Neurosurgery for Refractory Schizophrenia: A Systematic Literature Review

Schizophrenia is a chronic and disabling psychiatric disease that can be refractory to conventional treatment. The present study aims to gather information about the circuitry related to schizophrenia to describe possible surgical targets, and to establish whether psychosurgery can be a safe and effective treatment option for refractory schizophrenia. A systematic review of the literature was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. An electronic search was performed in the Pubmed and BVSalud databases using medical subject headings (MeSH) combined with Boolean operators. Out of the 724 studies retrieved, 13 were included in the review. Regarding leucotomy without a stereotactic approach, we found side effects such as irritability, nervous excitement, cases of disinhibition, and compromised normal social control. In other stereotactic procedures, there was some improvement, mainly regarding aggressiveness and positive symptoms; an anterior capsulotomy had an efficacy rate of 74% according to the Clinical Global Impression (CGI) rating scales. The only deep brain stimulation (DBS) case report found in our study described a significant improvement in the positive and negative symptoms. The use of a stereotactic approach enables psychosurgery to be a safe and effective treatment option in cases of refractory schizophrenia, improving the quality of life and the symptoms. Cognitive and negative symptoms remain a challenge in the treatment of schizophrenia, revealing that more targets in the circuitrymust be surgically explored. Furthermore,more clinical trials are needed to compare these many surgical techniques and targets, using a standard evaluation parameter. The results show that DBS has a promising future in the treatment of refractory schizophrenia.

Epilepsia gelástica / Gelastic epilepsy

Con motivo de la publicación de un caso en el cual la risa involuntaria e inmotivada constituye la única manifestación clínica de Epilepsia en la edad adulta, se hace una revisión histórica del problema, se discute la fisiología de la risa normal, se enmarca la Epilepsia Gelástica en el contexto de la risa patológica y se comentan múltiples etiologías, diversas localizaciones lesionales y un espectro de patrones clínicos y electroencefalográficos en relación con Epilepsia Gelástica

Meningoencefalite a vírus e síndrome de Klüver-Bucy: relato de dois casos / Viral meningoencephalitis and Klüver-Bucy syndrome: report of 2 cases

Säo apresentados dois casos de meningoencefalite viral, de provável etiologia herpetica, que desenvolveram síndrome de Klüver-Bucy parcial. Aspectos clinicopatológicos, diagnósticos e terapêuticos da meningoencefalite herpética säo discutidos revisando-se também conceitos acerca da síndrome de Klüver-Bucy