RESUMO
Resumen El quilotórax se produce ante la ruptura, desgarro u obstrucción del conducto torácico o sus afluentes principales, lo que resulta en la liberación de quilo al espacio pleural. Ocurre más frecuentemente asociado a trauma o a lesiones malignas; pero han sido descritas otras causas. El diagnóstico se obtiene mediante toracocentesis y la determinación de las concentraciones de triglicéridos y colesterol en el líquido pleural. Las complicaciones incluyen la desnutrición, inmunosupresión y compromiso respiratorio. El tratamiento puede ser conservador o agresivo en función de la situación clínica.
Abstract Chylothorax occurs when there is rupture, laceration or obstruction of the thoracic duct or its main tributaries, resulting in the release of chyle into the pleural space. It most commonly occurs from trauma or malignancy, but other causes have been described. Diagnosis involves thoracocentesis and cholesterol and triglyceride measurement in the pleural fluid. Complications include malnutrition, immunosuppression and respiratory distress. Treatment may be either conservative or aggressive depending on the clinical scenario.
Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Toracostomia , Quilo , Quilomícrons , Quilotórax/diagnóstico , Cavidade Torácica , ToracenteseRESUMO
PURPOSE: We investigated the biocompatibility of n-butyl-2-cyanoacrylate (NBCA) in the cervical deep tissues of rats to assess its biocompatibility. METHODS: A total of 30 Sprague-Dawley rats were injected with NBCA. After 30, 90, 180, and 360 days, cubes of tissue (1 cm × 1 cm × 1 cm) surrounding the NBCA and normal tissue from the other side of the neck were excised from each rat. The adhesion of NBCA to adjacent structures was examined histologically. Cells were counted per high-power field (HPF), and fibrosis was graded with the measurement of fibrotic thickening. RESULTS: All animals displayed normal behavior without any symptoms of distress throughout the study. There was no recognizable inflammatory reaction, foreign body reaction, or fibrosis in the 30 control samples. The analyses of experimental samples showed significantly decreased inflammatory cell counts over time (lymphoplasma cell count decreased from 100 (range, 70–100) to 30 (range, 30–50) per HPF, P = 0.010; neutrophil count decreased from 2 (range, 2–30) to 0 (range, 0–2) per HPF, P = 0.017). However, there was no significant difference in the number of multinuclear giant cells throughout the study period (a decrease from 22 [range, 16–34] to 16 [range, 12–22] per HPF, P = 0.287). The level of fibrosis was Common Toxicity Criteria ver. 4.0 Grade 1 without further thickening (P = 0.600). However, maturation of fibrosis progressed gradually. CONCLUSION: NBCA was biologically tolerable in the cervical deep tissues of rats. However, precautions are needed with respect to preventing a sustained foreign body reaction and fibrosis.
Assuntos
Animais , Ratos , Materiais Biocompatíveis , Contagem de Células , Quilo , Cianoacrilatos , Embucrilato , Fibrose , Reação a Corpo Estranho , Células Gigantes , Pescoço , Esvaziamento Cervical , Neutrófilos , Estudos Prospectivos , Ratos Sprague-DawleyRESUMO
With improving survival of children with complex congenital heart disease (CCHD), postoperative complications, like protein-losing enteropathy (PLE) are increasingly encountered. A 3-year-old girl with surgically corrected CCHD (ventricular inversion/L-transposition of the great arteries, ventricular septal defect, pulmonary atresia, post-double switch procedure [Rastelli and Glenn]) developed chylothoraces. She was treated with pleurodesis, thoracic duct ligation and subsequently developed chylous ascites and PLE (serum albumin ≤0.9 g/dL) and was malnourished, despite nutritional rehabilitation. Lymphangioscintigraphy/single-photon emission computed tomography showed lymphatic obstruction at the cisterna chyli level. A segmental chyle leak and chylous lymphangiectasia were confirmed by gastrointestinal endoscopy, magnetic resonance (MR) enterography, and MR lymphangiography. Selective glue embolization of leaking intestinal lymphatic trunks led to prompt reversal of PLE. Serum albumin level and weight gain markedly improved and have been maintained for over 3 years. Selective interventional embolization reversed this devastating lymphatic complication of surgically corrected CCHD.
Assuntos
Criança , Pré-Escolar , Feminino , Humanos , Adesivos , Artérias , Procedimentos Cirúrgicos Cardíacos , Quilo , Ascite Quilosa , Embolização Terapêutica , Endoscopia Gastrointestinal , Cardiopatias Congênitas , Comunicação Interventricular , Ligadura , Anormalidades Linfáticas , Linfografia , Pleurodese , Complicações Pós-Operatórias , Enteropatias Perdedoras de Proteínas , Atresia Pulmonar , Reabilitação , Albumina Sérica , Ducto Torácico , Tomografia Computadorizada de Emissão , Aumento de PesoRESUMO
Chylothorax, the accumulation of chyle in the pleural space, is a rare condition, but can lead to serious complications in neonates. Conservative therapy for chylothorax includes enteral feeding with medium-chain triglyceride-enriched diet or parenteral nutrition and administration of octreotide. Surgical management is considered in cases where there is no response to conservative therapy; however, the standardized approach to refractory neonatal chylothorax is still controversial. Chemical pleurodesis can be used when medical therapies for chylothorax fail, to avoid more invasive surgical procedures. We report an extremely preterm infant born at 26 weeks of gestation with refractory chylothorax after patent ductus arteriosus ligation. The infant was successfully treated with pleurodesis using 4% povidone-iodine, without long-term side effects.
Assuntos
Humanos , Lactente , Recém-Nascido , Gravidez , Quilo , Quilotórax , Dieta , Permeabilidade do Canal Arterial , Nutrição Enteral , Recém-Nascido de Peso Extremamente Baixo ao Nascer , Lactente Extremamente Prematuro , Recém-Nascido Prematuro , Ligadura , Octreotida , Nutrição Parenteral , Pleurodese , Povidona-IodoRESUMO
Chyle only occurs in the peritoneal cavity or around the pericardium through damage to the lymph nodes or improper drainage of the lymph and is characterized by a colostrum-like color and being rich in triglyceride. We encountered a case of a newborn infant with abdominal distention and further diagnosed chylous ascites and hydrocele by inspecting and analyzing the fluid obtained from the abdominal cavity and scrotum. Additionally, a lymphoscintigraphy was performed, which showed a decrease in the uptake of radioactive isotopes in the left iliac nodes and a delayed appearance. Here, we report a case of chyle diagnosed through puncture analysis and its subsequent successful treatment.
Assuntos
Humanos , Recém-Nascido , Cavidade Abdominal , Quilo , Ascite Quilosa , Drenagem , Linfonodos , Linfocintigrafia , Pericárdio , Cavidade Peritoneal , Punções , Radioisótopos , Escroto , TriglicerídeosRESUMO
Dynamic enhanced magnetic resonance lymphangiography can be used to provide anatomic and dynamic information for various lymphatic diseases, including thoracic duct injury, and can also help to guide the thoracic duct embolization procedure. We present a case of postoperative chylothorax demonstrated by dynamic enhanced MR lymphangiography. In this case, the chyle leakage site and location of cisterna chyli were clearly visualized by dynamic enhanced MR lymphangiography, thus allowing for management with thoracic duct embolization.
Assuntos
Quilo , Quilotórax , Doenças Linfáticas , Linfografia , Ducto TorácicoRESUMO
PURPOSE: The use of sealing devices such as Harmonic scalpel and Ligasure is increasing steadily in thyroid surgery. The Harmonic Focus (HF) is an ultrasonic device that enables simultaneous vessel sealing and tissue coagulation, designed for open surgery such as thyroidectomy. The aim of this study is to assess the efficiency and safety of HF use in thyroid surgery compared to Conventional Tying (CT). METHODS: A prospective study was conducted to compare the efficacy of HF versus CT. We evaluated 50 patients who underwent surgery for thyroid tumor at Korea University Anam Hospital. All patients underwent total thyroidectomy with central neck dissection after being randomly allocated into two groups: HF group and CT group. The differences in surgical outcomes and postoperative complications by device use, i.e. group assignment, were statistically analyzed. RESULTS: There were no differences in number of retrieved lymph nodes (P=0.595), number of resected parathyroid glands (P=0.330), immediate postoperative iPTH (P=0.252), length of hospitalization (P=0.375) between HF group and CT group. However, operative time was shorter in HF group than CT group (106.07±20.92 min vs. 136.54±38.24 min, P=0.046). Postoperative complications of wound infection, seroma, hematoma, chyle leakage, vocal cord palsy, and hypoparathyroidism did not differ between groups. CONCLUSION: HF is a safe, effective, and time-saving technique; outcomes are comparable with CT. Both intraoperative and postoperative variables were similar between groups. Future larger studies are warranted to further investigate the effect on postoperative complications.
Assuntos
Humanos , Quilo , Hematoma , Hospitalização , Hipoparatireoidismo , Coreia (Geográfico) , Linfonodos , Esvaziamento Cervical , Pescoço , Duração da Cirurgia , Glândulas Paratireoides , Complicações Pós-Operatórias , Estudos Prospectivos , Seroma , Glândula Tireoide , Tireoidectomia , Ultrassom , Paralisia das Pregas Vocais , Infecção dos FerimentosRESUMO
Traumatic chylothorax after blunt chest trauma alone is considered rare. Our patient was a 27-year-old female who was in a motorcycle accident and sustained blunt thoracic and traumatic thoracic aortic injuries with T1–T2 vertebral subluxation. She underwent thoracic endovascular aortic repair from T4 to T9 without any thoracic or spinal surgery. On postoperative day 7, the drainage from her left chest turned into a milky-white fluid indicative of chyle leakage. The patient was treated conservatively for 2 weeks and then the chest drain was safely removed. The results show that traumatic chylothorax can be successfully managed with conservative treatment.
Assuntos
Adulto , Feminino , Humanos , Quilo , Quilotórax , Drenagem , Motocicletas , Traumatismos Torácicos , TóraxRESUMO
Traumatic chylothorax after blunt chest trauma alone is considered rare. Our patient was a 27-year-old female who was in a motorcycle accident and sustained blunt thoracic and traumatic thoracic aortic injuries with T1–T2 vertebral subluxation. She underwent thoracic endovascular aortic repair from T4 to T9 without any thoracic or spinal surgery. On postoperative day 7, the drainage from her left chest turned into a milky-white fluid indicative of chyle leakage. The patient was treated conservatively for 2 weeks and then the chest drain was safely removed. The results show that traumatic chylothorax can be successfully managed with conservative treatment.
Assuntos
Adulto , Feminino , Humanos , Quilo , Quilotórax , Drenagem , Motocicletas , Traumatismos Torácicos , TóraxRESUMO
En la actualidad, el uso de accesos venosos centrales es esencial en las unidades neonatales. Las venas de los neonatos son \r\npequeñas y frágiles y las líneas venosas usualmente se requieren por largos periodos, lo cual incrementa la propensión a complica\r\n-\r\nciones traumáticas o iatrogénicas. El ultrasonido puede aumentar la precisión y seguridad de inserción del catéter venoso central \r\ny reducir las complicaciones en niños y neonatos cuando se canaliza la vena yugular, pero no reemplaza los métodos rutinarios \r\nde confirmación.\r\nSe presenta a continuación el caso de un neonato que desarrolló hidrotórax como consecuencia de la extravasación de nutrición \r\nparenteral en el espacio pleural derecho tras la colocación de un catéter en la vena yugular interna derecha.
Currently, the use of central venous accesses in newborn units \r\nis essential. The veins of newborns are small and fragile, and \r\nvenous lines are usually needed for long periods, increasing \r\nthe susceptibility of traumatic or iatrogenic complications. \r\nUltrasound may increase the accuracy and safety for CVC \r\ninsertions and reduce complications in newborns and children \r\nwhen the jugular vein is cannulated, but it does not replace the \r\ntraditional confirmation methods.\r\nHere we have the case of a newborn that developed hydro\r\n-\r\nthorax due to the extravasations for parenteral nutrition in the \r\nright pleural space, after placing a catheter in the inner right \r\njugular vein.
Na atualidade, o uso de acessos venosos centrais é essencial \r\nnas unidades neonatais. As veias dos recém-nascidos são \r\npequenas e frágeis e as linhas venosas são geralmente neces\r\n-\r\nsárias por períodos longos, aumentando a suscetibilidade a \r\ncomplicações traumáticas ou iatrogênicas. O ultrassom pode \r\naumentar a precisão e segurança de inserção do cateter \r\nvenoso central e reduzir as complicações em crianças e recém-\r\nnascidos, quando a veia jugular for canalizada, no entanto, não \r\nsubstitui os métodos rotineiros de confirmação.\r\nA seguir é apresentado o caso de um recém-nascido que \r\ndesenvolveu hidrotórax como consequência do extravasa\r\n-\r\nmento de nutrição parenteral no espaço pleural direito, após a \r\ncolocação de um cateter na veia jugular interna direita.
Assuntos
Recém-Nascido , Cateterismo Venoso Central , Quilo , Quilotórax , Nutrição Parenteral , CatéteresRESUMO
OBJECTIVES: Somatostatin inhibits lymph production and reduces lymph flow into the lymphatic duct. We hypothesized that octreotide, a long-acting somatostatin analog, would reduce drainage after neck dissection (ND) by reducing the overall lymphatic flow in the neck as well as thoracic duct flow. METHODS: From 2012 to 2014, total 123 patients who had undergone left-sided comprehensive ND, were divided into an octreotide group (49 patients) and a control group (74 patients). Seventeen patients from the octreotide group and 17 from the control group were individually matched by age (±10 years), sex, body mass index (±1 kg/m2), type of cancer, surgeon, and the extent of surgery. These 34 patients were finally included in the study. RESULTS: The total fluid drainage volume (540.9 mL vs. 707.9 mL) and drainage volume during the period of octreotide use (the first 5 postoperative days) (461.1 mL vs. 676.4 mL) were significantly lower in the octreotide group. The duration of drain placement (6.3 days vs. 9.4 days) was also shorter in the octreotide group. In the octreotide group, the mean triglyceride concentration in the drainage fluid was significantly lower than that in the control group (43.1 mg/dL vs. 88.8 mg/dL). There was no complication associated with the use of octreotide. CONCLUSION: Our study has shown that postoperative octreotide injections reduce postoperative drainage and the duration of drain placement. Further studies with larger patient populations are warranted to confirm these results and to evaluate the clinical benefits for patients.
Assuntos
Humanos , Índice de Massa Corporal , Estudos de Casos e Controles , Quilo , Drenagem , Esvaziamento Cervical , Pescoço , Octreotida , Estudos Prospectivos , Somatostatina , Ducto Torácico , TriglicerídeosRESUMO
<p><b>OBJECTIVE</b>To identify the value of lymphography in the location and treatment decision of chyle leakage.</p><p><b>METHODS</b>The clinic data of 177 patients suffered from chyle leakage admitted in 6 medical centers in Shanghai from February 1998 to December 2014 was analyzed retrospectively. There were 94 male and 83 female patients aging from 9 to 84 years with a mean of 49 years, including 128 cases of chyluria, 34 cases of primary chylothorax and 15 cases of other chyle leakage. All patients had failed to conservative treatment more than 2 weeks. Pedal lymphography was performed in every patient to investigate the site and range of chyle leakage. Effect of surgical or conservative management was compared according to the different results of lymphography.</p><p><b>RESULTS</b>No serious complication was noticed. For all 177 patients, lymphography showed localized lymphatic diseases in 148 cases (83.6%), including 125 cases of lymphatic renal pelvic leaks, 14 cases of unilateral identified leak within thorax and 9 cases of chyle leakage in neck, heart, abdomen or scrotum. Among these patients, surgical treatment cured 129 and improved 3 patients but failed in 2 patients, while the remaining 14 cases had their leaks decreased after lymphography and cured by conservative management. For those 15 patients having disseminated lymphatic diseases or 14 with no abnormality under lymphography, surgery only cured 2 and improved 1 patient but failed in 8 patients (with 3 death), whereas continuous conservative treatment cured 11 patients, improved 5 patients but only failed in 2 patients (with one death). For localized leakage, surgical treatment showed better efficacy (98.5% vs. 3/11), whereas conservative treatment had significantly higher successful rate than surgical interventions in patients with disseminated lymphatic diseases or no abnormality under lymphography (16/18 vs. 3/11).</p><p><b>CONCLUSIONS</b>Lymphography could identify the location and range of complicate chyle leakage failed to primary conservative management. Patients with disseminated lymphatic diseases or no abnormality under lymphography would be better managed by continuous non-operative treatment partly due to therapeutic effect of lymphography, while surgical intervention could be a good option for patients having localized lymphatic etiology.</p>
Assuntos
Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Cavidade Abdominal , Quilo , Quilotórax , Diagnóstico , Cirurgia Geral , Coração , Pelve Renal , Doenças Linfáticas , Linfografia , Pescoço , Estudos Retrospectivos , EscrotoRESUMO
Chylous ascites is a rare form of ascites characterized by milky peritoneal fluid rich in triglycerides due to the accumulation of chyle in the peritoneal cavity. This affliction occurs as a result of a disruption of lymph flow associated with traumatic injury or obstruction of the lymphatic system. There are various causes of chylous ascites, such as lymphatic anomalies, malignancy, cirrhosis, infection, trauma, surgery, and nephrotic syndrome. We report a rare case of an 81-year-old male with sepsis caused by bilateral pneumonia who presented with chylous ascites.
Assuntos
Idoso de 80 Anos ou mais , Humanos , Masculino , Ascite , Líquido Ascítico , Quilo , Ascite Quilosa , Fibrose , Hipoalbuminemia , Sistema Linfático , Síndrome Nefrótica , Cavidade Peritoneal , Pneumonia , Sepse , TriglicerídeosRESUMO
After mastectomy and axillary node dissection, chylous leakage is rare. However, considerable anatomical variation in the termination of the thoracic duct has been reported. Hence, during breast surgery, injury to the lateral terminating branch is not unlikely and might lead to retrograde chyle leak. Herein, we describe a patient who had a chylous leakage at her wound site after a left simple mastectomy and axillary node dissection and for whom lymphoscintigraphy with Tc-99m albumin nanocolloid was performed. In this case, additional hybrid single-photon emission computed tomography/computed tomography study was done, and has helped with the accurate identification of the chyle leakage site, thus aiding in surgical management.
Assuntos
Humanos , Mama , Neoplasias da Mama , Quilo , Linfocintigrafia , Mastectomia , Mastectomia Simples , Ducto Torácico , Tomografia Computadorizada de Emissão de Fóton Único , Ferimentos e LesõesRESUMO
Chylothorax, a relatively rare condition of pleural effusion, is defined as an accumulation of chyle resulting from damage to the thoracic duct associated with chyle leakage from the lymphatic system into the pleural cavity. The etiologies of this condition are numerous, and the most important approach for management of chylothorax is to determine the definite cause. We report on a case of an unusual complication of chylothorax that occurred after central catheterization and direct instillation of total parenteral nutrition into the pleural cavity.
Assuntos
Cateterismo , Cateterismo Venoso Central , Catéteres , Quilo , Quilotórax , Sistema Linfático , Nutrição Parenteral , Nutrição Parenteral Total , Cavidade Pleural , Derrame Pleural , Veia Subclávia , Ducto TorácicoRESUMO
PURPOSE: The aim of this study is to describe our initial experience and assess the feasibility and safety of robotic and laparoscopic lateral pelvic node dissection (LPND) in advanced rectal cancer. METHODS: Between November 2007 and November 2012, extended minimally invasive surgery for LPND was performed in 21 selected patients with advanced rectal cancer, including 11 patients who underwent robotic LPND and 10 who underwent laparoscopic LPND. Extended lymphadenectomy was performed when LPN metastasis was suspected on preoperative magnetic resonance imaging even after chemoradiation. RESULTS: All 21 procedures were technically successful without the need for conversion to open surgery. The median operation time was 396 minutes (range, 170-581 minutes) and estimated blood loss was 200 mL (range, 50-700 mL). The median length of stay was 10 days (range, 5-24 days) and time to removal of the urinary catheter was 3 days (range, 1-21 days). The median total number of lymph nodes harvested was 24 (range, 8-43), and total number of lateral pelvic lymph nodes was 7 (range, 2-23). Six patients (28.6%) developed postoperative complications; three with an anastomotic leakages, two with ileus and one patient with chyle leakage. Two patients (9.5%) developed urinary incontinence. There was no mortality within 30 days. During a median follow-up of 14 months, two patients developed lung metastasis and there was no local recurrence. CONCLUSION: Robotic and laparoscopic LPND is technically feasible and safe. Minimally invasive techniques for LPND in selected patients can be an acceptable alternative to an open LPND.
Assuntos
Humanos , Fístula Anastomótica , Quilo , Conversão para Cirurgia Aberta , Seguimentos , Íleus , Laparoscopia , Tempo de Internação , Pulmão , Excisão de Linfonodo , Linfonodos , Imageamento por Ressonância Magnética , Mortalidade , Metástase Neoplásica , Complicações Pós-Operatórias , Neoplasias Retais , Recidiva , Robótica , Procedimentos Cirúrgicos Minimamente Invasivos , Cateteres Urinários , Incontinência UrináriaRESUMO
Bilateral chylothoraxis an extremely rare complication of modified radical neck dissection. It is a potentially life-threatening condition that can lead to severe respiratory, nutritional, metabolic, and immunologic disorders. Use of a multi-disciplinary approach including drainage of chyle, reduction of chyle formation, adequate nutritional support, use of somatostatin or its analogue, surgical ligation of the thoracic duct, and thoracic duct embolization is the best method for treatment of bilateral chylothorax. We report on a case of bilateral chylothorax following total thyroidectomy with modified radical neck dissection and discuss its management.
Assuntos
Quilo , Quilotórax , Drenagem , Ligadura , Esvaziamento Cervical , Apoio Nutricional , Somatostatina , Ducto Torácico , Neoplasias da Glândula Tireoide , TireoidectomiaAssuntos
Idoso , Quilo , Comportamento Alimentar , Glossectomia , Humanos , Leucócitos/citologia , Masculino , Esvaziamento Cervical , Estadiamento de Neoplasias , Neoplasias da Língua/diagnóstico , Neoplasias da Língua/patologia , Neoplasias da Língua/cirurgia , Resultado do Tratamento , Triglicerídeos/metabolismoRESUMO
Chylopericardium is a very rare, yet potentially fatal, complication following intrathoracic surgery, and can further lead to other life-threatening complications such as cardiac tamponade. A 54-year-old female underwent right upper lobectomy for lung cancer. Chylothorax developed on the 2nd postoperative day, and was managed conservatively with dietary modification. On the 9th postoperative day, the patient suddenly developed hypotension and severe cardiac dysfunction requiring cardiopulmonary resuscitation followed by VA ECMO. Transthoracic echocardiography revealed a large amount of pericardial effusion. Prompt pericardiocentesis was performed and the aspirated fluid showed features of chyle. Thoracic duct ligation with pericardial window operation was performed because the daily amount of chyle drained did not decrease after 3 weeks. Here, we review etiologies and therapeutic options of chylopericardial tamponade following intrathoracic surgery, which should not be underestimated even when the patient seems to demonstrate a good recovery.
Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Tamponamento Cardíaco , Reanimação Cardiopulmonar , Quilo , Quilotórax , Ecocardiografia , Oxigenação por Membrana Extracorpórea , Comportamento Alimentar , Hipotensão , Ligadura , Neoplasias Pulmonares , Derrame Pericárdico , Pericardiocentese , Ducto TorácicoRESUMO
Chyle leakage is a rare complication of surgery for thyroid cancer that generally develops after lateral neck dissection. Here, we describe chyle leakages experienced after central neck dissection (CND). A total of 615 patients with thyroid cancer were treated by total thyroidectomy with CND between Jan 2012 and Dec 2012 at our facility, and three (0.49%) developed chyle leakages. The amounts of leakage were all less than 100 ml/day. One patient was resolved with conservative management, while the others were treated with conservative treatment and fibrin glue injection in chylous lymphocele. Chyle leakage after CND is very uncommon, and most cases involve minor leakage. Fibrin glue could be a treatment option for chyle leakage following CND.