Treatment related fluctuation in a case of Guillain Barre Syndrome after plasma exchange

A patient with Guillain-Barre syndrome, who improved after initial treatment with plasma exchange, experienced a relapse of two functional grads 16 days after the completion of treatment. Subsequent treatment with a combination of plasma exchange and intravenous immunoglobulins led to a rapid clinical improvement. The patient experienced complete recovery within 2 months of the treatment

Oligoclonal IgG and intrathecal IgG synthesis in patients with infections of the central nervous system from Kuwait

We analysed paired CSFand serum samples from 33 inpatients from Mubarak Al-Kabeer Hospital in Kuwait with well defined CNS infections for oligoclonal IgG bands using isoelectric focusing on agarose [AIEF] with immunoperoxidase staining. Of the 33 patients, 9 had oligoclonal bands in the CSF: 6 had evidence of intrathecal synthesis of IgG [bands in CSF but not in parallel serum] and 3 had evidence of systemic immune stimulation [oligoclonal bands in the CSF and in parallel serum]. Both IgG band patterns were scattered among all specific diagnoses, most notably in CNS infections with a single identifiable agent. The test was highly positive in chronic CNS infections like cryptococcal meningitis and could be the first warning to the clinician of this rare condition