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1.
Rev. Odontol. Araçatuba (Impr.) ; 41(1): 30-33, jan.-abr. 2020. ilus
Artigo em Português | LILACS (Américas), BBO | ID: biblio-1102370

RESUMO

As próteses removíveis são consideradas facilitadoras em potencial da estomatite protética, caracterizada por aspectos hiperplásicos e eritematosos na mucosa de suporte. Este trabalho tem como objetivo relatar as principais manifestações orais da estomatite protética em um paciente geriátrico associada a candidíase oral pseudomembranosa. Paciente do gênero masculino, setenta e quatro anos, apresentava uma lesão exofítica, na região de palato com dois centímetros de extensão, além da presença de candidíase pseudomembranosa, fazia o uso de uma prótese parcial superior removível há aproximadamente dez anos. Foi levantada a hipótese diagnóstica de estomatite protética associada a candidíase pseudomembranosa. A terapêutica instituída consistiu no uso de antifúngico por um período de quinze dias e biópsia incisional. O exame histopatológico confirmou o diagnóstico de hiperplasia fibrosa inflamatória. Foi recomendado a confecção de uma nova prótese para que fosse evitado a recorrência da lesão, e o paciente também foi instruído quanto a sua higiene oral evitando-se desta forma a recorrência da candidíase. O cirurgião-dentista deve ser capaz de reconhecer e diagnosticar a estomatite protética em sua prática diária e tratar o paciente de acordo com a sua etiologia, oferecendo desta forma para o paciente um maior conforto e melhores condições de vida(AU)


Removable total dentures are considered potential facilitators of prosthetic stomatitis, characterized by hyperplastic and erythematous aspects in the supporting mucosa. This paper aims to report the main oral manifestations of prosthetic stomatitis in an elderly patient associated with pseudomembranous oral candidiasis. A seventyseven-year-old male patient presented with an exophytic lesion in the palate region of two centimeters in length, in addition to the presence of pseudomembranous candidiasis, and had been using a removable upper partial denture for approximately ten years. The diagnostic hypothesis of prosthetic stomatitis associated with pseudomembranous candidiasis was raised. The therapy instituted consisted of the use of antifungal for a period of fifteen days and incisional biopsy. Histopathological examination confirmed the diagnosis of inflammatory fibrous hyperplasia. It was recommended to make a new prosthesis to avoid recurrence of the lesion, and the patient was also instructed as to its oral hygiene, thus avoiding the recurrence of candidiasis. The dentist should be able to recognize and diagnose prosthetic stomatitis in his daily practice and treat the patient according to its etiology, thus offering the patient greater comfort and better living conditions(AU)


Assuntos
Humanos , Masculino , Idoso , Estomatite sob Prótese , Prótese Dentária , Estomatite , Estomatite sob Prótese/diagnóstico , Estomatite sob Prótese/terapia , Candidíase Bucal
2.
Rev. cuba. estomatol ; 57(1): e1965, ene.-mar. 2020. tab, graf
Artigo em Espanhol | LILACS (Américas), CUMED | ID: biblio-1126482

RESUMO

RESUMEN Introducción: Algunos tipos de cáncer suelen ser tratados con fármacos quimioterapéuticos que afectan de forma indirecta la cavidad bucal, los cuales susceptibilizan al paciente a contraer infecciones bucales como candidiasis bucal. Se ha evidenciado que una condición oncológica facilita una infección bucal por Candida albicans, sin embargo, otras especies de Candida se les relaciona poco. Objetivo: Identificar especies de Candida spp. en cavidad bucal de pacientes sometidos a quimioterapia. Métodos: Estudio descriptivo de corte transversal. Se tomaron 60 muestras de igual número de pacientes por conveniencia de un Instituto Oncológico en Barranquilla, Colombia. Previo a un examen clínico de diagnóstico de candidiasis bucal. Se tomaron hisopados en las superficies infectadas para realizar un examen directo -tinción de Gram y cultivo en agar dextrosa Sabouraud con cloranfenicol incubadas a 37 ºC durante 48 h y posteriormente cultivadas en medio CHROMagar® Candida- para identificación de diferentes especies. Se aplicó estadística descriptiva y de correlación. Resultados. El 55 por ciento de los pacientes correspondió al sexo femenino, con edades mayores a 60 años. El cáncer de mama fue el más frecuente en el 30 por ciento. La quimioterapia aplicada a todos fue el 5-fluorouracilo combinado con ciclofosfamida. El tipo clínico de candidiasis atrófica en lengua fue más frecuente en el 37 por ciento, seguida de candidiasis pseudomembranosa en lengua en el 33 por ciento. El 90 por ciento de muestras presentó algún tipo de Candida, crecimiento de una única especie y cultivos mixtos con más de una especie de Candida. Se evidenció el 13,3 por ciento de C. albicans y otro 13,3 por ciento de Candida spp. no albicans. Ninguno de los diagnósticos oncológicos tuvo una asociación estadísticamente significativa con las especies de Candida. Conclusiones: Se evidencia que la especie de C. albicans en candidiasis bucal en pacientes con cáncer, fue la más frecuente, con predominio en mayor proporción cultivos mixtos de Candida no albicans (C. glabrata, C. tropicalis) poco relacionados con este tipo de enfermedad(AU)


ABSTRACT Introduction: Some types of cancer are often treated with chemotherapeutic drugs which indirectly affect the oral cavity, thus making the patient vulnerable to infections such as oral candidiasis. Oral infection by Candida albicans has been found to be fostered by oncological conditions, but other Candida species have not been sufficiently analyzed in such a context. Objective: Identify Candida spp. in the oral cavity of patients undergoing cancer chemotherapy. Methods: A descriptive cross-sectional study was conducted of 60 samples of an equal number of patients selected by convenience sampling at an Oncological Institute in Barranquilla, Colombia, following diagnostic clinical examination for oral candidiasis. Swab samples were taken from the infected surfaces to perform direct examination - Gram staining and Sabouraud dextrose agar culture with chloramphenicol incubated at 37ºC for 48 h and then cultured in CHROMagar® Candida medium - for identification of various species. Analysis was based on correlation and descriptive statistics. Results: Of the total patients evaluated 55 percent were female and aged over 60 years. Breast cancer prevailed with 30%. The chemotherapy applied in all cases was 5-fluorouracil combined with cyclophosphamide. Atrophic candidiasis of the tongue was the most common clinical type with 37 percent, followed by pseudomembranous candidiasis of the tongue with 33 percent. Of the samples examined, 90 percent contained some sort of Candida, growth of a single species and mixed cultures with more than one Candida species. C. albicans represented 13.3 percent and non-albicans spp. another 13.3 percent. None of the oncological diagnostic analyses had a statistically significant association to Candida species. Conclusions: The species C. albicans was the most commonly found in oral candidiasis among cancer patients, with a predominance of non-albicans Candida spp. (C. glabrata, C. tropicalis) mixed cultures, a fact not generally related to this condition(AU)


Assuntos
Humanos , Candida albicans , Candidíase Bucal/diagnóstico , Neoplasias/tratamento farmacológico , Epidemiologia Descritiva , Estudos Transversais , Estudos Observacionais como Assunto
3.
Rev. Pesqui. (Univ. Fed. Estado Rio J., Online) ; 12: 505-509, jan.-dez. 2020. tab
Artigo em Inglês, Português | LILACS (Américas), BDENF | ID: biblio-1097201

RESUMO

Objetivo: avaliar a eficácia antimicrobiana da terapia fotodinâmica no tratamento da candidíase oral em pessoas vivendo com HIV/aids. Método: estudo experimental, qualitativo e descritivo com 18 pessoas vivendo com HIV/aids que manifestavam a candidíase oral, maiores de 18 anos, que estavam em tratamento no Hospital Universitário Gaffrée e Guinle. Este grupo subdividiu-se em um grupo controle, composto por sete pessoas, que recebeu tratamento com a terapia fotodinâmica e antifúngicos, e um grupo experimental, com 11, que recebeu apenas a terapia fotodinâmica. A evolução do tratamento de cada participante foi acompanhada por registros fotográficos em duas consultas, inicial e final. Esta pesquisa foi aprovada pelo Comitê de Ética em Pesquisa do hospital, parecer número 2.431.107. Resultados: a maioria dos participantes apresentou melhora clínica, ainda que discreta, e em apenas um houve piora clínica. Conclusão: a terapia fotodinâmica antimicrobiana pode ser eficaz no tratamento da candidíase oral em pessoas vivendo com HIV/Aids


Objective: evaluate the antimicrobial efficacy of photodynamic therapy in the treatment of oral candidiasis in people living with HIV/ aids. Method: experimental, qualitative and descriptive study with 18 people living with HIV/aids who presented oral candidiasis, over 18 years of age, who were being treated at the Gaffrée and Guinle University Hospital. This group was subdivided into a control group, composed of seven people, who received treatment with photodynamic and antifungal therapy, and an experimental group, with 11, who received only the photodynamic therapy. The evolution of the treatment of each participant was followed by photographic registers in two appointments, initial and final. This research was approved by the Research Ethics Committee from the hospital, dictum number 2.431.107. Results: most of the participants showed clinical improvement, albeit discrete, and in only one there was clinical worsening. Conclusion: antimicrobial photodynamic therapy may be effective in the treatment of oral candidiasis in people living with HIV/Aids


Objetivo: evaluar la eficacia antimicrobiana de la terapia fotodinámica en el tratamiento de la candidiasis bucal en personas que viven con VIH/sida. Método: estudio experimental, cualitativo y descriptivo con 18 personas viviendo con VIH/sida que manifestaban la candidiasis bucal, mayores de 18 años, que estaban en tratamiento en el Hospital Universitario Gaffrée y Guinle. Este grupo se subdividió en grupo control, compuesto por siete personas, que recibió tratamiento con la terapia fotodinámica y antifúngicos, y un grupo experimental, con 11, que recibió sólo la terapia fotodinámica. La evolución del tratamiento de cada participante fue acompañada por registros fotográficos en dos consultas, inicial y final. La investigación fue aprobada por el Comité de Ética en Investigación del lugar, dictamen número 2.431.107. Resultados: la mayoría de los participantes presentó mejoría clínica, aunque discreta, y en apenas uno hubo empeoramiento clínico. Conclusión: la terapia fotodinámica antimicrobiana puede ser eficaz en el tratamiento de la candidiasis bucal en personas que viven con el VIH/Sida


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Fotoquimioterapia/estatística & dados numéricos , Candidíase Bucal/terapia , Infecções Oportunistas Relacionadas com a AIDS/terapia , Fotoquimioterapia/métodos , Candidíase Bucal/epidemiologia , Síndrome de Imunodeficiência Adquirida/terapia , HIV , Farmacorresistência Fúngica
4.
Braz. dent. sci ; 23(4): 1-7, 2020. tab
Artigo em Inglês | LILACS (Américas), BBO | ID: biblio-1121326

RESUMO

Objective: Oral candidiasis is an infection that occurs in the oral cavity and is caused by candida species, often Candida albicans. This infection commonly occurs in a condition of immunosuppression caused by dexamethasone. Due to the side effects of antifungal therapy, developing a standardized immunosuppressed animal model to induce oral candidiasis for new therapies is required. The aim of this study is to observe oral candidiasis in immunosuppressed Wistar rats post dexamethasone injection at 7.2 mg/kg and 16 mg/kg doses. Material and Methods: Twenty-one Wistar rats were divided into three groups: control group, treatment group 1 (injected with dexamethasone at a concentration of 7.2 mg/kg), and treatment group 2 (at a concentration of 16 mg/kg) for five days. Immunosuppression status was observed by leukocyte count and all the subjects' palates were inoculated with C. albicans 0.1 ml of 15x108 UFC/ml 24 hours later. The subjects' tongues were observed and confirmed by laboratory examination on day 10. A statistical analysis was performed using one way ANOVA, Kruskal­Wallis, Tukey HSD, and Mann-Whitney U tests. Results: A significant clinical appearance of the subjects' tongues was observed only between C and T1 (p=0.023; p<0.05). Significant hyphal formation was observed between C and T1 (p= 0.037; p<0.05) and between C and T2 (p=0.007; p<0.05), and no significant difference was observed between T1 and T2. A significant increase in the colony count was also observed in similar results. Conclusion: Dexamethasone injection at doses of 7.2 mg/kg and 16 mg/kg is effective in triggering immunosuppression to induce oral candidiasis in immunosuppressed Wistar rats. (AU)


Candidíase oral é uma infecção que ocorre na cavidade oral e é causada por espécies de Candida, freqüentemente Candida albicans. Esta infecção geralmente ocorre em uma condição de imunossupressão causada por dexametasona. Devido aos efeitos colaterais de terapia antifúngica, o desenvolvimento de um padrão de modelo animal imunossuprimido para induzir candidíase oral para testar novas terapias se faz necessário. O objetivo deste estudo é observar candidíase oral em ratos Wistar imunossuprimidos pós-injeção de dexametasona utilizando doses de 7,2 mg /kg e 16 mg / kg. Material e métodos: Vinte e um ratos Wistar foram divididos em três grupos: grupo controle, tratamento grupo 1 (injetado com dexametasona na concentração de 7,2 mg / kg), e tratamento grupo 2 (concentração de 16 mg / kg) por cinco dias. A imunossupressão foi observada pela contagem de leucócitos e todos os palatos dos animais foram inoculados com C. albicans 0,1 ml de 15x108 UFC / ml após 24horas. As línguas dos animais foram observadas e confirmadas por exame laboratorial após 10 dias. A análise estatística foi realizada usando os testes de ANOVA um fator, kruskal ­ Wallis, Tukey HSD e de Mann-Whitney. Resultados: Significante diferença na aparência clínica da língua dos animais foi observada apenas entre C e T1 (p = 0,023; p <0,05). Significativa diferença na formação de hifas foi observada entre C e T1(p = 0,037; p <0,05) e entre C e T2 (p = 0,007; p <0,05), e nenhuma diferença significativa foi observada entre T1 e T2. Um aumento significativo na contagem de colônias foi também observado com resultados semelhantes. Conclusão: Injeção de dexametasona utilizando doses de 7,2 mg / kg e 16 mg / kg é eficaz no desencadeamento da imunossupressão para induzir candidíase oral em ratos Wistar imunossuprimidos. (AU)


Assuntos
Ratos , Candidíase Bucal , Dexametasona , Imunossupressão
5.
Rev. Soc. Cardiol. Estado de Säo Paulo ; 29(4 (Supl)): 441-445, out.-dez. 2019. tab, ilus
Artigo em Português | LILACS (Américas) | ID: biblio-1047354

RESUMO

A Fibrose Pulmonar Idiopática (FPI) é uma doença crônica do interstício pulmonar que se manifesta por fibrose progressiva com alta prevalência de insuficiência respiratória. Como toda doença crônica e progressiva, a FPI necessita de acompanhamento por uma equipe multiprofissional de Cuidados Paliativos (CP) a fim de proporcionar um cuidado integral, considerando todas as queixas e necessidades do paciente. Em uma enfermaria de CP de um hospital terciário, um paciente do sexo masculino, 77 anos, foi admitido por FPI avançada para controle de sintomas e cuidados de fim de vida. Durante a oroscopia realizada pela equipe, recebeu diagnóstico de candidíase oral, onde foi solicitada avaliação do cirurgião-dentista. Na avaliação odontológica, queixou-se de língua ressecada e perda do paladar. Paciente acamado, dispneico em repouso, em uso contínuo de máscara de venturi e lábios ressecados, com presença de placas brancas ressecadas (resíduos alimentares) em palato duro e mole, mucosa jugal e gengival, língua ressecada com saburra e hipossalivação. Foi realizada a higiene oral, prescrição de substituto salivar e hidratante labial. O procedimento foi longo e intermitente devido à dificuldade do paciente de se manter sem o suporte de oxigênio. Após o procedimento, o paciente relatou melhora de 90% dos sintomas bucais. Conclusão: O caso apresentou as alterações bucais e os cuidados odontológicos em um paciente com FPI e também evidenciou a importância da avaliação especializada realizada pelo cirurgião-dentista inserido em uma equipe multiprofissional em CP, que, além do diagnóstico diferencial, proporcionou alívio dos sintomas bucais e conforto ao paciente em sua fase final de vida


Idiopathic Pulmonary Fibrosis (IPF) is a chronic interstitial lung disease manifested by progressive fibrosis with a high prevalence of respiratory failure. As all chronic and progressive diseases, IPF needs follow-up by a multidisciplinary Palliative Care (PC) team in order to provide comprehensive care considering all patient's complaints and needs. In a PC inpatient unit of a tertiary hospital, a 77-year-old male patient was admitted because of advanced IPF for symptom control and end-of-life care. During the oroscopy done by the team, he was diagnosed with oral candidiasis, where evaluation by the dentist was requested. In the dental evaluation, he complained of dry tongue and taste loss. Bedridden patient, dyspnea at rest, in continuous use of venturi mask and dry lips, dry white plaques (food residues) in hard and soft palate, jugal and gingival mucosa, dry tongue with oral coating and hyposalivation. Oral hygiene was performed, salivary substitute and lip moisturizer were prescribed. The procedure was long and intermittent due to the difficulty of the patient with staying without oxygen support. After the procedure, the patient reported 90% improvement in oral symptoms. Conclusion: The case showed the oral disorders and dental care in a patient with IPF and highlighted the importance of specialized evaluation performed by the dentist inserted in a multidisciplinary PC team which, besides the differential diagnosis, provided symptom relief of the mouth and comfort to the patient in his end of life


Assuntos
Manifestações Bucais , Cuidados Paliativos , Fibrose Pulmonar Idiopática , Higiene Bucal , Equipe de Assistência ao Paciente , Insuficiência Respiratória , Candidíase Bucal , Doença Crônica , Odontólogos , Diagnóstico Diferencial , Diagnóstico Bucal , Pneumopatias
6.
Pesqui. bras. odontopediatria clín. integr ; 19(1): 4802, 01 Fevereiro 2019. tab
Artigo em Inglês | LILACS (Américas), BBO | ID: biblio-998255

RESUMO

Objective: To determine the prevalence of Candida species in the saliva of patients with clinically suspected oral potentially malignant disorders (OPMD) and healthy cohorts. Material and Methods: Unstimulated saliva was collected from patients with OPMD (n=100) and age and sex matched healthy subjects (n=170). The samples were inoculated onto Sabouraud Dextrose Agar and incubated for a week. The colonies of the isolates were enumerated using a colony counter. The isolates were identified using standard phenotypic methods. The significance of oral candidal carriage was calculated using Independent T test. Odds and Risk ratio was calculated using Pearson's Chi-square test. Results: Oral candida carriage was present in 51% of patients with OPMD while healthy cohorts had a prevalence of 20.6%. A good statistical significance was observed for the prevalence of oral candidal carriage for patients with OPMD in comparison to healthy cohorts (p=0.013). Significant Odds and risk ratio was observed for the prevalence of Candida species among OPMD. Majority of the isolates in both groups were C. albicans. Colony forming units were high among patients with OPMD. Conclusion: A significant association of oral candidal carriage to oral potentially malignant disorders in comparison to healthy cohorts was observed. Candidal species may be potent risk factor for transition of OPMD to oral Squamous Cell Carcinoma.


Assuntos
Humanos , Masculino , Feminino , Fenótipo , Candidíase Bucal/prevenção & controle , Leucoplasia Oral , Neoplasias Bucais/patologia , Estudos de Casos e Controles , Fibrose Oral Submucosa/patologia , Candida albicans , Distribuição de Qui-Quadrado , Índia
7.
Annals of Dermatology ; : S22-S23, 2019.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-762416

RESUMO

No abstract available.


Assuntos
Candidíase Bucal , Candida , Candida albicans , Feminino , Humanos , Idoso , Diabetes Mellitus , Antifúngicos
8.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-761780

RESUMO

Avian trematodes, Urogonimus turdi (Digenea: Leucochloridiidae), were collected from the intestine of wild birds, Zoothera aurea, 2013–2017 in the Daejeon Metropolitan City, Korea. The body was ellipsoidal, attenuated and/or round ends, 1,987–2,120 long and 819–831 μm wide. The oral sucker was subterminal, rounded anteriorly, and 308–425×351–432 μm in size; the prepharynx and esophagus were almost lacking; pharynx was well-developed, 142–179×78–170 μm in size; intestine narrow, bifurcating just after pharynx, ascending to the oral sucker before looping posteriorly and terminating near the posterior end; ventral sucker larger, in almost median, 536–673×447–605 μm and approximately 1.5 times larger than oral sucker. A phylogenetic tree constructed with 18S ribosomal RNA showed inter- and intraspecific relationships. Based on these morphological and molecular findings, we report here a U. turdi from White’s thrushes in Korea.


Assuntos
Aves , Candidíase Bucal , Esôfago , Intestinos , Coreia (Geográfico) , Faringe , República da Coreia , RNA Ribossômico 18S , Aves Canoras , Árvores
9.
J. oral res. (Impresa) ; 7(8): 391-394, nov. 30, 2018. ilus
Artigo em Inglês | LILACS (Américas) | ID: biblio-1121123

RESUMO

Pseudomembranous candidiasis is the most frequent type of infection by candida spp., and candida albicans is the most common species to cause it. candidiasis can be due to other candida species less frequently, as is the case of candida tropicalis a pathogenic species that can cause infection in immunocompromised patients. the aim of this case report is to describe a pathological condition produce by candida tropicalis.


Assuntos
Humanos , Masculino , Adulto , Candidíase , Candidíase Bucal/etiologia , Candida tropicalis , Candida albicans , HIV
10.
An. bras. dermatol ; 93(3): 356-361, May-June 2018. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-949881

RESUMO

Abstract: BACKGROUND: Candidiasis is the most common opportunistic fungal infection of the oral cavity caused by fungi of the genus Candida and usually associated with immunosuppressed individuals. OBJECTIVES: To evaluate the presence of oral candidiasis and identify the presence of Candida spp. in liver transplant recipients and assess the association between the presence of the fungus and sociodemographic variables, dietary habits and environmental exposure. METHODS: A cross-sectional study was performed with 49 patients who had undergone liver transplants at Hospital São Vicente de Paulo in Passo Fundo - RS. Patient information was collected to obtain sociodemographic data, eating habits and environmental exposure. Fungal infections were screened by oral clinical examination and the presence of Candida spp by the collection of oral samples with a sterile swab, seeded in Sabouraud Dextrose Agar, incubated at 25°C and observed at 48 hours. To identify Candida albicans, the germ tube test was performed. RESULTS: In 49 patient samples, 39% had the yeast of the genus Candida isolated and, of these patients, 12% had candidiasis, 66% of atrophic type and 34% pseudomembranous. Eleven yeast species were (58%) Candida non-albicans and eight (42%) Candida albicans. STUDY LIMITATIONS: The present study presents as a limitation the inclusion of patients in different stages of immunosuppression. CONCLUSION: The high incidence of Candida non-albicans in the oral cavity of transplant patients with a long period of transplantation is warning to a more effective control of the health of these individuals, especially those with older age.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Adulto Jovem , Infecções Oportunistas/microbiologia , Candida/isolamento & purificação , Candidíase Bucal/diagnóstico , Transplante de Fígado , Boca/microbiologia , Candida/classificação , Candidíase Bucal/patologia , Estudos Transversais , Hospedeiro Imunocomprometido , Antifúngicos/uso terapêutico
11.
Braz. j. biol ; 78(2): 368-374, May-Aug. 2018. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-888882

RESUMO

Abstract This study analyzed the antifungal activity of phytoconstituents from linalool on Candida spp. strains, in vitro, isolated from patients with clinical diagnoses of oral candidiasis associated with the use of a dental prosthesis. Biological samples were collected from 12 patients using complete dentures or removable partial dentures and who presented mucous with diffuse erythematous or stippled features, indicating a clinical diagnosis of candidiasis. To identify fungal colonies of the genus Candida, samples were plated onto CHROMagar Candida®. The antifungal activity of linalool, a monoterpene unsaturated constituent of basil oil, was performed using the broth microdilution technique. Then, the minimum inhibitory concentration (MIC), the two subsequent stronger concentrations and the positive controls were subcultured on Sabouraud Dextrose Agar plates to determine the minimum fungicidal concentration (MFC). The experiments were performed in triplicate and nystatin was used as a positive control in all tests. Diagnoses of oral candidiasis were verified in eight patients (66.6%) and the most prevalent fungal species was Candida albicans (37.5%), followed by Candida krusei (25.0%); and Candida tropicalis (4.2%). The best antifungal activity of linalool was observed on Candida tropicalis (MIC = 500 mg/mL), followed by Candida albicans (MIC = 1.000 mg/mL), and Candida krusei (MIC = 2.000 mg/mL).Under the study conditions and based on the results obtained, it can be concluded that the Candida strains tested were susceptible to linalool.


Resumo Este estudo analisou a atividade antifúngica do fitoconstituinte linalol em cepas de Candida ssp, in vitro, isolados de pacientes com o diagnóstico clínico de candidíase oral associado ao uso de prótese dentária. As amostras biológicas foram coletadas de 12 pacientes portadores de próteses totais ou próteses parciais removíveis e que apresentavam características de mucosa eritematosa difusa ou pontilhadas, indicando um diagnóstico clínico de candidíase. Para identificar colônias de fungos do gênero Candida, as amostras foram semeadas em CHROMagar Candida®. A atividade antifúngica do linalol, um componente insaturado monoterpene de óleo de manjericão, foi realizada através da técnica de microdiluição em caldo. Em seguida, a concentração inibitória mínima (MIC), as duas concentrações consecutivas mais fortes e os controles positivos foram subcultivados em placas de Agar Sabouraud Dextrose para determinar a concentração fungicida mínima (MFC). Os experimentos foram realizados em triplicata e a nistatina foi usada como controle positivo em todos os testes. O diagnóstico de candidíase oral foi comprovado em oito pacientes (66,6%) e as espécies de fungos mais prevalentes foram Candida albicans (37,5%), seguido por Candida krusei (25,0%); e Candida tropicalis (4,2%). A melhor atividade antifúngica do linalol foi observada em Candida tropicalis (MIC = 500 mg/ml), seguido por Candida albicans (CIM = 1,000 mg/mL), e Candida krusei (CIM = 2,000 mg/mL). Sob as condições do estudo e com base nos resultados obtidos, pode-se concluir que as estirpes de Candida testadas foram susceptíveis a linalol.


Assuntos
Humanos , Candida/efeitos dos fármacos , Candidíase Bucal/microbiologia , Monoterpenos/farmacologia , Antifúngicos/farmacologia , Testes de Sensibilidade Microbiana , Monoterpenos Acíclicos
12.
Biosci. j. (Online) ; 34(2): 525-533, mar./apr. 2018. ilus, tab
Artigo em Inglês | LILACS (Américas) | ID: biblio-966755

RESUMO

Candida species inhabit the oral cavity of all individuals who wear complete denture and whose material is the same as that used in splints. Assess the growth of C. albicans in occlusal and palatal splints used for treatment of TMD so that the potential risks of oral microbiota can be assessed. The growth of Candida spp. was assessed in the saliva of 27 individuals wearing splints for treatment of TMD. They were divided into two groups: G1 (n = 14), individuals wearing occlusal splint; and G2 (n = 13), individuals wearing palatal splint. Saliva samples were collected during placement of the splints (T1) and after 4 months (T2), being stored in PBS (10 mL) after 60-second rinses. It was observed that patients wearing occlusal splints (G1) had an increase of 0.648 CFU/mL (Log 10), with statistically significant differences (P = 0.043) for C. albicans (42.33%), C. glabrata (5.52%), C. krusei (41.72%) and C. tropicalis (10.43%). In the group of patients wearing palatal splints (G2), there was a decrease of 0.101 CFU/mL (Log 10), was observed with (P = 0.964) only the presence of C. albicans. The results suggest that growth of Candida species was greater in patients wearing occlusal splints compared to those wearing palatal ones as the presence of different yeast species was found in the former.


Espécies de Candida habitam a cavidade oral de 60-100% de indivíduos usuários de prótese total, cujo material é o mesmo utilizado em placas miorrelaxante. Avaliar o crescimento de C. albicans. em placas relaxantes musculares oclusais e palatais, usadas para o tratamento de DTM, na intenção de verificar riscos em potencial à microbiota bucal. Avaliou-se o crescimento de Candida spp. na saliva de 27 indivíduos, usuários de placa miorrelaxante, em tratamento para DTM no ICT-UNESP. Os indivíduos foram divididos em dois grupos: G1(n=14) ­ placa com recobrimento oclusal; e G2 (n=13) ­ sem recobrimento. As coletas foram com PBS (10mL), em bochechos por 60seg, na instalação das placas (T1) e após 4 meses (T2). Observou-se que pacientes usuários da placa miorrelaxante com recobrimento oclusal (grupo G1) apresentaram aumento de 0,648 UFC/mL (Log10) com diferença estatisticamente significante (p=0,043) analisando-se 42,33% C. albicans, 5,52% C. glabrata, 41,72% C. krusei e 10,43% C. tropicalis. No grupo de pacientes que utilizaram a placa sem recobrimento (grupo G2), observou-se diminuição de 0,101 UFC/mL (Log10) com (p=0,954) apresentando apenas C. albicans. Os resultados sugerem que os pacientes que fizeram uso de placa miorrelaxante com recobrimento oclusal apresentaram maior crescimento de Candida spp. em relação aos usuários de placa sem recobrimento, verificando-se a presença de diferentes espécies da levedura.


Assuntos
Candida , Contagem de Colônia Microbiana , Higiene Bucal , Candidíase Bucal , Placas Oclusais , Prótese Dentária
13.
Braz. j. microbiol ; 49(1): 148-151, Jan.-Mar. 2018. tab
Artigo em Inglês | LILACS (Américas) | ID: biblio-889204

RESUMO

ABSTRACT The aim of this study was to isolate and identify Candida species from the oral cavity of denture wearers with denture-related stomatitis who were attended at the University Federal of Pará (Belém City, Pará State, Brazil). A total of 36 denture wearers with denture-related stomatitis were included, and type I (50%), type II (33%) and type III (17%) stomatitis were observed. Candida spp. were isolated from 89% of the cases and included five different Candida species. C. albicans was the most frequently recovered species (78% of the cases), followed by C. famata and C. tropicalis. We observed a significant association between Candida species isolation and unsatisfactory denture condition (p = 0.0017). Our results demonstrated the highly frequency of Candida species isolation in denture wearers with denture-related stomatitis and showed the relationship between these species and poor denture maintenance.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Candida/isolamento & purificação , Candidíase Bucal/microbiologia , Estomatite sob Prótese/microbiologia , Brasil , Candida/classificação , Candida/genética , Dentaduras/microbiologia
14.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-772307

RESUMO

The hyphal development of Candida albicans (C. albicans) has been considered as an essential virulent factor for host cell damage. However, the missing link between hyphae and virulence of C. albicans is also been discovered. Here, we identified that the null mutants of ERG3 and ERG11, two key genes in ergosterol biosynthesis pathway, can form typical hyphae but failed to cause the oral mucosal infection in vitro and in vivo for the first time. In particular, the erg3Δ/Δ and erg11Δ/Δ strains co-cultured with epithelial cells significantly reduced the adhesion, damage, and cytokine (interleukin-1α (IL-1α)) production, whereas the invasion was not affected in vitro. Importantly, they were incapable of extensive hyphal invasion, formation of micro-abscesses, and tongue epithelium damage compared to wild type due to the decrease of the colonization and epithelial infection area in a murine oropharyngeal candidiasis model. The fluconazole (FLC), an antifungal targeted at ergosterol biosynthesis, relieved the epithelial infection of C. albicansin vitro and in vivo even under non-growth inhibitory dosage confirming the virulent contribution of ergosterol biosynthesis pathway. The erg3Δ/Δ and erg11Δ/Δ strains were cleared by macrophages similar to wild type, whereas their virulence factors including agglutinin-like sequence 1 (Als1), secreted aspartyl proteinase 6 (Sap6), and hyphal wall protein-1 (Hwp1) were significantly reduced indicated that the non-toxicity might not result from the change on immune tolerance but the defective virulence. The incapacity of erg3Δ/Δ and erg11Δ/Δ in epithelial infection highlights the contribution of ergosterol biosynthesis pathway to C. albicans pathogenesis and fluconazole can not only eliminate the fungal pathogens but also reduced their virulence even at low dosage.


Assuntos
Animais , Antifúngicos , Farmacologia , Candida albicans , Genética , Virulência , Candidíase Bucal , Tratamento Farmacológico , Genética , Microbiologia , Fluconazol , Farmacologia , Genes Fúngicos , Genética , Camundongos , Microscopia Eletrônica de Varredura , Canais de Potássio , Genética , Virulência
15.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-719107

RESUMO

Chronic mucocutaneous candidiasis (CMC) is characterized by increased susceptibility to chronic and recurrent infections of the skin, mucous membranes, and nails by Candida species. It is a primary immunodeficiency disorder that is difficult to diagnose because of its heterogeneous clinical manifestations and genetic background. A 20-month-old boy who did not grow in height for 3 months was diagnosed as having hypothyroidism and he had hepatitis which was found at 5 years old. He presented with persistent oral thrush and vesicles on the body, the cause of which could not be identified from laboratory findings. No microorganism was detected in the throat culture; however, the oral thrush persisted. Immunological tests showed that immunoglobulin (Ig) subclass IgG and cluster of differentiation (CD)3, CD4, and CD8 levels were within normal limits. We prescribed oral levothyroxine and fluconazole mouth rinse. The patient was examined using diagnostic exome sequencing at the age of 6 years, and a c.1162A>G (p.K388E) STAT1 gene mutation was identified. A diagnosis of CMC based on the STAT1 gene mutation was, thus, made. At the age of 8 years, the boy developed a malar-like rash on his face. We conducted tests for detection of antinuclear antibodies and anti-dsDNA antibodies, which showed positive results; therefore, systemic lupus erythematosus (SLE) was also suspected. Whole exome sequencing is important to diagnose rare diseases in children. A STAT1 gene mutation should be suspected in patients with chronic fungal infections with a thyroid disease and/or SLE.


Assuntos
Anticorpos , Anticorpos Antinucleares , Candida , Candidíase , Candidíase Mucocutânea Crônica , Candidíase Bucal , Criança , Diagnóstico , Exantema , Exoma , Fluconazol , Patrimônio Genético , Hepatite , Hepatite Crônica , Humanos , Hipotireoidismo , Imunoglobulina G , Imunoglobulinas , Testes Imunológicos , Lactente , Lúpus Eritematoso Sistêmico , Masculino , Boca , Membrana Mucosa , Faringe , Doenças Raras , Pele , Doenças da Glândula Tireoide , Tiroxina
16.
Braz. j. oral sci ; 17: e18150, 2018. ilus
Artigo em Inglês | LILACS (Américas), BBO | ID: biblio-963931

RESUMO

Aim: To investigate the relationship between oral candidiasis and users of dental prostheses. Methods: A cross-sectional study was carried out which the inclusion of adults and elderly people of both genders using dental prostheses. Lectures were given with guidelines on oral hygiene techniques and dental prostheses, preventive measures of candidiasis, highlighting their influence on the oral and general health of the individual for the 240 users of dental prostheses. Of this number, 153 did not want to participate in the clinical examination. Signals and symptoms were analyzed in 87 patients, and lesions were present in only 21, and a cytological complement of the lesions was performed. Data were analyzed using SPSS version 15.0 with Chi-square (χ2 ) test at p < 0.05. Results: The 21 patients presented oral candidiasis, with erythematous (prosthetic) stomatitis being the most prevalent. There was a correlation between the presence of Candida and the use of prostheses (p- value 0.00*). Candidiasis was associated with poorly adapted prostheses, poor oral hygiene, inadequate prostheses and prolonged use of them. Conclusion: There was a correlation between oral candidiasis and users of dental prostheses. The most prevalent type of candidiasis was erythematous stomatitis (prosthetic), and nystatin was used to treat all cases. The preventive activities carried out were extremely important, since patients were not aware of oral candidiasis and the factors that trigger it, such as poor oral hygiene and dental prostheses


Assuntos
Humanos , Masculino , Feminino , Candida albicans , Candidíase Bucal , Prótese Dentária , Higiene Bucal , Saúde Bucal
17.
Clin. biomed. res ; 38(2): 155-166, 2018.
Artigo em Português | LILACS (Américas) | ID: biblio-1025562

RESUMO

Apesar de a espécie Candida albicans ser efetivamente o microrganismo mais frequentemente associado a estomatite protética, as espécies de Candida não albicans já foram isoladas nas superfícies de dentaduras e da mucosa oral de indivíduos com essa lesão eritematosa. A virulência das espécies de Candida e a capacidade de adesão a polímeros acrílicos são condições prévias para a colonização e o desenvolvimento de biofilmes em superfícies de dentaduras. Estudos recentes focam na tentativa de modificação das resinas acrílicas para diminuir a adesão de cepas patogênicas e formadoras de biofilme do gênero Candida spp. Dentro desse aspecto, esta revisão sistematiza o atual panorama epidemiológico da estomatite protética associada ao uso de próteses dentárias, bem como as atuais e novas opções de combate ao biofilme fúngico especializado na adesão desse tipo de biomaterial. (AU)


Although the Candida albicans species is effectively the microorganism most frequently associated with prosthetic stomatitis, Candida non-albicans species have already been isolated from the denture and oral mucosal surfaces of individuals with this erythematous lesion. The virulence of Candida species and the ability to adhesion to acrylic polymers are preconditions for the colonization and development of biofilms on denture surfaces. Recent studies focus on the attempt to modify the acrylic resins to reduce the adhesion of pathogenic and biofilm forming strains of the genus Candida spp. In this aspect, this review systematizes the current epidemiological panorama of prosthetic stomatitis associated with the use of dental prostheses, as well as new options for combating the fungal biofilm specialized in the adhesion of this type of biomaterial. (AU)


Assuntos
Humanos , Candida albicans/patogenicidade , Infecções Relacionadas à Prótese , Prótese Dentária/efeitos adversos , Biofilmes , Estomatite sob Prótese , Resinas Acrílicas/efeitos adversos , Candidíase Bucal , Placa Dentária/prevenção & controle
18.
Araçatuba; s.n; 2018. 186 p. ilus, tab, graf.
Tese em Português | LILACS (Américas), BBO | ID: biblio-1009528

RESUMO

O objetivo deste estudo foi avaliar a atividade antimicrobiana/antibiofilme e a viabilidade celular de nanopartículas de prata (NPsAg) obtidas por uma síntese 'green' associadas ou não ao ß-glicerofosfato de cálcio (GPCa) contra Streptococcus mutans e espécies de Candida (cepas de referência e isolados clínicos orais incluindo cepas resistentes ao fluconazol). O efeito destes nanocompostos em combinação com o tirosol (TIR), fluconazol (FLC), nistatina (NIT) e anfotericina B (AnB) também foi avaliado. Além disso, nós avaliamos comparativamente as alterações do transcriptoma de células de C. glabrata CBS138 após exposição às NPsAg e ao Íon prata (Ag+ ). Inicialmente, as NPsAg foram sintetizadas por meio da redução do nitrato de prata com extratos de diferentes partes (casca, folha e semente) de uma romã (Punica granatum L.) associadas ou não ao GPCa. A Concentração Inibitória Mínima (CIM) e as Concentrações Fungicida/Bactericida Mínima (CFM e CBM) dos nanocompostos (NPsAg e NPsAgGPCa) associados ou não ao TIR contra S. mutans e C. albicans foram determinadas pelo método de microdiluição. E, a ação das NPsAg combinadas com FLC, NIT e AnB também foi avaliada em condição planctônica contra isolados clínicos orais de espécies de Candida. O efeito dos nanocompostos associados ou não ao TIR sobre a viabilidade celular de fibroblastos da linhagem L929 e a produção de citocinas foi avaliado através dos ensaios de MTT e ELISA, respectivamente. O número de hifas foi quantificado em biofilmes de C. albicans formados na presença das NPsAg com ou sem soro fetal bovino (SFB). O efeito das NPsAg em inibir a formação do biofilme (em C. albicans e C. glabrata) também foi investigado através do ensaio de PrestoBlue e por meio da microscopia eletrônica de varredura. Os nanocompostos (NPsAg e NPsAg-GPCa) associados ou não ao TIR foram aplicados sobre biofilmes de S. mutans e de espécies de Candida (12 e 24 h) e, após 24 h de contato, sua atividade antibiofilme foi determinada por meio da enumeração das unidades formadoras de colônias (UFCs) e ensaio de PrestoBlue. Além disso, uma análise transcriptômica foi realizada utilizando microchips de DNA ('microarrays') a fim de avaliar quais genes estão mais ou menos expressos como resposta às NPsAg (no estado planctônico e formando biofilmes) e ao Íon Ag+ (formando biofilmes). As soluções antimicrobianas sintetizadas neste estudo (NPsAg e NPsAgGPCa) apresentaram atividade antimicrobiana contra os microrganismos testados. Além disso, menores valores de CIM foram obtidos quando estes nanocompostos foram associados ao TIR, FLC, NIT e AnB apresentando um efeito sinérgico. NPsAg e NPsAgGPCa não foram tóxicas às células L929, aumentaram a produção de fator de crescimento celular e não promoveram alterações significativas na liberação de Interleucina-6. Os nacompostos associados ao TIR não apresentaram efeito citotóxico sobre culturas de L929, exceto para a maior concentração (NPsAg ­ 39,05 µg/mL + TIR ­ 1,25 mM). A presença das NPsAg reduziu drasticamente o número de hifas em biofilmes de C. albicans na presença ou na ausência de SFB. A quantidade de biofilme das espécies de Candida formado na presença das NPsAg reduziu para mais de 50%. Após 24 h de tratamento com os nanocompostos (NPsAg e NPsAg-GPCa) em biofilmes de S. mutans, houve uma redução significativa no número de UFCs sendo similar à clorexidina. Uma redução na viabilidade de biofilmes de C. glabrata também foi observada após exposição às NPsAg (24 h). Entretanto, os nanocompostos (NPsAg e NPsAg-GPCa) associados ou não ao TIR não foram efetivos contra biofilmes de C. albicans. Após exposição às NPsAg e ao Íon Ag+ , alterações no transcriptoma de células de C. glabrata CBS138 foram observadas: no estado planctônico, houve uma superexpressão dos genes responsáveis pela biossíntese de metionina e de lisina e uma subexpressão dos genes relacionados com o transporte transmembrana; e, as células expostas às NPsAg responderam de forma distinta em relação ao Íon Ag+ , indicando que as NPsAg podem apresentar um mecanismo de ação diferente. Estes achados podem auxiliar nas decisões terapêuticas com formulações contendo NPsAg ou NPsAg-GPCa associadas ou não a diferentes drogas em pacientes com cárie dentária e candidíase oral(AU)


The aim of this study was to evaluate the antimicrobial/antibiofilm activities and the cell viability of silver nanoparticles (AgNPs) obtained by a 'green' synthesis associated or not to ß-calcium glycerophosphate (CaGP) against Streptococcus mutans and Candida species (reference strains and oral clinical isolates including azole-resistant strains). The effect of these nanocompounds in combination with tyrosol (TYR), fluconazole (FLC), nystatin (NYT) and amphotericin B (AmB) also was evaluated. Furthermore, we evaluated, comparatively, the transcriptome alterations of cells of C. glabrata CBS138 after exposition to AgNPs and to silver ion (Ag+ ). Initially, AgNPs were synthesized by reducing silver nitrate with extracts of different parts (peel, leaves and seeds) of a pomegranate (Punica granatum L.) associated or not to CaGP. Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal/Bactericidal Concentrations (MFC and MBC) of the nanocomposites (AgNPs and AgNPs-CaGP) associated or not to TYR against S. mutans and C. albicans were determined by the microdilution method. And, the action of the AgNPs combined with FLC, NYT and AmB also was evaluated in planktonic condition against oral clinical isolates of Candida species. The effect of the nanocomposites associated or not to TYR on cell viability of fibroblasts (L929) and cytokines production was evaluated through MTT and ELISA assays, respectively. The number of cells undergoing filamentation was quantified in C. albicans biofilms formed in the presence of AgNPs with or without fetal bovine serum (FBS). The effect of AgNPs in inhibit the formation of biofilm (in C. albicans and C. glabrata) also was investigated through PrestoBlue assay and scanning electron microscope. Biofilms of S. mutans and Candida species (12 and 24 h) were treated with nanocomposites (AgNPs and AgNPsCaGP) associated or not to TYR for 24 h and, then, the viability of these biofilms was determined through PrestoBlue assay and colony forming units (CFUs). Moreover, a transcriptome analysis was performed using microarrays to determine which genes are up- or down-regulated as response to AgNPs (in the planktonic state and forming biofilms) and to Ag+ ion (forming biofilms). Antimicrobial solutions synthesized in this study (AgNPs and AgNPs-CaGP) presented antimicrobial activity against tested microorganisms. Furthermore, lower values of MIC were obtained when these nanocompounds were associated to TYR, FLC, NYT and AmB showing a synergistic effect. AgNPs and AgNPs-CaGP were not toxic to L929 cells, increased the stem cell factor production and did not promote significant alterations in the Interleukine-6 release. The nanocomposites associated to TYR did not present cytotoxic effect on L929 cultures, except for the higher concentration (AgNPs ­ 39.05 µg/mL + TYR ­ 1.25 mM). The incubation in the presence of the AgNPs drastically reduced the number of cells exhibiting hyphae, this effect being observed either in the presence or absence of FBS. The amount of biofilm formed by Candida species in the presence of the AgNPs was reduced by more than 50% the one formed in the absence of the nanoparticles, this reduction being further increased to more than 90% when the concentration of the AgNPs was increased. After 24 h of treatment with the nanocompounds (AgNPs and AgNPs-CaGP) in S. mutans biofilms, there was a significant reduction in the number of CFUs being similar to chlorhexidine. A reduction in the viability of C. glabrata biofilms also was observed after exposition to AgNPs (24 h). However, the nanocomposites (AgNPs and AgNPs-CaGP) associated or not to TYR were not effective against C. albicans biofilms. After exposition to AgNPs and to Ag+ ion, alterations in the transcriptome of cells of C. glabrata CBS138 were observed: in the planktonic state, genes responsible by the methionine and lysine biosynthesis are up-regulated, and genes related with the transmembrane transport are down-regulated. And, finally, the cells exposed to AgNPs responded differently in relation to the Ag+ ion, indicating that the AgNPs might present a different mechanism of action. All these results may help guide therapeutic decisions with formulation containing AgNPs or AgNPs-CaGP associated or not with different compounds in patients with dental caries and oral candidiasis(AU)


Assuntos
Prata , Fosfatos de Cálcio , Candidíase Bucal , Cárie Dentária , Nanopartículas , Streptococcus mutans , Candida albicans
19.
J. appl. oral sci ; 25(3): 324-334, May-June 2017. tab, graf
Artigo em Inglês | LILACS (Américas) | ID: biblio-893630

RESUMO

Abstract The development of opportunistic infections due to poor denture hygiene conditions justified the search for effective hygiene protocols for controlling denture biofilm. Objective This study evaluated Ricinus communis and sodium hypochlorite solutions in terms of biofilm removal ability, remission of candidiasis, antimicrobial activity, and participant satisfaction. Material and Methods It was conducted a controlled clinical trial, randomized, double-blind, and crossover. Sixty-four denture wearers with (n=24) and without candidiasis (n=40) were instructed to brush (3 times/day) and immerse their dentures (20 min/day) in different storage solutions (S1 / S2: 0.25% / 0.5% sodium hypochlorite; S3: 10% R. communis; S4: Saline).The trial period for each solution was seven days and a washout period of seven days was used before starting the use of another solution. The variables were analyzed at baseline and after each trial period. The biofilm of inner surfaces of maxillary dentures was disclosed, photographed, and total and dyed areas were measured (Image Tool software). The percentage of biofilm was calculated. Remission of candidiasis was assessed by visual scale and score were attributed. Antimicrobial activity was assessed by the DNA-Checkerboard hybridization method. Patient satisfaction was measured using a questionnaire. Results S1 (4.41±7.98%) and S2 (2.93±5.23%) were more effective then S3 (6.95±10.93%) in biofilm remotion(P<0.0001). All solutions were different from the control (11.07±11.99%). S3 was the most effective solution in remission of candidiasis (50%), followed by S1 (46%). Concerning antimicrobial action, S1/S2 were similar and resulted in the lowest microorganism mean count (P=0.04), followed by S3. No significant differences were found with patient's satisfaction. Conclusions 10% R. communis and 0.25% sodium hypochlorite were effective in biofilm removal, causing remission of candidiasis and reducing the formation of microbial colonies in denture surfaces. All solutions were approved by patients.


Assuntos
Humanos , Masculino , Feminino , Idoso , Ricinus/química , Hipoclorito de Sódio , Candidíase Bucal/tratamento farmacológico , Biofilmes/efeitos dos fármacos , Higienizadores de Dentadura , Prótese Total Superior/microbiologia , Anti-Infecciosos Locais , Propriedades de Superfície , Fatores de Tempo , Contagem de Colônia Microbiana , Modelos Logísticos , Método Duplo-Cego , Reprodutibilidade dos Testes , Análise de Variância , Resultado do Tratamento , Satisfação do Paciente
20.
Rev. bras. geriatr. gerontol. (Online) ; 20(3): 432-443, May-June 2017. ilus
Artigo em Inglês, Português | LILACS (Américas) | ID: biblio-898751

RESUMO

Abstract Objective: an integrative review of the treatment of oral candidiasis, root caries and xerostomia among the elderly population, focusing on Primary Health Care, was carried out. Method: scientific articles were collected from the MEDLINE/PUBMED database using the keywords "Geriatric dentistry" and "Oral health", crossed with corresponding descriptors, together with specific terms for the pathologies studied, and with "the clinical trial" filter activated. The abstracts of the articles were read by three researchers. Result: oral candidiasis: six randomized clinical trials and one quasi-experimental design study, on the treatment of prosthetic stomatitis by medication and/or the disinfection of dentures by different techniques, were identified; root caries: three randomized clinical trials were included, which tested the use of mouthwash with chlorhexidine solution and oral hygiene instruction associated or otherwise with other drugs; and xerostomia: two articles were analyzed using various medications, and the functional massage of the salivary glands and associated muscles. Conclusion: The results demonstrate a variety of treatment options for the studied clinical situations, although these should be adapted to the characteristics of the services and the population, as standard treatment in Primary Health Care has not been established. Strategies based on soft technologies, such as health education, seem to provide good results. The present study provides additional knowledge for health professionals in search of more resolutive and qualified dental care for the elderly in primary health care. AU


Resumo Objetivo: revisão integrativa sobre o tratamento de candidíase bucal, cárie radicular e xerostomia com foco na Atenção Primária à Saúde, na população idosa. Método: busca de artigos na base de dados MEDLINE/PUBMED sobre as alterações citadas, com os descritores "Geriatric dentistry", "Oral health", cruzados com descritores correspondentes às três patologias, ativado o filtro "Clinical trial", como também termos específicos para as situações clínicas estudadas. Foram excluídos os estudos que não possuíam o escopo da Atenção Primária ou da odontogeriatria. Resultado: candidíase bucal: foram analisados seis ensaios-clínicos randomizados e um quase-experimento sobre o tratamento da estomatite protética por medicamentos e/ou pela desinfecção das próteses por diferentes técnicas; cárie radicular: três ensaios clínicos randomizados foram incluídos, os quais testaram o uso de bochechos com solução de clorexidina e instrução de higiene bucal associada ou não a outros fármacos; e xerostomia: foram analisados dois artigos que utilizaram diversos fármacos e a massagem funcional de glândulas salivares e músculos associados. Conclusão: Os resultados demonstram variadas opções de tratamento para as situações clinicas destacadas devendo ser adequadas as características dos serviços e da população atendida, tendo em vista que não foi estabelecido um tratamento padrão a ser utilizado na Atenção Primária à Saúde. Estratégias com foco em tecnologias leves, tais como a educação em saúde, parecem prover bons resultados. Todavia, o estudo agrega conhecimento aos profissionais de saúde na busca de um atendimento odontológico cada vez mais resolutivo e qualificado para o idoso na atenção primária à saúde. AU


Assuntos
Candidíase Bucal , Saúde do Idoso , Saúde Bucal , Atenção Primária à Saúde , Cárie Radicular , Xerostomia
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