trained + Lesion + Exercise Group; and the Lesion Group showed an average lower than the Trained + Lesion and Lesion + Exercise Groups. Conclusion Resistance exercise produced increased nociception. When performed prior or after nerve damage, it proved effective in avoiding hypotrophy. The combination of the two protocols led to decrease in diameter and area of the muscle fiber.


RESUMO Objetivo Avaliar os efeitos do salto em meio aquático, na nocicepção e no músculo sóleo, em ratos Wistar treinados e não treinados, no tratamento de neuropatia compressiva do nervo isquiático. Métodos Foram distribuídos em cinco grupos 25 ratos Wistar: Controle, Lesão, Treinado + Lesão, Lesão + Exercício e Treinado + Lesão + Exercício. O treino foi com exercício de salto em meio aquático durante 20 dias, prévio à lesão, e o tratamento ocorreu após a lesão. Foram realizadas avaliações da nocicepção, sendo uma pré-lesão e sete pós-lesão. No último dia de experimento, os músculos sóleos direitos foram coletados, processados e analisados por meio de morfologia e morfometria. Resultados Na avaliação da nocicepção no local da lesão, o Grupo Controle apresentou média maior que os demais, e o Grupo Lesão foi maior que os Grupos Treinado + Lesão e Lesão + Exercício. O Grupo Controle apresentou limiar nociceptivo na pata maior com relação aos demais. Nas análises morfométricas, em relação ao Grupo Controle, todos os grupos lesionados apresentaram diminuição da área da fibra muscular; o Grupo Lesão apresentou-se menor que os Grupos Treinado + Lesão e Lesão + Exercício. No diâmetro da fibra muscular, o Grupo Controle apresentou média maior que os Grupos Treinado + Lesão e Treinado + Lesão + Exercício, e o Grupo Lesão apresentou média menor que os Grupos Treinado + Lesão e Lesão + Exercício. Conclusão O exercício físico resistido produziu aumento da nocicepção. Quando realizado previamente ou após a lesão nervosa, mostrou-se eficaz em evitar a hipotrofia. A associação dos dois protocolos levou à diminuição do diâmetro e da área da fibra muscular.


Assuntos
Animais , Masculino , Músculo Esquelético/fisiopatologia , Neuropatia Ciática/fisiopatologia , Neuropatia Ciática/terapia , Nociceptividade/fisiologia , Hidroterapia/métodos , Síndromes de Compressão Nervosa/fisiopatologia , Síndromes de Compressão Nervosa/terapia , Condicionamento Físico Animal/fisiologia , Valores de Referência , Fatores de Tempo , Distribuição Aleatória , Reprodutibilidade dos Testes , Resultado do Tratamento , Ratos Wistar
18.
Einstein (Säo Paulo) ; 15(1): 71-76, Jan.-Mar. 2017. graf
Artigo em Inglês | LILACS | ID: biblio-840300

RESUMO

ABSTRACT Objective To investigate if electrical stimulation through Russian current is able to maintain morphology of the cranial tibial muscle of experimentally denervated rats. Methods Thirty-six Wistar rats were divided into four groups: the Initial Control Group, Final Control Group, Experimental Denervated and Treated Group, Experimental Denervated Group. The electrostimulation was performed with a protocol of Russian current applied three times per week, for 45 days. At the end, the animals were euthanized and histological and morphometric analyses were performed. Data were submitted to statistical analysis with a significance level of p<0.05. Results The Experimental Denervated Group and the Experimental Denervated and Treated Group had cross-sectional area of smaller fiber compared to the Final Control Group. However, there was significant difference between the Experimental Denervated Group and Experimental Denervated and Treated Group, showing that electrical stimulation minimized muscle atrophy. The Experimental Denervated and Treated Group and Initial Control Group showed similar results. Conclusion Electrical stimulation through Russian current acted favorably in maintaining morphology of the cranial tibial muscle that was experimentally denervated, minimizing muscle atrophy.


RESUMO Objetivo Investigar se a estimulação elétrica pela corrente russa é capaz de manter a morfologia do músculo tibial cranial de ratos desnervados experimentalmente. Métodos Foram utilizados 36 ratos Wistar, distribuídos em quatro grupos: Grupo Controle Inicial, Grupo Controle Final, Grupo Experimental Desnervado Tratado, Grupo Experimental Desnervado. A eletroestimulação foi realizada com um protocolo de corrente russa aplicada três vezes por semanas, durante 45 dias. Ao final, os animais foram eutanasiados e, em seguida, foram realizadas as análises histológica e morfométrica. Os dados foram submetidos à análise estatística, com nível de significância de p<0,05. Resultados Os Grupos Experimental Desnervado e o Grupo Experimental Desnervado Tratado apresentaram área de secção transversal da fibra menor quando comparados ao Grupo Controle Final. Entretanto, constatou-se diferença significativa entre o Grupo Experimental Desnervado e o Grupo Experimental Desnervado Tratado, mostrando que a estimulação elétrica minimizou atrofia muscular. Ainda, observou-se que o Grupo Experimental Desnervado Tratado apresentou resultados semelhantes ao Grupo Controle Inicial. Conclusão A estimulação elétrica por meio da corrente russa foi favorável na manutenção da morfologia do músculo tibial cranial desnervado experimentalmente, minimizando a atrofia muscular.


Assuntos
Animais , Masculino , Atrofia Muscular/prevenção & controle , Terapia por Estimulação Elétrica/métodos , Músculo Esquelético/fisiopatologia , Músculo Esquelético/inervação , Denervação Muscular , Tíbia/inervação , Atrofia Muscular/fisiopatologia , Reprodutibilidade dos Testes , Resultado do Tratamento , Ratos Wistar , Músculo Esquelético/patologia , Anatomia Transversal
19.
Arq. bras. cardiol ; 108(1): 74-80, Jan. 2017. tab
Artigo em Inglês | LILACS | ID: biblio-838680

RESUMO

Abstract Cachexia is a prevalent pathological condition associated with chronic heart failure. Its occurrence predicts increased morbidity and mortality independent of important clinical variables such as age, ventricular function, or heart failure functional class. The clinical consequences of cachexia are dependent on both weight loss and systemic inflammation, which accompany cachexia development. Skeletal muscle wasting is an important component of cachexia; it often precedes cachexia development and predicts poor outcome in heart failure. Cachexia clinically affects several organs and systems. It is a multifactorial condition where underlying pathophysiological mechanisms are not completely understood making it difficult to develop specific prevention and treatment therapies. Preventive strategies have largely focused on muscle mass preservation. Different treatment options have been described, mostly in small clinical studies or experimental settings. These include nutritional support, neurohormonal blockade, reducing intestinal bacterial translocation, anemia and iron deficiency treatment, appetite stimulants, immunomodulatory agents, anabolic hormones, and physical exercise regimens. Currently, nonpharmacological therapy such as nutritional support and physical exercise are considered central to cachexia prevention and treatment.


Resumo Caquexia é condição patológica prevalente em pacientes com insuficiência cardíaca (IC) associada. Sua ocorrência constitui marcador de gravidade da doença e está associada a aumento da morbidade e mortalidade independentemente de variáveis clínicas importantes como idade, função ventricular ou classe funcional da IC. As consequências clínicas da caquexia dependem tanto da perda de peso como da inflamação sistêmica que acompanha seu desenvolvimento. Perda da musculatura esquelética é importante componente da caquexia; ela frequentemente precede o desenvolvimento desta condição e está associada a mau prognóstico da IC. A caquexia afeta vários órgãos e sistemas. Sua origem é multifatorial; como os mecanismos fisiopatológicos envolvidos em seu desenvolvimento não estão completamente entendidos, há grande dificuldade no desenvolvimento de terapia específica para a prevenção e tratamento. Estratégias para a prevenção visam, principalmente, a preservação da massa muscular. Diferentes opções de tratamento têm sido descritas, a maioria delas avaliada em estudos experimentais ou pequenos estudos clínicos. Estas incluem suporte nutricional, bloqueio de sistemas neuro-hormonais, redução de translocação bacteriana intestinal, tratamento da anemia e ferrodeficiência, estimulantes de apetite, agentes imunomodulatórios, hormônios anabólicos, e diferentes programas de exercícios físicos. Atualmente, a terapia não farmacológica como o suporte nutricional e exercícios físicos tem sido considerada de grande importância na prevenção e tratamento da caquexia associada à IC.


Assuntos
Humanos , Caquexia/terapia , Insuficiência Cardíaca/terapia , Caquexia/fisiopatologia , Redução de Peso/fisiologia , Apoio Nutricional , Músculo Esquelético/fisiopatologia , Terapia por Exercício , Insuficiência Cardíaca/fisiopatologia
20.
Braz. j. med. biol. res ; 50(12): 6327, 2017. tab, graf
Artigo em Inglês | LILACS, SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-888973

RESUMO

Heart failure is characterized by the inability of the cardiovascular system to maintain oxygen (O2) delivery (i.e., muscle blood flow in non-hypoxemic patients) to meet O2 demands. The resulting increase in fractional O2 extraction can be non-invasively tracked by deoxygenated hemoglobin concentration (deoxi-Hb) as measured by near-infrared spectroscopy (NIRS). We aimed to establish a simplified approach to extract deoxi-Hb-based indices of impaired muscle O2 delivery during rapidly-incrementing exercise in heart failure. We continuously probed the right vastus lateralis muscle with continuous-wave NIRS during a ramp-incremental cardiopulmonary exercise test in 10 patients (left ventricular ejection fraction <35%) and 10 age-matched healthy males. Deoxi-Hb is reported as % of total response (onset to peak exercise) in relation to work rate. Patients showed lower maximum exercise capacity and O2 uptake-work rate than controls (P<0.05). The deoxi-Hb response profile as a function of work rate was S-shaped in all subjects, i.e., it presented three distinct phases. Increased muscle deoxygenation in patients compared to controls was demonstrated by: i) a steeper mid-exercise deoxi-Hb-work rate slope (2.2±1.3 vs 1.0±0.3% peak/W, respectively; P<0.05), and ii) late-exercise increase in deoxi-Hb, which contrasted with stable or decreasing deoxi-Hb in all controls. Steeper deoxi-Hb-work rate slope was associated with lower peak work rate in patients (r=-0.73; P=0.01). This simplified approach to deoxi-Hb interpretation might prove useful in clinical settings to quantify impairments in O2 delivery by NIRS during ramp-incremental exercise in individual heart failure patients.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Consumo de Oxigênio/fisiologia , Hemoglobinas/análise , Músculo Esquelético/metabolismo , Insuficiência Cardíaca/fisiopatologia , Perna (Membro)/irrigação sanguínea , Estudos de Casos e Controles , Estudos Prospectivos , Músculo Esquelético/fisiopatologia , Espectroscopia de Luz Próxima ao Infravermelho , Teste de Esforço , Insuficiência Cardíaca/metabolismo , Perna (Membro)/fisiopatologia
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