Реферат
Objective To investigate the correlation of atrial arrhythmia with V1 lead P wave terminal potential (PTFV1) and left atrial diameter (LAD) in patients with obstructive sleep apnea syndrome (OSAS). Methods A total of 247 suspected OSAS patients, firstly hospitalized in Snoring Department of Gansu Provincial People's Hospital from Sep. 2017 to Apr. 2019, were included, and divided into four groups according to the apnea hypopnea index (AHI): AHI<5 as the control group (n=22), 5≤AHI<15 as the mild OSAS group (n=37), 15≤AHI<30 as the moderate OSAS group (n=46), and AHI≥30 as the severe OSAS group (n=142). Polysomnography (PSG) were collected, the incidence of atrial arrhythmia was observed by 24-h dynamic electrocardiogram, LAD was measured by echocardiography, and PTFV1 was measured by 12-lead electrocardiogram. The incidence of atrial arrhythmia in each group was compared, and the correlation between the occurrence of atrial arrhythmia and PTFV1 and LAD was analyzed. Results The incidences of atrial arrhythmia in the mild, moderate and severe group (16.2%, 23.9% and 17.6%, respectively) were significantly higher than that in the control group (0, P<0.05), but no significant difference existed among the mild, moderate and severe group. PTFV1 was positively associated with the incidence of atrial arrhythmia in patients with OSAS (r=0.394, P<0.01). LAD was positively correlated with the incidence of atrial arrhythmia in patients with OSAS (r=0.235, P<0.01). Conclusion The occurrence of atrial arrhythmia in OSAS patients is associated with the abnormal increase of PTFV1 and LAD, which indicates that the occurrence of atrial arrhythmia in OSAS patients is related to the electrical and structural remodeling of the left atrium.
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Objective: To investigate the chemical constituents from the stems of Syringa pinnatifolia. Methods: The chemical constituents were isolated and identified by chromatography on silica gel, ODS, and Sephadex LH-20 columns, as well as RP-HPLC. Their structures were elucidated on the basis of physicochemical properties and spectral analyses. Results: Eleven compounds were isolated from S. pinnatifolia and their structures were identified as secoisolariciresinol (1), (8R, 8'R, 9R)-4, 4'-dihydroxy-3, 3', 9-trimethoxy-9, 9'-epoxylignan (2), (8R, 8'R, 9S)-4, 4'-dihydroxy-3, 3', 9-trimethoxy-9, 9'-epoxylignan (3), (-)-pinoresinol (4), (8R, 8'R, 9'S)-4, 4'-dihydroxy-3, 3', 9'-trimethoxy-9, 9'-epoxylignan (5), (8R, 8'R, 9'R)-4, 4'-dihydroxy-3, 3', 9'-trimethoxy-9, 9'-epoxylignan (6), (9S)-9-O-methylcubebin (7), dibutylphthalate (8), piperphilippinin VI (9), balanophonin (10), and larixnaphthaone (11). Conclusion: Compounds 2-11 are isolated from the plant for the first time.