1.
Indian J Physiol Pharmacol
; 1992 Oct; 36(4): 247-50
Статья
в английский
| IMSEAR
| ID: sea-108059
Реферат
Nine new 2-(substituted acetyl) amino-5-alkyl-1,3,4-oxadiazoles were synthesised and confirmed on the basis of IR and nitrogen analysis. These were screened for spasmolytic, anti-inflammatory and their effects on blood pressure after determining ALD50. Compounds GK-4 i.e. 2-(diethylaminoacetyl)- amino-5-methyl-1,3,4-oxadiazole and GK-8 i.e. 2-(din-propylamino acetyl)-amino-5-ethyl-1,3,4-oxadiazole were found to be spasmolytic. Compound GK-6 i.e. 2-(diethylaminoacetyl)-amino-5-n-propyl-1,3,4-oxadiazole was found to be a potent hypotensive agent with the effect lasting for more than two hours.
Тема - темы
Animals , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Blood Pressure/drug effects , Body Temperature/drug effects , Cardiovascular System/drug effects , Cats , Drug Evaluation, Preclinical , Female , Guinea Pigs , Lethal Dose 50 , Male , Mice , Muscle Relaxation/drug effects , Muscle, Smooth/drug effects , Oxadiazoles/chemical synthesis , Parasympatholytics/pharmacology , Rats , Rectum/drug effects , Structure-Activity Relationship
2.
Indian Pediatr
; 1986 Jun; 23(6): 445-51
Статья
в английский
| IMSEAR
| ID: sea-14001
Тема - темы
Humans , Leg , Muscle Contraction , Muscles/physiopathology , Paralysis/physiopathology , Poliomyelitis/physiopathology
3.
Indian Pediatr
; 1986 Jun; 23(6): 439-43
Статья
в английский
| IMSEAR
| ID: sea-12612